The Aim of the EKD11 timecourse experiment is to investigate the host’s immune response to a primary P.chabaudi AS infection transmitted through different routes; Natural transmission (Mosquito), serially blood passaged (SBP), and recently transmissited blood passage (RTMT). The timecourse looks at the acute phase of the infection, using transcriptomics data taken from days 1, 2, 3, 4 and 6.

1 Pre-requisites

Loading the required R library packages and setting the directories for the project analysis

2 Experimental setup

2.1 Loading Genome data

Importing GTF file containing genome information for Mus musculus. GRCm38 version 86

2.2 Design file

This is a file containing all the meta data we need for the data analysis. The important factors for the analysis are: sample, day, delivery, replicate and grp (group)

2.3 Importing count data and normalisation

This section will import the results of the RNA-seq pipeline and normalise the data according to library size. A count, log(counts) and TPM data frame will then we created from the normalised results.

Below is the TPM database from the experiment, calculated from RSEM.

## It looks like you are importing RSEM genes.results files, setting txIn=FALSE
## reading in files with read_tsv
## 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 using counts and average transcript lengths from tximport
## estimating size factors
## using 'avgTxLength' from assays(dds), correcting for library size
## estimating dispersions
## gene-wise dispersion estimates
## mean-dispersion relationship
## final dispersion estimates
## fitting model and testing
## using 'avgTxLength' from assays(dds), correcting for library size

3 PCA Plot

PCA plot showing the separation of all samples within the study. The PCA is produced using top 1000 variable genes within the dataset.

I’ve made the PCA in a 3D scatter plot to try and see if there is any separation of the samples before day 3 from PC3 that doesn’t seem to appear when using just PC1 and PC2. PC3 only accounts for ~14% of the variance in the dataset, so I wasn’t expecting a large change, nonetheless I think the separation it does show is worth keeping. I’ve also added 2D plots of PC1 vs PC2, PC1 vs PC3 and PC2 vs PC3, which may be more useful.

4 Differential Gene Expression

4.1 DGE overview

The PCA’s may be indicating that, with the exception of day 1 of mosquito transmission, the groups are fairly homogeneous up to day 3. There are small clusters that form, however there seems to be one replicate in each group that bucks the trend in most cases. Doing direct group comparisons means that it’s likely to mask siginficant genes each tranmission group uses to fight the infection. If we identify what genes are differentially expressed within each transmission route throughout the time course, and then compare these gene lists, we can see what genes are shared/different between the transmission routes. This will hide some information, such as if a gene/geneset are shared between two transmission routes, but activated at different times, but this approach will narrow down our search in the first instance.

First of all we need to identify the DGE’s in each transmission route, by comparing them to the controls.

With the comparisons made and genes filtered to identify the DGE’s we can see how many genes were identified within in each group.

We can then find out the total number of genes used by each transmission group throughout the timecourse.

## [1] "MT: 2782 differntially expressed genes identified"
## [1] "RTMT: 2355 differentially expressed genes identified"
## [1] "SBP: 2021 differentially expressed genes identified"
## [1] "Total number of differentially expressed genes identified across all groups:  3222 genes"

4.2 Venn diagram

There seems to be a significant difference in the number of DGE’s between the transmission groups, which is to be expected, especially between SBP and both MT and RTMT. By the total number of unique DGE’s found across all groups, it is apparent that many of the genes identified are shared between two or more groups. We can construct a Venn diagram to see how the 2971 are divided across the transmission routes and see what is shared or unique between each route.

## Loading required package: futile.logger

The venn diagram tells us a lot of information about the transmission routes. For example it shows us that a lot of the DGE’s identified across the transmission groups are shared between them. One particular intersection that I think is of interest is the 303 genes that are shared between MT and RTMT, but not with SBP. If MT and RTMT share the same phenotype, which shows a greater level of attenuation of parasataemia, maybe the genes that drive this are within this set?

Whilst the venn diagram does give us a broad overview of the interplay of these groups and there DGE’s, it is hiding some resolution within the data. First of all, the diagram was constructed by identifying DGE’s within each transmission group but doesn’t take into account whether the gene was up or downregulated in respect to the Naive. This means that whilst a gene could be shared between two or more groups, it could upregualted in one whilst downregulated in another. Another key factor the venn diagram masks is the day the gene was first identified as differentially expressed in the groups. The earlier activation of the immune response is likely to be a key factor in the control of the infection, so a way to investigate this is required.

The issued raise in regards to the lack of information on up/down-regulated genes can be done just by separating out these genes and constructing two additional diagrams.

