EKD11 Analysis
Chris Alder
08/11/2019
The Aim of the EKD11 timecourse experiment is to investigate the host’s immune response to a primary P.chabaudi AS infection transmitted through different routes; Natural transmission (Mosquito), serially blood passaged (SBP), and recently transmissited blood passage (RTMT). The timecourse looks at the acute phase of the infection, using transcriptomics data taken from days 1, 2, 3, 4 and 6.
1 Pre-requisites
Loading the required R library packages and setting the directories for the project analysis
2 Experimental setup
2.1 Loading Genome data
Importing GTF file containing genome information for Mus musculus. GRCm38 version 86
2.2 Design file
This is a file containing all the meta data we need for the data analysis. The important factors for the analysis are: sample, day, delivery, replicate and grp (group)
2.3 Importing count data and normalisation
This section will import the results of the RNA-seq pipeline and normalise the data according to library size. A count, log(counts) and TPM data frame will then we created from the normalised results.
Below is the TPM database from the experiment, calculated from RSEM.
## It looks like you are importing RSEM genes.results files, setting txIn=FALSE## reading in files with read_tsv## 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 using counts and average transcript lengths from tximport
## estimating size factors
## using 'avgTxLength' from assays(dds), correcting for library size
## estimating dispersions
## gene-wise dispersion estimates
## mean-dispersion relationship
## final dispersion estimates
## fitting model and testing
## using 'avgTxLength' from assays(dds), correcting for library size3 PCA Plot
PCA plot showing the separation of all samples within the study. The PCA is produced using top 1000 variable genes within the dataset.
I’ve made the PCA in a 3D scatter plot to try and see if there is any separation of the samples before day 3 from PC3 that doesn’t seem to appear when using just PC1 and PC2. PC3 only accounts for ~14% of the variance in the dataset, so I wasn’t expecting a large change, nonetheless I think the separation it does show is worth keeping. I’ve also added 2D plots of PC1 vs PC2, PC1 vs PC3 and PC2 vs PC3, which may be more useful.
4 Differential Gene Expression
4.1 DGE overview
The PCA’s may be indicating that, with the exception of day 1 of mosquito transmission, the groups are fairly homogeneous up to day 3. There are small clusters that form, however there seems to be one replicate in each group that bucks the trend in most cases. Doing direct group comparisons means that it’s likely to mask siginficant genes each tranmission group uses to fight the infection. If we identify what genes are differentially expressed within each transmission route throughout the time course, and then compare these gene lists, we can see what genes are shared/different between the transmission routes. This will hide some information, such as if a gene/geneset are shared between two transmission routes, but activated at different times, but this approach will narrow down our search in the first instance.
First of all we need to identify the DGE’s in each transmission route, by comparing them to the controls.
With the comparisons made and genes filtered to identify the DGE’s we can see how many genes were identified within in each group.
We can then find out the total number of genes used by each transmission group throughout the timecourse.
## [1] "MT: 2782 differntially expressed genes identified"## [1] "RTMT: 2355 differentially expressed genes identified"## [1] "SBP: 2021 differentially expressed genes identified"## [1] "Total number of differentially expressed genes identified across all groups: 3222 genes"4.2 Venn diagram
There seems to be a significant difference in the number of DGE’s between the transmission groups, which is to be expected, especially between SBP and both MT and RTMT. By the total number of unique DGE’s found across all groups, it is apparent that many of the genes identified are shared between two or more groups. We can construct a Venn diagram to see how the 2971 are divided across the transmission routes and see what is shared or unique between each route.
## Loading required package: futile.logger
The venn diagram tells us a lot of information about the transmission routes. For example it shows us that a lot of the DGE’s identified across the transmission groups are shared between them. One particular intersection that I think is of interest is the 303 genes that are shared between MT and RTMT, but not with SBP. If MT and RTMT share the same phenotype, which shows a greater level of attenuation of parasataemia, maybe the genes that drive this are within this set?
Whilst the venn diagram does give us a broad overview of the interplay of these groups and there DGE’s, it is hiding some resolution within the data. First of all, the diagram was constructed by identifying DGE’s within each transmission group but doesn’t take into account whether the gene was up or downregulated in respect to the Naive. This means that whilst a gene could be shared between two or more groups, it could upregualted in one whilst downregulated in another. Another key factor the venn diagram masks is the day the gene was first identified as differentially expressed in the groups. The earlier activation of the immune response is likely to be a key factor in the control of the infection, so a way to investigate this is required.
The issued raise in regards to the lack of information on up/down-regulated genes can be done just by separating out these genes and constructing two additional diagrams.
First of all, we need to identify seperate out the up/down-regulated DGE’s from the lists we identified
## [1] "MT: 2782 DGE identified"## [1] "MT: 1784 Upregualted genes identified"## [1] "MT: 1036 Downregualted genes identified"## [1] "RTMT: 2355 DGE genes identified"## [1] "RTMT: 1356 Upregulated genes identified"## [1] "RTMT: 999 Downregulated genes identified"## [1] "SBP: 2021 DGE genes identified"## [1] "SBP: 1178 Upregulated genes identified"## [1] "SBP: 843 Downregulated genes identified"With the groups separated into their up/down regualted genes, we can construct separate Venn diagrams for each one.
4.3 RTMT vs MT - shared genes
4.3.1 heatmap overview
With the identification of DGE’s shared between MT and RTMT, we can start to investigate further this geneset. First of all, a heatmap of these genes will be helpful in identifying any expression trends between the groups. First of all we’ll use TPM’s to construct the heatmap.
## heat.list day delivery rep
## 61 naive.r1 0 naive 1
## 62 naive.r2 0 naive 2
## 63 naive.r3 0 naive 3
## 64 naive.r4 0 naive 4
## 1 sbp.d1.r1 1 sbp 1
## 2 sbp.d1.r2 1 sbp 2
## 3 sbp.d1.r3 1 sbp 3
## 4 sbp.d1.r4 1 sbp 4
## 41 rtmt.d1.r1 1 rtmt 1
## 42 rtmt.d1.r2 1 rtmt 2
## 43 rtmt.d1.r3 1 rtmt 3
## 44 rtmt.d1.r4 1 rtmt 4
## 21 mt.d1.r1 1 mt 1
## 22 mt.d1.r2 1 mt 2
## 23 mt.d1.r3 1 mt 3
## 24 mt.d1.r4 1 mt 4
## 5 sbp.d2.r1 2 sbp 1
## 6 sbp.d2.r2 2 sbp 2
## 7 sbp.d2.r3 2 sbp 3
## 8 sbp.d2.r4 2 sbp 4
## 45 rtmt.d2.r1 2 rtmt 1
## 46 rtmt.d2.r2 2 rtmt 2
## 47 rtmt.d2.r3 2 rtmt 3
## 48 rtmt.d2.r4 2 rtmt 4
## 25 mt.d2.r1 2 mt 1
## 26 mt.d2.r2 2 mt 2
## 27 mt.d2.r3 2 mt 3
## 28 mt.d2.r4 2 mt 4
## 9 sbp.d3.r1 3 sbp 1
## 10 sbp.d3.r2 3 sbp 2
## 11 sbp.d3.r3 3 sbp 3
## 12 sbp.d3.r4 3 sbp 4
## 49 rtmt.d3.r1 3 rtmt 1
## 50 rtmt.d3.r2 3 rtmt 2
## 51 rtmt.d3.r3 3 rtmt 3
## 52 rtmt.d3.r4 3 rtmt 4
## 29 mt.d3.r1 3 mt 1
## 30 mt.d3.r2 3 mt 2
## 31 mt.d3.r3 3 mt 3
## 32 mt.d3.r4 3 mt 4
## 13 sbp.d4.r1 4 sbp 1
## 14 sbp.d4.r2 4 sbp 2
## 15 sbp.d4.r3 4 sbp 3
## 16 sbp.d4.r4 4 sbp 4
## 53 rtmt.d4.r1 4 rtmt 1
## 54 rtmt.d4.r2 4 rtmt 2
## 55 rtmt.d4.r3 4 rtmt 3
## 56 rtmt.d4.r4 4 rtmt 4
## 33 mt.d4.r1 4 mt 1
## 34 mt.d4.r2 4 mt 2
## 35 mt.d4.r3 4 mt 3
## 36 mt.d4.r4 4 mt 4
## 17 sbp.d6.r1 6 sbp 1
## 18 sbp.d6.r2 6 sbp 2
## 19 sbp.d6.r3 6 sbp 3
## 20 sbp.d6.r4 6 sbp 4
## 57 rtmt.d6.r1 6 rtmt 1
## 58 rtmt.d6.r2 6 rtmt 2
## 59 rtmt.d6.r3 6 rtmt 3
## 60 rtmt.d6.r4 6 rtmt 4
## 37 mt.d6.r1 6 mt 1
## 38 mt.d6.r2 6 mt 2
## 39 mt.d6.r3 6 mt 3
## 40 mt.d6.r4 6 mt 4
Using TPMs hides a lot of pattern information, as only a few individual genes have such a high expression that it widens the scale of the heatmap, even when using log(TPM).
Z-scores, which measures how far a samples gene expression (in SD) is from the mean across all samples may be a better solution, as it normalises the data to account relative levels of expressions for a gene, and better highlights the variation between samples.
4.4 Day 4
## sbp.d4.r1 sbp.d4.r2 sbp.d4.r3 sbp.d4.r4 mt.d4.r1 mt.d4.r2
## Cdc45 0.290595 -0.457178 0.386845 0.060966 1.42695 1.604920
## Slfn4 1.703352 -1.130757 -0.279779 0.054411 1.41159 1.557750
## Mx1 1.192093 -1.165385 -0.137339 1.575103 1.29992 1.081355
## Il12rb1 1.062228 -1.135382 0.369164 1.160633 0.75893 1.136358
## Gnb1l -0.041556 0.478331 1.715561 1.011642 0.89434 0.644762
## Lgals9 0.845075 -1.053011 0.002111 0.673427 1.24232 1.531420
## Timp1 0.892153 -1.175029 -0.070954 1.143931 1.14244 1.448956
## Tubb6 1.069000 -0.619923 -0.098152 0.717715 1.11298 0.968664
## Peg3 -0.789701 0.281130 -0.057910 -0.223164 -0.93702 -1.455695
## Syce2 0.108319 -0.349306 0.317246 0.277326 1.15952 1.391497
## Abca13 0.898460 -0.483816 -0.391663 -0.368954 0.99877 1.193767
## Ccl24 0.831707 -1.033724 0.005555 0.744877 1.26001 1.395971
## Thop1 0.364803 0.205474 0.373715 0.720452 0.92295 1.541297
## Hspb1 1.382589 -0.628458 0.432371 2.864944 -0.91716 -0.750300
## Spo11 1.544588 -1.049804 -0.389877 0.945718 0.67098 0.523781
## Srm 1.013503 -0.725811 0.638081 0.850609 1.09814 1.229638
## Atp7b 0.312944 -0.217251 0.749894 0.091584 1.10692 1.349665
## Cd163 -1.109947 0.795306 0.476639 -0.141248 -1.18887 -1.880996
## Oit3 -1.242182 0.820377 0.092339 -0.656424 -1.15377 -1.307015
## Mlkl 1.054178 -1.148228 -0.067274 0.608568 1.12065 1.470835
## Enkd1 0.720846 -0.578228 -0.006081 0.751096 1.40412 1.512406
## Gzmb 0.183588 -0.906734 -0.070192 0.469050 0.96062 1.673681
## Cd274 1.121928 -1.179835 0.105092 0.929304 0.91991 1.179472
## Dhx58 1.132065 -0.989423 0.211480 1.451034 1.44409 1.080121
## Irf1 0.997282 -1.085325 0.570774 0.938813 0.84365 0.867053
## Pdk4 -1.087421 0.344103 -0.342869 -0.058053 -1.47129 -1.057142
## Pkib 1.351911 -0.325030 0.582697 1.055003 0.71519 0.662320
## Dram1 1.104088 -1.095168 0.182509 0.692363 1.05268 1.225845
## Ppa1 0.912590 -1.014504 0.247976 0.829031 1.15320 1.357108
## Nefh 1.168562 -0.868989 0.254636 0.479980 0.71108 1.527879
## Upp1 1.140272 -0.767930 -0.352334 0.303931 1.17134 1.467071
## Igfbp3 -0.896697 0.680872 -0.214557 -0.400615 -1.36989 -1.404092
## Nampt 0.985758 -1.071585 0.160113 0.817234 1.12575 1.295200
## Cmpk2 0.729382 -1.007336 0.033653 0.779614 1.36763 1.438877
## Serpina3n 1.011267 -1.332723 0.605127 0.732327 0.82057 0.234580
## Wars 1.153438 -1.233468 0.164411 1.048479 0.70608 0.991807
## Hsp90aa1 0.438838 -0.638406 0.746258 0.847996 0.97529 1.229654
## Thbs4 1.190402 -1.415414 0.621227 1.192599 0.20812 0.293231
## Plau 1.556374 -0.958332 -0.607275 0.290820 1.11634 1.648374
## Pnp 0.550221 -0.616947 0.310654 0.450135 1.33056 1.517987
## Gdf10 -0.872402 0.517573 0.003971 -0.089109 -1.61617 -1.272503
## Scara5 -0.190289 0.626734 0.064226 -0.300657 -1.09564 -2.096646
## Acod1 1.181495 -1.170482 -0.238035 0.678336 1.14662 1.527403
## Has2 0.913107 -1.224948 0.915842 0.994420 0.80314 1.051057
## Vdr 1.488454 -1.036752 -0.163986 1.069555 0.82540 0.818812
## Ly6c2 0.574323 -0.605606 -0.236691 0.756393 1.33931 1.613156
## Ly6i 0.766825 -0.802923 -0.216967 0.590750 1.61952 1.453325
## Parp9 0.975933 -1.175965 0.186061 1.082054 1.18372 1.239411
## Cela1 2.732614 -0.339340 1.106106 -0.839515 0.25630 -0.378102
## Cdkn1a 0.981534 -1.089294 0.385626 0.909994 1.00818 0.779793
## Fam132a 0.281846 -0.549356 0.732392 0.275672 0.83165 1.514520
## Ms4a6d 1.074184 -1.038438 -0.253827 0.136132 1.51554 1.525021
## Il33 0.727058 -1.538629 0.632636 0.695568 0.84350 0.955014
## Ifitm3 1.016412 -1.088033 0.105500 0.990597 1.29050 1.471190
## Irf7 1.059827 -1.145092 0.044739 1.252361 1.25574 1.326743
## Homer2 0.224341 -0.107971 0.808504 1.293190 -0.99013 2.284902
## Hk3 1.127935 -0.872360 -0.325371 0.741249 0.95288 1.337774
## Il1rl1 0.136716 -0.143828 0.499581 0.431034 0.94762 1.434488
## Stat1 1.133342 -1.331103 0.619904 1.141548 0.77714 0.684676
## Steap3 0.211685 -0.238498 1.101176 0.247128 0.97638 1.247939
## Mnda 0.886353 -1.000911 0.083907 0.889355 1.25705 1.232268
## Xcl1 0.467035 -1.171638 0.199796 1.503986 1.05818 1.014942
## Atf3 0.670873 -0.707898 -0.134528 0.830245 1.05783 1.316247
## Mcm10 0.112232 -0.595281 0.377333 0.276836 1.19734 1.527920
## Sapcd2 0.145292 0.055061 0.432854 -0.144001 1.36124 1.530406
## Il1rn 1.239478 -1.059147 0.078629 0.747930 1.29698 1.414302
## Dut 0.149865 -0.651150 0.383243 0.243420 1.28083 1.692064
## Hdc 1.805776 0.009917 0.386176 -0.088467 1.35957 0.984185
## Zbp1 1.003235 -1.124500 0.327676 0.946271 1.08861 1.115832
## Car1 0.099317 0.133330 0.746004 0.148102 1.15631 1.401773
## Procr 1.255925 -1.063133 -0.076071 0.816746 0.81695 1.536866
## Il21 0.347781 -0.111505 -0.592735 0.162347 1.20785 1.489435
## Ccdc109b 0.665107 0.148333 0.294192 0.535987 0.81800 0.474666
## Ifi44 1.132997 -1.381491 -0.026858 0.999129 1.22803 1.314496
## Gbp3 0.812588 -1.201132 0.068073 0.879069 1.02476 1.353863
## Gbp2 0.993796 -1.177887 0.337606 0.966980 0.96656 1.121703
## Tnc 1.080541 -0.828081 0.053570 1.483621 -0.03159 0.987324
## Smpdl3b 0.483179 -0.890244 -0.404693 0.676681 1.51393 1.263278
## Htra3 -1.480096 0.470597 -0.042283 0.058704 -1.33432 -1.670023
## Gbp9 1.163596 -1.133796 0.465062 1.255189 0.89506 0.872179
## Cxcl9 1.053720 -0.945375 0.506726 1.016986 0.89947 1.087962
## Oasl2 0.998332 -1.195324 -0.023732 0.977317 1.23151 1.320371
## Hsph1 0.531061 -0.377984 0.946192 1.091078 0.37917 0.383890
## Asns 0.487053 -0.073036 0.694714 0.208448 1.11489 1.319984
## Usp18 1.139916 -0.864288 0.153537 1.506089 1.39331 1.251514
## Bcl2l14 0.915421 -1.140906 0.210147 1.369291 0.70080 1.018200
## Ift122 -0.944891 -0.888203 -0.501329 -0.415125 0.01414 -0.006579
## Tmem159 -0.508367 -0.295823 -0.518822 -0.377512 -0.45028 -0.379907
## Gpt2 1.416272 -0.897057 0.306809 0.981705 0.36887 0.524872
## Mt2 0.892893 -0.348047 0.266479 0.448577 1.18401 1.342168
## Mt1 0.636675 -0.195293 0.878876 0.427865 0.74631 1.341028
## Ctrl 2.750017 -0.875962 1.166097 -0.269651 0.36990 -0.431347
## Psmb10 1.026874 -0.979829 0.175241 1.080194 1.04707 1.353790
## Chek1 0.334575 -0.385090 0.366675 0.235559 1.40828 1.839219
## Stra6 1.388981 -0.899327 0.425774 1.037646 0.26318 -0.044064
## Ptgs2 0.776065 -1.057363 -0.130562 0.517665 1.09303 1.813667
## Oas3 0.871875 -0.970831 -0.001516 0.971323 1.24113 1.380963
## Oas2 1.090540 -1.062892 0.025462 1.358822 1.33479 1.207650
## Rtp4 1.017170 -1.169042 0.002673 1.100015 1.27483 1.311528
## Apol6 1.004529 -1.349732 0.286550 1.133676 0.71920 1.197528
## Recql4 0.411190 -0.382863 0.678125 0.463907 1.29424 1.509146
## Pla2g4c -0.347213 -0.332430 0.747876 0.070173 1.13072 1.392876
## Tmem132c -0.785695 -0.257531 -0.533633 -0.070492 -1.68837 -0.638747
## Lif 1.774658 -0.862010 0.273900 1.285696 1.17669 0.932126
## Parp14 1.031125 -1.364133 0.205950 1.231243 1.07410 0.925550
## Gbp8 0.819051 -1.152177 0.445368 1.108987 0.64030 1.002123
## Ifit1 1.056044 -1.123221 0.068788 1.129483 1.30848 1.437677
## Cxcl10 0.900994 -1.193210 0.343507 0.932790 0.86244 1.031460
## Ubd 0.836317 -1.129633 0.206517 0.642047 0.91771 1.238914
## Ccl2 1.495576 -1.167034 0.176797 0.827278 0.82980 1.480981
## Isg15 0.928546 -0.871457 -0.027270 0.744505 1.46716 1.552080
## Npy1r -0.568756 0.946846 -0.414262 -0.533281 -1.11304 -1.518954
## Tmem255a -0.807149 0.327191 -0.071823 -0.428554 -0.83909 -1.632141
## Tap1 1.099831 -1.031130 0.284708 1.040993 0.89021 0.958606
## Dtl 0.120842 -0.175633 0.431137 0.114173 1.25523 1.484969
## Nme1 0.839695 -0.530162 0.087741 0.799370 0.90031 1.377395
## Fam13a -0.734717 0.318186 -0.407615 -0.245607 -0.93582 -1.669501
## Tgm2 1.582761 -0.831931 0.002498 0.721438 0.62253 1.214604
## Rmi2 1.210281 -0.963810 0.444347 1.037008 0.96806 1.364014
## Socs1 0.959920 -1.142510 0.524817 1.201400 0.82028 0.952261
## Fanci 0.101394 -0.059405 0.623711 0.297226 1.33428 1.577315
## Batf2 0.984716 -1.143042 0.143331 0.910247 0.94469 1.076961
## Stat2 1.337102 -1.202606 0.261623 1.353053 0.98519 0.846965
## Gbp7 0.850128 -1.138314 0.342306 0.924917 0.96141 1.158366
## Gbp2b 0.306552 -1.027049 -0.321036 0.789550 1.17702 1.606500
## Btnl9 -1.165947 0.895293 -0.445238 -0.336643 -1.25881 -1.581717
## Olfr56 1.018001 -1.114526 -0.134554 0.600895 0.98288 1.585679
## Il7 -0.794640 0.906737 -0.591171 -0.575124 -1.46748 -0.944972
## Xaf1 1.074791 -1.048458 0.056383 1.093516 1.36613 1.228786
## Serpina3g 0.830663 -1.189721 0.215231 0.777673 0.94263 1.140136
## Prelp -0.705526 0.497004 -0.401505 -0.130563 -1.31999 -1.545966
## Abca9 -1.336901 0.782809 0.164748 -0.129838 -1.33285 -1.943340
## Oasl1 1.057307 -0.896736 0.391074 1.259239 1.21285 1.315269
## Abca8a -1.431756 0.492356 0.211683 -0.544463 -1.70988 -0.499556
## Bag2 -0.339543 0.281124 0.969122 0.540000 1.17247 0.630575
## Cilp -1.054703 0.545744 -0.918723 -0.879425 -0.93546 -1.552746
## Maff 0.794339 -0.480629 0.246418 1.552601 0.56564 1.170680
## Mmp3 1.181730 -0.739122 0.169053 -0.199196 1.10926 1.855141
## Phf11a 0.956543 -1.131772 -0.074513 0.992647 1.32360 1.230007
## Gvin1 1.000988 -1.086952 0.465908 0.992674 0.92467 0.948827
## Ifit2 0.897512 -0.981553 0.030689 1.223762 1.25119 1.404630
## Fam26f 0.867805 -1.165909 0.186357 0.944657 0.88510 