First of all, we need to identify seperate out the up/down-regulated DGE’s from the lists we identified

## [1] "MT: 2782 DGE identified"
## [1] "MT: 1784 Upregualted genes identified"
## [1] "MT: 1036 Downregualted genes identified"
## [1] "RTMT: 2355 DGE genes identified"
## [1] "RTMT: 1356 Upregulated genes identified"
## [1] "RTMT: 999 Downregulated genes identified"
## [1] "SBP: 2021 DGE genes identified"
## [1] "SBP: 1178 Upregulated genes identified"
## [1] "SBP: 843 Downregulated genes identified"

With the groups separated into their up/down regualted genes, we can construct separate Venn diagrams for each one.

4.3 RTMT vs MT - shared genes

4.3.1 heatmap overview

With the identification of DGE’s shared between MT and RTMT, we can start to investigate further this geneset. First of all, a heatmap of these genes will be helpful in identifying any expression trends between the groups. First of all we’ll use TPM’s to construct the heatmap.

##     heat.list day delivery rep
## 61   naive.r1   0    naive   1
## 62   naive.r2   0    naive   2
## 63   naive.r3   0    naive   3
## 64   naive.r4   0    naive   4
## 1   sbp.d1.r1   1      sbp   1
## 2   sbp.d1.r2   1      sbp   2
## 3   sbp.d1.r3   1      sbp   3
## 4   sbp.d1.r4   1      sbp   4
## 41 rtmt.d1.r1   1     rtmt   1
## 42 rtmt.d1.r2   1     rtmt   2
## 43 rtmt.d1.r3   1     rtmt   3
## 44 rtmt.d1.r4   1     rtmt   4
## 21   mt.d1.r1   1       mt   1
## 22   mt.d1.r2   1       mt   2
## 23   mt.d1.r3   1       mt   3
## 24   mt.d1.r4   1       mt   4
## 5   sbp.d2.r1   2      sbp   1
## 6   sbp.d2.r2   2      sbp   2
## 7   sbp.d2.r3   2      sbp   3
## 8   sbp.d2.r4   2      sbp   4
## 45 rtmt.d2.r1   2     rtmt   1
## 46 rtmt.d2.r2   2     rtmt   2
## 47 rtmt.d2.r3   2     rtmt   3
## 48 rtmt.d2.r4   2     rtmt   4
## 25   mt.d2.r1   2       mt   1
## 26   mt.d2.r2   2       mt   2
## 27   mt.d2.r3   2       mt   3
## 28   mt.d2.r4   2       mt   4
## 9   sbp.d3.r1   3      sbp   1
## 10  sbp.d3.r2   3      sbp   2
## 11  sbp.d3.r3   3      sbp   3
## 12  sbp.d3.r4   3      sbp   4
## 49 rtmt.d3.r1   3     rtmt   1
## 50 rtmt.d3.r2   3     rtmt   2
## 51 rtmt.d3.r3   3     rtmt   3
## 52 rtmt.d3.r4   3     rtmt   4
## 29   mt.d3.r1   3       mt   1
## 30   mt.d3.r2   3       mt   2
## 31   mt.d3.r3   3       mt   3
## 32   mt.d3.r4   3       mt   4
## 13  sbp.d4.r1   4      sbp   1
## 14  sbp.d4.r2   4      sbp   2
## 15  sbp.d4.r3   4      sbp   3
## 16  sbp.d4.r4   4      sbp   4
## 53 rtmt.d4.r1   4     rtmt   1
## 54 rtmt.d4.r2   4     rtmt   2
## 55 rtmt.d4.r3   4     rtmt   3
## 56 rtmt.d4.r4   4     rtmt   4
## 33   mt.d4.r1   4       mt   1
## 34   mt.d4.r2   4       mt   2
## 35   mt.d4.r3   4       mt   3
## 36   mt.d4.r4   4       mt   4
## 17  sbp.d6.r1   6      sbp   1
## 18  sbp.d6.r2   6      sbp   2
## 19  sbp.d6.r3   6      sbp   3
## 20  sbp.d6.r4   6      sbp   4
## 57 rtmt.d6.r1   6     rtmt   1
## 58 rtmt.d6.r2   6     rtmt   2
## 59 rtmt.d6.r3   6     rtmt   3
## 60 rtmt.d6.r4   6     rtmt   4
## 37   mt.d6.r1   6       mt   1
## 38   mt.d6.r2   6       mt   2
## 39   mt.d6.r3   6       mt   3
## 40   mt.d6.r4   6       mt   4

Using TPMs hides a lot of pattern information, as only a few individual genes have such a high expression that it widens the scale of the heatmap, even when using log(TPM).

Z-scores, which measures how far a samples gene expression (in SD) is from the mean across all samples may be a better solution, as it normalises the data to account relative levels of expressions for a gene, and better highlights the variation between samples.