1.312745
## Olfml2a -0.952413 0.539789 -0.352976 -0.472728 -1.03742 -1.513198
## Bst2 1.286247 -1.124898 0.138624 1.288011 1.02082 1.178876
## Irgm1 0.913897 -1.124964 0.500989 0.915828 0.97178 1.114764
## Kcne4 0.958364 -1.073103 0.378552 0.547735 0.84160 1.218424
## Gm12185 0.998053 -1.667083 0.066933 1.044483 0.93344 1.065786
## Zg16 2.777124 -0.613659 1.182488 -0.699110 0.31754 -0.463654
## Apol10b 1.037762 -0.816034 -0.113547 1.295965 0.76460 1.015462
## Mmp13 1.324741 -1.014366 -0.271173 0.626630 1.08155 1.431118
## Kcnj16 -1.032729 0.885013 0.217690 -0.518548 -1.26324 -1.397130
## Fpr2 1.373182 -0.560716 -0.694596 0.193298 1.28403 1.554903
## Epha3 -2.057914 -0.156762 0.144286 -0.334476 -1.05666 -0.732480
## Oas1a 0.990761 -1.062589 0.142968 1.065174 1.40385 1.266798
## Socs3 0.852326 -0.798917 0.289839 0.824829 0.94066 1.199542
## Slamf8 1.004582 -1.239395 -0.078989 0.795167 1.04247 1.378707
## Iigp1 0.932331 -1.217259 0.307809 0.829244 0.95199 1.118475
## Ifi205 0.790396 -0.964714 -0.255414 1.021780 1.17295 1.371698
## Ifng 0.578705 -1.040125 0.182143 0.653956 0.97267 1.251894
## Cebpb 1.327610 0.051947 0.579625 1.190621 0.80881 0.707842
## Gm5431 1.047000 -1.396070 0.136661 1.437370 1.37980 0.711924
## Fcgr4 0.623282 -1.011918 -0.225667 0.688847 1.04555 1.430416
## Pla2g16 0.787279 -0.959697 0.242036 0.713664 1.17702 1.323712
## Obscn -0.674877 1.273513 -0.220622 -0.774609 -0.84136 -1.190691
## Serpina10 1.013912 -1.401951 0.630447 0.742406 0.53105 0.045020
## Tubb3 0.727464 -1.082102 -0.222711 0.482824 1.24596 1.676644
## Ifit3b 1.450077 -1.082114 0.067267 1.685603 1.13077 0.850902
## Serpina3f 0.917294 -1.252431 0.310579 0.867154 0.85791 1.053144
## Cenpm 0.200657 -0.358941 0.279341 0.333327 1.54119 1.643672
## Phf11d 1.378483 -0.947565 -0.319705 1.253972 1.12338 1.299103
## Gm4841 0.815275 -1.295282 -0.040600 0.422945 1.14127 1.319231
## Irgm2 0.961745 -1.308185 0.504834 1.057152 0.80754 0.883197
## Rnf213 1.298885 -1.202722 0.231809 1.375939 1.18118 1.018519
## Cited4 0.193820 -0.273085 1.167805 0.691120 1.18527 1.364404
## Ccl19 1.286585 -0.999250 0.913894 1.505859 0.59050 0.245175
## Ifi204 0.765517 -1.018608 -0.214208 0.991798 1.09421 1.405071
## Pydc4 1.303457 -1.069764 0.473443 1.403086 1.08289 0.785352
## Gm4951 0.814885 -1.234608 0.013269 0.807012 0.87687 1.243475
## Nlrc5 1.154553 -1.352565 0.416473 1.072079 0.80291 0.748404
## Amy2a5 2.178780 -0.487146 1.048410 -0.769218 0.08444 -0.454605
## Ifit3 1.236307 -1.372506 0.060631 1.472691 1.16271 1.008174
## Grem1 -1.073609 0.900696 -1.276232 -0.872745 -0.52558 -0.816067
## Ly6a 0.889524 -0.934586 -0.028186 0.716153 1.18536 1.513377
## Aunip 0.188541 -0.481171 0.364887 0.209226 1.29080 1.432714
## Gm4070 0.913349 -1.136502 0.420128 0.945919 0.89719 0.916795
## Igtp 0.922185 -1.134176 0.432706 0.938780 0.94434 1.061941
## Ifi47 0.907409 -1.056951 0.371256 0.892864 1.02451 1.234332
## Tgtp2 0.912225 -1.215213 0.619528 1.046939 0.85070 1.005039
## Tgtp1 0.903381 -1.178443 0.464837 0.960740 0.99680 1.086501
## Ifit1bl1 1.135052 -0.989998 0.257895 1.304446 1.18256 0.990538
## Gm43302 1.015331 -1.778251 0.449231 0.915620 0.82423 0.884713
## Gbp4 1.042340 -1.080395 0.377900 1.007806 0.85607 1.006584
## Gm12216 1.355298 -1.297423 0.114024 1.359503 0.43683 0.754284
## Ctsf -1.656819 0.574440 -0.352806 -1.497374 -0.57097 -0.552389
## Cfb 1.133543 -0.938200 -0.047825 0.862333 1.08977 1.335928
## Hspa1b 0.613521 -0.789308 0.909800 1.435516 0.27064 0.288787
## F830016B08Rik 1.008702 -1.358823 0.103914 0.570551 0.74234 1.212338
## Gm17334 1.107068 -1.353709 0.674703 1.071578 0.92026 0.851966
## Gm20390 0.681780 -0.564323 0.734306 0.775108 1.42879 1.484467
## Phf11b 1.086513 -0.870121 0.011116 1.071200 1.13988 1.404234
## Hspa1a 0.483626 -0.908298 0.778535 1.276639 -0.03809 0.328362
## Gal3st2 -2.019820 -0.237684 -0.841282 0.026854 -1.20516 -0.290090
## Hist1h3g -0.019408 0.107487 0.660848 0.019219 1.10875 1.459748
## Gbp6 0.973826 -1.139211 0.406584 0.967733 0.92273 1.022120
## Gbp10 1.019705 -1.168679 0.254807 1.039087 0.93141 0.992719
## Gbp5 0.964990 -1.141439 0.268460 0.914454 0.90439 1.079331
## Chaf1a 0.300665 -0.769839 0.392644 0.303976 1.32043 1.472475
## Atp1a2 -0.744885 0.609242 -0.720894 0.675226 -1.25501 -1.570728
## Ehf -0.364048 1.071270 0.501778 -0.329903 -1.42849 -1.643722
## Mybpc1 -0.855942 1.312374 -0.448585 -0.148160 -1.07241 -1.079680
## Fos 0.739962 -0.890952 -0.628006 1.380393 1.03002 0.400733
## Trip13 0.131587 -1.028545 -0.060589 0.064809 1.40524 1.884417
## Dhfr -0.103561 -0.673959 0.215558 0.351583 1.44217 1.687428
## Shcbp1 -0.014743 -0.333766 0.106546 -0.513049 1.30047 1.667179
## Spata24 0.029369 -0.341242 0.647301 0.185568 1.49598 1.679841
## Lox 0.514960 0.321303 -0.400533 0.442674 -1.22769 -1.303689
## Msr1 0.693168 -1.190085 -0.348745 0.186397 1.21270 1.384122
## Il2ra 0.850178 -1.356766 -0.087927 0.736202 1.09820 1.396396
## Rad51 0.025241 -0.339290 0.030304 0.220446 1.42345 1.454670
## Slc7a11 0.763072 -1.386573 0.487031 0.548674 0.89494 0.568403
## Extl2 -0.572074 -0.489104 -0.594059 -0.375370 1.84857 0.203919
## Auts2 -0.970143 0.248668 0.333045 0.455780 0.20929 -1.195016
## Klra2 0.663488 -1.063303 -0.537462 0.862964 1.35237 1.113831
## Bcat1 0.309175 -0.894054 -0.307223 0.329401 0.96415 1.277056
## Pcsk6 -0.626145 1.228699 0.332402 0.018519 -1.43936 -1.509296
## Cd209a -0.749690 0.562797 0.516410 0.427677 -1.26004 -1.597131
## Prrg3 -0.813834 0.379959 0.742056 -0.914693 -0.49766 0.446468
## Lrr1 0.040100 -1.009574 0.301811 -0.462033 1.18295 1.680520
## Fxyd1 -0.270361 0.310306 -0.260188 -0.060797 -1.08370 -1.226437
## Eme1 0.070795 -0.506982 -0.427362 0.317327 1.15810 1.793418
## C130074G19Rik 0.005483 0.654095 -0.174941 -0.001217 -1.37641 -1.658014
## Tnip3 -0.180243 -0.721296 -0.854107 -0.531052 0.79585 1.796536
## Mab21l3 0.681140 -0.901954 -0.268002 1.289212 0.21314 0.326893
## Ifitm10 -0.434299 1.817913 -0.623677 -0.172487 -0.87468 -1.783592
## AI464131 -0.688685 0.179817 -0.071635 0.169020 -0.70399 -1.794565
## Sned1 -0.923862 0.795270 -0.016801 0.324773 -1.65151 -1.223326
## Bex4 0.113338 -0.057596 0.940072 -0.208013 1.03915 0.956921
## Vstm4 -0.828553 0.531898 0.494217 0.019170 -1.20709 -1.720740
## Rnd1 0.537828 -0.564769 -0.247837 -0.013243 0.91532 0.783784
## Sphk1 0.193248 -0.632061 0.515193 0.042480 1.12605 1.582933
## Efcc1 -0.130631 0.266640 -0.999420 0.021483 -1.83781 -1.282677
## Lilr4b 0.842889 -0.982785 -0.657454 -0.049063 1.02991 1.481203
## Gm21887 1.121315 0.345252 1.237683 1.327318 -0.06813 0.100647
## mt.d4.r3 mt.d4.r4 rtmt.d4.r1 rtmt.d4.r2 rtmt.d4.r3
## Cdc45 -0.310313 1.33445 -1.15709 5.579e-01 0.575281
## Slfn4 -0.886211 1.00922 -0.21877 -5.278e-01 -0.001034
## Mx1 -1.020438 0.50629 -0.98726 3.432e-01 0.654637
## Il12rb1 -1.181724 1.15462 -1.06682 3.788e-01 0.610855
## Gnb1l -1.008975 1.28030 -0.39508 -4.732e-01 -0.109102
## Lgals9 -0.794993 1.32157 -0.99404 6.317e-01 0.578267
## Timp1 -0.807550 1.24130 -0.55812 3.030e-01 0.845385
## Tubb6 -0.779705 1.56672 -1.16596 5.671e-01 0.729532
## Peg3 0.346132 -0.22342 0.77429 -1.665e+00 -0.628752
## Syce2 -0.058199 1.24815 -1.10912 8.385e-01 0.843710
## Abca13 0.042460 2.03534 0.75185 -2.937e-01 0.012002
## Ccl24 -1.274910 1.61768 -0.81576 -1.218e-01 0.594508
## Thop1 -0.445993 1.62644 -0.71215 5.752e-01 0.040448
## Hspb1 -1.045865 -0.62058 -0.43633 -2.841e-01 -0.291211
## Spo11 0.445645 0.45364 -0.77250 1.003e+00 0.797312
## Srm -0.753434 1.30370 -1.06393 2.101e-01 0.606951
## Atp7b 0.409782 1.18841 -1.27255 8.320e-01 0.382492
## Cd163 0.730019 -1.31639 0.48783 -5.025e-01 -0.279315
## Oit3 1.242761 -0.97364 0.63985 -1.024e+00 -0.457304
## Mlkl -0.830465 1.67658 -0.89967 1.288e-02 0.454472
## Enkd1 -0.453443 1.46921 -1.00159 -7.343e-01 0.584285
## Gzmb -1.052568 2.33920 -0.79315 -3.430e-02 0.239260
## Cd274 -1.012018 1.24830 -0.81090 4.174e-01 0.667570
## Dhx58 -0.951706 0.71670 -1.16609 2.683e-01 0.306345
## Irf1 -0.823543 1.04294 -0.82359 5.511e-01 0.902654
## Pdk4 1.316168 -1.31375 0.62164 -8.678e-01 -0.422894
## Pkib -1.271616 0.99873 -0.83024 4.194e-01 0.886897
## Dram1 -0.924243 1.48492 -0.59305 1.947e-01 0.661235
## Ppa1 -0.730950 1.18748 -1.01527 2.145e-01 0.852959
## Nefh -0.703698 1.71025 -0.69051 -7.127e-05 0.637813
## Upp1 -0.937719 1.87171 -0.48427 -5.072e-02 0.476065
## Igfbp3 1.053224 -1.42734 0.70590 -5.625e-01 -0.451546
## Nampt -0.950558 1.28558 -0.88519 3.383e-01 0.735376
## Cmpk2 -0.536109 0.78862 -1.06877 8.310e-01 0.645585
## Serpina3n -0.310043 0.41551 -0.23049 7.463e-01 1.222651
## Wars -1.064358 1.15346 -0.82411 4.138e-01 0.900180
## Hsp90aa1 0.033552 1.32931 -1.73224 -3.323e-02 0.662864
## Thbs4 0.044137 0.57751 -0.47842 7.919e-01 0.625431
## Plau -0.769812 1.62642 -0.76384 2.308e-01 0.127771
## Pnp -0.370907 1.26987 -1.12548 6.847e-01 0.479218
## Gdf10 1.015301 -1.53353 0.84636 -7.541e-01 -0.440022
## Scara5 0.400445 -1.17072 0.82114 -1.687e-02 -1.025346
## Acod1 -0.590357 1.54316 -1.06905 2.185e-01 0.487029
## Has2 -0.610477 1.07625 -1.06235 6.754e-01 0.543603
## Vdr -0.232632 1.50163 -0.73483 8.743e-02 0.449741
## Ly6c2 -0.773501 1.72777 -0.72194 -7.077e-02 0.478594
## Ly6i -1.192581 1.42946 -0.68550 -1.716e-01 0.554884
## Parp9 -0.828880 0.92435 -0.84754 5.255e-01 0.684355
## Cela1 -0.285088 -0.50059 1.20263 -3.092e-02 0.226227
## Cdkn1a -0.692249 1.90394 -0.67637 3.053e-01 0.438114
## Fam132a 0.305220 0.98894 -0.94519 1.243e+00 0.438224
## Ms4a6d -0.820160 1.75877 -0.88332 -2.111e-01 0.394160
## Il33 0.105636 0.63137 -0.57070 6.714e-01 1.085088
## Ifitm3 -1.101613 1.00590 -1.02295 1.547e-01 0.517000
## Irf7 -0.939432 1.10328 -0.74887 3.925e-01 0.320814
## Homer2 0.168147 -0.34799 -0.25148 8.634e-01 0.047227
## Hk3 -1.094223 1.48203 -0.66618 3.629e-01 0.496527
## Il1rl1 0.357032 1.29886 -1.33036 9.423e-01 0.310054
## Stat1 -0.805112 0.69315 -0.79048 5.989e-01 0.850025
## Steap3 0.411938 0.98586 -1.12532 9.644e-01 0.365527
## Mnda -1.012634 1.36777 -0.75733 2.751e-01 0.552248
## Xcl1 -0.924974 1.07793 -0.64307 3.447e-01 0.809163
## Atf3 -0.705748 1.66356 -0.52063 1.189e-01 0.780051
## Mcm10 0.181950 1.40425 -1.27576 6.974e-01 0.611185
## Sapcd2 -0.213268 1.81356 -0.50012 -4.726e-01 0.595930
## Il1rn -0.783610 1.57191 -0.83072 1.086e-01 0.109658
## Dut -0.177034 1.53238 -1.11646 6.816e-01 0.455594
## Hdc -0.980179 1.08510 0.37293 -7.364e-01 0.553242
## Zbp1 -0.831118 1.02377 -0.77614 4.782e-01 0.711561
## Car1 0.377499 0.56665 -1.30196 9.891e-01 0.451511
## Procr -0.941462 1.73238 -0.93128 -4.201e-02 0.324809
## Il21 -0.323217 2.14288 -0.61591 -3.609e-01 0.680726
## Ccdc109b -1.593039 2.06912 -1.16586 4.413e-01 0.798005
## Ifi44 -0.864554 1.08849 -0.53135 -1.224e-01 0.681941
## Gbp3 -0.984722 1.34242 -0.93939 2.251e-01 0.704083
## Gbp2 -0.869098 1.01728 -0.86085 5.565e-01 0.819337
## Tnc -1.855952 1.48195 -0.06680 1.511e-01 -0.294146
## Smpdl3b -0.335938 1.60408 -0.39843 1.685e-01 0.234765
## Htra3 0.750375 -0.47449 0.81832 -7.755e-01 -0.770862
## Gbp9 -1.058040 0.50028 -0.78874 5.865e-01 0.918671
## Cxcl9 -0.953420 1.01123 -0.83402 4.837e-01 0.776425
## Oasl2 -1.045235 1.14491 -0.71788 4.294e-01 0.488824
## Hsph1 0.612808 0.89730 -1.31289 -8.189e-01 0.981220
## Asns -0.004198 0.70026 -1.17743 1.106e+00 0.720859
## Usp18 -0.995894 0.52719 -0.95683 1.660e-01 0.523158
## Bcl2l14 -1.223246 0.98889 -0.93078 8.014e-01 0.864689
## Ift122 -0.889688 -0.41223 -0.08846 -8.245e-01 -0.259069
## Tmem159 0.093612 -0.14953 0.04468 -1.646e-01 -0.558897
## Gpt2 -0.473849 2.02750 -1.01325 -1.934e-01 -0.362581
## Mt2 -0.288724 1.34411 -1.23175 6.571e-01 0.495258
## Mt1 -0.012761 1.38858 -0.63210 6.354e-01 0.277525
## Ctrl -0.658739 -0.57350 1.21071 -6.837e-01 0.311691
## Psmb10 -0.757977 1.12663 -0.85191 3.677e-01 0.553877
## Chek1 -0.673636 1.08430 -0.97760 6.786e-01 0.164845
## Stra6 -0.147844 0.39770 -0.54577 5.550e-01 1.540750
## Ptgs2 -0.911831 1.85886 -0.84814 1.685e-01 0.241010
## Oas3 -0.578230 1.05614 -0.97332 6.385e-01 0.427818
## Oas2 -0.887888 0.99983 -0.96661 -9.448e-02 0.447169
## Rtp4 -1.246178 0.77429 -0.79808 4.010e-01 0.630642
## Apol6 -1.018900 1.30028 -0.97244 4.166e-01 0.663266
## Recql4 0.025673 1.11144 -1.31963 7.620e-01 0.474506
## Pla2g4c -0.007859 1.19505 -1.46692 1.322e+00 0.283299
## Tmem132c 1.363899 -1.56343 0.81085 5.905e-01 -0.745409
## Lif -0.909203 0.65491 -0.79398 -1.727e-01 0.514548
## Parp14 -0.954581 0.88621 -0.81028 3.805e-01 0.786591
## Gbp8 -0.981757 1.44380 -0.92791 2.125e-01 0.841298
## Ifit1 -1.094992 0.82679 -1.01688 4.576e-01 0.505875
## Cxcl10 -0.866544 1.32519 -0.97541 4.586e-01 0.841171
## Ubd -0.869986 1.51230 -0.88682 3.505e-01 0.744957
## Ccl2 -0.754913 1.55068 -0.93215 3.435e-02 0.283653
## Isg15 -0.962480 0.94825 -1.07605 5.283e-01 0.482945
## Npy1r 0.856765 -1.03243 0.76388 -1.345e+00 -0.456215
## Tmem255a 0.403720 -2.03040 0.77634 -3.645e-01 -0.255565
## Tap1 -1.042218 1.11291 -0.41769 4.197e-01 0.636701
## Dtl 0.049414 1.05751 -1.29251 9.428e-01 0.741391
## Nme1 -0.210952 1.56903 -0.92397 -3.549e-02 0.438094
## Fam13a 0.949765 -1.60113 0.57566 -5.649e-01 -0.554482
## Tgm2 -0.898778 1.58519 -0.86010 2.497e-01 0.497070
## Rmi2 -1.035042 1.16238 -0.71838 1.982e-01 0.534950
## Socs1 -0.887805 1.18343 -0.93114 3.351e-01 0.802524
## Fanci -0.345428 1.13240 -1.01187 1.019e+00 0.544495
## Batf2 -1.189306 1.66743 -0.63763 -1.573e-01 0.549955
## Stat2 -0.992289 0.79403 -0.78105 3.176e-01 0.657312
## Gbp7 -0.853470 1.18854 -0.94157 5.504e-01 0.818673
## Gbp2b -0.765272 1.83051 -0.75179 -6.238e-02 0.469066
## Btnl9 0.820649 -1.34924 0.91301 2.154e-01 -0.690834
## Olfr56 -0.891618 1.35965 -0.86090 7.018e-01 0.613674
## Il7 0.840197 -1.28984 1.07927 -6.064e-01 -0.390470
## Xaf1 -0.865759 0.58455 -1.09198 6.114e-01 0.599121
## Serpina3g -0.879204 1.35672 -0.59810 4.281e-01 0.784919
## Prelp 0.802561 -1.27807 0.96084 -4.989e-01 -0.924232
## Abca9 0.803707 -1.22834 0.78374 -3.316e-01 -0.306130
## Oasl1 -0.851660 0.63817 -1.56568 3.186e-01 0.402184
## Abca8a 0.352928 -1.45348 1.32224 1.071e-01 -0.345263
## Bag2 0.220944 1.05200 -1.93241 5.976e-01 0.839645
## Cilp 1.336798 -1.32341 0.90760 -1.003e-01 -0.305794
## Maff -0.677340 0.96964 -0.46923 1.081e-01 0.849017
## Mmp3 -0.648826 1.66029 -0.59866 4.755e-01 0.084453
## Phf11a -1.830497 1.15931 -0.29327 2.396e-01 0.569664
## Gvin1 -0.955279 0.89989 -0.69813 5.001e-01 0.885885
## Ifit2 -1.204218 1.00655 -1.13848 3.164e-01 0.509993
## Fam26f -0.938394 1.53444 -0.76138 1.695e-01 0.643833
## Olfml2a 0.817982 -1.20734 1.07106 2.031e-01 -1.215609
## Bst2 -0.900294 0.95863 -0.87153 7.102e-02 0.620794
## Irgm1 -0.892476 1.08008 -0.81518 5.050e-01 0.811026
## Kcne4 -0.337988 1.46625 -0.50678 1.604e-01 0.732191
## Gm12185 -0.549681 1.13493 -0.71248 5.456e-01 0.687659
## Zg16 -0.391825 -0.52311 1.15738 -3.676e-01 0.147305
## Apol10b -1.515528 1.16767 -0.85339 4.337e-01 0.514894
## Mmp13 -0.880654 1.59238 -0.96483 4.983e-02 0.523700
## Kcnj16 0.863524 -1.63410 0.89127 -3.040e-01 -0.455971
## Fpr2 -1.306588 1.74401 -0.64784 5.204e-02 0.167446
## Epha3 1.027730 -0.50163 0.38404 -9.509e-01 -0.614626
## Oas1a -0.832728 1.14260 -0.79335 6.539e-02 0.535767
## Socs3 -0.904271 1.78769 -0.44327 3.435e-02 0.504529
## Slamf8 -1.203773 1.52135 -0.73618 4.839e-02 0.621533
## Iigp1 -0.906253 1.13339 -0.72499 4.750e-01 0.830811
## Ifi205 -1.107910 1.46718 -0.79222 2.290e-02 0.571987
## Ifng -0.836756 1.96762 -0.50844 1.676e-01 0.404777
## Cebpb -0.672271 1.43212 -0.56301 -7.682e-01 0.215301
## Gm5431 -1.133689 0.93739 -1.11368 -2.948e-02 0.631682
## Fcgr4 -0.806943 1.36318 -0.80864 4.307e-01 0.758604
## Pla2g16 -0.974407 1.18193 -0.78044 5.912e-01 0.773061
## Obscn 0.072025 -0.88914 0.95936 -2.589e-01 -1.358610
## Serpina10 -0.351936 0.54319 -0.96834 1.098e+00 1.227528
## Tubb3 -0.975045 1.77056 -0.71086 8.528e-02 0.644707
## Ifit3b -1.349914 0.24718 -1.28444 4.602e-01 0.231869
## Serpina3f -0.773189 1.25229 -0.73758 4.437e-01 0.803032
## Cenpm -0.459872 1.28051 -0.85345 8.435e-01 0.143869
## Phf11d -0.845480 1.18415 -0.74702 -1.174e-01 0.231848
## Gm4841 -0.681395 1.53650 -0.68724 9.993e-02 0.592233
## Irgm2 -0.889494 0.92105 -0.79721 5.050e-01 0.956932
## Rnf213 -0.900257 0.63563 -1.03198 3.756e-01 0.545998
## Cited4 0.185186 0.13768 -1.33660 7.802e-01 0.597270
## Ccl19 -0.323624 -0.35228 -0.57249 3.249e-01 1.052737
## Ifi204 -0.982574 1.40355 -0.63603 8.409e-02 0.584826
## Pydc4 -1.061275 0.21332 -0.99605 5.825e-01 0.678454
## Gm4951 -0.973809 1.43437 -0.71167 2.044e-01 0.787029
## Nlrc5 -0.848777 0.59236 -0.51083 5.697e-01 0.937017
## Amy2a5 0.324230 -0.90723 1.63292 -9.072e-01 1.304377
## Ifit3 -1.199485 0.69616 -0.97489 4.133e-01 0.487626
## Grem1 1.594544 -0.95475 0.97297 -1.082e+00 -0.437600
## Ly6a -1.032006 1.50690 -0.63478 7.940e-05 0.530562
## Aunip -0.189519 1.41978 -1.09190 8.956e-01 0.734317
## Gm4070 -0.878025 0.98788 -0.54753 5.350e-01 0.917653
## Igtp -0.744467 1.06024 -0.76515 5.311e-01 0.805203
## Ifi47 -0.852390 1.07231 -0.87706 4.728e-01 0.812775
## Tgtp2 -0.785673 0.89281 -0.70569 5.222e-01 0.866434
## Tgtp1 -0.785544 1.05646 -0.83481 5.285e-01 0.803172
## Ifit1bl1 -1.075656 0.66808 -1.22487 4.364e-01 0.693912
## Gm43302 -0.717391 1.02819 -0.74889 5.634e-01 0.770269
## Gbp4 -0.891694 1.08806 -0.86203 4.910e-01 0.870797
## Gm12216 -1.252892 0.53100 -0.11690 5.745e-01 0.584697
## Ctsf 1.148920 -1.43884 0.48143 8.033e-01 -0.023603
## Cfb -0.823057 1.60604 -0.99327 2.395e-02 0.543718
## Hspa1b 0.350478 1.01156 -1.37871 -6.504e-01 0.971683
## F830016B08Rik -0.707048 1.58083 -0.70113 1.622e-01 0.723027
## Gm17334 -0.892454 0.50628 -0.84434 5.693e-01 0.844871
## Gm20390 -0.427456 0.99891 -1.00992 -7.440e-02 0.828203
## Phf11b -1.119385 1.09596 -0.92080 3.704e-01 0.470474
## Hspa1a 0.212451 1.05536 -1.02463 -8.770e-01 1.110681
## Gal3st2 1.046352 -0.48177 0.05941 -4.989e-01 -0.405616
## Hist1h3g 0.181800 1.35193 -1.15875 6.531e-01 0.637411
## Gbp6 -0.753312 1.10021 -0.76349 4.905e-01 0.773345
## Gbp10 -1.014010 1.08678 -0.81103 4.556e-01 0.838734
## Gbp5 -0.952509 1.28525 -0.89710 3.691e-01 0.859556
## Chaf1a -0.176858 1.37921 -1.09693 1.018e+00 0.450705
## Atp1a2 0.181104 -0.75217 0.41697 -8.281e-01 -0.462139
## Ehf 0.432429 -0.41290 0.82425 -9.707e-01 -0.972484
## Mybpc1 0.315803 -1.96586 0.54364 -4.155e-01 -0.282577
## Fos 0.448721 0.57234 -1.12123 9.476e-01 0.060094
## Trip13 -0.859274 1.67227 -0.44720 4.240e-01 0.381154
## Dhfr -0.152086 1.32441 -1.32108 7.341e-01 0.702616
## Shcbp1 -0.164222 1.56265 -0.87639 8.685e-01 0.517160
## Spata24 -0.782036 0.73310 -0.58593 7.655e-01 1.147471
## Lox 1.021256 -0.26747 0.71746 -7.689e-01 -1.635197
## Msr1 -0.628590 1.94709 0.08279 -5.951e-01 0.711963
## Il2ra -0.526412 1.05676 -0.75571 3.495e-01 1.173707
## Rad51 -0.146919 1.24438 -0.83597 7.568e-01 0.684086
## Slc7a11 0.368638 0.84383 -0.40635 7.593e-01 1.193928
## Extl2 -0.541449 -0.46021 3.04918 -3.271e-01 -0.189642
## Auts2 0.274232 -0.55030 0.69715 -5.278e-01 -1.422362
## Klra2 -1.170516 0.96726 -0.71820 3.961e-01 0.904268
## Bcat1 -0.501152 1.26607 -0.65341 1.643e+00 0.310272
## Pcsk6 -0.238064 -0.03419 0.03606 -3.174e-01 -0.628716
## Cd209a 0.228940 -2.18782 0.17003 -3.662e-01 -0.059820
## Prrg3 -0.472167 -0.70196 0.50692 -9.694e-01 -1.505807
## Lrr1 -0.357068 0.67812 -1.17340 1.302e+00 1.105790
## Fxyd1 -0.262604 -0.87770 0.87477 -7.624e-01 -1.083577
## Eme1 -0.299715 1.74818 -0.75478 7.199e-01 0.353452
## C130074G19Rik 0.683217 -0.97896 0.35017 -9.206e-01 -0.777299
## Tnip3 -0.114057 2.46236 -0.40215 3.027e-01 0.052278
## Mab21l3 0.104970 0.35987 0.01534 5.937e-01 1.333302
## Ifitm10 -0.662135 -0.33363 0.38555 -8.489e-01 -0.539233
## AI464131 0.455373 -1.26007 0.76943 -7.626e-01 -1.173249
## Sned1 1.134252 -1.60853 0.56954 -6.307e-01 -0.391010
## Bex4 0.464715 0.52568 -1.03967 1.295e+00 0.799698
## Vstm4 0.827827 -1.42977 0.62138 -6.613e-01 -0.725137
## Rnd1 -0.532473 1.63012 -0.85072 1.734e+00 0.777060
## Sphk1 0.408029 1.11187 -1.35115 1.139e+00 0.381226
## Efcc1 1.058547 0.39643 0.43205 -1.141e+00 -0.490886
## Lilr4b -0.646614 2.20780 0.02708 8.205e-02 0.280375
## Gm21887 -0.179950 0.84277 -1.19288 -1.096e+00 -0.906416
## rtmt.d4.r4 naive.r1 naive.r2 naive.r3 naive.r4
## Cdc45 0.07413 -1.6194 -0.7630 -0.34559 -1.65936
## Slfn4 0.61738 -1.5390 -0.9195 -0.76606 -0.08473
## Mx1 0.50182 -1.1570 -0.9840 -0.98250 -0.72057
## Il12rb1 0.76747 -1.0811 -0.6705 -0.93382 -1.32973
## Gnb1l 0.17819 -1.2392 -1.0720 0.08889 -1.95287
## Lgals9 0.29583 -1.2500 -1.0921 -0.88225 -1.05533
## Timp1 -0.32096 -0.5555 -1.5640 -0.92957 -1.03549
## Tubb6 0.45478 -1.4114 -0.8273 -1.09900 -1.18500
## Peg3 -0.61071 1.5581 1.0076 1.14894 1.47487
## Syce2 0.19576 -1.6606 -1.0240 -0.38806 -1.79073
## Abca13 0.41443 -1.6228 -1.1460 -0.66593 -1.37418
## Ccl24 0.54385 -0.9302 -0.7829 -0.89901 -1.13592
## Thop1 0.06361 -1.4786 -0.9152 -1.25065 -1.63174
## Hspb1 0.89143 -0.1887 -0.4422 -0.11224 0.14580
## Spo11 0.60087 -1.3717 -0.6103 -1.93679 -0.85502
## Srm 0.27215 -1.1036 -0.8061 -1.44517 -1.32488
## Atp7b -0.23964 -1.4843 -0.8097 -0.36277 -2.03746
## Cd163 -0.46616 1.1942 0.9002 1.17049 1.13081
## Oit3 -0.29417 1.5397 1.0455 0.63696 1.09085
## Mlkl 0.47862 -1.2658 -1.0122 -0.96278 -0.69034
## Enkd1 0.63258 -0.9648 -1.1534 -0.96577 -1.21695
## Gzmb 0.29756 -1.0584 -0.9005 -0.69545 -0.65175
## Cd274 0.76945 -1.1458 -1.0297 -1.22342 -0.95679
## Dhx58 0.46664 -1.2542 -0.8743 -1.18724 -0.65387
## Irf1 0.84299 -1.1644 -1.1860 -1.41010 -1.06426
## Pdk4 0.23024 1.0109 1.1093 0.20824 1.78061
## Pkib 0.61008 -1.0573 -1.5047 -1.22970 -1.06373
## Dram1 0.52756 -1.4900 -1.0881 -1.05930 -0.87603
## Ppa1 0.49479 -1.4482 -0.8813 -1.17583 -0.98363
## Nefh 0.35337 -1.1116 -1.3706 -1.06019 -1.03791
## Upp1 0.31927 -1.2481 -0.7999 -1.06116 -1.04748
## Igfbp3 -0.31544 1.2759 1.1092 0.88959 1.32788
## Nampt 0.57207 -1.3047 -1.0810 -1.05394 -0.96846
## Cmpk2 0.24370 -1.5952 -1.1642 -0.15998 -1.32646
## Serpina3n 1.04189 -0.8520 -0.8452 -2.05278 -1.20708
## Wars 0.85047 -0.8876 -0.9233 -1.38659 -1.06270
## Hsp90aa1 0.56269 -1.2562 -0.7757 -0.97488 -1.41583
## Thbs4 1.27212 -1.2663 -1.7183 -1.02725 -0.91099
## Plau 0.14834 -0.9075 -0.9656 -0.91947 -0.85331
## Pnp 0.01527 -1.4629 -1.1618 -0.23253 -1.63808
## Gdf10 -0.16489 1.2460 1.1421 0.83856 1.13280
## Scara5 -0.44799 1.4577 0.5862 0.96648 1.42122
## Acod1 0.20686 -0.9823 -1.0414 -1.04615 -0.85162
## Has2 0.53626 -1.3805 -1.1279 -1.03423 -1.06867
## Vdr 0.64547 -1.3254 -1.3883 -0.90670 -1.09787
## Ly6c2 0.27535 -1.3443 -1.0029 -1.13349 -0.87563
## Ly6i 0.61963 -1.0783 -1.0850 -0.99250 -0.80897
## Parp9 0.59355 -1.1787 -1.1729 -1.10603 -1.08483
## Cela1 -1.11073 -0.7957 0.3682 -0.53358 -1.07854
## Cdkn1a 0.32336 -1.0313 -1.2776 -1.25114 -1.01790
## Fam132a -0.25455 -1.5462 -0.8105 -0.52259 -1.98331
## Ms4a6d 0.29334 -1.0913 -0.9665 -0.91502 -0.51754
## Il33 0.77708 -0.8687 -1.2257 -1.69154 -1.22913
## Ifitm3 0.61676 -1.2058 -0.9200 -1.06040 -0.76977
## Irf7 0.29182 -1.4153 -1.0967 -0.86143 -0.84102
## Homer2 0.35543 -1.5563 -0.6527 -0.76140 -1.37708
## Hk3 0.78957 -1.3055 -1.0252 -1.08819 -0.91376
## Il1rl1 -0.23979 -1.6759 -1.0651 -0.17990 -1.72283
## Stat1 1.00404 -1.2473 -1.1704 -1.28649 -0.87188
## Steap3 -0.13308 -1.5759 -1.0646 -0.41645 -1.95819
## Mnda 0.64497 -1.3384 -1.1398 -1.16680 -0.77313
## Xcl1 0.73343 -1.3089 -0.8131 -1.38023 -0.96723
## Atf3 0.45063 -1.1379 -1.4023 -1.50617 -0.77312
## Mcm10 -0.13187 -1.3778 -1.1804 -0.14503 -1.68025
## Sapcd2 0.22612 -1.8017 -1.1773 -0.84726 -1.00433
## Il1rn 0.13336 -0.9807 -1.3421 -1.02763 -0.67688
## Dut 0.14751 -1.4590 -0.8835 -1.04754 -1.23174
## Hdc -0.05281 -1.4224 -1.1171 -1.20963 -0.94984
## Zbp1 0.75059 -1.2165 -1.0606 -1.42137 -1.01553
## Car1 -0.13123 -1.6734 -0.8503 -0.06165 -2.05107
## Procr 0.30274 -0.6950 -1.0323 -1.19941 -0.80580
## Il21 0.41086 -1.1010 -0.9301 -1.21961 -1.18694
## Ccdc109b 0.46594 -0.7909 -1.2526 -1.06621 -0.84210
## Ifi44 0.60532 -1.4285 -0.9927 -0.98632 -0.71627
## Gbp3 0.83409 -1.2477 -0.9285 -1.10259 -0.84008
## Gbp2 0.73044 -1.2056 -1.1229 -1.27494 -0.99891
## Tnc 1.14544 -0.7693 -0.8696 -0.55021 -1.11784
## Smpdl3b 0.82714 -1.5101 -1.1926 -1.20627 -0.83326
## Htra3 -0.06192 1.2215 1.3211 0.68414 1.28473
## Gbp9 0.82233 -1.2133 -1.1416 -1.26963 -0.87372
## Cxcl9 0.67016 -1.0042 -1.3495 -1.35403 -1.06587
## Oasl2 0.57542 -1.3696 -1.1705 -1.03251 -0.61133
## Hsph1 1.01817 -0.6184 -0.1929 -1.69022 -1.82955
## Asns -0.22806 -1.6345 -0.9565 -0.30537 -1.97332
## Usp18 0.39134 -1.1548 -1.0552 -0.92030 -1.10476
## Bcl2l14 0.55921 -0.9517 -0.9464 -1.30618 -0.92888
## Ift122 -0.59419 2.6481 1.4444 1.21326 0.50446
## Tmem159 -0.40675 0.3795 3.6012 -0.46798 0.15955
## Gpt2 1.09159 -0.9695 -1.0016 -1.36310 -0.44331
## Mt2 -0.08671 -1.6043 -0.8950 -0.46683 -1.70919
## Mt1 -0.02733 -1.7511 -0.9465 -0.81545 -1.95169
## Ctrl -0.45987 -0.9124 0.4040 -0.61492 -0.73229
## Psmb10 0.55859 -1.2617 -1.1801 -1.11692 -1.14153
## Chek1 0.31643 -1.5929 -0.3809 -0.75943 -1.65882
## Stra6 0.98767 -0.9837 -0.8941 -1.91602 -1.16585
## Ptgs2 0.15091 -1.0518 -0.8595 -0.86511 -0.89542
## Oas3 0.16974 -1.6267 -1.3017 -0.06213 -1.24305
## Oas2 0.56035 -1.3638 -1.0233 -1.05796 -0.56764
## Rtp4 0.62718 -1.3826 -1.0706 -1.01898 -0.45378
## Apol6 0.60667 -0.8674 -1.3543 -1.03983 -0.72572
## Recql4 -0.14671 -1.4034 -1.1867 -0.79180 -1.49906
## Pla2g4c 0.27258 -1.4053 -0.9455 -0.31723 -1.59205
## Tmem132c -0.51578 1.2824 0.8078 0.49766 1.44597
## Lif 0.39665 -1.1196 -1.2966 -0.66979 -1.18530
## Parp14 0.87142 -1.2835 -1.0071 -1.09373 -0.87941
## Gbp8 0.87504 -1.2398 -1.0863 -1.08047 -0.92009
## Ifit1 0.39590 -1.1479 -1.1623 -0.75274 -0.88864
## Cxcl10 0.79058 -1.1633 -1.1775 -1.05589 -1.05486
## Ubd 0.87262 -1.0891 -1.1517 -1.06557 -1.12908
## Ccl2 0.10524 -1.0354 -1.0024 -0.95414 -0.93838
## Isg15 0.12608 -1.4408 -1.0359 -0.10274 -1.26115
## Npy1r -0.15514 1.2583 1.3535 0.87210 1.08536
## Tmem255a 0.35629 0.9568 1.4593 0.83406 1.31550
## Tap1 0.89998 -1.1954 -1.0848 -1.43788 -1.13448
## Dtl -0.14739 -1.4596 -1.0282 -0.22764 -1.86650
## Nme1 0.55307 -1.6221 -0.4167 -1.36678 -1.45854
## Fam13a 0.27119 1.5896 0.8121 0.66748 1.52986
## Tgm2 0.47398 -1.0616 -1.3045 -1.06941 -0.92349
## Rmi2 0.32075 -1.2848 -1.0688 -0.97693 -1.19225
## Socs1 0.71165 -1.2287 -1.1762 -1.11367 -1.01144
## Fanci -0.53511 -1.5756 -0.9854 -0.55958 -1.55777
## Batf2 0.88766 -1.1021 -0.8736 -0.99783 -1.06414
## Stat2 0.76218 -1.2464 -1.1446 -1.17238 -0.77574
## Gbp7 0.70284 -1.3096 -1.0998 -1.10660 -1.04820
## Gbp2b 0.69359 -1.1623 -0.9022 -1.03637 -0.84439
## Btnl9 -0.14543 1.3836 0.6193 1.13234 0.99429
## Olfr56 0.32549 -1.3365 -1.0244 -0.90265 -0.92295
## Il7 -0.71947 0.9559 1.3011 1.19343 1.10287
## Xaf1 0.61136 -1.3447 -1.2951 -0.94235 -0.63765
## Serpina3g 0.86113 -1.2826 -1.2239 -1.25348 -0.91025
## Prelp -0.14015 1.3848 1.1701 0.88201 1.24753
## Abca9 0.06618 1.0877 0.9860 0.96226 0.97186
## Oasl1 0.62759 -1.2070 -0.9619 -0.90571 -0.83367
## Abca8a -0.73918 0.9433 1.2152 1.08025 0.99856
## Bag2 0.11954 -0.7837 -1.0599 -0.30615 -2.00127
## Cilp 0.23705 0.9762 1.2047 1.04423 0.81821
## Maff 0.59905 -0.8081 -1.6700 -1.52001 -1.23018
## Mmp3 -0.22255 -0.6536 -1.0613 -1.07344 -1.33884
## Phf11a 0.31035 -1.1315 -0.8452 -1.05911 -0.41580
## Gvin1 0.90452 -1.3075 -1.1218 -1.34693 -1.00690
## Ifit2 0.52205 -1.1878 -0.8538 -1.05273 -0.74415
## Fam26f 0.64629 -1.0649 -1.1965 -1.23567 -0.82792
## Olfml2a -0.36764 1.2699 0.9182 0.97592 1.32334
## Bst2 0.59732 -1.3310 -1.0721 -1.13289 -0.72761
## Irgm1 0.72175 -1.3040 -1.1603 -1.18830 -1.04998
## Kcne4 0.64203 -0.8233 -1.5646 -1.62724 -1.01248
## Gm12185 0.74808 -0.8760 -1.2622 -1.13329 -1.02433
## Zg16 -0.74995 -0.8053 0.5071 -0.39887 -1.07585
## Apol10b 0.92167 -1.4750 -1.0621 -0.86759 -0.44850
## Mmp13 0.39703 -0.9167 -1.1401 -1.02950 -0.80970
## Kcnj16 -0.49097 0.8888 1.1365 1.14131 1.07252
## Fpr2 0.12155 -0.9746 -1.1954 -0.60020 -0.51050
## Epha3 0.26245 1.2907 0.3413 1.46427 1.49063
## Oas1a 0.35262 -1.5023 -1.2965 -0.94415 -0.53434
## Socs3 0.48940 -1.1679 -1.1384 -1.49068 -0.97972
## Slamf8 0.64971 -0.8319 -0.8786 -1.21659 -0.87647
## Iigp1 0.87728 -1.2446 -1.2356 -1.22689 -0.90078
## Ifi205 0.76619 -1.1370 -0.9502 -1.03566 -0.94198
## Ifng 0.69183 -1.0947 -1.1365 -1.32302 -0.93162
## Cebpb 0.44432 -1.4832 -1.2045 -1.69883 -0.36823
## Gm5431 0.67769 -1.1667 -0.9390 -0.94815 -0.23280
## Fcgr4 0.97157 -1.3463 -0.9625 -1.12069 -1.02943
## Pla2g16 0.37697 -1.2366 -1.2472 -0.39834 -1.57024
## Obscn -0.84536 1.1708 1.2898 1.41950 0.86908
## Serpina10 1.26524 -1.4282 -1.3186 -0.82057 -0.80739
## Tubb3 0.15050 -0.8346 -0.9727 -1.02798 -0.95786
## Ifit3b 0.58405 -1.0485 -0.7553 -1.01988 -0.16786
## Serpina3f 0.91590 -1.3007 -1.1587 -1.26469 -0.93370
## Cenpm 0.02292 -1.2452 -0.9468 -0.55442 -1.87034
## Phf11d 0.49623 -1.5435 -0.6092 -1.19003 -0.64720
## Gm4841 1.03446 -1.3058 -1.0366 -1.17277 -0.74209
## Irgm2 0.93502 -1.2739 -1.1160 -1.25320 -0.89448
## Rnf213 0.60130 -1.3174 -0.9378 -1.06848 -0.80623
## Cited4 0.04427 -1.9713 -0.7045 -0.54838 -1.51318
## Ccl19 1.04876 -1.1011 -1.1081 -1.68594 -0.82553
## Ifi204 0.80633 -1.4841 -0.8835 -1.04969 -0.86665
## Pydc4 0.77121 -1.2626 -0.8754 -1.32879 -0.69985
## Gm4951 0.98008 -1.1234 -1.1073 -1.32299 -0.68756
## Nlrc5 0.99509 -1.2375 -0.9388 -1.69600 -0.70404
## Amy2a5 -0.44902 -0.6587 -0.5149 -0.51797 -0.90723
## Ifit3 0.61282 -1.1321 -0.9548 -0.90939 -0.60721
## Grem1 -0.17759 1.2231 0.8277 0.47064 1.22696
## Ly6a 0.58593 -1.3037 -0.9469 -1.21078 -0.83694
## Aunip -0.39487 -1.2526 -1.0391 -0.24653 -1.84023
## Gm4070 0.91256 -1.4606 -1.1192 -1.38484 -0.91970
## Igtp 0.80685 -1.2773 -1.1470 -1.31188 -1.12330
## Ifi47 0.69189 -1.2341 -1.0679 -1.29387 -1.09786
## Tgtp2 0.81734 -1.2873 -1.3296 -1.16488 -1.04485
## Tgtp1 0.72010 -1.2063 -1.1000 -1.32352 -1.09182
## Ifit1bl1 0.68603 -1.2510 -0.7526 -1.23397 -0.82687
## Gm43302 0.72808 -0.8405 -1.4637 -1.34114 -0.28926
## Gbp4 0.76470 -1.1120 -1.1569 -1.39501 -1.00718
## Gm12216 1.26385 -1.0349 -1.0772 -1.30314 -0.89154
## Ctsf -0.74000 0.6481 0.9201 1.51501 0.74146
## Cfb 0.38586 -1.1689 -0.9646 -1.16375 -0.88156
## Hspa1b 1.22573 -0.7843 -0.7462 -1.63254 -1.09634
## F830016B08Rik 0.97024 -1.2937 -1.0528 -1.19696 -0.76365
## Gm17334 0.97575 -1.2675 -0.8550 -1.21474 -1.09393
## Gm20390 -0.11408 -1.5309 -0.7808 -1.31903 -1.11067
## Phf11b 0.56462 -1.1420 -1.0754 -1.15840 -0.92829
## Hspa1a 1.43175 -0.3705 -0.3775 -1.93261 -1.14881
## Gal3st2 -0.13449 1.5316 1.7381 0.96561 0.74694
## Hist1h3g -0.45724 -1.6599 -1.1246 -0.05079 -1.70959
## Gbp6 0.82273 -1.2866 -1.1679 -1.34801 -1.02133
## Gbp10 0.84896 -1.0817 -0.9291 -1.35531 -1.10793
## Gbp5 0.79598 -1.1051 -1.1294 -1.26613 -0.94989
## Chaf1a -0.10970 -1.5445 -1.2244 -0.40394 -1.31231
## Atp1a2 -0.50819 1.2078 1.9963 0.61195 1.14353
## Ehf -0.98069 0.9284 0.8346 1.15182 1.35835
## Mybpc1 -0.36744 0.8184 1.5173 0.81827 1.31044
## Fos 1.24245 -1.0351 -0.7014 -2.04499 -0.40070
## Trip13 0.39889 -1.2337 -1.0661 -0.58439 -1.08260
## Dhfr 0.01912 -1.2418 -1.0036 -0.55965 -1.42117
## Shcbp1 -0.14928 -1.8142 -0.9970 0.09238 -1.25222
## Spata24 -0.10843 -1.0782 -1.2558 -1.17524 -1.35717
## Lox -1.22895 1.4550 0.8430 0.17276 1.34394
## Msr1 0.45303 -0.7525 -1.5749 -0.74526 -0.83604
## Il2ra 0.52964 -1.1678 -1.0811 -1.11751 -1.09728
## Rad51 0.05930 -2.1641 -0.9101 -0.14311 -1.35914
## Slc7a11 0.64231 -1.3491 -1.6647 -1.48703 -0.77641
## Extl2 -0.18253 -0.4183 -0.3036 -0.43579 -0.21239
## Auts2 -1.36782 2.3052 0.7540 1.08569 -0.32964
## Klra2 1.16963 -1.4428 -0.8560 -0.81331 -0.82834
## Bcat1 0.43330 -0.3029 -0.5659 -1.96738 -1.34010
## Pcsk6 -1.40885 1.0481 1.3035 1.75103 0.48382
## Cd209a 0.13898 1.2850 0.8248 0.88730 1.17871
## Prrg3 -0.64596 0.6703 1.2026 0.15618 2.41701
## Lrr1 0.47358 -1.4689 -0.6389 -0.37655 -1.27892
## Fxyd1 -0.90150 1.2605 1.5475 1.31142 1.48480
## Eme1 0.10749 -1.4311 -0.4709 -0.72519 -1.65257
## C130074G19Rik -0.76649 1.4768 1.3911 0.99838 1.09465
## Tnip3 0.67044 -0.9128 -0.5357 -0.93379 -0.89492
## Mab21l3 1.36306 -1.8109 -1.8055 -0.90818 -0.58602
## Ifitm10 -0.30442 1.3470 0.6284 0.84261 1.55555
## AI464131 -0.13962 1.3447 1.4311 1.15872 1.08626
## Sned1 -0.46464 1.1014 0.9770 0.87106 1.13713
## Bex4 -0.67184 -1.2153 -0.6013 0.08301 -2.42381
## Vstm4 -0.41348 1.0804 1.1835 0.92804 1.29961
## Rnd1 -0.12491 -0.3828 -1.7156 -1.52187 -0.42426
## Sphk1 -0.38133 -1.0482 -1.2942 -0.08330 -1.71014
## Efcc1 -0.68712 1.3292 1.5965 0.64671 0.82220
## Lilr4b 0.36215 -1.2709 -0.7068 -1.07107 -0.92873
## Gm21887 -1.46189 0.6220 1.0383 -0.14799 -1.58216## heat.list day delivery rep
## 13 naive.r1 0 naive 1
## 14 naive.r2 0 naive 2
## 15 naive.r3 0 naive 3
## 16 naive.r4 0 naive 4
## 1 sbp.d4.r1 4 sbp 1
## 2 sbp.d4.r2 4 sbp 2
## 3 sbp.d4.r3 4 sbp 3
## 4 sbp.d4.r4 4 sbp 4
## 9 rtmt.d4.r1 4 rtmt 1
## 10 rtmt.d4.r2 4 rtmt 2
## 11 rtmt.d4.r3 4 rtmt 3
## 12 rtmt.d4.r4 4 rtmt 4
## 5 mt.d4.r1 4 mt 1
## 6 mt.d4.r2 4 mt 2
## 7 mt.d4.r3 4 mt 3
## 8 mt.d4.r4 4 mt 4
4.5 Day 3