4.4 Day 4

##               sbp.d4.r1 sbp.d4.r2 sbp.d4.r3 sbp.d4.r4 mt.d4.r1  mt.d4.r2
## Cdc45          0.290595 -0.457178  0.386845  0.060966  1.42695  1.604920
## Slfn4          1.703352 -1.130757 -0.279779  0.054411  1.41159  1.557750
## Mx1            1.192093 -1.165385 -0.137339  1.575103  1.29992  1.081355
## Il12rb1        1.062228 -1.135382  0.369164  1.160633  0.75893  1.136358
## Gnb1l         -0.041556  0.478331  1.715561  1.011642  0.89434  0.644762
## Lgals9         0.845075 -1.053011  0.002111  0.673427  1.24232  1.531420
## Timp1          0.892153 -1.175029 -0.070954  1.143931  1.14244  1.448956
## Tubb6          1.069000 -0.619923 -0.098152  0.717715  1.11298  0.968664
## Peg3          -0.789701  0.281130 -0.057910 -0.223164 -0.93702 -1.455695
## Syce2          0.108319 -0.349306  0.317246  0.277326  1.15952  1.391497
## Abca13         0.898460 -0.483816 -0.391663 -0.368954  0.99877  1.193767
## Ccl24          0.831707 -1.033724  0.005555  0.744877  1.26001  1.395971
## Thop1          0.364803  0.205474  0.373715  0.720452  0.92295  1.541297
## Hspb1          1.382589 -0.628458  0.432371  2.864944 -0.91716 -0.750300
## Spo11          1.544588 -1.049804 -0.389877  0.945718  0.67098  0.523781
## Srm            1.013503 -0.725811  0.638081  0.850609  1.09814  1.229638
## Atp7b          0.312944 -0.217251  0.749894  0.091584  1.10692  1.349665
## Cd163         -1.109947  0.795306  0.476639 -0.141248 -1.18887 -1.880996
## Oit3          -1.242182  0.820377  0.092339 -0.656424 -1.15377 -1.307015
## Mlkl           1.054178 -1.148228 -0.067274  0.608568  1.12065  1.470835
## Enkd1          0.720846 -0.578228 -0.006081  0.751096  1.40412  1.512406
## Gzmb           0.183588 -0.906734 -0.070192  0.469050  0.96062  1.673681
## Cd274          1.121928 -1.179835  0.105092  0.929304  0.91991  1.179472
## Dhx58          1.132065 -0.989423  0.211480  1.451034  1.44409  1.080121
## Irf1           0.997282 -1.085325  0.570774  0.938813  0.84365  0.867053
## Pdk4          -1.087421  0.344103 -0.342869 -0.058053 -1.47129 -1.057142
## Pkib           1.351911 -0.325030  0.582697  1.055003  0.71519  0.662320
## Dram1          1.104088 -1.095168  0.182509  0.692363  1.05268  1.225845
## Ppa1           0.912590 -1.014504  0.247976  0.829031  1.15320  1.357108
## Nefh           1.168562 -0.868989  0.254636  0.479980  0.71108  1.527879
## Upp1           1.140272 -0.767930 -0.352334  0.303931  1.17134  1.467071
## Igfbp3        -0.896697  0.680872 -0.214557 -0.400615 -1.36989 -1.404092
## Nampt          0.985758 -1.071585  0.160113  0.817234  1.12575  1.295200
## Cmpk2          0.729382 -1.007336  0.033653  0.779614  1.36763  1.438877
## Serpina3n      1.011267 -1.332723  0.605127  0.732327  0.82057  0.234580
## Wars           1.153438 -1.233468  0.164411  1.048479  0.70608  0.991807
## Hsp90aa1       0.438838 -0.638406  0.746258  0.847996  0.97529  1.229654
## Thbs4          1.190402 -1.415414  0.621227  1.192599  0.20812  0.293231
## Plau           1.556374 -0.958332 -0.607275  0.290820  1.11634  1.648374
## Pnp            0.550221 -0.616947  0.310654  0.450135  1.33056  1.517987
## Gdf10         -0.872402  0.517573  0.003971 -0.089109 -1.61617 -1.272503
## Scara5        -0.190289  0.626734  0.064226 -0.300657 -1.09564 -2.096646
## Acod1          1.181495 -1.170482 -0.238035  0.678336  1.14662  1.527403
## Has2           0.913107 -1.224948  0.915842  0.994420  0.80314  1.051057
## Vdr            1.488454 -1.036752 -0.163986  1.069555  0.82540  0.818812
## Ly6c2          0.574323 -0.605606 -0.236691  0.756393  1.33931  1.613156
## Ly6i           0.766825 -0.802923 -0.216967  0.590750  1.61952  1.453325
## Parp9          0.975933 -1.175965  0.186061  1.082054  1.18372  1.239411
## Cela1          2.732614 -0.339340  1.106106 -0.839515  0.25630 -0.378102
## Cdkn1a         