## sbp.d3.r1 sbp.d3.r2 sbp.d3.r3 sbp.d3.r4 mt.d3.r1
## Cdc45 -1.00289 -0.9543746 0.0752548 3.117e-01 0.275581
## Il12rb1 -0.71030 -0.4064072 -0.5086540 3.218e-01 1.854990
## Gnb1l 1.55396 -0.3553318 0.0670669 5.470e-01 0.976381
## Lgals9 -1.01407 -0.4723919 -0.3631331 -1.823e-01 1.535581
## Uhrf1 -1.45653 -1.0468761 0.3042956 2.772e-01 0.390601
## Hpn -0.21310 0.0594541 -0.1899847 1.327e+00 0.596095
## Chaf1a -1.05359 -1.6558046 0.2576024 3.609e-02 0.766204
## Syce2 -1.76805 -0.6048044 0.4400295 2.378e-01 0.253602
## Abca13 -0.86074 -0.0273248 0.2204630 -8.163e-01 0.656730
## Ccl24 -0.76581 -0.2227142 -0.3160276 2.586e-01 1.706524
## Mcm5 -1.14410 -1.2937953 0.3271767 1.712e-01 0.663787
## Atp7b -1.78449 -1.0921680 0.3869646 1.073e+00 0.384352
## Gmnn -1.42098 -1.2075595 0.2040709 2.961e-01 0.483828
## Pole -0.85129 -1.5891897 0.7676668 4.916e-01 0.701145
## Mlkl -1.07410 -0.9810406 -0.2464786 -2.026e-01 1.776857
## Hmgb3 -1.29513 -1.4495216 0.5456203 7.807e-01 -0.060613
## Gzmb -0.71666 -0.3397392 -0.3505251 -3.481e-01 1.397225
## Cdc6 -1.30883 -1.5283558 0.7233319 5.615e-01 0.298404
## Mapt 1.10938 0.7481967 -0.2006224 -1.096e-01 -1.171245
## Irf1 -0.04168 -0.6801739 -0.0135482 -2.615e-01 2.260363
## Slfn3 -0.68404 -0.5986075 -0.2762956 -1.253e-01 0.591418
## Mtfr2 -1.35398 -0.5747404 0.2891889 1.469e-01 0.557148
## Ppa1 -0.48933 -1.1100524 -0.4586197 -1.466e-01 1.804495
## Nefh -1.06419 -1.0284110 0.6824476 -7.159e-01 1.578295
## Upp1 -0.21553 -1.1712954 -0.0752641 -6.862e-01 1.091924
## Nampt -0.74490 -0.5359029 -0.5035724 -3.448e-01 1.985799
## Cmpk2 -1.63372 -0.6173777 0.0007689 -1.057e-01 1.084928
## Fam64a -0.20921 -0.7796740 0.3505722 -6.396e-01 0.410831
## Top2a -1.39592 -1.1440559 0.2786360 1.148e-01 0.202262
## Serpina3n 0.26055 -1.5965745 0.1889259 -4.375e-01 1.334625
## Wars -0.60440 -0.7587759 -0.4292658 -3.401e-01 2.247650
## Hsp90aa1 -0.38926 -0.0755808 -0.2240133 -4.443e-01 1.364269
## Thbs4 0.38389 -0.8511855 0.3247845 -1.524e+00 1.819246
## Dhfr -1.41887 -1.1750158 0.3808530 2.773e-02 0.581167
## Cenpk -1.38170 -1.0986446 0.2621448 3.046e-01 0.318094
## Fam107a 0.25605 -0.3036187 0.0399632 -7.762e-01 -1.792481
## Pnp -1.55214 -0.8919229 0.2500491 2.444e-01 0.770789
## Pbk -1.17841 -1.1649409 0.4834809 3.550e-01 -0.393413
## Acod1 -0.86683 -0.3098034 -0.4326139 -6.158e-01 1.236949
## Shcbp1 -1.14169 -0.8573537 0.1908737 1.223e-01 -0.046310
## Has2 0.13095 -0.8358193 -0.0134468 1.198e-01 2.140002
## Dscc1 -0.98879 -1.3715182 -0.0484118 -2.119e-01 0.946107
## Vdr -0.22362 0.2691464 -0.3892628 -1.819e-01 2.327556
## Ly6c2 -1.46122 -0.6607925 -0.4063723 -3.590e-01 1.761084
## Ly6i -0.97716 0.0071066 -0.1020800 -1.904e-01 1.336305
## Chaf1b -2.17405 -0.7770393 0.0515944 3.405e-01 0.074414
## Fam132a -1.68375 -1.3696487 0.2687599 1.108e+00 0.391989
## Il33 -0.10394 -1.3317229 0.2761683 -2.133e-01 1.579421
## Irf7 -1.35219 0.1798835 -0.2644601 -6.047e-01 1.833537
## Tyms -1.77099 -1.0887653 0.7368132 3.028e-02 0.474949
## Hk3 -1.18821 -0.4110442 -0.4875521 9.657e-05 2.161583
## Il1rl1 -1.55286 -0.9035323 0.3345335 5.701e-01 -0.271914
## Stat1 -0.41693 -0.8610771 -0.1194334 -2.275e-01 2.267506
## Steap3 -1.82951 -0.7261806 0.4067175 7.643e-01 0.175985
## Ube2t -0.85756 -0.5934756 -0.0506598 4.580e-01 0.184505
## Mnda -0.95894 -0.1714864 -0.4285407 -4.243e-01 1.826391
## Xcl1 -0.28931 -0.0585939 -0.8414515 4.657e-01 2.237966
## Atf3 -0.48937 -0.3014441 -0.3140809 1.478e-02 2.154716
## Mcm10 -0.94287 -1.1070162 0.3978430 2.352e-01 0.356999
## Il2ra -0.51224 -1.4114145 -0.3334503 -3.302e-01 1.931852
## Sapcd2 -0.91115 0.4272891 -0.4924481 -6.617e-01 0.768569
## Il1rn -0.85183 -0.7007480 -0.8517246 5.051e-03 1.621651
## Gatm -1.49749 -0.9076623 -0.1398564 4.990e-01 1.263968
## Dut -1.20949 -0.6782561 0.0307049 1.007e-01 0.514098
## Rad51 -1.09690 -1.3836008 0.3367755 6.701e-01 -0.106635
## Bub1 -1.30941 -0.9909382 0.0045892 -5.834e-02 0.078454
## Gins1 -1.44117 -1.1854432 0.5466238 -1.382e-01 0.720197
## Aurka -1.34862 -1.0566779 0.4406829 3.657e-01 0.139031
## Zbp1 -0.92464 -0.5262233 -0.2729190 -2.916e-01 2.097357
## Car1 -1.65769 -0.9343186 0.4031853 8.217e-01 0.230684
## Il21 0.43831 -1.8180389 -1.0796405 -1.749e-01 0.273484
## Ifi44 -0.77926 -0.0001395 -0.7315818 -9.532e-01 1.491352
## Gbp3 -0.88664 -0.6712987 -0.2374000 -4.172e-01 1.937856
## Gbp2 -0.50516 -0.9238856 -0.0576186 -3.433e-01 2.042873
## Smpdl3b -1.06361 0.1740358 -0.5194535 -1.871e-01 0.565169
## Htra3 0.12733 0.4356402 0.8102531 6.929e-02 -1.822514
## Cxcl9 -0.37100 -0.8767183 -0.0284235 -2.502e-02 2.015951
## Oasl2 -1.34190 -0.2132220 -0.5621882 -3.182e-01 1.720325
## Hsph1 0.16515 0.6325867 0.7455875 -1.020e+00 1.177829
## Tfr2 -1.83576 -0.6240264 0.5734727 8.912e-01 -0.184161
## Asns -1.36597 -1.3977339 0.3686386 7.715e-01 0.192291
## Klrg1 -1.41493 0.1836429 0.2334399 6.082e-01 -0.067726
## Klra2 -0.73842 -0.2611060 -0.6375168 -1.572e-01 2.175731
## Bcat1 0.15176 -0.9067816 -0.9060016 -3.008e-01 0.305607
## Rad51ap1 -1.27361 -1.5774871 -0.3361952 2.506e-01 0.241840
## Ddias -1.48161 -0.8405708 0.6457222 1.457e-01 -0.214918
## Sult1a1 0.72536 0.2374594 0.5657610 2.598e-01 -1.560371
## Plk1 -1.43550 -1.2285185 0.7182481 1.770e-01 0.089648
## Tmem159 0.12579 -0.2278823 -0.2562193 -7.996e-02 -0.319576
## Cenpi -1.24731 -0.0368463 0.3414692 1.434e-01 0.244247
## Adgrg2 0.52026 1.2016435 -0.4920495 6.254e-01 -0.784241
## Cenpn -1.20507 -1.0345641 0.4031434 6.194e-01 -0.121804
## Mt2 -1.27263 -0.8941914 0.1020056 6.508e-01 0.530698
## Mt1 -1.04776 -1.0043137 0.0584651 3.511e-01 -0.269869
## Chek1 -0.88986 -0.6741015 -0.1908342 2.547e-01 0.515225
## Mns1 -1.37462 -0.8899928 0.3589302 4.179e-01 0.298200
## Ptgs2 -0.19165 -0.6570809 -0.0876610 -4.960e-01 1.968098
## Traip -1.37885 -0.5630436 0.0349635 5.664e-01 0.648270
## Oas3 -1.91476 -0.3990022 -0.0121213 -2.179e-01 1.152500
## C330027C09Rik -1.16994 -0.8782777 -0.2656930 3.509e-02 0.078874
## Rtp4 -1.21235 -0.2964659 -0.2556362 -8.037e-01 1.860852
## Apol6 -0.04127 -0.9885300 -0.4842109 -3.301e-01 2.301384
## Recql4 -1.54652 -0.7012294 0.6027529 6.960e-01 0.128916
## Pla2g4c -1.40441 -0.9565463 0.6493394 -1.976e-02 -0.365706
## Polq -1.26465 -0.9668482 0.6109785 3.391e-01 0.357374
## Kif4 -1.08457 -1.1317647 0.7648339 1.393e-01 -0.265661
## Tmem132c 0.69788 -0.1559072 -0.0480812 9.726e-01 -0.835057
## Brip1 -1.42293 -1.2627885 0.2490738 2.477e-01 1.263177
## Lif -1.14646 -1.1120827 -0.3910535 1.274e-01 2.167115
## Gbp8 -0.48163 -0.8147731 -0.2694757 -5.647e-01 2.330641
## Ifit1 -1.21707 -0.1833553 -0.5365811 -5.498e-01 1.752630
## BC030867 -0.90525 -1.4243718 0.8272917 7.708e-01 0.976695
## Cxcl10 -0.44722 0.0350729 -0.2466375 -5.790e-01 2.201292
## Ubd -0.24976 -1.0026379 -0.2146225 -3.575e-01 1.995293
## Ccl2 -0.80095 0.1111142 0.0521684 -8.818e-01 2.252411
## Fignl1 -1.71510 -1.1753562 0.5885354 3.625e-01 0.347464
## Isg15 -1.53321 -0.4902026 -0.1224560 -3.188e-01 1.179919
## Kif15 -1.35644 -1.0842821 0.4249608 2.711e-01 0.136300
## Dtl -1.40218 -1.3326195 0.5075110 4.801e-01 0.298041
## Fam13a -0.03714 -0.1741327 -0.3132962 1.537e-01 -1.722014
## Rmi2 -0.84074 -0.5231555 -0.5744709 -2.551e-01 1.707813
## Socs1 -0.11213 -0.6825090 -0.2050275 -1.534e-01 2.095512
## Eme1 -0.51163 -0.8525594 0.7482065 -2.126e-01 0.105595
## Fanci -1.21773 -1.1472294 0.5620480 8.421e-02 0.333645
## Batf2 -0.16921 -0.9721780 0.1610371 -2.493e-01 2.091295
## 2810417H13Rik -1.10025 -1.4852675 0.0486063 -5.694e-02 0.563593
## Gbp7 -0.50249 -0.8251562 -0.2255678 -3.992e-01 1.987120
## Gbp2b -0.39266 -0.5040570 -0.5420351 -2.641e-01 1.695925
## Olfr56 -0.45117 -0.6631033 -0.4735225 -4.961e-01 2.145524
## Il7 0.10487 0.2571932 0.0715595 6.221e-01 -2.373964
## Pklr -1.93386 -0.7398195 0.4774436 8.428e-01 0.192008
## Serpina3g -0.40789 -0.8767089 -0.3607608 -2.230e-01 1.930449
## Abca8a 0.45454 0.9503977 -0.1696940 9.756e-01 -2.128444
## Mmp3 0.31443 -1.4635032 0.3574032 -2.083e-01 1.272588
## Tnip3 -0.27225 -1.4315818 0.8266180 -1.649e-01 1.085385
## Gvin1 -0.64146 -0.6856696 -0.1817729 -4.199e-01 2.149411
## Ifit2 -0.67272 -0.2264693 -0.5228728 -3.695e-01 2.183581
## Fam26f -0.44412 -0.5574813 -0.3497197 -4.849e-01 2.192473
## Irgm1 -0.52926 -0.6339817 -0.1458111 -5.041e-01 2.081960
## Kcne4 -0.44250 -0.9762106 -0.0025052 7.724e-02 1.677406
## Bex4 -1.51878 -0.6122834 0.2010267 7.973e-01 -0.017790
## Ccr4 -0.14841 -1.0988341 -0.1596822 -9.610e-01 1.877540
## Ckap2l -1.21117 -1.2239403 0.4737405 9.106e-02 -0.003965
## Gm12185 -0.54444 -0.6648030 -0.7385737 -4.661e-02 1.974257
## 2610318N02Rik -0.09738 -0.4097538 -0.2899462 -1.141e+00 1.173903
## Tcf19 -1.38498 -1.1400293 0.2665928 2.252e-02 0.520630
## Mmp13 -0.48194 -0.2877189 -0.1700527 -1.016e-01 1.724102
## Socs3 -0.04058 -1.2798197 -0.4986069 -7.999e-01 1.550335
## Slamf8 -0.42047 -0.7902629 -0.3863071 -2.559e-01 1.869153
## Iigp1 -0.36252 -0.6872299 -0.2457011 -1.748e-01 2.049824
## Ifng 0.07376 -0.9021854 0.2915040 2.460e-01 1.517490
## Fam72a -0.62949 -0.8442533 0.2023889 -3.293e-02 1.573291
## Fcgr4 -0.94423 -0.3096028 -0.4982612 -1.272e-01 1.868332
## Obscn 0.65461 0.5140171 -0.0676935 -2.992e-01 -1.711907
## Sphk1 -1.37019 -1.2492449 0.3345496 9.431e-01 0.462712
## Serpina10 -0.07571 0.0187480 -0.0847875 -2.967e-01 1.321082
## Tubb3 -0.12107 -0.2129766 -0.4685152 -1.485e-01 1.278633
## Serpina3f -0.40051 -1.0264934 -0.2823183 -3.487e-02 1.924086
## Zbtb16 0.82723 0.1441139 0.5824573 -3.262e-01 -1.580232
## Gm4841 -0.28783 -0.0692659 -0.3161695 -3.413e-01 1.434346
## Slfn9 -0.97018 -0.7514766 -0.4617539 -6.946e-01 1.701956
## Irgm2 -0.39814 -0.6511341 -0.1289512 -3.698e-01 2.224527
## Cited4 -1.88399 -0.4292520 0.2424331 4.656e-01 -0.108271
## Gm4951 -0.67247 -0.3190204 -0.2726685 -2.298e-01 1.976740
## Nlrc5 -0.48614 -0.6057065 -0.0474994 -5.599e-01 2.165702
## Amy2a5 -0.53783 -0.2549223 -0.3718040 -3.712e-01 2.793867
## Spc24 -1.36285 -0.9347684 0.3403295 3.211e-01 0.359547
## Ifit3 -1.43473 -0.0709558 -0.5106886 -5.951e-01 2.181392
## Cenpw -1.00811 -0.6630699 0.1882173 -3.732e-01 0.592144
## Ly6a -1.15459 -0.7084434 -0.5718676 -2.514e-01 1.758362
## Aunip -1.33181 -1.4549967 0.2577256 2.999e-01 0.261119
## Gm4070 -0.64333 -0.5960155 -0.3717842 -3.432e-01 2.054069
## Igtp -0.42725 -0.7499942 -0.0413580 -2.965e-01 2.006078
## Ifi47 -0.50169 -0.5892356 -0.1792620 -4.135e-01 2.120739
## Tgtp2 -0.38427 -0.9124103 0.0195377 -1.969e-01 2.110313
## Tgtp1 -0.15871 -1.0754947 0.0794456 -3.127e-01 1.862872
## Ifit1bl1 -1.18839 -0.6541509 -0.1407076 -9.688e-01 1.924738
## Gm43302 -0.37582 -0.2747891 -0.0374983 3.178e-01 1.725787
## Gbp4 -0.20767 -0.7430294 -0.1312915 -3.214e-01 2.199508
## Hspa1b 0.42688 0.7733723 0.8755168 -1.016e+00 1.515016
## F830016B08Rik -0.27087 -0.4694319 -0.3416594 -4.328e-01 2.038845
## Gm17334 0.06181 -0.6960358 0.2581659 -6.211e-01 2.584261
## Apol11b -1.71055 -0.6369424 0.2438432 1.905e-01 -0.147812
## Hist1h3g -1.23856 -1.3211616 0.6907071 3.091e-01 0.246747
## Gbp6 -0.43949 -0.9328082 -0.1654602 -3.678e-01 2.108544
## Gbp10 -0.02519 -0.4840985 -0.1648056 -6.319e-01 2.001543
## Gbp5 -0.47147 -0.7491704 -0.1976365 -3.193e-01 2.172689
## Cela3b -0.61078 -0.6107764 -0.6107764 -6.108e-01 2.004383
## Ctrb1 -0.60760 -0.6076009 -0.6076009 -6.076e-01 2.015430
## Ttc41 -1.46099 -1.6013120 -1.3519021 -1.014e+00 0.745419
## Reg1 -0.54528 -0.5452801 -0.5452801 -5.453e-01 2.188136
## Amy2a3 -0.55514 -0.5551352 -0.5551352 -5.551e-01 1.826532
## Amy2a2 -0.55514 -0.5551352 -0.5551352 -5.551e-01 1.826532
## Amy2a4 -0.55514 -0.5551352 -0.5551352 -5.551e-01 1.826532
## mt.d3.r2 mt.d3.r3 mt.d3.r4 rtmt.d3.r1 rtmt.d3.r2
## Cdc45 2.7686 0.953591 -0.164198 -0.58268 0.291730
## Il12rb1 2.5736 -1.076768 0.552904 -0.58407 -0.340362
## Gnb1l 1.2161 0.474695 0.806773 -1.46327 -0.500138
## Lgals9 3.0787 -0.079506 0.447807 -0.27620 -0.375688
## Uhrf1 2.3403 0.875433 0.079860 -0.63322 0.368488
## Hpn 2.3949 0.689898 0.629650 -0.92648 -0.746571
## Chaf1a 2.5046 1.137741 0.250588 -0.61629 0.287068
## Syce2 2.3288 0.481176 0.525607 -0.85878 0.269227
## Abca13 3.0530 0.477156 0.110873 -0.30278 -1.013422
## Ccl24 3.0389 -0.269399 0.157679 -0.64983 -0.198010
## Mcm5 2.5044 0.929374 0.039050 -0.84326 0.323713
## Atp7b 2.0126 1.035988 0.323879 -0.39616 0.012069
## Gmnn 2.5386 1.034703 -0.103041 -0.80925 0.283671
## Pole 2.5043 0.661853 0.354163 -0.71032 0.150761
## Mlkl 2.7480 -0.309518 0.594939 -0.50333 -0.047344
## Hmgb3 2.2090 1.108608 -0.006397 -0.42252 0.277808
## Gzmb 3.1713 0.133046 0.441237 -0.31067 -0.256882
## Cdc6 1.9538 1.160990 -0.304418 -0.56585 0.492453
## Mapt -2.2042 -0.304587 -1.185139 0.07672 1.226192
## Irf1 2.1067 -0.224233 0.931837 -0.24959 -0.004875
## Slfn3 2.9990 0.890913 -0.004291 -0.95382 -0.209273
## Mtfr2 2.6026 0.839028 -0.100782 -0.84760 -0.048190
## Ppa1 2.7060 0.372706 0.361423 -0.82073 -0.222125
## Nefh 2.4197 -0.038019 0.605404 -0.40660 0.241903
## Upp1 2.7580 1.370749 -0.022434 0.44551 -0.644952
## Nampt 2.7790 -0.363082 0.600973 -0.44007 -0.208209
## Cmpk2 2.6801 0.352191 0.282035 -0.53997 -0.242702
## Fam64a 2.7652 0.178015 1.162508 -0.61981 0.084129
## Top2a 2.5048 1.025599 -0.250520 -0.75839 0.252835
## Serpina3n 1.1613 -0.058972 0.903541 -0.17404 0.704090
## Wars 2.4773 0.229689 0.524679 -0.69569 -0.321589
## Hsp90aa1 2.6072 0.570175 0.746129 -1.12840 -0.443833
## Thbs4 1.3786 0.296440 1.188475 -0.11178 0.520236
## Dhfr 2.8058 0.712411 0.013888 -0.83318 0.162322
## Cenpk 2.2383 1.269715 -0.202771 -0.94153 0.376234
## Fam107a -1.6384 -0.385973 -0.625301 0.66848 1.008882
## Pnp 2.5655 0.912305 0.063519 -0.78155 0.015912
## Pbk 2.3913 1.352903 -0.400163 -0.67602 -0.008990
## Acod1 3.3396 0.036946 0.013383 -0.46663 -0.470184
## Shcbp1 2.5755 0.973283 -0.031361 -0.93982 0.368477
## Has2 2.2706 0.144254 0.871495 -0.40161 -0.279053
## Dscc1 2.5179 0.951262 0.030162 -0.51895 0.252828
## Vdr 2.0940 -0.091803 0.551569 -0.53385 -0.522744
## Ly6c2 2.6618 0.257896 0.647776 -0.29741 -0.162758
## Ly6i 3.1760 -0.838547 0.407722 -0.10014 -0.383442
## Chaf1b 2.3605 1.274233 -0.083028 -0.54301 0.298719
## Fam132a 1.8653 1.149166 0.149160 -0.32526 0.493334
## Il33 1.4185 0.379330 0.823633 0.10004 0.403493
## Irf7 2.6683 -0.215551 0.525919 -0.33519 -0.072428
## Tyms 2.3916 0.894091 -0.124710 -0.45376 0.326383
## Hk3 2.6309 0.061971 0.330049 -0.35722 -0.290712
## Il1rl1 2.1701 1.297563 0.321817 -0.18428 0.493657
## Stat1 2.0737 -0.168815 1.124818 -0.47947 -0.124354
## Steap3 2.1134 1.081864 0.169041 -0.94429 0.382484
## Ube2t 2.4425 1.659537 -0.545765 -0.41897 0.047728
## Mnda 2.7080 0.191417 0.742129 -0.35500 -0.096592
## Xcl1 2.2621 0.407617 0.638778 -0.57028 -0.461928
## Atf3 2.6022 -0.548799 0.242312 -0.49613 -0.370588
## Mcm10 2.7083 0.728778 -0.170520 -0.70408 0.336755
## Il2ra 2.3366 -0.014804 1.200035 -0.02014 -0.276456
## Sapcd2 2.8653 0.757800 -0.518837 -0.08968 0.675548
## Il1rn 2.9048 -0.001937 0.354683 -0.55927 0.256328
## Gatm 2.6607 0.795657 0.080566 -0.22382 -0.147851
## Dut 2.9460 0.601031 0.113484 -0.69845 0.195462
## Rad51 2.2843 1.428579 -0.062747 -0.69909 0.272982
## Bub1 2.7050 0.752565 0.107775 -0.77538 0.413564
## Gins1 2.6744 0.895309 -0.462186 -0.34947 0.107700
## Aurka 2.1265 1.034914 0.064867 -0.48874 0.312963
## Zbp1 2.4239 -0.197859 0.875277 -0.30592 -0.128990
## Car1 1.8829 0.992393 0.330627 -0.19830 0.322244
## Il21 2.4839 0.340975 -0.296810 0.27697 0.896349
## Ifi44 2.8104 -0.685207 0.662927 -0.62614 -0.284237
## Gbp3 2.7409 0.065236 0.727836 -0.33404 -0.217552
## Gbp2 2.4946 -0.053584 0.869671 -0.51126 -0.218359
## Smpdl3b 2.8222 0.062798 0.292718 -0.02509 0.534578
## Htra3 -2.5121 0.350984 -0.663193 -0.19286 0.522127
## Cxcl9 2.3857 -0.182441 0.868163 -0.41061 -0.112345
## Oasl2 2.7912 -0.164739 0.512111 -0.35931 -0.382802
## Hsph1 1.1493 -0.068182 0.900389 -0.54528 0.184484
## Tfr2 1.8639 1.176114 0.363170 -0.48258 0.051434
## Asns 2.1348 1.039297 0.295367 -0.73330 0.396246
## Klrg1 2.4452 1.568741 0.727691 -0.41231 -0.251204
## Klra2 2.4290 -0.865934 0.878450 0.02249 -0.640574
## Bcat1 2.4753 -0.098399 0.632705 0.60207 0.499142
## Rad51ap1 2.4349 0.950596 -0.321251 -0.33550 1.125974
## Ddias 2.5995 0.758656 -0.522305 0.01177 0.510731
## Sult1a1 -2.2468 -1.045769 -0.950526 -0.32619 0.706247
## Plk1 2.1288 1.063644 -0.056757 -1.09496 0.254891
## Tmem159 -0.1782 -0.643234 -0.581866 -0.69936 -0.274096
## Cenpi 2.5422 1.271020 -0.610972 -0.79845 0.274050
## Adgrg2 -2.1778 -1.048788 -1.056594 0.05438 -0.485290
## Cenpn 2.5793 1.105152 0.561522 -0.93169 0.108836
## Mt2 2.6096 0.724482 0.148087 -0.23041 0.142247
## Mt1 1.9903 1.671717 0.224223 0.28013 0.137944
## Chek1 2.7299 0.937657 0.725329 -0.48239 -0.053284
## Mns1 2.5320 1.114919 0.024179 -0.77366 0.258865
## Ptgs2 2.7397 -0.330703 0.734762 -0.82001 -0.422101
## Traip 2.4584 0.953007 -0.678935 -0.39022 0.107438
## Oas3 2.4689 0.323464 0.418157 -0.86568 -0.263718
## C330027C09Rik 2.7462 1.155597 0.313821 -0.46595 0.081963
## Rtp4 2.4438 -0.875385 0.576789 -0.02748 0.075464
## Apol6 2.3595 -0.442341 0.794016 -0.44118 -0.139892
## Recql4 2.3153 1.125417 0.641648 -0.52491 0.056124
## Pla2g4c 1.9938 0.901597 0.353723 -0.79187 1.037389
## Polq 2.5793 0.973621 -0.078759 -0.78514 -0.092550
## Kif4 2.3010 1.373400 -0.232469 -0.87180 0.226623
## Tmem132c -2.8644 -0.499600 -0.259678 0.93347 0.445327
## Brip1 2.8211 0.330925 0.137768 -0.74411 -0.425834
## Lif 2.0477 0.052473 -0.047974 -0.19381 -0.004560
## Gbp8 2.2828 0.203582 1.016935 -0.69974 -0.457066
## Ifit1 2.7656 -0.335793 0.681921 -0.37479 -0.915192
## BC030867 2.2569 1.257637 -0.484386 -0.49158 0.177234
## Cxcl10 2.4888 -0.146602 0.879415 -0.54755 -0.609523
## Ubd 2.6532 -0.384951 0.840145 -0.46507 -0.182481
## Ccl2 2.5033 -0.004581 0.109771 -0.20452 0.165752
## Fignl1 2.3175 0.999063 -0.033184 -0.72053 0.335775
## Isg15 2.7991 0.458569 0.188426 -0.79260 -0.425053
## Kif15 2.4801 0.928872 -0.108923 -0.71964 0.306614
## Dtl 2.2222 1.097948 -0.024945 -0.75449 0.455194
## Fam13a -2.5762 -0.107135 0.048714 0.62964 0.732363
## Rmi2 2.5449 0.731287 0.826189 -0.81620 -0.045244
## Socs1 2.3692 -0.319510 0.722157 -0.46225 -0.139974
## Eme1 3.0392 0.200371 -0.050561 -0.11709 -0.228893
## Fanci 2.5998 0.851071 -0.454448 -0.50985 0.444106
## Batf2 2.7229 -0.242601 0.328110 -0.43138 -0.355729
## 2810417H13Rik 2.7847 0.807164 -0.250661 -0.64124 0.324712
## Gbp7 2.6198 0.193883 0.724066 -0.51049 -0.278370
## Gbp2b 3.1072 -0.013268 0.301389 -0.51164 -0.367664
## Olfr56 2.6168 -0.347577 0.620291 -0.44356 -0.683426
## Il7 -2.0349 -0.957747 -0.229144 -0.13059 0.614501
## Pklr 1.8104 1.010565 0.246308 -0.57845 0.420421
## Serpina3g 2.6223 -0.005927 0.805545 -0.43931 -0.256719
## Abca8a -2.0999 0.206659 -0.741875 0.52723 -0.409900
## Mmp3 2.6937 -0.076854 0.318665 -0.02844 -0.329797
## Tnip3 2.8173 0.089704 0.357761 0.21010 -0.483921
## Gvin1 2.3254 0.013011 0.942489 -0.50211 -0.195635
## Ifit2 2.5778 -0.678576 0.753958 -0.47238 -0.335979
## Fam26f 2.6196 -0.265466 0.484169 -0.01992 -0.129366
## Irgm1 2.5288 -0.276245 0.794389 -0.42976 -0.097818
## Kcne4 2.0573 0.267466 0.273232 0.09591 0.749329
## Bex4 1.7712 0.788949 0.548136 -0.39380 0.633041
## Ccr4 2.1556 1.323913 0.589395 -0.79258 0.108802
## Ckap2l 2.4065 0.974020 0.001918 -0.77831 0.266743
## Gm12185 2.7069 -0.566605 0.697852 -0.49241 -0.054193
## 2610318N02Rik 2.7528 0.572906 0.706081 -0.49466 -0.464282
## Tcf19 2.6886 1.064235 -0.445450 -0.53542 0.472381
## Mmp13 2.8842 0.105056 0.009471 0.52625 -0.691738
## Socs3 2.1091 0.426462 1.220665 0.20833 0.134046
## Slamf8 2.8070 -0.390780 0.770442 -0.34992 -0.266401
## Iigp1 2.4812 0.049682 0.955016 -0.53453 -0.307544
## Ifng 2.8313 -0.063815 0.560223 -0.24599 -0.455004
## Fam72a 2.8344 0.415211 -0.318212 -0.45477 -0.470784
## Fcgr4 2.8290 -0.141033 0.577799 -0.50787 -0.472121
## Obscn -2.3546 -1.219315 0.776089 0.29463 -0.143063
## Sphk1 1.9638 1.221061 0.019515 -0.74444 0.290327
## Serpina10 1.2531 0.769898 1.077050 0.13286 -0.178743
## Tubb3 3.2035 -1.232264 -0.349231 -0.60424 -0.290714
## Serpina3f 2.5057 0.018319 0.919613 -0.49622 -0.204962
## Zbtb16 -1.9050 -1.087589 -0.468226 0.15142 -0.015161
## Gm4841 3.0887 0.095771 0.531771 -0.93995 -0.470125
## Slfn9 2.9638 -0.284473 0.446404 -0.02961 -0.441787
## Irgm2 2.2371 -0.129021 1.108241 -0.53638 -0.090245
## Cited4 1.7639 1.323357 0.335191 -1.10068 0.170908
## Gm4951 2.6633 -0.255952 0.855295 -0.72892 -0.743011
## Nlrc5 1.8521 -0.165018 1.217037 -0.69180 0.026506
## Amy2a5 0.5799 -0.702566 -0.247129 -0.31277 2.065251
## Spc24 2.6809 1.024700 -0.469583 -0.91565 0.483070
## Ifit3 2.2890 -0.677419 0.843483 -0.17101 -0.526784
## Cenpw 2.7348 1.159627 -0.101339 -1.18858 -0.037293
## Ly6a 2.7469 -0.165911 0.550486 -0.55403 -0.100067
## Aunip 2.3373 0.835925 -0.221405 0.15407 0.260086
## Gm4070 2.1912 0.237747 1.171481 -0.64216 -0.070065
## Igtp 2.3807 -0.099418 0.919335 -0.46441 0.017644
## Ifi47 2.4870 -0.286730 0.795527 -0.33857 -0.145566
## Tgtp2 2.2149 -0.056165 1.077176 -0.38575 -0.022077
## Tgtp1 2.3200 -0.006929 1.001503 -0.39430 -0.017066
## Ifit1bl1 2.4423 -0.327851 1.048851 -0.64823 -0.177728
## Gm43302 2.0088 -1.204474 1.126086 -1.14996 -0.068284
## Gbp4 2.2638 -0.325485 0.938627 -0.35195 -0.185696
## Hspa1b 1.4089 -0.864508 0.750156 -0.81001 0.339292
## F830016B08Rik 2.5825 -0.354422 0.962983 -0.56018 -0.345207
## Gm17334 1.8871 -0.302339 0.450915 -0.02210 0.018524
## Apol11b 2.5969 1.077515 -0.264395 -0.59449 -0.117360
## Hist1h3g 2.1504 1.086918 -0.366269 -0.48647 0.352488
## Gbp6 2.1665 0.023186 1.083833 -0.31630 0.035075
## Gbp10 2.3891 -0.031070 1.058741 -0.47784 -0.731692
## Gbp5 2.4981 -0.191480 0.873413 -0.34645 -0.274282
## Cela3b 1.2612 -0.340819 -0.344348 -0.35985 2.027239
## Ctrb1 1.2274 -0.607601 -0.607601 -0.43232 1.982522
## Ttc41 -0.7179 1.553751 -0.135726 0.74446 -0.187929
## Reg1 1.1858 -0.545280 -0.545280 -0.54528 1.912841
## Amy2a3 1.5007 -0.555135 -0.555135 -0.55514 1.945135
## Amy2a2 1.5007 -0.555135 -0.555135 -0.55514 1.945135
## Amy2a4 1.5007 -0.555135 -0.555135 -0.55514 1.945135
## rtmt.d3.r3 rtmt.d3.r4 naive.r1 naive.r2 naive.r3 naive.r4
## Cdc45 0.459602 0.092274 -1.29874 -0.20455 0.32879 -1.34976
## Il12rb1 0.509004 -0.090266 -0.65098 0.02409 -0.40883 -1.05969
## Gnb1l 0.784217 -0.955586 -0.99640 -0.81805 0.42012 -1.75754
## Lgals9 -0.362176 0.079259 -0.78750 -0.53892 -0.20846 -0.48099
## Uhrf1 0.446615 0.525867 -1.39218 -0.31073 0.58175 -1.35089
## Hpn -0.680739 0.472066 -0.08188 -0.70727 -1.04730 -1.57607
## Chaf1a -0.147917 0.363051 -1.05130 -0.65874 0.34730 -0.76659
## Syce2 0.690147 0.792616 -1.16836 -0.49348 0.18076 -1.30637
## Abca13 -0.198200 0.135753 -1.17230 -0.25000 0.67849 -0.69136
## Ccl24 -0.717008 -0.366028 -0.40358 -0.17440 -0.35510 -0.72376
## Mcm5 0.200370 0.579699 -1.31756 -0.41785 0.32418 -1.04639
## Atp7b -0.174530 0.621286 -0.93840 -0.20548 0.28013 -1.53936
## Gmnn 0.060002 0.464496 -1.08249 -0.52797 0.66927 -0.88343
## Pole -0.373116 0.378825 -0.95145 -0.34197 0.12755 -1.32053
## Mlkl -0.642525 0.246009 -0.79560 -0.38709 -0.30749 0.13132
## Hmgb3 0.209089 0.542581 -1.17782 -0.42210 0.49969 -1.33901
## Gzmb -0.349098 -0.635317 -0.89298 -0.59737 -0.21362 -0.13182
## Cdc6 0.329241 0.573332 -1.09129 -0.34526 0.52690 -1.47590
## Mapt 0.639072 -0.183060 1.77986 -0.36610 -0.21540 0.36050
## Irf1 0.110553 -0.048477 -0.90736 -0.94037 -1.28377 -0.75389
## Slfn3 0.462418 0.263677 -1.37806 -0.47640 0.22645 -0.72780
## Mtfr2 -0.112191 0.862531 -1.23594 -0.38625 0.56884 -1.20654
## Ppa1 -0.036365 0.257652 -1.04803 -0.18989 -0.63576 -0.34483
## Nefh 0.326383 0.497162 -0.72742 -1.09244 -0.65488 -0.62347
## Upp1 -0.720479 -0.189676 -0.85377 -0.06297 -0.52391 -0.49977
## Nampt 0.069016 -0.093832 -0.88170 -0.51568 -0.47144 -0.33157
## Cmpk2 0.205193 0.280893 -1.15616 -0.57513 0.77850 -0.79386
## Fam64a -0.267036 0.073441 -0.38026 -0.25914 0.11144 -1.98143
## Top2a 0.372325 0.325690 -0.86457 -0.39107 0.95932 -1.23185
## Serpina3n 1.327506 0.513959 -0.56702 -0.55886 -2.00831 -0.99326
## Wars 0.021719 -0.142407 -0.26214 -0.32048 -1.07783 -0.54838
## Hsp90aa1 0.058283 0.635059 -1.03295 -0.34990 -0.63307 -1.25990
## Thbs4 0.395788 0.130129 -1.03345 -1.61400 -0.72639 -0.57705
## Dhfr 0.061901 0.579111 -0.72824 -0.40201 0.20595 -0.97380
## Cenpk 0.481137 0.399440 -0.99647 -0.20742 0.62996 -1.45115
## Fam107a 1.417934 0.510774 0.62930 0.93590 -1.15399 1.20872
## Pnp 0.164347 0.336131 -0.94513 -0.57146 0.58182 -1.16255
## Pbk 0.466675 0.633816 -1.03463 -0.17855 0.58208 -1.23013
## Acod1 -0.155178 -0.160167 -0.29102 -0.39901 -0.40777 -0.05192
## Shcbp1 0.310848 0.524267 -1.51954 -0.51745 0.81838 -0.83038
## Has2 -0.178612 -0.474346 -1.25411 -0.83183 -0.67536 -0.73293
## Dscc1 -0.123749 0.752783 -0.89985 -0.92459 0.62698 -0.99022
## Vdr -0.242347 0.517366 -1.16339 -1.27981 -0.38854 -0.74232
## Ly6c2 -0.277478 0.196752 -0.89685 -0.33266 -0.54842 -0.12230
## Ly6i -0.470717 -0.213341 -0.56447 -0.57624 -0.41510 -0.09549
## Chaf1b 0.357500 0.495203 -0.89976 -0.20981 0.25188 -0.81785
## Fam132a 0.219649 0.448125 -1.03640 -0.24018 0.07138 -1.50948
## Il33 0.979336 0.493215 -0.68210 -1.16317 -1.79101 -1.16785
## Irf7 -0.364956 0.038237 -1.11866 -0.58166 -0.18524 -0.15084
## Tyms 0.280236 -0.035424 -0.89158 -0.09646 0.65140 -1.32409
## Hk3 -0.225815 -0.286179 -0.82475 -0.39578 -0.49212 -0.22519
## Il1rl1 -0.311045 0.792026 -1.25327 -0.58407 0.38585 -1.30471
## Stat1 0.225071 0.023895 -0.98338 -0.86868 -1.04181 -0.42361
## Steap3 0.085667 0.851254 -0.95136 -0.44551 0.19575 -1.32960
## Ube2t -0.450943 0.413908 -1.01757 -0.17989 0.55711 -1.64846
## Mnda -0.168467 -0.183559 -1.04530 -0.72684 -0.77014 -0.13882
## Xcl1 -0.846750 -0.743272 -0.76175 -0.21399 -0.84057 -0.38426
## Atf3 0.224282 -0.314127 -0.49388 -0.91661 -1.08270 0.08948
## Mcm10 0.110297 0.531487 -0.98311 -0.72908 0.60340 -1.37235
## Il2ra 0.155180 -0.056444 -0.74143 -0.61731 -0.66940 -0.64043
## Sapcd2 -0.642482 0.099905 -1.56626 -0.51859 0.03511 -0.22843
## Il1rn -0.075824 -0.407813 -0.38053 -0.97259 -0.45741 0.11712
## Gatm -0.104180 0.288075 -1.08818 -0.74848 -0.07219 -0.65822
## Dut 0.295286 0.747005 -1.18231 -0.34264 -0.58193 -0.85069
## Rad51 -0.109177 0.389192 -1.55893 -0.23360 0.57697 -0.70819
## Bub1 0.319793 0.558537 -1.38011 -0.09396 0.62250 -0.95465
## Gins1 0.083721 0.471973 -1.02476 -0.53258 0.42892 -0.79502
## Aurka 0.406374 0.475066 -1.17213 -0.51125 0.91828 -1.70702
## Zbp1 0.205781 0.037554 -0.80623 -0.56696 -1.12079 -0.49769
## Car1 0.158517 0.750020 -1.32684 -0.44442 0.40109 -1.73178
## Il21 0.810342 0.585934 -0.67205 -0.42550 -0.84322 -0.79608
## Ifi44 -0.422060 0.605297 -0.87755 -0.21374 -0.20407 0.20726
## Gbp3 -0.183237 -0.467493 -0.86876 -0.34959 -0.63278 -0.20586
## Gbp2 0.222764 -0.088564 -0.81852 -0.68851 -0.92739 -0.49376
## Smpdl3b 0.248095 0.783910 -1.52612 -0.93518 -0.96061 -0.26635
## Htra3 -0.006936 -0.486901 0.97686 1.12010 0.20410 1.06779
## Cxcl9 0.388267 -0.248794 -0.54832 -1.10016 -1.10740 -0.64685
## Oasl2 -0.286728 0.234928 -0.86555 -0.58373 -0.38827 0.20817
## Hsph1 0.097867 1.072681 -0.55298 -0.03054 -1.86889 -2.03994
## Tfr2 -0.012446 0.738359 -1.16995 -0.03128 0.36007 -1.67751
## Asns 0.099891 0.808108 -1.06717 -0.39276 0.25497 -1.40419
## Klrg1 -0.803708 -0.419447 -1.16022 -1.00421 -0.37061 0.13748
## Klra2 -0.092541 -0.538324 -0.98725 -0.22603 -0.17062 -0.19012
## Bcat1 -0.514881 0.934677 0.22711 -0.10843 -1.89671 -1.09632
## Rad51ap1 0.077996 0.395995 -0.60025 -0.47680 0.56824 -1.12505
## Ddias 0.297556 0.183508 -0.69669 -0.70850 0.75131 -1.43985
## Sult1a1 0.789541 -0.110701 1.06047 1.27698 -0.11643 0.73513
## Plk1 0.220076 0.815401 -0.72919 -0.42968 0.84737 -1.34044
## Tmem159 -0.177576 -0.341254 0.37640 3.58831 -0.46845 0.15716
## Cenpi -0.064327 -0.036193 -1.02805 -0.25684 0.78918 -1.52664
## Adgrg2 0.176596 0.070281 0.58802 1.98654 0.11602 0.70559
## Cenpn 0.196166 0.163283 -0.39303 -0.78721 0.14613 -1.40951
## Mt2 -0.457363 0.651346 -1.27325 -0.30076 0.28631 -1.41701
## Mt1 -0.327014 1.263396 -1.28063 -0.34302 -0.19029 -1.51436
## Chek1 0.117865 -0.044331 -1.39570 0.21877 -0.28543 -1.48347
## Mns1 -0.279474 0.393929 -0.95009 -0.13555 0.49105 -1.48663
## Ptgs2 -0.641776 -0.804770 -0.50885 -0.13364 -0.14455 -0.20371
## Traip 0.933496 0.092697 -1.39445 -0.41523 0.21712 -1.19110
## Oas3 0.230150 0.232127 -0.99272 -0.58968 0.94727 -0.51698
## C330027C09Rik 0.140756 0.188937 -1.13192 -0.27189 0.72539 -1.28291
## Rtp4 0.161608 0.338089 -1.11419 -0.63365 -0.55414 0.31633
## Apol6 -0.559095 -0.478679 -0.16803 -0.99341 -0.46031 0.07219
## Recql4 0.192785 0.550021 -1.11462 -0.84184 -0.34482 -1.23497
## Pla2g4c 0.742873 0.762590 -1.17691 -0.56730 0.26579 -1.42459
## Polq 0.199317 0.425079 -1.04607 -0.57003 0.59410 -1.27482
## Kif4 0.415991 0.267649 -0.79486 -0.55716 0.83897 -1.38949
## Tmem132c 0.020029 -0.963849 0.94078 0.41851 0.07725 1.12073
## Brip1 0.141917 0.067101 -0.67021 -0.12931 -0.01312 -0.59050
## Lif 0.858607 0.407320 -0.77052 -1.04173 -0.08119 -0.87121
## Gbp8 -0.109612 -0.434592 -0.71269 -0.50679 -0.49899 -0.28391
## Ifit1 0.039307 0.094383 -0.52846 -0.54867 0.02275 -0.16684
## BC030867 -0.825893 -0.093687 -0.62178 -0.38751 0.18242 -1.21457
## Cxcl10 -0.091452 -0.267321 -0.74954 -0.77277 -0.57434 -0.57266
## Ubd 0.070546 -0.189957 -0.59163 -0.70696 -0.54834 -0.66526
## Ccl2 -0.403856 -0.107716 -0.80079 -0.73637 -0.64230 -0.61156
## Fignl1 0.257370 0.429038 -0.91116 -0.48155 0.58959 -1.19005
## Isg15 0.142950 -0.091489 -0.86289 -0.34555 0.84661 -0.63333
## Kif15 0.288226 0.481262 -0.97082 -0.31708 0.72154 -1.48180
## Dtl 0.337004 0.566645 -0.96200 -0.48215 0.40842 -1.41464
## Fam13a 0.476594 -0.117903 1.46425 0.20467 -0.02962 1.36749
## Rmi2 -0.202210 0.315440 -0.96987 -0.61563 -0.46494 -0.81807
## Socs1 0.322719 0.230323 -1.08409 -0.99252 -0.88345 -0.70505
## Eme1 0.254355 0.329750 -1.20702 0.20465 -0.16921 -1.53254
## Fanci 0.646460 0.521284 -1.17725 -0.45199 0.07120 -1.15532
## Batf2 -0.183926 -0.780403 -0.65533 -0.22221 -0.45766 -0.58337
## 2810417H13Rik 0.517229 0.601476 -1.01789 -0.30759 -0.07432 -0.71336
## Gbp7 0.021727 0.053613 -0.97809 -0.65030 -0.66090 -0.56967
## Gbp2b -0.551785 -0.337012 -0.66742 -0.27967 -0.47969 -0.19355
## Olfr56 0.238211 -0.561073 -0.85572 -0.33844 -0.13673 -0.17038
## Il7 0.242342 0.308049 0.58490 1.13663 0.96448 0.81975
## Pklr -0.268162 1.135252 -1.27032 -0.16723 0.17671 -1.35404
## Serpina3g 0.163083 -0.045116 -0.91220 -0.81743 -0.86521 -0.31111
## Abca8a -0.622820 -0.058445 0.59047 1.03265 0.81320 0.68039
## Mmp3 0.452743 -0.968619 0.18504 -0.64342 -0.66815 -1.20745
## Tnip3 0.260457 -0.659605 -0.83818 -0.11467 -0.87839 -0.80383
## Gvin1 0.275387 0.064986 -0.94332 -0.68183 -0.99880 -0.52015
## Ifit2 -0.190117 -0.128459 -0.86382 -0.30139 -0.63637 -0.11665
## Fam26f -0.010906 -0.520167 -0.60080 -0.82408 -0.89047 -0.19880
## Irgm1 0.195597 0.044562 -0.95618 -0.73325 -0.77672 -0.56216
## Kcne4 0.367082 0.195683 -0.39862 -1.57186 -1.67095 -0.69804
## Bex4 0.188132 0.656148 -0.95705 -0.27059 0.49434 -2.30797
## Ccr4 -0.354552 -0.086103 -0.59686 -1.00233 -0.58580 -0.26907
## Ckap2l 0.311283 0.374884 -1.09321 -0.31612 1.04973 -1.32321
## Gm12185 -0.038688 0.012158 -0.27028 -0.83783 -0.64843 -0.48830
## 2610318N02Rik 0.304855 0.516467 -0.77556 -0.91651 -1.14194 -0.29556
## Tcf19 0.379622 0.062490 -1.17958 -0.59384 0.37979 -0.57759
## Mmp13 -0.186863 -0.965214 -0.48109 -0.90954 -0.69745 -0.27592
## Socs3 0.360284 0.257935 -0.86943 -0.82139 -1.39370 -0.56371
## Slamf8 0.006450 -0.749494 -0.26469 -0.34168 -0.89902 -0.33815
## Iigp1 0.033814 -0.134776 -0.92185 -0.90814 -0.89485 -0.39759
## Ifng -0.082807 -0.500045 -0.77459 -0.84180 -1.14119 -0.51279
## Fam72a 0.600124 -0.781319 -0.77425 0.11931 -0.62231 -0.81635
## Fcgr4 -0.089999 0.033168 -0.89397 -0.33133 -0.56323 -0.42943
## Obscn -0.305386 0.486988 0.81930 0.99560 1.18767 0.37231
## Sphk1 -0.038967 0.749755 -0.66283 -0.96324 0.51524 -1.47108
## Serpina10 1.429452 -0.059148 -1.81967 -1.65812 -0.92438 -0.90495
## Tubb3 0.360257 0.035988 -0.17644 -0.40275 -0.49329 -0.37838
## Serpina3f 0.120927 0.040981 -0.98169 -0.76222 -0.92601 -0.41431
## Zbtb16 1.361853 1.098623 0.78240 0.01597 -0.91703 1.33530
## Gm4841 -0.368568 -0.236157 -0.88905 -0.48915 -0.69137 -0.05165
## Slfn9 -0.053100 -0.090243 -0.70508 -0.21867 -0.22307 -0.18813
## Irgm2 0.026272 -0.098564 -1.00962 -0.77069 -0.97829 -0.43532
## Cited4 0.539771 1.147472 -1.47865 -0.09099 0.08002 -0.97683
## Gm4951 -0.108618 -0.360360 -0.54581 -0.52162 -0.84529 0.10822
## Nlrc5 0.475963 0.002039 -0.93469 -0.49067 -1.61614 -0.14170
## Amy2a5 -0.537507 -0.470566 -0.41846 -0.25408 -0.25765 -0.70257
## Spc24 0.030115 -0.115061 -0.95167 0.10952 0.50007 -1.09974
## Ifit3 -0.630448 0.065348 -0.52560 -0.26862 -0.20284 0.23501
## Cenpw 0.227473 0.545559 -1.23404 -0.74658 0.36236 -0.45793
## Ly6a 0.169417 0.268749 -0.87970 -0.28358 -0.72449 -0.09977
## Aunip 0.427482 0.905262 -0.86399 -0.61892 0.29059 -1.53832
## Gm4070 0.272322 -0.004467 -1.15856 -0.66743 -1.04953 -0.38036
## Igtp 0.294635 0.066821 -0.99582 -0.79911 -1.04796 -0.76334
## Ifi47 0.225511 0.006283 -0.88933 -0.63123 -0.98217 -0.67778
## Tgtp2 0.223826 -0.146924 -1.00101 -1.06156 -0.82540 -0.65328
## Tgtp1 0.365577 0.068464 -0.97224 -0.81190 -1.14904 -0.79955
## Ifit1bl1 -0.025387 0.073779 -0.66748 0.02830 -0.64377 -0.07544
## Gm43302 0.366769 0.108576 -0.42543 -1.34102 -1.16095 0.38435
## Gbp4 0.298218 -0.037158 -0.76093 -0.83191 -1.20857 -0.59506
## Hspa1b -0.166636 0.863116 -0.61031 -0.55413 -1.86057 -1.07026
## F830016B08Rik -0.208012 -0.077294 -0.99380 -0.59106 -0.83204 -0.10751
## Gm17334 0.078265 -0.087213 -1.15471 -0.50355 -1.07138 -0.88066
## Apol11b 0.507129 -0.022970 -0.29663 -0.64698 1.01316 -1.19087
## Hist1h3g 0.736136 0.438499 -1.25292 -0.63627 0.60073 -1.31013
## Gbp6 0.255779 0.092683 -1.00881 -0.82791 -1.10237 -0.60468
## Gbp10 0.197831 0.032767 -0.72385 -0.47700 -1.16632 -0.76620
## Gbp5 -0.006087 -0.199676 -0.68479 -0.72466 -0.94913 -0.43002
## Cela3b -0.610776 -0.610776 -0.61078 1.24916 -0.61078 -0.61078
## Ctrb1 -0.607601 -0.428566 -0.42875 1.34725 -0.42216 -0.60760
## Ttc41 -0.134901 0.804719 1.34954 0.24518 0.32493 0.83655
## Reg1 -0.545280 -0.545280 -0.54528 1.25663 -0.54528 -0.54528
## Amy2a3 -0.555135 -0.555135 -0.55514 1.38927 -0.55514 -0.55514
## Amy2a2 -0.555135 -0.555135 -0.55514 1.38927 -0.55514 -0.55514
## Amy2a4 -0.555135 -0.555135 -0.55514 1.38927 -0.55514 -0.55514## heat.list day delivery rep
## 13 naive.r1 0 naive 1
## 14 naive.r2 0 naive 2
## 15 naive.r3 0 naive 3
## 16 naive.r4 0 naive 4
## 1 sbp.d3.r1 3 sbp 1
## 2 sbp.d3.r2 3 sbp 2
## 3 sbp.d3.r3 3 sbp 3
## 4 sbp.d3.r4 3 sbp 4
## 9 rtmt.d3.r1 3 rtmt 1
## 10 rtmt.d3.r2 3 rtmt 2
## 11 rtmt.d3.r3 3 rtmt 3
## 12 rtmt.d3.r4 3 rtmt 4
## 5 mt.d3.r1 3 mt 1
## 6 mt.d3.r2 3 mt 2
## 7 mt.d3.r3 3 mt 3
## 8 mt.d3.r4 3 mt 4
4.6 Ifng
## [1] "ENSMUSG00000055170"
## [1] 843## [1] 855## [1] 7664.7 Heatmap of ISGs unique to MT and RTMT
## sbp.d6.r1 sbp.d6.r2 sbp.d6.r3 sbp.d6.r4 mt.d6.r1 mt.d6.r2
## B3gnt8 -0.068448 0.216193 0.007990 -0.57523 -0.68598 -0.82295
## Ccrl2 0.103731 0.355740 0.359574 -0.06783 0.36246 0.27072
## Epb41l1 0.304218 -0.860643 0.105673 -0.97897 -0.77185 -1.28460
## Eya1 -0.208376 0.225788 -0.081829 -0.11969 -0.25338 -0.01342
## Igfbp4 -0.825054 -0.487663 -0.940250 -0.23272 0.04256 0.37101
## Lox -0.067240 -1.971500 -0.696712 -0.24098 1.10214 0.96383
## Oaf 0.743467 -0.677860 -0.115009 0.25231 1.75428 0.36168
## Pola2 0.385802 0.734549 0.339242 0.18755 0.75815 0.42683
## Acpp 0.293898 -0.152581 0.054735 -0.11824 -1.41588 -0.25106
## Adamtsl4 0.441989 -0.186479 -1.062666 0.60908 -1.52635 -0.17512
## Agpat9 0.173475 -0.096227 0.791701 0.20059 -1.63511 -0.48557
## AI607873 0.108824 0.195724 0.472340 0.41240 0.26028 0.47222
## Ank 0.080367 -0.342630 -0.258593 -0.66890 -0.96959 -0.97788
## Aox1 -1.342519 0.051220 0.182260 0.30563 -0.33386 -0.67756
## B2m 0.358161 0.279908 0.429032 0.52719 0.55250 0.65481
## Basp1 0.072513 -0.072171 0.284211 0.21118 0.72323 0.79703
## Bcl2a1b 0.054528 0.181623 0.198186 -0.04103 0.22173 0.72975
## Blvra 0.765710 -0.145010 0.016556 -0.02292 0.89534 0.96906
## Brwd1 -0.589696 -0.429789 -0.242214 -0.27882 -0.99232 -0.52502
## C1rl -0.391445 0.243637 -0.165320 0.51652 0.96067 0.87028
## Casp12 -0.117099 0.647364 0.430509 0.53670 0.94380 0.64570
## Ccdc125 -0.171015 -0.435226 0.163099 -0.07484 -0.65996 -0.86642
## Cfh -0.376435 -0.009423 -0.354583 -0.28383 -0.74368 -0.60008
## Cish -0.088582 0.533734 -0.515993 0.26389 0.23010 0.99768
## Clic4 0.418385 0.250312 0.314014 0.36999 0.45057 0.46998
## Csrp1 0.311618 0.203074 0.264403 0.59433 0.54692 0.66599
## Ctla2b -0.093533 0.006361 -0.568235 0.24648 1.11660 1.01564
## Ctsd 0.096685 -0.217004 0.271347 0.05289 0.96476 0.93651
## Cttnbp2nl 0.036532 -0.070586 0.147890 0.30394 0.76699 0.86733
## Dnase1l3 0.143341 -0.002492 0.013074 0.21613 0.67673 0.85256
## Eepd1 -0.114446 -0.148122 -0.570796 -0.37894 -0.66331 -0.61803
## Fam162a 0.656002 -0.315084 0.551854 0.11972 0.77598 0.39468
## Fam214a -0.336903 -0.500910 -0.012488 -0.69783 -0.06457 -0.89470
## Fas 0.019560 0.196372 0.019069 0.53570 0.59400 0.38769
## Fblim1 -0.179557 -0.252501 0.133833 0.35290 1.45217 0.78371
## Fbxl20 -0.119433 -0.256183 -0.199434 -0.37133 -0.93250 -0.65309
## Fcgr3 0.059735 -0.350111 0.189398 0.04490 1.13705 0.99473
## Fgf2 -0.825406 -0.273888 0.805424 0.27347 -0.68333 -0.60367
## Fry -0.169645 -0.044576 0.149844 0.28219 -1.00866 -0.52716
## Gca -0.408708 0.196835 -0.294657 -0.89241 1.64169 0.17573
## Gnb4 -0.109532 0.291090 0.047257 0.20946 0.24338 0.77939
## Gpnmb -0.384956 -1.142113 0.003326 0.72635 -0.40280 0.95238
## Gsr 0.366322 0.295519 0.285841 0.51252 0.68960 0.52267
## Id2 0.176781 0.023377 0.450923 0.50561 0.22054 0.81812
## Ier3 0.032120 -0.567241 0.177572 -0.22154 0.54460 0.81921
## Insr -0.350611 -0.311431 -0.155202 -0.32668 -0.55959 -0.61032
## L1cam -0.792212 0.170780 0.092717 0.16730 -1.59554 -0.54391
## Ly75 0.239449 0.169868 0.140238 0.25730 0.65251 0.60689
## Mab21l3 -0.227400 -0.418116 -0.270087 -0.18287 0.24608 1.10150
## Map2k6 -0.181955 0.061798 -0.122101 -0.35565 -0.93567 -0.47382
## Matn2 -0.165827 -0.452114 -0.188527 -0.01037 -0.18867 -0.27899
## Metrnl -0.093432 0.140604 0.216662 0.12641 0.55787 0.81905
## Nifk 