0.981534 -1.089294  0.385626  0.909994  1.00818  0.779793
## Fam132a        0.281846 -0.549356  0.732392  0.275672  0.83165  1.514520
## Ms4a6d         1.074184 -1.038438 -0.253827  0.136132  1.51554  1.525021
## Il33           0.727058 -1.538629  0.632636  0.695568  0.84350  0.955014
## Ifitm3         1.016412 -1.088033  0.105500  0.990597  1.29050  1.471190
## Irf7           1.059827 -1.145092  0.044739  1.252361  1.25574  1.326743
## Homer2         0.224341 -0.107971  0.808504  1.293190 -0.99013  2.284902
## Hk3            1.127935 -0.872360 -0.325371  0.741249  0.95288  1.337774
## Il1rl1         0.136716 -0.143828  0.499581  0.431034  0.94762  1.434488
## Stat1          1.133342 -1.331103  0.619904  1.141548  0.77714  0.684676
## Steap3         0.211685 -0.238498  1.101176  0.247128  0.97638  1.247939
## Mnda           0.886353 -1.000911  0.083907  0.889355  1.25705  1.232268
## Xcl1           0.467035 -1.171638  0.199796  1.503986  1.05818  1.014942
## Atf3           0.670873 -0.707898 -0.134528  0.830245  1.05783  1.316247
## Mcm10          0.112232 -0.595281  0.377333  0.276836  1.19734  1.527920
## Sapcd2         0.145292  0.055061  0.432854 -0.144001  1.36124  1.530406
## Il1rn          1.239478 -1.059147  0.078629  0.747930  1.29698  1.414302
## Dut            0.149865 -0.651150  0.383243  0.243420  1.28083  1.692064
## Hdc            1.805776  0.009917  0.386176 -0.088467  1.35957  0.984185
## Zbp1           1.003235 -1.124500  0.327676  0.946271  1.08861  1.115832
## Car1           0.099317  0.133330  0.746004  0.148102  1.15631  1.401773
## Procr          1.255925 -1.063133 -0.076071  0.816746  0.81695  1.536866
## Il21           0.347781 -0.111505 -0.592735  0.162347  1.20785  1.489435
## Ccdc109b       0.665107  0.148333  0.294192  0.535987  0.81800  0.474666
## Ifi44          1.132997 -1.381491 -0.026858  0.999129  1.22803  1.314496
## Gbp3           0.812588 -1.201132  0.068073  0.879069  1.02476  1.353863
## Gbp2           0.993796 -1.177887  0.337606  0.966980  0.96656  1.121703
## Tnc            1.080541 -0.828081  0.053570  1.483621 -0.03159  0.987324
## Smpdl3b        0.483179 -0.890244 -0.404693  0.676681  1.51393  1.263278
## Htra3         -1.480096  0.470597 -0.042283  0.058704 -1.33432 -1.670023
## Gbp9           1.163596 -1.133796  0.465062  1.255189  0.89506  0.872179
## Cxcl9          1.053720 -0.945375  0.506726  1.016986  0.89947  1.087962
## Oasl2          0.998332 -1.195324 -0.023732  0.977317  1.23151  1.320371
## Hsph1          0.531061 -0.377984  0.946192  1.091078  0.37917  0.383890
## Asns           0.487053 -0.073036  0.694714  0.208448  1.11489  1.319984
## Usp18          1.139916 -0.864288  0.153537  1.506089  1.39331  1.251514
## Bcl2l14        0.915421 -1.140906  0.210147  1.369291  0.70080  1.018200
## Ift122        -0.944891 -0.888203 -0.501329 -0.415125  0.01414 -0.006579
## Tmem159       -0.508367 -0.295823 -0.518822 -0.377512 -0.45028 -0.379907
## Gpt2           1.416272 -0.897057  0.306809  0.981705  0.36887  0.524872
## Mt2            0.892893 -0.348047  0.266479  0.448577  1.18401  1.342168
## Mt1            0.636675 -0.195293  0.878876  0.427865  0.74631  1.341028
## Ctrl           2.750017 -0.875962  1.166097 -0.269651  0.36990 -0.431347
## Psmb10         1.026874 -0.979829  0.175241  1.080194  1.04707  1.353790
## Chek1          0.334575 -0.385090  0.366675  0.235559  1.40828  1.839219
## Stra6          1.388981 -0.899327  0.425774  1.037646  0.26318 -0.044064
## Ptgs2          0.776065 -1.057363 -0.130562  0.517665  1.09303  1.813667
## Oas3           0.871875 -0.970831 -0.001516  0.971323  1.24113  1.380963
## Oas2           1.090540 -1.062892  0.025462  1.358822  1.33479  1.207650
## Rtp4           1.017170 -1.169042  0.002673  1.100015  1.27483  1.311528
## Apol6          1.004529 -1.349732  0.286550  