0.657968 0.453728 0.411428 0.48073 0.73288 0.39412
## Mrps34 0.562970 0.337623 0.483235 -0.17415 0.98932 0.60277
## Mylip -0.392342 -0.228153 -0.191603 -0.58269 -0.63558 -0.55508
## Myo1f 0.244002 0.310985 0.090381 0.61004 0.35441 0.67959
## Nabp1 0.009371 -0.306950 -0.082334 -0.13875 0.67435 0.90274
## Nlrp10 -0.559423 0.064624 0.556405 -0.91394 -0.67258 -1.36596
## Nod1 -0.175392 -0.021001 0.286739 0.20398 0.71820 0.59972
## Nos2 -0.410736 -0.834258 -1.066556 0.17268 -0.05019 0.58656
## Nr1h3 -0.139151 0.035889 0.137890 0.20694 0.80149 0.81564
## Parp10 0.396646 0.286746 0.621691 0.23909 0.56896 0.55205
## Phxr4 -0.608728 0.070346 -0.593876 -0.03455 -1.33935 -0.31520
## Pla2g4a -0.032111 0.014100 -0.096796 0.09352 0.71192 0.69907
## Pnpt1 0.511881 0.397341 0.697635 0.37021 0.49421 0.26745
## Prune2 0.636161 -0.084140 -0.347718 0.38979 -0.05354 0.78542
## Pxdc1 -0.175717 0.447687 -0.484176 -0.43304 -0.60863 -0.76335
## Rab19 0.054549 0.677060 0.737528 -0.08461 0.25095 0.56883
## Ralgds 0.153852 0.008135 0.172480 0.13241 -0.19796 0.57540
## Rangap1 0.366060 0.421082 0.219512 0.44846 0.81322 0.49480
## Rasal2 -0.508312 0.101306 -0.338181 -0.64536 -0.83680 -0.39273
## Rora -0.526267 -0.297645 -0.247467 -0.20906 -0.98958 -0.11729
## Sap30 -0.146863 0.269187 -0.068467 0.75680 0.72282 0.73539
## Sdc3 0.192417 -0.097863 0.165791 0.34313 1.10182 0.86510
## Sdc4 0.177226 0.003971 0.170796 0.33308 0.10794 0.47878
## Serpinb6b 0.264923 0.113999 0.214410 0.31921 0.59259 0.82522
## Slc2a6 0.057992 -0.146768 0.045767 0.07957 0.03710 0.53347
## Specc1 0.963486 -0.145926 -0.269338 -0.49539 -0.24902 -0.83173
## Stk39 0.132417 0.388930 -0.006416 0.83877 -0.01709 0.47649
## Tfec 0.026965 -0.184640 0.180969 -0.31362 0.96342 1.09857
## Tmem191c 0.350134 -0.556451 -0.321022 -0.01527 -0.44122 -0.44279
## Tmod1 0.825343 0.048555 0.407916 -0.44207 0.20244 -0.92295
## Xylt1 0.524417 -0.232340 -0.468489 -1.11818 -1.52079 -0.77060
## mt.d6.r3 mt.d6.r4 rtmt.d6.r1 rtmt.d6.r2 rtmt.d6.r3 rtmt.d6.r4
## B3gnt8 -0.7910 -0.17029 -0.828974 -1.316003 -0.9205 -0.11885
## Ccrl2 0.3123 0.16238 0.448964 1.635882 0.7333 0.85335
## Epb41l1 0.5893 0.09446 -0.846986 -1.333715 -0.4710 0.16631
## Eya1 0.0816 -1.28874 -0.529355 -1.312371 -1.0007 -0.78434
## Igfbp4 -0.4968 -0.83448 -0.970779 -0.813677 -0.3595 -0.53327
## Lox -1.1061 0.52659 -0.643685 -1.303332 0.7762 -0.27157
## Oaf 0.7998 1.31655 0.174018 0.384023 0.3247 0.21034
## Pola2 0.3749 0.57476 0.721367 0.497285 0.6604 0.76020
## Acpp -0.7446 -0.50001 -0.333528 -0.312014 -1.6467 -0.56569
## Adamtsl4 -0.5914 0.62138 -0.667320 -0.438321 -0.9219 -0.88326
## Agpat9 -0.7930 0.25757 -0.940459 -0.387573 -1.4476 -0.53161
## AI607873 0.5441 0.57537 1.073519 0.906621 0.8962 0.51827
## Ank -0.6188 -0.59144 -0.287606 0.145195 -0.5887 -0.96494
## Aox1 -1.0292 -0.61181 0.090929 -0.532648 -1.1462 -0.82153
## B2m 0.4604 0.63400 0.637036 0.682516 0.7714 0.64718
## Basp1 1.2428 0.73982 0.659180 0.458385 0.6829 0.49711
## Bcl2a1b 0.9150 0.38959 0.674020 1.096771 0.7554 1.10142
## Blvra 0.7992 1.08616 0.380117 0.396298 0.6767 0.40037
## Brwd1 -0.1403 -0.79800 -0.464915 -0.222922 -0.9813 -0.77798
## C1rl -0.1119 0.79247 0.940861 0.449145 0.9660 0.94280
## Casp12 0.4329 0.36837 0.844930 0.104185 1.4035 -0.01445
## Ccdc125 -0.8603 -1.06032 -0.623845 -0.203610 -0.6435 -0.83654
## Cfh -0.3760 -0.83769 -0.636810 -0.819704 -0.4008 -0.96077
## Cish 0.9487 -0.06136 0.653375 0.993235 0.7360 0.98929
## Clic4 0.3593 0.56944 0.686170 1.078215 0.8016 0.74548
## Csrp1 0.4287 0.72752 0.599589 0.577970 0.9484 0.68856
## Ctla2b 1.3033 0.46063 0.749699 0.478116 0.9090 0.25226
## Ctsd 0.5422 0.67052 0.419618 0.595659 1.2071 0.71816
## Cttnbp2nl 0.7944 0.57882 0.745086 0.616451 1.1291 0.42197
## Dnase1l3 1.1550 0.62318 0.495358 0.623121 0.9478 0.54850
## Eepd1 -0.2661 -0.88489 -0.654193 0.157954 -1.1610 -0.76567
## Fam162a 0.7675 0.76272 0.462685 0.860402 0.2519 1.03361
## Fam214a -0.8193 -0.56867 -0.672144 -0.866074 -0.3632 -0.65144
## Fas 0.4084 0.53446 0.723333 0.863447 0.8061 1.22994
## Fblim1 0.6797 0.42364 0.776845 0.783294 0.7699 0.35457
## Fbxl20 -0.8650 -0.58648 -0.476061 -0.499448 -0.9132 -0.63298
## Fcgr3 1.1401 0.88930 0.689034 0.453849 0.7534 0.06396
## Fgf2 -1.2077 -0.67732 0.103702 -1.115532 -0.4438 -0.88446
## Fry -0.9161 -1.09477 -0.382675 -0.449469 -1.0281 -0.78006
## Gca 0.8700 -0.46647 0.344741 0.979535 1.3960 0.88880
## Gnb4 1.1406 0.27127 0.898090 0.944983 1.0354 0.49276
## Gpnmb -0.1126 0.79567 0.696414 0.909600 1.5078 1.19806
## Gsr 0.5689 0.71397 1.099984 0.579650 0.5073 0.41548
## Id2 0.5989 0.70328 0.860023 0.337549 0.7737 0.98082
## Ier3 0.6572 0.40864 0.264675 0.957404 1.2500 1.38727
## Insr -0.6954 -0.54238 -0.510962 -0.598217 -0.7369 -1.12639
## L1cam -0.8351 -0.36927 -0.376009 -0.386019 -0.3124 -1.04792
## Ly75 0.8009 0.40265 0.550795 0.765636 0.9796 0.88721
## Mab21l3 1.0504 0.73441 0.724708 1.211621 0.8952 0.73488
## Map2k6 -0.1728 -0.67146 -1.052422 -0.971408 -0.1400 -1.17653
## Matn2 -1.1625 -0.16110 -0.896315 -1.219159 -0.7401 -0.74106
## Metrnl 0.6052 0.77180 0.986297 0.729171 0.9168 0.55117
## Nifk 0.5070 0.50504 0.642438 0.712170 0.6432 0.52672
## Mrps34 0.1333 0.77814 0.837998 0.685784 0.8981 0.15048
## Mylip -0.3565 -0.71419 -0.678916 -0.792171 -0.7844 -0.64947
## Myo1f 0.6498 0.64606 0.648957 0.410100 0.7891 1.02383
## Nabp1 1.1392 0.55361 0.643676 0.541619 1.0148 1.02916
## Nlrp10 -0.6356 -0.78102 0.003491 -0.144072 -1.1335 -0.17464
## Nod1 1.0160 0.50885 0.699875 0.490361 0.8509 1.06135
## Nos2 0.8612 -0.01503 0.722548 1.508476 1.1758 1.44309
## Nr1h3 1.0003 0.73498 0.520767 0.607772 0.9418 0.66533
## Parp10 0.4417 0.47637 0.777154 1.161164 0.2757 0.68701
## Phxr4 -0.5883 -0.51002 0.010499 -0.793528 -0.6432 -0.85899
## Pla2g4a 0.7833 0.66823 0.891342 0.628951 1.0184 0.75923
## Pnpt1 0.4576 0.87229 0.656027 0.853070 0.4898 0.48371
## Prune2 0.9826 0.89178 0.887909 0.340584 0.8816 0.83987
## Pxdc1 -0.5438 -0.69584 -0.830835 -0.876979 -0.9406 -0.39166
## Rab19 0.7797 0.55306 0.503343 0.371410 0.7878 1.11829
## Ralgds 0.5179 0.87060 0.717045 0.827697 1.2072 1.13189
## Rangap1 0.4475 0.49546 0.641972 0.930298 0.5496 0.71012
## Rasal2 -0.6602 -0.33915 -0.597364 -0.891925 -0.7575 -0.53018
## Rora -0.9284 -0.76948 -0.504869 -0.510683 -0.6751 -0.64612
## Sap30 0.7490 0.73631 0.904453 0.517960 0.5927 0.55417
## Sdc3 0.8211 0.93411 0.352123 0.493606 0.8581 0.25711
## Sdc4 0.8079 0.49586 0.920945 1.071935 1.0467 0.71483
## Serpinb6b 0.8806 0.54167 0.547696 0.348336 0.9535 0.86398
## Slc2a6 0.2687 0.33828 0.779988 1.410183 1.0884 1.36015
## Specc1 -1.2632 0.39268 -0.116618 0.857969 -1.2188 -0.57953
## Stk39 1.0461 0.24295 0.754990 0.402048 1.1103 0.78443
## Tfec 1.2872 0.83142 0.428181 -0.006777 1.0525 0.51545
## Tmem191c -0.9028 -0.78291 -0.837828 -1.240250 -0.4435 -0.25706
## Tmod1 -0.8753 0.31478 -0.643039 0.604897 -1.1996 -0.70547
## Xylt1 -0.4754 -0.08086 -0.730239 -0.085410 -0.5249 -0.48195
## naive.r1 naive.r2 naive.r3 naive.r4
## B3gnt8 1.9985 1.3553 1.406039 1.3141
## Ccrl2 -1.7853 -1.7764 0.009435 -1.9784
## Epb41l1 1.3415 0.6538 1.328507 1.9640
## Eya1 2.3215 1.8668 0.718854 0.3776
## Igfbp4 2.0851 1.1768 0.998637 1.8201
## Lox 1.4300 0.5792 -0.352401 1.2756
## Oaf -1.5235 -1.0541 -1.146285 -1.8045
## Pola2 -1.6836 -1.7978 -0.851530 -2.0881
## Acpp 1.5546 1.7153 0.726536 1.6952
## Adamtsl4 2.0846 0.2388 1.720830 0.7361
## Agpat9 1.8742 0.4719 1.658180 0.8895
## AI607873 -1.9273 -1.4965 -1.732230 -1.2799
## Ank 1.4169 1.2387 2.425480 0.9624
## Aox1 1.1820 1.7848 1.445940 1.4527
## B2m -1.7585 -1.5057 -1.858294 -1.5117
## Basp1 -1.7731 -1.7197 -1.737220 -1.0661
## Bcl2a1b -1.7098 -1.4571 -1.674111 -1.4360
## Blvra -1.7009 -1.7418 -1.126556 -1.6483
## Brwd1 1.5488 1.4706 1.992497 1.4314
## C1rl -1.3876 -1.2517 -1.884837 -1.4896
## Casp12 -1.3274 -1.6871 -1.638162 -1.5737
## Ccdc125 1.7043 1.1455 1.511976 1.9107
## Cfh 1.8835 1.9584 1.078405 1.4795
## Cish -1.6693 -1.8128 -0.392966 -1.8050
## Clic4 -1.7354 -1.8793 -1.258302 -1.6405
## Csrp1 -1.6193 -1.9585 -1.589163 -1.3901
## Ctla2b -1.6379 -1.4570 -1.211753 -1.5697
## Ctsd -1.6687 -1.5870 -1.486900 -1.5158
## Cttnbp2nl -1.6759 -1.7964 -1.579803 -1.2858
## Dnase1l3 -1.6796 -1.7684 -1.737774 -1.1065
## Eepd1 1.9481 2.1669 0.842030 1.1105
## Fam162a -1.6629 -1.3982 -1.407113 -1.8538
## Fam214a 1.7966 1.8486 1.308104 1.4950
## Fas -1.3156 -1.3424 -1.997551 -1.6625
## Fblim1 -1.1200 -1.7292 -1.579255 -1.6502
## Fbxl20 1.7201 1.4169 1.632626 1.7355
## Fcgr3 -1.5956 -1.4986 -1.437607 -1.5336
## Fgf2 2.1701 1.3050 0.963444 1.0939
## Fry 1.6436 0.9888 2.038534 1.2982
## Gca -1.3258 -1.1421 -1.819409 -0.1438
## Gnb4 -1.5316 -1.6612 -1.383120 -1.6682
## Gpnmb -1.6910 -0.9635 -0.654898 -1.4376
## Gsr -1.7371 -1.3414 -1.682459 -1.7967
## Id2 -1.4123 -1.4765 -1.849889 -1.7108
## Ier3 -1.3535 -1.8923 -0.999729 -1.4644
## Insr 1.5722 1.5630 1.915661 1.4734
## L1cam 2.0022 0.9004 1.307733 1.6173
## Ly75 -1.6063 -1.5564 -1.943771 -1.3466
## Mab21l3 -1.7726 -1.7689 -1.141956 -0.9169
## Map2k6 1.2437 1.7107 1.807943 1.4297
## Matn2 1.3859 1.9394 1.323482 1.5561
## Metrnl -1.6272 -1.9134 -1.145544 -1.6414
## Nifk -1.8136 -1.5792 -1.654899 -1.6198
## Mrps34 -2.1414 -1.4194 -1.475840 -1.2489
## Mylip 1.6715 1.5088 1.971397 1.4094
## Myo1f -1.9401 -1.6156 -1.761002 -1.1405
## Nabp1 -1.4782 -1.5238 -1.854080 -1.1244
## Nlrp10 1.0604 1.6866 1.936251 1.0730
## Nod1 -1.8259 -1.5433 -1.797454 -1.0728
## Nos2 -1.9416 -1.1520 -0.600398 -0.3996
## Nr1h3 -1.6828 -1.3710 -1.741572 -1.5344
## Parp10 -1.5832 -1.9098 -1.758573 -1.2327
## Phxr4 1.9367 1.7022 1.125632 1.4403
## Pla2g4a -2.0821 -1.4488 -1.682049 -0.9262
## Pnpt1 -1.9467 -1.7412 -1.189353 -1.6740
## Prune2 -1.6849 -1.3417 -1.439458 -1.6842
## Pxdc1 1.9291 1.4120 1.350446 1.6054
## Rab19 -1.8998 -1.7292 -1.668716 -1.0202
## Ralgds -1.9429 -1.4765 -1.383521 -1.3137
## Rangap1 -1.7191 -1.7203 -1.169684 -1.9289
## Rasal2 2.2183 1.3756 1.555519 1.2470
## Rora 1.0965 1.6267 1.898703 1.8001
## Sap30 -1.9708 -1.3715 -1.167627 -1.8135
## Sdc3 -1.6772 -1.7061 -1.760742 -1.1424
## Sdc4 -1.5381 -1.7116 -1.691607 -1.3886
## Serpinb6b -1.7461 -1.7143 -1.710441 -1.2953
## Slc2a6 -1.4031 -1.1077 -1.468728 -1.8734
## Specc1 0.9114 0.3254 2.626245 -0.9077
## Stk39 -0.9825 -1.6005 -2.149310 -1.4215
## Tfec -1.3407 -1.6908 -1.221610 -1.6265
## Tmem191c 2.4960 1.2183 0.915953 1.2608
## Tmod1 0.2292 0.9768 2.561455 -1.3830
## Xylt1 1.3623 1.3019 1.739903 1.5606## heat.list day delivery rep
## 13 naive.r1 0 naive 1
## 14 naive.r2 0 naive 2
## 15 naive.r3 0 naive 3
## 16 naive.r4 0 naive 4
## 1 sbp.d6.r1 6 sbp 1
## 2 sbp.d6.r2 6 sbp 2
## 3 sbp.d6.r3 6 sbp 3
## 4 sbp.d6.r4 6 sbp 4
## 9 rtmt.d6.r1 6 rtmt 1
## 10 rtmt.d6.r2 6 rtmt 2
## 11 rtmt.d6.r3 6 rtmt 3
## 12 rtmt.d6.r4 6 rtmt 4
## 5 mt.d6.r1 6 mt 1
## 6 mt.d6.r2 6 mt 2
## 7 mt.d6.r3 6 mt 3
## 8 mt.d6.r4 6 mt 4
4.8 ISGs SBP and RTMT Day 4
## sbp.d4.r1 sbp.d4.r2 sbp.d4.r3 sbp.d4.r4 mt.d4.r1 mt.d4.r2
## Apol10b 1.03776 -0.816034 -0.113547 1.29597 0.76460 1.0155
## Apol6 1.00453 -1.349732 0.286550 1.13368 0.71920 1.1975
## Asns 0.48705 -0.073036 0.694714 0.20845 1.11489 1.3200
## Aunip 0.18854 -0.481171 0.364887 0.20923 1.29080 1.4327
## Batf2 0.98472 -1.143042 0.143331 0.91025 0.94469 1.0770
## Bcl2l14 0.91542 -1.140906 0.210147 1.36929 0.70080 1.0182
## Ccl2 1.49558 -1.167034 0.176797 0.82728 0.82980 1.4810
## Cd163 -1.10995 0.795306 0.476639 -0.14125 -1.18887 -1.8810
## Cd274 1.12193 -1.179835 0.105092 0.92930 0.91991 1.1795
## Cdc45 0.29059 -0.457178 0.386845 0.06097 1.42695 1.6049
## Chaf1a 0.30067 -0.769839 0.392644 0.30398 1.32043 1.4725
## Cmpk2 0.72938 -1.007336 0.033653 0.77961 1.36763 1.4389
## Cxcl10 0.90099 -1.193210 0.343507 0.93279 0.86244 1.0315
## Cxcl9 1.05372 -0.945375 0.506726 1.01699 0.89947 1.0880
## Dtl 0.12084 -0.175633 0.431137 0.11417 1.25523 1.4850
## Fam132a 0.28185 -0.549356 0.732392 0.27567 0.83165 1.5145
## Fam13a -0.73472 0.318186 -0.407615 -0.24561 -0.93582 -1.6695
## Fam26f 0.86780 -1.165909 0.186357 0.94466 0.88510 1.3127
## Fanci 0.10139 -0.059405 0.623711 0.29723 1.33428 1.5773
## Fcgr4 0.62328 -1.011918 -0.225667 0.68885 1.04555 1.4304
## Fos 0.73996 -0.890952 -0.628006 1.38039 1.03002 0.4007
## Gbp11 0.89572 -1.071483 0.373509 1.16661 0.92032 1.1054
## Gbp2 0.99380 -1.177887 0.337606 0.96698 0.96656 1.1217
## Gbp3 0.81259 -1.201132 0.068073 0.87907 1.02476 1.3539
## Gbp4 1.04234 -1.080395 0.377900 1.00781 0.85607 1.0066
## Gbp2b 0.30655 -1.027049 -0.321036 0.78955 1.17702 1.6065
## Gm43302 1.01533 -1.778251 0.449231 0.91562 0.82423 0.8847
## Gbp7 0.85013 -1.138314 0.342306 0.92492 0.96141 1.1584
## Gm12185 0.99805 -1.667083 0.066933 1.04448 0.93344 1.0658
## Gm12250 0.85159 -1.234870 0.479825 0.89913 0.97399 1.0634
## Ifit1bl1 1.13505 -0.989998 0.257895 1.30445 1.18256 0.9905
## Gm17334 1.10707 -1.353709 0.674703 1.07158 0.92026 0.8520
## Gm1966 1.11996 -1.060158 0.688260 1.11701 0.80220 0.7133
## Gm4070 0.91335 -1.136502 0.420128 0.94592 0.89719 0.9168
## Gm4841 0.81527 -1.295282 -0.040600 0.42295 1.14127 1.3192
## Gm4951 0.81488 -1.234608 0.013269 0.80701 0.87687 1.2435
## Gvin1 1.00099 -1.086952 0.465908 0.99267 0.92467 0.9488
## Has2 0.91311 -1.224948 0.915842 0.99442 0.80314 1.0511
## Hk3 1.12793 -0.872360 -0.325371 0.74125 0.95288 1.3378
## Hspa1a 0.48363 -0.908298 0.778535 1.27664 -0.03809 0.3284
## Hspa1b 0.61352 -0.789308 0.909800 1.43552 0.27064 0.2888
## Htra3 -1.48010 0.470597 -0.042283 0.05870 -1.33432 -1.6700
## Ifi204 0.76552 -1.018608 -0.214208 0.99180 1.09421 1.4051
## Ifi44 1.13300 -1.381491 -0.026858 0.99913 1.22803 1.3145
## Ifi47 0.90741 -1.056951 0.371256 0.89286 1.02451 1.2343
## Ifit1 1.05604 -1.123221 0.068788 1.12948 1.30848 1.4377
## Ifit2 0.89751 -0.981553 0.030689 1.22376 1.25119 1.4046
## Ifit3 1.23631 -1.372506 0.060631 1.47269 1.16271 1.0082
## Igfbp3 -0.89670 0.680872 -0.214557 -0.40061 -1.36989 -1.4041
## Igtp 0.92219 -1.134176 0.432706 0.93878 0.94434 1.0619
## Iigp1 0.93233 -1.217259 0.307809 0.82924 0.95199 1.1185
## Il12rb1 1.06223 -1.135382 0.369164 1.16063 0.75893 1.1364
## Il1rn 1.23948 -1.059147 0.078629 0.74793 1.29698 1.4143
## Il2ra 0.85018 -1.356766 -0.087927 0.73620 1.09820 1.3964
## Irf1 0.99728 -1.085325 0.570774 0.93881 0.84365 0.8671
## Irf7 1.05983 -1.145092 0.044739 1.25236 1.25574 1.3267
## Acod1 1.18149 -1.170482 -0.238035 0.67834 1.14662 1.5274
## Irgm1 0.91390 -1.124964 0.500989 0.91583 0.97178 1.1148
## Irgm2 0.96174 -1.308185 0.504834 1.05715 0.80754 0.8832
## Klra2 0.66349 -1.063303 -0.537462 0.86296 1.35237 1.1138
## Lgals9 0.84508 -1.053011 0.002111 0.67343 1.24232 1.5314
## Lif 1.77466 -0.862010 0.273900 1.28570 1.17669 0.9321
## Lox 0.51496 0.321303 -0.400533 0.44267 -1.22769 -1.3037
## Lrr1 0.04010 -1.009574 0.301811 -0.46203 1.18295 1.6805
## Ly6a 0.88952 -0.934586 -0.028186 0.71615 1.18536 1.5134
## Ly6i 0.76683 -0.802923 -0.216967 0.59075 1.61952 1.4533
## Mab21l3 0.68114 -0.901954 -0.268002 1.28921 0.21314 0.3269
## Maff 0.79434 -0.480629 0.246418 1.55260 0.56564 1.1707
## Mcm10 0.11223 -0.595281 0.377333 0.27684 1.19734 1.5279
## Mlkl 1.05418 -1.148228 -0.067274 0.60857 1.12065 1.4708
## Mmp13 1.32474 -1.014366 -0.271173 0.62663 1.08155 1.4311
## Mnda 0.88635 -1.000911 0.083907 0.88935 1.25705 1.2323
## Mt2 0.89289 -0.348047 0.266479 0.44858 1.18401 1.3422
## Mx1 1.19209 -1.165385 -0.137339 1.57510 1.29992 1.0814
## Nampt 0.98576 -1.071585 0.160113 0.81723 1.12575 1.2952
## Nlrc5 1.15455 -1.352565 0.416473 1.07208 0.80291 0.7484
## Oas3 0.87187 -0.970831 -0.001516 0.97132 1.24113 1.3810
## Oasl2 0.99833 -1.195324 -0.023732 0.97732 1.23151 1.3204
## Oit3 -1.24218 0.820377 0.092339 -0.65642 -1.15377 -1.3070
## Parp9 0.97593 -1.175965 0.186061 1.08205 1.18372 1.2394
## Pla2g16 0.78728 -0.959697 0.242036 0.71366 1.17702 1.3237
## Ppa1 0.91259 -1.014504 0.247976 0.82903 1.15320 1.3571
## Ptgs2 0.77606 -1.057363 -0.130562 0.51766 1.09303 1.8137
## Rad51 0.02524 -0.339290 0.030304 0.22045 1.42345 1.4547
## Rnd1 0.53783 -0.564769 -0.247837 -0.01324 0.91532 0.7838
## Rtp4 1.01717 -1.169042 0.002673 1.10002 1.27483 1.3115
## Serpina3f 0.91729 -1.252431 0.310579 0.86715 0.85791 1.0531
## Serpina3g 0.83066 -1.189721 0.215231 0.77767 0.94263 1.1401
## Serpina3n 1.01127 -1.332723 0.605127 0.73233 0.82057 0.2346
## Shcbp1 -0.01474 -0.333766 0.106546 -0.51305 1.30047 1.6672
## Slamf8 1.00458 -1.239395 -0.078989 0.79517 1.04247 1.3787
## Slc7a11 0.76307 -1.386573 0.487031 0.54867 0.89494 0.5684
## Smpdl3b 0.48318 -0.890244 -0.404693 0.67668 1.51393 1.2633
## Socs1 0.95992 -1.142510 0.524817 1.20140 0.82028 0.9523
## Socs3 0.85233 -0.798917 0.289839 0.82483 0.94066 1.1995
## Sphk1 0.19325 -0.632061 0.515193 0.04248 1.12605 1.5829
## Stat1 1.13334 -1.331103 0.619904 1.14155 0.77714 0.6847
## Steap3 0.21168 -0.238498 1.101176 0.24713 0.97638 1.2479
## Syce2 0.10832 -0.349306 0.317246 0.27733 1.15952 1.3915
## Tap1 1.09983 -1.031130 0.284708 1.04099 0.89021 0.9586
## Tgtp1 0.90338 -1.178443 0.464837 0.96074 0.99680 1.0865
## Tgtp2 0.91222 -1.215213 0.619528 1.04694 0.85070 1.0050
## Tnip3 -0.18024 -0.721296 -0.854107 -0.53105 0.79585 1.7965
## Trip13 0.13159 -1.028545 -0.060589 0.06481 1.40524 1.8844
## Tubb3 0.72746 -1.082102 -0.222711 0.48282 1.24596 1.6766
## Ubd 0.83632 -1.129633 0.206517 0.64205 0.91771 1.2389
## Upp1 1.14027 -0.767930 -0.352334 0.30393 1.17134 1.4671
## Vdr 1.48845 -1.036752 -0.163986 1.06956 0.82540 0.8188
## Wars 1.15344 -1.233468 0.164411 1.04848 0.70608 0.9918
## Xaf1 1.07479 -1.048458 0.056383 1.09352 1.36613 1.2288
## Zbp1 1.00323 -1.124500 0.327676 0.94627 1.08861 1.1158
## Abca9 -1.33690 0.782809 0.164748 -0.12984 -1.33285 -1.9433
## Apol10b 1.03776 -0.816034 -0.113547 1.29597 0.76460 1.0155
## Apol6 1.00453 -1.349732 0.286550 1.13368 0.71920 1.1975
## Asns 0.48705 -0.073036 