1.133676  0.71920  1.197528
## Recql4         0.411190 -0.382863  0.678125  0.463907  1.29424  1.509146
## Pla2g4c       -0.347213 -0.332430  0.747876  0.070173  1.13072  1.392876
## Tmem132c      -0.785695 -0.257531 -0.533633 -0.070492 -1.68837 -0.638747
## Lif            1.774658 -0.862010  0.273900  1.285696  1.17669  0.932126
## Parp14         1.031125 -1.364133  0.205950  1.231243  1.07410  0.925550
## Gbp8           0.819051 -1.152177  0.445368  1.108987  0.64030  1.002123
## Ifit1          1.056044 -1.123221  0.068788  1.129483  1.30848  1.437677
## Cxcl10         0.900994 -1.193210  0.343507  0.932790  0.86244  1.031460
## Ubd            0.836317 -1.129633  0.206517  0.642047  0.91771  1.238914
## Ccl2           1.495576 -1.167034  0.176797  0.827278  0.82980  1.480981
## Isg15          0.928546 -0.871457 -0.027270  0.744505  1.46716  1.552080
## Npy1r         -0.568756  0.946846 -0.414262 -0.533281 -1.11304 -1.518954
## Tmem255a      -0.807149  0.327191 -0.071823 -0.428554 -0.83909 -1.632141
## Tap1           1.099831 -1.031130  0.284708  1.040993  0.89021  0.958606
## Dtl            0.120842 -0.175633  0.431137  0.114173  1.25523  1.484969
## Nme1           0.839695 -0.530162  0.087741  0.799370  0.90031  1.377395
## Fam13a        -0.734717  0.318186 -0.407615 -0.245607 -0.93582 -1.669501
## Tgm2           1.582761 -0.831931  0.002498  0.721438  0.62253  1.214604
## Rmi2           1.210281 -0.963810  0.444347  1.037008  0.96806  1.364014
## Socs1          0.959920 -1.142510  0.524817  1.201400  0.82028  0.952261
## Fanci          0.101394 -0.059405  0.623711  0.297226  1.33428  1.577315
## Batf2          0.984716 -1.143042  0.143331  0.910247  0.94469  1.076961
## Stat2          1.337102 -1.202606  0.261623  1.353053  0.98519  0.846965
## Gbp7           0.850128 -1.138314  0.342306  0.924917  0.96141  1.158366
## Gbp2b          0.306552 -1.027049 -0.321036  0.789550  1.17702  1.606500
## Btnl9         -1.165947  0.895293 -0.445238 -0.336643 -1.25881 -1.581717
## Olfr56         1.018001 -1.114526 -0.134554  0.600895  0.98288  1.585679
## Il7           -0.794640  0.906737 -0.591171 -0.575124 -1.46748 -0.944972
## Xaf1           1.074791 -1.048458  0.056383  1.093516  1.36613  1.228786
## Serpina3g      0.830663 -1.189721  0.215231  0.777673  0.94263  1.140136
## Prelp         -0.705526  0.497004 -0.401505 -0.130563 -1.31999 -1.545966
## Abca9         -1.336901  0.782809  0.164748 -0.129838 -1.33285 -1.943340
## Oasl1          1.057307 -0.896736  0.391074  1.259239  1.21285  1.315269
## Abca8a        -1.431756  0.492356  0.211683 -0.544463 -1.70988 -0.499556
## Bag2          -0.339543  0.281124  0.969122  0.540000  1.17247  0.630575
## Cilp          -1.054703  0.545744 -0.918723 -0.879425 -0.93546 -1.552746
## Maff           0.794339 -0.480629  0.246418  1.552601  0.56564  1.170680
## Mmp3           1.181730 -0.739122  0.169053 -0.199196  1.10926  1.855141
## Phf11a         0.956543 -1.131772 -0.074513  0.992647  1.32360  1.230007
## Gvin1          1.000988 -1.086952  0.465908  0.992674  0.92467  0.948827
## Ifit2          0.897512 -0.981553  0.030689  1.223762  1.25119  1.404630
## Fam26f         0.867805 -1.165909  0.186357  0.944657  0.88510  1.312745
## Olfml2a       -0.952413  0.539789 -0.352976 -0.472728 -1.03742 -1.513198
## Bst2           1.286247 -1.124898  0.138624  1.288011  1.02082  1.178876
## Irgm1          0.913897 -1.124964  0.500989  0.915828  0.97178  1.114764
## Kcne4          0.958364 -1.073103  0.378552  0.547735  0.84160  1.218424
## Gm12185        0.998053 -1.667083  0.066933  1.044483  0.93344  1.065786
## Zg16           2.777124 -0.613659  1.182488 -0.699110  0.31754 -0.463654
## Apol10b        1.037762 -0.816034 -0.113547  1.295965  0.76460  1.015462
## Mmp13          1.324741 -1.014366 -0.271173  0.626630  1.08155  1.431118