0.694714 0.20845 1.11489 1.3200
## Aunip 0.18854 -0.481171 0.364887 0.20923 1.29080 1.4327
## Bag2 -0.33954 0.281124 0.969122 0.54000 1.17247 0.6306
## Batf2 0.98472 -1.143042 0.143331 0.91025 0.94469 1.0770
## Bcl2l14 0.91542 -1.140906 0.210147 1.36929 0.70080 1.0182
## Bst2 1.28625 -1.124898 0.138624 1.28801 1.02082 1.1789
## Ccl19 1.28658 -0.999250 0.913894 1.50586 0.59050 0.2452
## Ccl2 1.49558 -1.167034 0.176797 0.82728 0.82980 1.4810
## Cd163 -1.10995 0.795306 0.476639 -0.14125 -1.18887 -1.8810
## Cd274 1.12193 -1.179835 0.105092 0.92930 0.91991 1.1795
## Cdc45 0.29059 -0.457178 0.386845 0.06097 1.42695 1.6049
## Cdkn1a 0.98153 -1.089294 0.385626 0.90999 1.00818 0.7798
## Cebpb 1.32761 0.051947 0.579625 1.19062 0.80881 0.7078
## Cela1 2.73261 -0.339340 1.106106 -0.83951 0.25630 -0.3781
## Cmpk2 0.72938 -1.007336 0.033653 0.77961 1.36763 1.4389
## Ctrl 2.75002 -0.875962 1.166097 -0.26965 0.36990 -0.4313
## Ctsf -1.65682 0.574440 -0.352806 -1.49737 -0.57097 -0.5524
## Cxcl10 0.90099 -1.193210 0.343507 0.93279 0.86244 1.0315
## Cxcl9 1.05372 -0.945375 0.506726 1.01699 0.89947 1.0880
## Dhx58 1.13207 -0.989423 0.211480 1.45103 1.44409 1.0801
## Dram1 1.10409 -1.095168 0.182509 0.69236 1.05268 1.2258
## Dtl 0.12084 -0.175633 0.431137 0.11417 1.25523 1.4850
## Fam132a 0.28185 -0.549356 0.732392 0.27567 0.83165 1.5145
## Fam13a -0.73472 0.318186 -0.407615 -0.24561 -0.93582 -1.6695
## Fam26f 0.86780 -1.165909 0.186357 0.94466 0.88510 1.3127
## Fanci 0.10139 -0.059405 0.623711 0.29723 1.33428 1.5773
## Fcgr4 0.62328 -1.011918 -0.225667 0.68885 1.04555 1.4304
## Fpr2 1.37318 -0.560716 -0.694596 0.19330 1.28403 1.5549
## Gbp11 0.89572 -1.071483 0.373509 1.16661 0.92032 1.1054
## Gbp2 0.99380 -1.177887 0.337606 0.96698 0.96656 1.1217
## Gbp3 0.81259 -1.201132 0.068073 0.87907 1.02476 1.3539
## Gbp4 1.04234 -1.080395 0.377900 1.00781 0.85607 1.0066
## Gbp2b 0.30655 -1.027049 -0.321036 0.78955 1.17702 1.6065
## Gm43302 1.01533 -1.778251 0.449231 0.91562 0.82423 0.8847
## Gbp7 0.85013 -1.138314 0.342306 0.92492 0.96141 1.1584
## Gbp8 0.81905 -1.152177 0.445368 1.10899 0.64030 1.0021
## Gbp9 1.16360 -1.133796 0.465062 1.25519 0.89506 0.8722
## Gm12185 0.99805 -1.667083 0.066933 1.04448 0.93344 1.0658
## Gm12250 0.85159 -1.234870 0.479825 0.89913 0.97399 1.0634
## Ifit1bl1 1.13505 -0.989998 0.257895 1.30445 1.18256 0.9905
## Gm17334 1.10707 -1.353709 0.674703 1.07158 0.92026 0.8520
## Gm1966 1.11996 -1.060158 0.688260 1.11701 0.80220 0.7133
## Gm4070 0.91335 -1.136502 0.420128 0.94592 0.89719 0.9168
## Gm4841 0.81527 -1.295282 -0.040600 0.42295 1.14127 1.3192
## Gm4951 0.81488 -1.234608 0.013269 0.80701 0.87687 1.2435
## Gm5431 1.04700 -1.396070 0.136661 1.43737 1.37980 0.7119
## Gvin1 1.00099 -1.086952 0.465908 0.99267 0.92467 0.9488
## Has2 0.91311 -1.224948 0.915842 0.99442 0.80314 1.0511
## Hdc 1.80578 0.009917 0.386176 -0.08847 1.35957 0.9842
## Hk3 1.12793 -0.872360 -0.325371 0.74125 0.95288 1.3378
## Hspa1a 0.48363 -0.908298 0.778535 1.27664 -0.03809 0.3284
## Hspa1b 0.61352 -0.789308 0.909800 1.43552 0.27064 0.2888
## Hsph1 0.53106 -0.377984 0.946192 1.09108 0.37917 0.3839
## Htra3 -1.48010 0.470597 -0.042283 0.05870 -1.33432 -1.6700
## Ifit3b 1.45008 -1.082114 0.067267 1.68560 1.13077 0.8509
## Ifi204 0.76552 -1.018608 -0.214208 0.99180 1.09421 1.4051
## Ifi205 0.79040 -0.964714 -0.255414 1.02178 1.17295 1.3717
## Ifi44 1.13300 -1.381491 -0.026858 0.99913 1.22803 1.3145
## Ifi47 0.90741 -1.056951 0.371256 0.89286 1.02451 1.2343
## Ifit1 1.05604 -1.123221 0.068788 1.12948 1.30848 1.4377
## Ifit2 0.89751 -0.981553 0.030689 1.22376 1.25119 1.4046
## Ifit3 1.23631 -1.372506 0.060631 1.47269 1.16271 1.0082
## Ifitm3 1.01641 -1.088033 0.105500 0.99060 1.29050 1.4712
## Igfbp3 -0.89670 0.680872 -0.214557 -0.40061 -1.36989 -1.4041
## Igtp 0.92219 -1.134176 0.432706 0.93878 0.94434 1.0619
## Iigp1 0.93233 -1.217259 0.307809 0.82924 0.95199 1.1185
## Il12rb1 1.06223 -1.135382 0.369164 1.16063 0.75893 1.1364
## Il1rn 1.23948 -1.059147 0.078629 0.74793 1.29698 1.4143
## Irf1 0.99728 -1.085325 0.570774 0.93881 0.84365 0.8671
## Irf7 1.05983 -1.145092 0.044739 1.25236 1.25574 1.3267
## Acod1 1.18149 -1.170482 -0.238035 0.67834 1.14662 1.5274
## Irgm1 0.91390 -1.124964 0.500989 0.91583 0.97178 1.1148
## Irgm2 0.96174 -1.308185 0.504834 1.05715 0.80754 0.8832
## Isg15 0.92855 -0.871457 -0.027270 0.74450 1.46716 1.5521
## Lgals9 0.84508 -1.053011 0.002111 0.67343 1.24232 1.5314
## Lif 1.77466 -0.862010 0.273900 1.28570 1.17669 0.9321
## Ly6a 0.88952 -0.934586 -0.028186 0.71615 1.18536 1.5134
## Ly6c2 0.57432 -0.605606 -0.236691 0.75639 1.33931 1.6132
## Ly6i 0.76683 -0.802923 -0.216967 0.59075 1.61952 1.4533
## Maff 0.79434 -0.480629 0.246418 1.55260 0.56564 1.1707
## Mcm10 0.11223 -0.595281 0.377333 0.27684 1.19734 1.5279
## Mlkl 1.05418 -1.148228 -0.067274 0.60857 1.12065 1.4708
## Mmp13 1.32474 -1.014366 -0.271173 0.62663 1.08155 1.4311
## Mnda 0.88635 -1.000911 0.083907 0.88935 1.25705 1.2323
## Mt1 0.63667 -0.195293 0.878876 0.42787 0.74631 1.3410
## Mt2 0.89289 -0.348047 0.266479 0.44858 1.18401 1.3422
## Mx1 1.19209 -1.165385 -0.137339 1.57510 1.29992 1.0814
## Nampt 0.98576 -1.071585 0.160113 0.81723 1.12575 1.2952
## Nlrc5 1.15455 -1.352565 0.416473 1.07208 0.80291 0.7484
## Nme1 0.83969 -0.530162 0.087741 0.79937 0.90031 1.3774
## Oas1a 0.99076 -1.062589 0.142968 1.06517 1.40385 1.2668
## Oas2 1.09054 -1.062892 0.025462 1.35882 1.33479 1.2076
## Oas3 0.87187 -0.970831 -0.001516 0.97132 1.24113 1.3810
## Oasl1 1.05731 -0.896736 0.391074 1.25924 1.21285 1.3153
## Oasl2 0.99833 -1.195324 -0.023732 0.97732 1.23151 1.3204
## Oit3 -1.24218 0.820377 0.092339 -0.65642 -1.15377 -1.3070
## Parp14 1.03112 -1.364133 0.205950 1.23124 1.07410 0.9255
## Parp9 0.97593 -1.175965 0.186061 1.08205 1.18372 1.2394
## Phf11a 0.95654 -1.131772 -0.074513 0.99265 1.32360 1.2300
## Phf11d 1.37848 -0.947565 -0.319705 1.25397 1.12338 1.2991
## Pkib 1.35191 -0.325030 0.582697 1.05500 0.71519 0.6623
## Pla2g16 0.78728 -0.959697 0.242036 0.71366 1.17702 1.3237
## Plau 1.55637 -0.958332 -0.607275 0.29082 1.11634 1.6484
## Pnp 0.55022 -0.616947 0.310654 0.45014 1.33056 1.5180
## Ppa1 0.91259 -1.014504 0.247976 0.82903 1.15320 1.3571
## Procr 1.25593 -1.063133 -0.076071 0.81675 0.81695 1.5369
## Psmb10 1.02687 -0.979829 0.175241 1.08019 1.04707 1.3538
## Ptgs2 0.77606 -1.057363 -0.130562 0.51766 1.09303 1.8137
## Pydc4 1.30346 -1.069764 0.473443 1.40309 1.08289 0.7854
## Rnf213 1.29889 -1.202722 0.231809 1.37594 1.18118 1.0185
## Rtp4 1.01717 -1.169042 0.002673 1.10002 1.27483 1.3115
## Serpina3f 0.91729 -1.252431 0.310579 0.86715 0.85791 1.0531
## Serpina3g 0.83066 -1.189721 0.215231 0.77767 0.94263 1.1401
## Serpina3n 1.01127 -1.332723 0.605127 0.73233 0.82057 0.2346
## Slamf8 1.00458 -1.239395 -0.078989 0.79517 1.04247 1.3787
## Slfn4 1.70335 -1.130757 -0.279779 0.05441 1.41159 1.5578
## Smpdl3b 0.48318 -0.890244 -0.404693 0.67668 1.51393 1.2633
## Socs1 0.95992 -1.142510 0.524817 1.20140 0.82028 0.9523
## Socs3 0.85233 -0.798917 0.289839 0.82483 0.94066 1.1995
## Srm 1.01350 -0.725811 0.638081 0.85061 1.09814 1.2296
## Stat1 1.13334 -1.331103 0.619904 1.14155 0.77714 0.6847
## Stat2 1.33710 -1.202606 0.261623 1.35305 0.98519 0.8470
## Steap3 0.21168 -0.238498 1.101176 0.24713 0.97638 1.2479
## Syce2 0.10832 -0.349306 0.317246 0.27733 1.15952 1.3915
## Tap1 1.09983 -1.031130 0.284708 1.04099 0.89021 0.9586
## Tgm2 1.58276 -0.831931 0.002498 0.72144 0.62253 1.2146
## Tgtp1 0.90338 -1.178443 0.464837 0.96074 0.99680 1.0865
## Tgtp2 0.91222 -1.215213 0.619528 1.04694 0.85070 1.0050
## Timp1 0.89215 -1.175029 -0.070954 1.14393 1.14244 1.4490
## Tmem255a -0.80715 0.327191 -0.071823 -0.42855 -0.83909 -1.6321
## Tnc 1.08054 -0.828081 0.053570 1.48362 -0.03159 0.9873
## Tubb3 0.72746 -1.082102 -0.222711 0.48282 1.24596 1.6766
## Tubb6 1.06900 -0.619923 -0.098152 0.71772 1.11298 0.9687
## Ubd 0.83632 -1.129633 0.206517 0.64205 0.91771 1.2389
## Upp1 1.14027 -0.767930 -0.352334 0.30393 1.17134 1.4671
## Usp18 1.13992 -0.864288 0.153537 1.50609 1.39331 1.2515
## Vdr 1.48845 -1.036752 -0.163986 1.06956 0.82540 0.8188
## Wars 1.15344 -1.233468 0.164411 1.04848 0.70608 0.9918
## Xaf1 1.07479 -1.048458 0.056383 1.09352 1.36613 1.2288
## Zbp1 1.00323 -1.124500 0.327676 0.94627 1.08861 1.1158
## mt.d4.r3 mt.d4.r4 rtmt.d4.r1 rtmt.d4.r2 rtmt.d4.r3 rtmt.d4.r4
## Apol10b -1.515528 1.1677 -0.85339 0.4337289 0.514894 0.92167
## Apol6 -1.018900 1.3003 -0.97244 0.4166140 0.663266 0.60667
## Asns -0.004198 0.7003 -1.17743 1.1062550 0.720859 -0.22806
## Aunip -0.189519 1.4198 -1.09190 0.8956344 0.734317 -0.39487
## Batf2 -1.189306 1.6674 -0.63763 -0.1572878 0.549955 0.88766
## Bcl2l14 -1.223246 0.9889 -0.93078 0.8013715 0.864689 0.55921
## Ccl2 -0.754913 1.5507 -0.93215 0.0343500 0.283653 0.10524
## Cd163 0.730019 -1.3164 0.48783 -0.5025186 -0.279315 -0.46616
## Cd274 -1.012018 1.2483 -0.81090 0.4174181 0.667570 0.76945
## Cdc45 -0.310313 1.3344 -1.15709 0.5578545 0.575281 0.07413
## Chaf1a -0.176858 1.3792 -1.09693 1.0183176 0.450705 -0.10970
## Cmpk2 -0.536109 0.7886 -1.06877 0.8310213 0.645585 0.24370
## Cxcl10 -0.866544 1.3252 -0.97541 0.4585692 0.841171 0.79058
## Cxcl9 -0.953420 1.0112 -0.83402 0.4837435 0.776425 0.67016
## Dtl 0.049414 1.0575 -1.29251 0.9428173 0.741391 -0.14739
## Fam132a 0.305220 0.9889 -0.94519 1.2431722 0.438224 -0.25455
## Fam13a 0.949765 -1.6011 0.57566 -0.5649456 -0.554482 0.27119
## Fam26f -0.938394 1.5344 -0.76138 0.1694839 0.643833 0.64629
## Fanci -0.345428 1.1324 -1.01187 1.0193084 0.544495 -0.53511
## Fcgr4 -0.806943 1.3632 -0.80864 0.4306558 0.758604 0.97157
## Fos 0.448721 0.5723 -1.12123 0.9476391 0.060094 1.24245
## Gbp11 -0.882095 1.2295 -0.65231 0.3933427 0.702450 0.45346
## Gbp2 -0.869098 1.0173 -0.86085 0.5564883 0.819337 0.73044
## Gbp3 -0.984722 1.3424 -0.93939 0.2251070 0.704083 0.83409
## Gbp4 -0.891694 1.0881 -0.86203 0.4909837 0.870797 0.76470
## Gbp2b -0.765272 1.8305 -0.75179 -0.0623803 0.469066 0.69359
## Gm43302 -0.717391 1.0282 -0.74889 0.5634416 0.770269 0.72808
## Gbp7 -0.853470 1.1885 -0.94157 0.5504144 0.818673 0.70284
## Gm12185 -0.549681 1.1349 -0.71248 0.5456387 0.687659 0.74808
## Gm12250 -0.856067 1.1037 -0.72964 0.4573584 0.920532 0.75487
## Ifit1bl1 -1.075656 0.6681 -1.22487 0.4363658 0.693912 0.68603
## Gm17334 -0.892454 0.5063 -0.84434 0.5692591 0.844871 0.97575
## Gm1966 -1.074622 0.4266 -0.74691 0.6393753 1.025932 0.98268
## Gm4070 -0.878025 0.9879 -0.54753 0.5349880 0.917653 0.91256
## Gm4841 -0.681395 1.5365 -0.68724 0.0999311 0.592233 1.03446
## Gm4951 -0.973809 1.4344 -0.71167 0.2043559 0.787029 0.98008
## Gvin1 -0.955279 0.8999 -0.69813 0.5001008 0.885885 0.90452
## Has2 -0.610477 1.0763 -1.06235 0.6753655 0.543603 0.53626
## Hk3 -1.094223 1.4820 -0.66618 0.3628932 0.496527 0.78957
## Hspa1a 0.212451 1.0554 -1.02463 -0.8769896 1.110681 1.43175
## Hspa1b 0.350478 1.0116 -1.37871 -0.6503782 0.971683 1.22573
## Htra3 0.750375 -0.4745 0.81832 -0.7754773 -0.770862 -0.06192
## Ifi204 -0.982574 1.4036 -0.63603 0.0840915 0.584826 0.80633
## Ifi44 -0.864554 1.0885 -0.53135 -0.1224125 0.681941 0.60532
## Ifi47 -0.852390 1.0723 -0.87706 0.4727541 0.812775 0.69189
## Ifit1 -1.094992 0.8268 -1.01688 0.4576419 0.505875 0.39590
## Ifit2 -1.204218 1.0066 -1.13848 0.3163863 0.509993 0.52205
## Ifit3 -1.199485 0.6962 -0.97489 0.4132760 0.487626 0.61282
## Igfbp3 1.053224 -1.4273 0.70590 -0.5624834 -0.451546 -0.31544
## Igtp -0.744467 1.0602 -0.76515 0.5310537 0.805203 0.80685
## Iigp1 -0.906253 1.1334 -0.72499 0.4750411 0.830811 0.87728
## Il12rb1 -1.181724 1.1546 -1.06682 0.3788204 0.610855 0.76747
## Il1rn -0.783610 1.5719 -0.83072 0.1085717 0.109658 0.13336
## Il2ra -0.526412 1.0568 -0.75571 0.3494787 1.173707 0.52964
## Irf1 -0.823543 1.0429 -0.82359 0.5510743 0.902654 0.84299
## Irf7 -0.939432 1.1033 -0.74887 0.3925371 0.320814 0.29182
## Acod1 -0.590357 1.5432 -1.06905 0.2184818 0.487029 0.20686
## Irgm1 -0.892476 1.0801 -0.81518 0.5050357 0.811026 0.72175
## Irgm2 -0.889494 0.9211 -0.79721 0.5050466 0.956932 0.93502
## Klra2 -1.170516 0.9673 -0.71820 0.3960998 0.904268 1.16963
## Lgals9 -0.794993 1.3216 -0.99404 0.6316929 0.578267 0.29583
## Lif -0.909203 0.6549 -0.79398 -0.1727414 0.514548 0.39665
## Lox 1.021256 -0.2675 0.71746 -0.7688537 -1.635197 -1.22895
## Lrr1 -0.357068 0.6781 -1.17340 1.3024910 1.105790 0.47358
## Ly6a -1.032006 1.5069 -0.63478 0.0000794 0.530562 0.58593
## Ly6i -1.192581 1.4295 -0.68550 -0.1716454 0.554884 0.61963
## Mab21l3 0.104970 0.3599 0.01534 0.5936615 1.333302 1.36306
## Maff -0.677340 0.9696 -0.46923 0.1081148 0.849017 0.59905
## Mcm10 0.181950 1.4042 -1.27576 0.6973745 0.611185 -0.13187
## Mlkl -0.830465 1.6766 -0.89967 0.0128802 0.454472 0.47862
## Mmp13 -0.880654 1.5924 -0.96483 0.0498276 0.523700 0.39703
## Mnda -1.012634 1.3678 -0.75733 0.2750600 0.552248 0.64497
## Mt2 -0.288724 1.3441 -1.23175 0.6571230 0.495258 -0.08671
## Mx1 -1.020438 0.5063 -0.98726 0.3432440 0.654637 0.50182
## Nampt -0.950558 1.2856 -0.88519 0.3382774 0.735376 0.57207
## Nlrc5 -0.848777 0.5924 -0.51083 0.5697001 0.937017 0.99509
## Oas3 -0.578230 1.0561 -0.97332 0.6385077 0.427818 0.16974
## Oasl2 -1.045235 1.1449 -0.71788 0.4294215 0.488824 0.57542
## Oit3 1.242761 -0.9736 0.63985 -1.0238144 -0.457304 -0.29417
## Parp9 -0.828880 0.9243 -0.84754 0.5254683 0.684355 0.59355
## Pla2g16 -0.974407 1.1819 -0.78044 0.5912197 0.773061 0.37697
## Ppa1 -0.730950 1.1875 -1.01527 0.2145155 0.852959 0.49479
## Ptgs2 -0.911831 1.8589 -0.84814 0.1685095 0.241010 0.15091
## Rad51 -0.146919 1.2444 -0.83597 0.7567505 0.684086 0.05930
## Rnd1 -0.532473 1.6301 -0.85072 1.7344075 0.777060 -0.12491
## Rtp4 -1.246178 0.7743 -0.79808 0.4009643 0.630642 0.62718
## Serpina3f -0.773189 1.2523 -0.73758 0.4437319 0.803032 0.91590
## Serpina3g -0.879204 1.3567 -0.59810 0.4281183 0.784919 0.86113
## Serpina3n -0.310043 0.4155 -0.23049 0.7463056 1.222651 1.04189
## Shcbp1 -0.164222 1.5627 -0.87639 0.8685367 0.517160 -0.14928
## Slamf8 -1.203773 1.5213 -0.73618 0.0483946 0.621533 0.64971
## Slc7a11 0.368638 0.8438 -0.40635 0.7593127 1.193928 0.64231
## Smpdl3b -0.335938 1.6041 -0.39843 0.1684796 0.234765 0.82714
## Socs1 -0.887805 1.1834 -0.93114 0.3351023 0.802524 0.71165
## Socs3 -0.904271 1.7877 -0.44327 0.0343458 0.504529 0.48940
## Sphk1 0.408029 1.1119 -1.35115 1.1393206 0.381226 -0.38133
## Stat1 -0.805112 0.6932 -0.79048 0.5988993 0.850025 1.00404
## Steap3 0.411938 0.9859 -1.12532 0.9643731 0.365527 -0.13308
## Syce2 -0.058199 1.2481 -1.10912 0.8384590 0.843710 0.19576
## Tap1 -1.042218 1.1129 -0.41769 0.4196578 0.636701 0.89998
## Tgtp1 -0.785544 1.0565 -0.83481 0.5284628 0.803172 0.72010
## Tgtp2 -0.785673 0.8928 -0.70569 0.5221855 0.866434 0.81734
## Tnip3 -0.114057 2.4624 -0.40215 0.3026635 0.052278 0.67044
## Trip13 -0.859274 1.6723 -0.44720 0.4240324 0.381154 0.39889
## Tubb3 -0.975045 1.7706 -0.71086 0.0852845 0.644707 0.15050
## Ubd -0.869986 1.5123 -0.88682 0.3505216 0.744957 0.87262
## Upp1 -0.937719 1.8717 -0.48427 -0.0507237 0.476065 0.31927
## Vdr -0.232632 1.5016 -0.73483 0.0874288 0.449741 0.64547
## Wars -1.064358 1.1535 -0.82411 0.4137854 0.900180 0.85047
## Xaf1 -0.865759 0.5846 -1.09198 0.6113997 0.599121 0.61136
## Zbp1 -0.831118 1.0238 -0.77614 0.4782392 0.711561 0.75059
## Abca9 0.803707 -1.2283 0.78374 -0.3316173 -0.306130 0.06618
## Apol10b -1.515528 1.1677 -0.85339 0.4337289 0.514894 0.92167
## Apol6 -1.018900 1.3003 -0.97244 0.4166140 0.663266 0.60667
## Asns -0.004198 0.7003 -1.17743 1.1062550 0.720859 -0.22806
## Aunip -0.189519 1.4198 -1.09190 0.8956344 0.734317 -0.39487
## Bag2 0.220944 1.0520 -1.93241 0.5975825 0.839645 0.11954
## Batf2 -1.189306 1.6674 -0.63763 -0.1572878 0.549955 0.88766
## Bcl2l14 -1.223246 0.9889 -0.93078 0.8013715 0.864689 0.55921
## Bst2 -0.900294 0.9586 -0.87153 0.0710206 0.620794 0.59732
## Ccl19 -0.323624 -0.3523 -0.57249 0.3248564 1.052737 1.04876
## Ccl2 -0.754913 1.5507 -0.93215 0.0343500 0.283653 0.10524
## Cd163 0.730019 -1.3164 0.48783 -0.5025186 -0.279315 -0.46616
## Cd274 -1.012018 1.2483 -0.81090 0.4174181 0.667570 0.76945
## Cdc45 -0.310313 1.3344 -1.15709 0.5578545 0.575281 0.07413
## Cdkn1a -0.692249 1.9039 -0.67637 0.3053204 0.438114 0.32336
## Cebpb -0.672271 1.4321 -0.56301 -0.7681995 0.215301 0.44432
## Cela1 -0.285088 -0.5006 1.20263 -0.0309173 0.226227 -1.11073
## Cmpk2 -0.536109 0.7886 -1.06877 0.8310213 0.645585 0.24370
## Ctrl -0.658739 -0.5735 1.21071 -0.6837133 0.311691 -0.45987
## Ctsf 1.148920 -1.4388 0.48143 0.8033281 -0.023603 -0.74000
## Cxcl10 -0.866544 1.3252 -0.97541 0.4585692 0.841171 0.79058
## Cxcl9 -0.953420 1.0112 -0.83402 0.4837435 0.776425 0.67016
## Dhx58 -0.951706 0.7167 -1.16609 0.2683128 0.306345 0.46664
## Dram1 -0.924243 1.4849 -0.59305 0.1947324 0.661235 0.52756
## Dtl 0.049414 1.0575 -1.29251 0.9428173 0.741391 -0.14739
## Fam132a 0.305220 0.9889 -0.94519 1.2431722 0.438224 -0.25455
## Fam13a 0.949765 -1.6011 0.57566 -0.5649456 -0.554482 0.27119
## Fam26f -0.938394 1.5344 -0.76138 0.1694839 0.643833 0.64629
## Fanci -0.345428 1.1324 -1.01187 1.0193084 0.544495 -0.53511
## Fcgr4 -0.806943 1.3632 -0.80864 0.4306558 0.758604 0.97157
## Fpr2 -1.306588 1.7440 -0.64784 0.0520389 0.167446 0.12155
## Gbp11 -0.882095 1.2295 -0.65231 0.3933427 0.702450 0.45346
## Gbp2 -0.869098 1.0173 -0.86085 0.5564883 0.819337 0.73044
## Gbp3 -0.984722 1.3424 -0.93939 0.2251070 0.704083 0.83409
## Gbp4 -0.891694 1.0881 -0.86203 0.4909837 0.870797 0.76470
## Gbp2b -0.765272 1.8305 -0.75179 -0.0623803 0.469066 0.69359
## Gm43302 -0.717391 1.0282 -0.74889 0.5634416 0.770269 0.72808
## Gbp7 -0.853470 1.1885 -0.94157 0.5504144 0.818673 0.70284
## Gbp8 -0.981757 1.4438 -0.92791 0.2125342 0.841298 0.87504
## Gbp9 -1.058040 0.5003 -0.78874 0.5865367 0.918671 0.82233
## Gm12185 -0.549681 1.1349 -0.71248 0.5456387 0.687659 0.74808
## Gm12250 -0.856067 1.1037 -0.72964 0.4573584 0.920532 0.75487
## Ifit1bl1 -1.075656 0.6681 -1.22487 0.4363658 0.693912 0.68603
## Gm17334 -0.892454 0.5063 -0.84434 0.5692591 0.844871 0.97575
## Gm1966 -1.074622 0.4266 -0.74691 0.6393753 1.025932 0.98268
## Gm4070 -0.878025 0.9879 -0.54753 0.5349880 0.917653 0.91256
## Gm4841 -0.681395 1.5365 -0.68724 0.0999311 0.592233 1.03446
## Gm4951 -0.973809 1.4344 -0.71167 0.2043559 0.787029 0.98008
## Gm5431 -1.133689 0.9374 -1.11368 -0.0294804 0.631682 0.67769
## Gvin1 -0.955279 0.8999 -0.69813 0.5001008 0.885885 0.90452
## Has2 -0.610477 1.0763 -1.06235 0.6753655 0.543603 0.53626
## Hdc -0.980179 1.0851 0.37293 -0.7364492 0.553242 -0.05281
## Hk3 -1.094223 1.4820 -0.66618 0.3628932 0.496527 0.78957
## Hspa1a 0.212451 1.0554 -1.02463 -0.8769896 1.110681 1.43175
## Hspa1b 0.350478 1.0116 -1.37871 -0.6503782 0.971683 1.22573
## Hsph1 0.612808 0.8973 -1.31289 -0.8189453 0.981220 1.01817
## Htra3 0.750375 -0.4745 0.81832 -0.7754773 -0.770862 -0.06192
## Ifit3b -1.349914 0.2472 -1.28444 0.4602188 0.231869 0.58405
## Ifi204 -0.982574 1.4036 -0.63603 0.0840915 0.584826 0.80633
## Ifi205 -1.107910 1.4672 -0.79222 0.0228990 0.571987 0.76619
## Ifi44 -0.864554 1.0885 -0.53135 -0.1224125 0.681941 0.60532
## Ifi47 -0.852390 1.0723 -0.87706 0.4727541 0.812775 0.69189
## Ifit1 -1.094992 0.8268 -1.01688 0.4576419 0.505875 0.39590
## Ifit2 -1.204218 1.0066 -1.13848 0.3163863 0.509993 0.52205
## Ifit3 -1.199485 0.6962 -0.97489 0.4132760 0.487626 0.61282
## Ifitm3 -1.101613 1.0059 -1.02295 0.1547487 0.517000 0.61676
## Igfbp3 1.053224 -1.4273 0.70590 -0.5624834 -0.451546 -0.31544
## Igtp -0.744467 1.0602 -0.76515 0.5310537 0.805203 0.80685
## Iigp1 -0.906253 1.1334 -0.72499 0.4750411 0.830811 0.87728
## Il12rb1 -1.181724 1.1546 -1.06682 0.3788204 0.610855 0.76747
## Il1rn -0.783610 1.5719 -0.83072 0.1085717 0.109658 0.13336
## Irf1 -0.823543 1.0429 -0.82359 0.5510743 0.902654 0.84299
## Irf7 -0.939432 1.1033 -0.74887 0.3925371 0.320814 0.29182
## Acod1 -0.590357 1.5432 -1.06905 0.2184818 0.487029 0.20686
## Irgm1 -0.892476 1.0801 -0.81518 0.5050357 0.811026 0.72175
## Irgm2 -0.889494 0.9211 -0.79721 0.5050466 0.956932 0.93502
## Isg15 -0.962480 0.9483 -1.07605 0.5283167 0.482945 0.12608
## Lgals9 -0.794993 1.3216 -0.99404 0.6316929 0.578267 0.29583
## Lif -0.909203 0.6549 -0.79398 -0.1727414 0.514548 0.39665
## Ly6a -1.032006 1.5069 -0.63478 0.0000794 0.530562 0.58593
## Ly6c2 -0.773501 1.7278 -0.72194 -0.0707689 0.478594 0.27535
## Ly6i -1.192581 1.4295 -0.68550 -0.1716454 0.554884 0.61963
## Maff -0.677340 0.9696 -0.46923 0.1081148 0.849017 0.59905
## Mcm10 0.181950 1.4042 -1.27576 0.6973745 0.611185 -0.13187
## Mlkl -0.830465 1.6766 -0.89967 0.0128802 0.454472 0.47862
## Mmp13 -0.880654 1.5924 -0.96483 0.0498276 0.523700 0.39703
## Mnda -1.012634 1.3678 -0.75733 0.2750600 0.552248 0.64497
## Mt1 -0.012761 1.3886 -0.63210 0.6353905 0.277525 -0.02733
## Mt2 -0.288724 1.3441 -1.23175 0.6571230 0.495258 -0.08671
## Mx1 -1.020438 0.5063 -0.98726 0.3432440 0.654637 0.50182
## Nampt -0.950558 1.2856 -0.88519 0.3382774 0.735376 0.57207
## Nlrc5 -0.848777 0.5924 -0.51083 0.5697001 0.937017 0.99509
## Nme1 -0.210952 1.5690 -0.92397 -0.0354928 0.438094 0.55307
## Oas1a -0.832728 1.1426 -0.79335 0.0653851 0.535767 0.35262
## Oas2 -0.887888 0.9998 -0.96661 -0.0944791 0.447169 0.56035
## Oas3 -0.578230 1.0561 -0.97332 0.6385077 0.427818 0.16974
## Oasl1 -0.851660 0.6382 -1.56568 0.3186353 0.402184 0.62759
## Oasl2 -1.045235 1.1449 -0.71788 0.4294215 0.488824 0.57542
## Oit3 1.242761 -0.9736 0.63985 -1.0238144 -0.457304 -0.29417
## Parp14 -0.954581 0.8862 -0.81028 0.3805069 0.786591 0.87142
## Parp9 -0.828880 0.9243 -0.84754 0.5254683 0.684355 0.59355
## Phf11a -1.830497 1.1593 -0.29327 0.2396068 0.569664 0.31035
## Phf11d -0.845480 1.1842 -0.74702 -0.1173955 0.231848 0.49623
## Pkib -1.271616 0.9987 -0.83024 0.4194200 0.886897 0.61008
## Pla2g16 -0.974407 1.1819 -0.78044 0.5912197 0.773061 0.37697
## Plau -0.769812 1.6264 -0.76384 0.2307859 0.127771 0.14834
## Pnp -0.370907 1.2699 -1.12548 0.6847387 0.479218 0.01527
## Ppa1 -0.730950 1.1875 -1.01527 0.2145155 0.852959 0.49479
## Procr -0.941462 1.7324 -0.93128 -0.0420114 0.324809 0.30274
## Psmb10 -0.757977 1.1266 -0.85191 0.3677374 0.553877 0.55859
## Ptgs2 -0.911831 1.8589 -0.84814 0.1685095 0.241010 0.15091
## Pydc4 -1.061275 0.2133 -0.99605 0.5825475 0.678454 0.77121
## Rnf213 -0.900257 0.6356 -1.03198 0.3755949 0.545998 0.60130
## Rtp4 -1.246178 0.7743 -0.79808 0.4009643 0.630642 0.62718
## Serpina3f -0.773189 1.2523 -0.73758 0.4437319 0.803032 0.91590
## Serpina3g -0.879204 1.3567 -0.59810 0.4281183 0.784919 0.86113
## Serpina3n -0.310043 0.4155 -0.23049 0.7463056 1.222651 1.04189
## Slamf8 -1.203773 1.5213 -0.73618 0.0483946 0.621533 0.64971
## Slfn4 -0.886211 1.0092 -0.21877 -0.5278365 -0.001034 0.61738
## Smpdl3b -0.335938 1.6041 -0.39843 0.1684796 0.234765 0.82714
## Socs1 -0.887805 1.1834 -0.93114 0.3351023 0.802524 0.71165
## Socs3 -0.904271 1.7877 -0.44327 0.0343458 0.504529 0.48940
## Srm -0.753434 1.3037 -1.06393 0.2101428 0.606951 0.27215
## Stat1 -0.805112 0.6932 -0.79048 0.5988993 0.850025 1.00404
## Stat2 -0.992289 0.7940 -0.78105 0.3175716 0.657312 0.76218
## Steap3 0.411938 0.9859 -1.12532 0.9643731 0.365527 -0.13308
## Syce2 -0.058199 1.2481 -1.10912 0.8384590 0.843710 0.19576
## Tap1 -1.042218 1.1129 -0.41769 0.4196578 0.636701 0.89998
## Tgm2 -0.898778 1.5852 -0.86010 0.2496520 0.497070 0.47398
## Tgtp1 -0.785544 1.0565 -0.83481 0.5284628 0.803172 0.72010
## Tgtp2 -0.785673 0.8928 -0.70569 0.5221855 0.866434 0.81734
## Timp1 -0.807550 1.2413 -0.55812 0.3030225 0.845385 -0.32096
## Tmem255a 0.403720 -2.0304 0.77634 -0.3645285 -0.255565 0.35629
## Tnc -1.855952 1.4820 -0.06680 0.1510668 -0.294146 1.14544
## Tubb3 -0.975045 1.7706 -0.71086 0.0852845 0.644707 0.15050
## Tubb6 -0.779705 1.5667 -1.16596 0.5670802 0.729532 0.45478
## Ubd -0.869986 1.5123 -0.88682 0.3505216 0.744957 0.87262
## Upp1 -0.937719 1.8717 -0.48427 -0.0507237 0.476065 0.31927
## Usp18 -0.995894 0.5272 -0.95683 0.1660283 0.523158 0.39134
## Vdr -0.232632 1.5016 -0.73483 0.0874288 0.449741 0.64547
## Wars -1.064358 1.1535 -0.82411 0.4137854 0.900180 0.85047
## Xaf1 -0.865759 0.5846 -1.09198 0.6113997 0.599121 0.61136
## Zbp1 -0.831118 1.0238 -0.77614 0.4782392 0.711561 0.75059
## naive.r1 naive.r2 naive.r3 naive.r4
## Apol10b -1.4750 -1.0621 -0.86759 -0.44850
## Apol6 -0.8674 -1.3543 -1.03983 -0.72572
## Asns -1.6345 -0.9565 -0.30537 -1.97332
## Aunip -1.2526 -1.0391 -0.24653 -1.84023
## Batf2 -1.1021 -0.8736 -0.99783 -1.06414
## Bcl2l14 -0.9517 -0.9464 -1.30618 -0.92888
## Ccl2 -1.0354 -1.0024 -0.95414 -0.93838
## Cd163 1.1942 0.9002 1.17049 1.13081
## Cd274 -1.1458 -1.0297 -1.22342 -0.95679
## Cdc45 -1.6194 -0.7630 -0.34559 -1.65936
## Chaf1a -1.5445 -1.2244 -0.40394 -1.31231
## Cmpk2 -1.5952 -1.1642 -0.15998 -1.32646
## Cxcl10 -1.1633 -1.1775 -1.05589 -1.05486
## Cxcl9 -1.0042 -1.3495 -1.35403 -1.06587
## Dtl -1.4596 -1.0282 -0.22764 -1.86650
## Fam132a -1.5462 -0.8105 -0.52259 -1.98331
## Fam13a 1.5896 0.8121 0.66748 1.52986
## Fam26f -1.0649 -1.1965 -1.23567 -0.82792
## Fanci -1.5756 -0.9854 -0.55958 -1.55777
## Fcgr4 -1.3463 -0.9625 -1.12069 -1.02943
## Fos -1.0351 -0.7014 -2.04499 -0.40070
## Gbp11 -1.5027 -1.4864 -1.03473 -0.61058
## Gbp2 -1.2056 -1.1229 -1.27494 -0.99891
## Gbp3 -1.2477 -0.9285 -1.10259 -0.84008
## Gbp4 -1.1120 -1.1569 -1.39501 -1.00718
## Gbp2b -1.1623 -0.9022 -1.03637 -0.84439
## Gm43302 -0.8405 -1.4637 -1.34114 -0.28926
## Gbp7 -1.3096 -1.0998 -1.10660 -1.04820
## Gm12185 -0.8760 -1.2622 -1.13329 -1.02433
## Gm12250 -1.2520 -1.1104 -1.27644 -1.04503
## Ifit1bl1 -1.2510 -0.7526 -1.23397 -0.82687
## Gm17334 -1.2675 -0.8550 -1.21474 -1.09393
## Gm1966 -1.2403 -1.0057 -1.30793 -1.07971
## Gm4070 -1.4606 -1.1192 -1.38484 -0.91970
## Gm4841 -1.3058 -1.0366 -1.17277 -0.74209
## Gm4951 -1.1234 -1.1073 -1.32299 -0.68756
## Gvin1 -1.3075 -1.1218 -1.34693 -1.00690
## Has2 -1.3805 -1.1279 -1.03423 -1.06867
## Hk3 -1.3055 -1.0252 -1.08819 -0.91376
## Hspa1a -0.3705 -0.3775 -1.93261 -1.14881
## Hspa1b -0.7843 -0.7462 -1.63254 -1.09634
## Htra3 1.2215 1.3211 0.68414 1.28473
## Ifi204 -1.4841 -0.8835 -1.04969 -0.86665
## Ifi44 -1.4285 -0.9927 -0.98632 -0.71627
## Ifi47 -1.2341 -1.0679 -1.29387 -1.09786
## Ifit1 -1.1479 -1.1623 -0.75274 -0.88864
## Ifit2 -1.1878 -0.8538 -1.05273 -0.74415
## Ifit3 -1.1321 -0.9548 -0.90939 -0.60721
## Igfbp3 1.2759 1.1092 0.88959 1.32788
## Igtp -1.2773 -1.1470 -1.31188 -1.12330
## Iigp1 -1.2446 -1.2356 -1.22689 -0.90078
## Il12rb1 -1.0811 -0.6705 -0.93382 -1.32973
## Il1rn -0.9807 -1.3421 -1.02763 -0.67688
## Il2ra -1.1678 -1.0811 -1.11751 -1.09728
## Irf1 -1.1644 -1.1860 -1.41010 -1.06426
## Irf7 -1.4153 -1.0967 -0.86143 -0.84102
## Acod1 -0.9823 -1.0414 -1.04615 -0.85162
## Irgm1 -1.3040 -1.1603 -1.18830 -1.04998
## Irgm2 -1.2739 -1.1160 -1.25320 -0.89448
## Klra2 -1.4428 -0.8560 -0.81331 -0.82834
## Lgals9 -1.2500 -1.0921 -0.88225 -1.05533
## Lif -1.1196 -1.2966 -0.66979 -1.18530
## Lox 1.4550 0.8430 0.17276 1.34394
## Lrr1 -1.4689 -0.6389 -0.37655 -1.27892
## Ly6a -1.3037 -0.9469 -1.21078 -0.83694
## Ly6i -1.0783 -1.0850 -0.99250 -0.80897
## Mab21l3 -1.8109 -1.8055 -0.90818 -0.58602
## Maff -0.8081 -1.6700 -1.52001 -1.23018
## Mcm10 -1.3778 -1.1804 -0.14503 -1.68025
## Mlkl -1.2658 -1.0122 -0.96278 -0.69034
## Mmp13 -0.9167 -1.1401 -1.02950 -0.80970
## Mnda -1.3384 -1.1398 -1.16680 -0.77313
## Mt2 -1.6043 -0.8950 -0.46683 -1.70919
## Mx1 -1.1570 -0.9840 -0.98250 -0.72057
## Nampt -1.3047 -1.0810 -1.05394 -0.96846
## Nlrc5 -1.2375 -0.9388 -1.69600 -0.70404
## Oas3 -1.6267 -1.3017 -0.06213 -1.24305
## Oasl2 -1.3696 -1.1705 -1.03251 -0.61133
## Oit3 1.5397 1.0455 0.63696 1.09085
## Parp9 -1.1787 -1.1729 -1.10603 -1.08483
## Pla2g16 -1.2366 -1.2472 -0.39834 -1.57024
## Ppa1 -1.4482 -0.8813 -1.17583 -0.98363
## Ptgs2 -1.0518 -0.8595 -0.86511 -0.89542
## Rad51 -2.1641 -0.9101 -0.14311 -1.35914
## Rnd1 -0.3828 -1.7156 -1.52187 -0.42426
## Rtp4 -1.3826 -1.0706 -1.01898 -0.45378
## Serpina3f -1.3007 -1.1587 -1.26469 -0.93370
## Serpina3g -1.2826 -1.2239 -1.25348 -0.91025
## Serpina3n -0.8520 -0.8452 -2.05278 -1.20708
## Shcbp1 -1.8142 -0.9970 0.09238 -1.25222
## Slamf8 -0.8319 -0.8786 -1.21659 -0.87647
## Slc7a11 -1.3491 -1.6647 -1.48703 -0.77641
## Smpdl3b -1.5101 -1.1926 -1.20627 -0.83326
## Socs1 -1.2287 -1.1762 -1.11367 -1.01144
## Socs3 -1.1679 -1.1384 -1.49068 -0.97972
## Sphk1 -1.0482 -1.2942 -0.08330 -1.71014
## Stat1 -1.2473 -1.1704 -1.28649 -0.87188
## Steap3 -1.5759 -1.0646 -0.41645 -1.95819
## Syce2 -1.6606 -1.0240 -0.38806 -1.79073
## Tap1 -1.1954 -1.0848 -1.43788 -1.13448
## Tgtp1 -1.2063 -1.1000 -1.32352 -1.09182
## Tgtp2 -1.2873 -1.3296 -1.16488 -1.04485
## Tnip3 -0.9128 -0.5357 -0.93379 -0.89492
## Trip13 -1.2337 -1.0661 -0.58439 -1.08260
## Tubb3 -0.8346 -0.9727 -1.02798 -0.95786
## Ubd -1.0891 -1.1517 -1.06557 -1.12908
## Upp1 -1.2481 -0.7999 -1.06116 -1.04748
## Vdr -1.3254 -1.3883 -0.90670 -1.09787
## Wars -0.8876 -0.9233 -1.38659 -1.06270
## Xaf1 -1.3447 -1.2951 -0.94235 -0.63765
## Zbp1 -1.2165 -1.0606 -1.42137 -1.01553
## Abca9 1.0877 0.9860 0.96226 0.97186
## Apol10b -1.4750 -1.0621 -0.86759 -0.44850
## Apol6 -0.8674 -1.3543 -1.03983 -0.72572
## Asns -1.6345 -0.9565 -0.30537 -1.97332
## Aunip -1.2526 -1.0391 -0.24653 -1.84023
## Bag2 -0.7837 -1.0599 -0.30615 -2.00127
## Batf2 -1.1021 -0.8736 -0.99783 -1.06414
## Bcl2l14 -0.9517 -0.9464 -1.30618 -0.92888
## Bst2 -1.3310 -1.0721 -1.13289 -0.72761
## Ccl19 -1.1011 -1.1081 -1.68594 -0.82553
## Ccl2 -1.0354 -1.0024 -0.95414 -0.93838
## Cd163 1.1942 0.9002 1.17049 1.13081
## Cd274 -1.1458 -1.0297 -1.22342 -0.95679
## Cdc45 -1.6194 -0.7630 -0.34559 -1.65936
## Cdkn1a -1.0313 -1.2776 -1.25114 -1.01790
## Cebpb -1.4832 -1.2045 -1.69883 -0.36823
## Cela1 -0.7957 0.3682 -0.53358 -1.07854
## Cmpk2 -1.5952 -1.1642 -0.15998 -1.32646
## Ctrl -0.9124 0.4040 -0.61492 -0.73229
## Ctsf 0.6481 0.9201 1.51501 0.74146
## Cxcl10 -1.1633 -1.1775 -1.05589 -1.05486
## Cxcl9 -1.0042 -1.3495 -1.35403 -1.06587
## Dhx58 -1.2542 -0.8743 -1.18724 -0.65387
## Dram1 -1.4900 -1.0881 -1.05930 -0.87603
## Dtl -1.4596 -1.0282 -0.22764 -1.86650
## Fam132a -1.5462 -0.8105 -0.52259 -1.98331
## Fam13a 1.5896 0.8121 0.66748 1.52986
## Fam26f -1.0649 -1.1965 -1.23567 -0.82792
## Fanci -1.5756 -0.9854 -0.55958 -1.55777
## Fcgr4 -1.3463 -0.9625 -1.12069 -1.02943
## Fpr2 -0.9746 -1.1954 -0.60020 -0.51050
## Gbp11 -1.5027 -1.4864 -1.03473 -0.61058
## Gbp2 -1.2056 -1.1229 -1.27494 -0.99891
## Gbp3 -1.2477 -0.9285 -1.10259 -0.84008
## Gbp4 -1.1120 -1.1569 -1.39501 -1.00718
## Gbp2b -1.1623 -0.9022 -1.03637 -0.84439
## Gm43302 -0.8405 -1.4637 -1.34114 -0.28926
## Gbp7 -1.3096 -1.0998 -1.10660 -1.04820
## Gbp8 -1.2398 -1.0863 -1.08047 -0.92009
## Gbp9 -1.2133 -1.1416 -1.26963 -0.87372
## Gm12185 -0.8760 -1.2622 -1.13329 -1.02433
## Gm12250 -1.2520 -1.1104 -1.27644 -1.04503
## Ifit1bl1 -1.2510 -0.7526 -1.23397 -0.82687
## Gm17334 -1.2675 -0.8550 -1.21474 -1.09393
## Gm1966 -1.2403 -1.0057 -1.30793 -1.07971
## Gm4070 -1.4606 -1.1192 -1.38484 -0.91970
## Gm4841 -1.3058 -1.0366 -1.17277 -0.74209
## Gm4951 -1.1234 -1.1073 -1.32299 -0.68756
## Gm5431 -1.1667 -0.9390 -0.94815 -0.23280
## Gvin1 -1.3075 -1.1218 -1.34693 -1.00690
## Has2 -1.3805 -1.1279 -1.03423 -1.06867
## Hdc -1.4224 -1.1171 -1.20963 -0.94984
## Hk3 -1.3055 -1.0252 -1.08819 -0.91376
## Hspa1a -0.3705 -0.3775 -1.93261 -1.14881
## Hspa1b -0.7843 -0.7462 -1.63254 -1.09634
## Hsph1 -0.6184 -0.1929 -1.69022 -1.82955
## Htra3 1.2215 1.3211 0.68414 1.28473
## Ifit3b -1.0485 -0.7553 -1.01988 -0.16786
## Ifi204 -1.4841 -0.8835 -1.04969 -0.86665
## Ifi205 -1.1370 -0.9502 -1.03566 -0.94198
## Ifi44 -1.4285 -0.9927 -0.98632 -0.71627
## Ifi47 -1.2341 -1.0679 -1.29387 -1.09786
## Ifit1 -1.1479 -1.1623 -0.75274 -0.88864
## Ifit2 -1.1878 -0.8538 -1.05273 -0.74415
## Ifit3 -1.1321 -0.9548 -0.90939 -0.60721
## Ifitm3 -1.2058 -0.9200 -1.06040 -0.76977
## Igfbp3 1.2759 1.1092 0.88959 1.32788
## Igtp -1.2773 -1.1470 -1.31188 -1.12330
## Iigp1 -1.2446 -1.2356 -1.22689 -0.90078
## Il12rb1 -1.0811 -0.6705 -0.93382 -1.32973
## Il1rn -0.9807 -1.3421 -1.02763 -0.67688
## Irf1 -1.1644 -1.1860 -1.41010 -1.06426
## Irf7 -1.4153 -1.0967 -0.86143 -0.84102
## Acod1 -0.9823 -1.0414 -1.04615 -0.85162
## Irgm1 -1.3040 -1.1603 -1.18830 -1.04998
## Irgm2 -1.2739 -1.1160 -1.25320 -0.89448
## Isg15 -1.4408 -1.0359 -0.10274 -1.26115
## Lgals9 -1.2500 -1.0921 -0.88225 -1.05533
## Lif -1.1196 -1.2966 -0.66979 -1.18530
## Ly6a -1.3037 -0.9469 -1.21078 -0.83694
## Ly6c2 -1.3443 -1.0029 -1.13349 -0.87563
## Ly6i -1.0783 -1.0850 -0.99250 -0.80897
## Maff -0.8081 -1.6700 -1.52001 -1.23018
## Mcm10 -1.3778 -1.1804 -0.14503 -1.68025
## Mlkl -1.2658 -1.0122 -0.96278 -0.69034
## Mmp13 -0.9167 -1.1401 -1.02950 -0.80970
## Mnda -1.3384 -1.1398 -1.16680 -0.77313
## Mt1 -1.7511 -0.9465 -0.81545 -1.95169
## Mt2 -1.6043 -0.8950 -0.46683 -1.70919
## Mx1 -1.1570 -0.9840 -0.98250 -0.72057
## Nampt -1.3047 -1.0810 -1.05394 -0.96846
## Nlrc5 -1.2375 -0.9388 -1.69600 -0.70404
## Nme1 -1.6221 -0.4167 -1.36678 -1.45854
## Oas1a -1.5023 -1.2965 -0.94415 -0.53434
## Oas2 -1.3638 -1.0233 -1.05796 -0.56764
## Oas3 -1.6267 -1.3017 -0.06213 -1.24305
## Oasl1 -1.2070 -0.9619 -0.90571 -0.83367
## Oasl2 -1.3696 -1.1705 -1.03251 -0.61133
## Oit3 1.5397 1.0455 0.63696 1.09085
## Parp14 -1.2835 -1.0071 -1.09373 -0.87941
## Parp9 -1.1787 -1.1729 -1.10603 -1.08483
## Phf11a -1.1315 -0.8452 -1.05911 -0.41580
## Phf11d -1.5435 -0.6092 -1.19003 -0.64720
## Pkib -1.0573 -1.5047 -1.22970 -1.06373
## Pla2g16 -1.2366 -1.2472 -0.39834 -1.57024
## Plau -0.9075 -0.9656 -0.91947 -0.85331
## Pnp -1.4629 -1.1618 -0.23253 -1.63808
## Ppa1 -1.4482 -0.8813 -1.17583 -0.98363
## Procr -0.6950 -1.0323 -1.19941 -0.80580
## Psmb10 -1.2617 -1.1801 -1.11692 -1.14153
## Ptgs2 -1.0518 -0.8595 -0.86511 -0.89542
## Pydc4 -1.2626 -0.8754 -1.32879 -0.69985
## Rnf213 -1.3174 -0.9378 -1.06848 -0.80623
## Rtp4 -1.3826 -1.0706 -1.01898 -0.45378
## Serpina3f -1.3007 -1.1587 -1.26469 -0.93370
## Serpina3g -1.2826 -1.2239 -1.25348 -0.91025
## Serpina3n -0.8520 -0.8452 -2.05278 -1.20708
## Slamf8 -0.8319 -0.8786 -1.21659 -0.87647
## Slfn4 -1.5390 -0.9195 -0.76606 -0.08473
## Smpdl3b -1.5101 -1.1926 -1.20627 -0.83326
## Socs1 -1.2287 -1.1762 -1.11367 -1.01144
## Socs3 -1.1679 -1.1384 -1.49068 -0.97972
## Srm -1.1036 -0.8061 -1.44517 -1.32488
## Stat1 -1.2473 -1.1704 -1.28649 -0.87188
## Stat2 -1.2464 -1.1446 -1.17238 -0.77574
## Steap3 -1.5759 -1.0646 -0.41645 -1.95819
## Syce2 -1.6606 -1.0240 -0.38806 -1.79073
## Tap1 -1.1954 -1.0848 -1.43788 -1.13448
## Tgm2 -1.0616 -1.3045 -1.06941 -0.92349
## Tgtp1 -1.2063 -1.1000 -1.32352 -1.09182
## Tgtp2 -1.2873 -1.3296 -1.16488 -1.04485
## Timp1 -0.5555 -1.5640 -0.92957 -1.03549
## Tmem255a 0.9568 1.4593 0.83406 1.31550
## Tnc -0.7693 -0.8696 -0.55021 -1.11784
## Tubb3 -0.8346 -0.9727 -1.02798 -0.95786
## Tubb6 -1.4114 -0.8273 -1.09900 -1.18500
## Ubd -1.0891 -1.1517 -1.06557 -1.12908
## Upp1 -1.2481 -0.7999 -1.06116 -1.04748
## Usp18 -1.1548 -1.0552 -0.92030 -1.10476
## Vdr -1.3254 -1.3883 -0.90670 -1.09787
## Wars -0.8876 -0.9233 -1.38659 -1.06270
## Xaf1 -1.3447 -1.2951 -0.94235 -0.63765
## Zbp1 -1.2165 -1.0606 -1.42137 -1.01553## heat.list day delivery rep
## 13 naive.r1 0 naive 1
## 14 naive.r2 0 naive 2
## 15 naive.r3 0 naive 3
## 16 naive.r4 0 naive 4
## 1 sbp.d4.r1 4 sbp 1
## 2 sbp.d4.r2 4 sbp 2
## 3 sbp.d4.r3 4 sbp 3
## 4 sbp.d4.r4 4 sbp 4
## 9 rtmt.d4.r1 4 rtmt 1
## 10 rtmt.d4.r2 4 rtmt 2
## 11 rtmt.d4.r3 4 rtmt 3
## 12 rtmt.d4.r4 4 rtmt 4
## 5 mt.d4.r1 4 mt 1
## 6 mt.d4.r2 4 mt 2
## 7 mt.d4.r3 4 mt 3
## 8 mt.d4.r4 4 mt 4