## Kcnj16        -1.032729  0.885013  0.217690 -0.518548 -1.26324 -1.397130
## Fpr2           1.373182 -0.560716 -0.694596  0.193298  1.28403  1.554903
## Epha3         -2.057914 -0.156762  0.144286 -0.334476 -1.05666 -0.732480
## Oas1a          0.990761 -1.062589  0.142968  1.065174  1.40385  1.266798
## Socs3          0.852326 -0.798917  0.289839  0.824829  0.94066  1.199542
## Slamf8         1.004582 -1.239395 -0.078989  0.795167  1.04247  1.378707
## Iigp1          0.932331 -1.217259  0.307809  0.829244  0.95199  1.118475
## Ifi205         0.790396 -0.964714 -0.255414  1.021780  1.17295  1.371698
## Ifng           0.578705 -1.040125  0.182143  0.653956  0.97267  1.251894
## Cebpb          1.327610  0.051947  0.579625  1.190621  0.80881  0.707842
## Gm5431         1.047000 -1.396070  0.136661  1.437370  1.37980  0.711924
## Fcgr4          0.623282 -1.011918 -0.225667  0.688847  1.04555  1.430416
## Pla2g16        0.787279 -0.959697  0.242036  0.713664  1.17702  1.323712
## Obscn         -0.674877  1.273513 -0.220622 -0.774609 -0.84136 -1.190691
## Serpina10      1.013912 -1.401951  0.630447  0.742406  0.53105  0.045020
## Tubb3          0.727464 -1.082102 -0.222711  0.482824  1.24596  1.676644
## Ifit3b         1.450077 -1.082114  0.067267  1.685603  1.13077  0.850902
## Serpina3f      0.917294 -1.252431  0.310579  0.867154  0.85791  1.053144
## Cenpm          0.200657 -0.358941  0.279341  0.333327  1.54119  1.643672
## Phf11d         1.378483 -0.947565 -0.319705  1.253972  1.12338  1.299103
## Gm4841         0.815275 -1.295282 -0.040600  0.422945  1.14127  1.319231
## Irgm2          0.961745 -1.308185  0.504834  1.057152  0.80754  0.883197
## Rnf213         1.298885 -1.202722  0.231809  1.375939  1.18118  1.018519
## Cited4         0.193820 -0.273085  1.167805  0.691120  1.18527  1.364404
## Ccl19          1.286585 -0.999250  0.913894  1.505859  0.59050  0.245175
## Ifi204         0.765517 -1.018608 -0.214208  0.991798  1.09421  1.405071
## Pydc4          1.303457 -1.069764  0.473443  1.403086  1.08289  0.785352
## Gm4951         0.814885 -1.234608  0.013269  0.807012  0.87687  1.243475
## Nlrc5          1.154553 -1.352565  0.416473  1.072079  0.80291  0.748404
## Amy2a5         2.178780 -0.487146  1.048410 -0.769218  0.08444 -0.454605
## Ifit3          1.236307 -1.372506  0.060631  1.472691  1.16271  1.008174
## Grem1         -1.073609  0.900696 -1.276232 -0.872745 -0.52558 -0.816067
## Ly6a           0.889524 -0.934586 -0.028186  0.716153  1.18536  1.513377
## Aunip          0.188541 -0.481171  0.364887  0.209226  1.29080  1.432714
## Gm4070         0.913349 -1.136502  0.420128  0.945919  0.89719  0.916795
## Igtp           0.922185 -1.134176  0.432706  0.938780  0.94434  1.061941
## Ifi47          0.907409 -1.056951  0.371256  0.892864  1.02451  1.234332
## Tgtp2          0.912225 -1.215213  0.619528  1.046939  0.85070  1.005039
## Tgtp1          0.903381 -1.178443  0.464837  0.960740  0.99680  1.086501
## Ifit1bl1       1.135052 -0.989998  0.257895  1.304446  1.18256  0.990538
## Gm43302        1.015331 -1.778251  0.449231  0.915620  0.82423  0.884713
## Gbp4           1.042340 -1.080395  0.377900  1.007806  0.85607  1.006584
## Gm12216        1.355298 -1.297423  0.114024  1.359503  0.43683  0.754284
## Ctsf          -1.656819  0.574440 -0.352806 -1.497374 -0.57097 -0.552389
## Cfb            1.133543 -0.938200 -0.047825  0.862333  1.08977  1.335928
## Hspa1b         0.613521 -0.789308  0.909800  1.435516  0.27064  0.288787
## F830016B08Rik  1.008702 -1.358823  0.103914  0.570551  0.74234  1.212338
## Gm17334        1.107068 -1.353709  0.674703  1.071578  0.92026  0.851966
## Gm20390        0.681780 -0.564323  0.734306  0.775108  1.42879  1.484467
## Phf11b         1.086513 -0.870121  0.011116  1.071200  1.13988  1.404234
## Hspa1a         0.483626 -0.908298  0.778535  1.276639 -0.03809  0.328362
## Gal3st2       -2.019820 -0.237684 -0.841282  0.026854 -1.20516 -0.290090
## Hist1h3g      -0.019408  0.107487  0.660848  0.019219  1.10875  1.459748
## Gbp6           0.973826 -1.139211  0.406584  0.967733  0.92273  1.022120
## Gbp10          1.019705 -1.168679  0.254807  1.039087  0.93141  0.992719
## Gbp5           0.964990 -1.141439  0.268460  0.914454  0.90439  1.079331
## Chaf1a         0.300665 -0.769839  0.392644  0.303976  1.32043  1.472475
## Atp1a2        -0.744885  0.609242 -0.720894  0.675226 -1.25501 -1.570728
## Ehf           -0.364048  1.071270  0.501778 -0.329903 -1.42849 -1.643722
## Mybpc1        -0.855942  1.312374 -0.448585 -0.148160 -1.07241 -1.079680
## Fos            0.739962 -0.890952 -0.628006  1.380393  1.03002  0.400733
## Trip13         0.131587 -1.028545 -0.060589  0.064809  1.40524  1.884417
## Dhfr          -0.103561 -0.673959  0.215558  0.351583  1.44217  1.687428
## Shcbp1        -0.014743 -0.333766  0.106546 -0.513049  1.30047  1.667179
## Spata24        0.029369 -0.341242  0.647301  0.185568  1.49598  1.679841
## Lox            0.514960  0.321303 -0.400533  0.442674 -1.22769 -1.303689
## Msr1           0.693168 -1.190085 -0.348745  0.186397  1.21270  1.384122
## Il2ra          0.850178 -1.356766 -0.087927  0.736202  1.09820  1.396396
## Rad51          0.025241 -0.339290  0.030304  0.220446  1.42345  1.454670
## Slc7a11        0.763072 -1.386573  0.487031  0.548674  0.89494  0.568403
## Extl2         -0.572074 -0.489104 -0.594059 -0.375370  1.84857  0.203919
## Auts2         -0.970143  0.248668  0.333045  0.455780  0.20929 -1.195016
## Klra2          0.663488 -1.063303 -0.537462  0.862964  1.35237  1.113831
## Bcat1          0.309175 -0.894054 -0.307223  0.329401  0.96415  1.277056
## Pcsk6         -0.626145  1.228699  0.332402  0.018519 -1.43936 -1.509296
## Cd209a        -0.749690  0.562797  0.516410  0.427677 -1.26004 -1.597131
## Prrg3         -0.813834  0.379959  0.742056 -0.914693 -0.49766  0.446468
## Lrr1           0.040100 -1.009574  0.301811 -0.462033  1.18295  1.680520
## Fxyd1         -0.270361  0.310306 -0.260188 -0.060797 -1.08370 -1.226437
## Eme1           0.070795 -0.506982 -0.427362  0.317327  1.15810  1.793418
## C130074G19Rik  0.005483  0.654095 -0.174941 -0.001217 -1.37641 -1.658014
## Tnip3         -0.180243 -0.721296 -0.854107 -0.531052  0.79585  1.796536
## Mab21l3        0.681140 -0.901954 -0.268002  1.289212  0.21314  0.326893
## Ifitm10       -0.434299  1.817913 -0.623677 -0.172487 -0.87468 -1.783592
## AI464131      -0.688685  0.179817 -0.071635  0.169020 -0.70399 -1.794565
## Sned1         -0.923862  0.795270 -0.016801  0.324773 -1.65151 -1.223326
## Bex4           0.113338 -0.057596  0.940072 -0.208013  1.03915  0.956921
## Vstm4         -0.828553  0.531898  0.494217  0.019170 -1.20709 -1.720740
## Rnd1           0.537828 -0.564769 -0.247837 -0.013243  0.91532  0.783784
## Sphk1          0.193248 -0.632061  0.515193  0.042480  1.12605  1.582933
## Efcc1         -0.130631  0.266640 -0.999420  0.021483 -1.83781 -1.282677
## Lilr4b         0.842889 -0.982785 -0.657454 -0.049063  1.02991  1.481203
## Gm21887        1.121315  0.345252  1.237683  1.327318 -0.06813  0.100647
##                mt.d4.r3 mt.d4.r4 rtmt.d4.r1 rtmt.d4.r2 rtmt.d4.r3
## Cdc45         -0.310313  1.33445   -1.15709  5.579e-01   0.575281
## Slfn4         -0.886211  1.00922   -0.21877 -5.278e-01  -0.001034
## Mx1           -1.020438  0.50629   -0.98726  3.432e-01   0.654637
## Il12rb1       -1.181724  1.15462   -1.06682  3.788e-01   0.610855
## Gnb1l         -1.008975  1.28030   -0.39508 -4.732e-01  -0.109102
## Lgals9        -0.794993  1.32157   -0.99404  6.317e-01   0.578267
## Timp1         -0.807550  1.24130   -0.55812  3.030e-01   0.845385
## Tubb6         -0.779705  1.56672   -1.16596  5.671e-01   0.729532
## Peg3           0.346132 -0.22342    0.77429 -1.665e+00  -0.628752
## Syce2         -0.058199  1.24815   -1.10912  8.385e-01   0.843710
## Abca13         0.042460  2.03534    0.75185 -2.937e-01   0.012002
## Ccl24         -1.274910  1.61768   -0.81576 -1.218e-01   0.594508
## Thop1         -0.445993  1.62644   -0.71215  5.752e-01   0.040448
## Hspb1         -1.045865 -0.62058   -0.43633 -2.841e-01  -0.291211
## Spo11          0.445645  0.45364   -0.77250  1.003e+00   0.797312
## Srm           -0.753434  1.30370   -1.06393  2.101e-01   0.606951
## Atp7b          0.409782  1.18841   -1.27255  8.320e-01   0.382492
## Cd163          0.730019 -1.31639    0.48783 -5.025e-01  -0.279315
## Oit3           1.242761 -0.97364    0.63985 -1.024e+00  -0.457304
## Mlkl          -0.830465  1.67658   -0.89967  1.288e-02   0.454472
## Enkd1         -0.453443  1.46921   -1.00159 -7.343e-01   0.584285
## Gzmb          -1.052568  2.33920   -0.79315 -3.430e-02   0.239260
## Cd274         -1.012018  1.24830   -0.81090  4.174e-01   0.667570
## Dhx58         -0.951706  0.71670   -1.16609  2.683e-01   0.306345
## Irf1          -0.823543  1.04294   -0.82359  5.511e-01   0.902654
## Pdk4           1.316168 -1.31375    0.62164 -8.678e-01  -0.422894
## Pkib          -1.271616  0.99873   -0.83024  4.194e-01   0.886897
## Dram1         -0.924243  1.48492   -0.59305  1.947e-01   0.661235
## Ppa1          -0.730950  1.18748   -1.01527  2.145e-01   0.852959
## Nefh          -0.703698  1.71025   -0.69051 -7.127e-05   0.637813
## Upp1          -0.937719  1.87171   -0.48427 -5.072e-02   0.476065
## Igfbp3         1.053224 -1.42734    0.70590 -5.625e-01  -0.451546
## Nampt         -0.950558  1.28558   -0.88519  3.383e-01   0.735376
## Cmpk2         -0.536109  0.78862   -1.06877  8.310e-01   0.645585
## Serpina3n     -0.310043  0.41551   -0.23049  7.463e-01   1.222651
## Wars          -1.064358  1.15346   -0.82411  4.138e-01   0.900180
## Hsp90aa1       0.033552  1.32931   -1.73224 -3.323e-02   0.662864
## Thbs4          0.044137  0.57751   -0.47842  7.919e-01   0.625431
## Plau          -0.769812  1.62642   -0.76384  2.308e-01   0.127771
## Pnp           -0.370907  1.26987   -1.12548  6.847e-01   0.479218
## Gdf10          1.015301 -1.53353    0.84636 -7.541e-01  -0.440022
## Scara5         0.400445 -1.17072    0.82114 -1.687e-02  -1.025346
## Acod1         -0.590357  1.54316   -1.06905  2.185e-01   0.487029
## Has2          -0.610477  1.07625   -1.06235  6.754e-01   0.543603
## Vdr           -0.232632  1.50163   -0.73483  8.743e-02   0.449741
## Ly6c2         -0.773501  1.72777   -0.72194 -7.077e-02   0.478594
## Ly6i          -1.192581  1.42946   -0.68550 -1.716e-01   0.554884
## Parp9         -0.828880  0.92435   -0.84754  5.255e-01   0.684355
## Cela1         -0.285088 -0.50059    1.20263 -3.092e-02   0.226227
## Cdkn1a        -0.692249  1.90394   -0.67637  3.053e-01   0.438114
## Fam132a        0.305220  0.98894   -0.94519  1.243e+00   0.438224
## Ms4a6d        -0.820160  1.75877   -0.88332 -2.111e-01   0.394160
## Il33           0.105636  0.63137   -0.57070  6.714e-01   1.085088
## Ifitm3        -1.101613  1.00590   -1.02295  1.547e-01   0.517000
## Irf7          -0.939432  1.10328   -0.74887  3.925e-01   0.320814
## Homer2         0.168147 -0.34799   -0.25148  8.634e-01   0.047227
## Hk3           -1.094223  1.48203   -0.66618  3.629e-01   0.496527
## Il1rl1         0.357032  1.29886   -1.33036  9.423e-01   0.310054
## Stat1         -0.805112  0.69315   -0.79048  5.989e-01   0.850025
## Steap3         0.411938  0.98586   -1.12532  9.644e-01   0.365527
## Mnda          -1.012634  1.36777   -0.75733  2.751e-01   0.552248
## Xcl1          -0.924974  1.07793   -0.64307  3.447e-01   0.809163
## Atf3          -0.705748  1.66356   -0.52063  1.189e-01   0.780051
## Mcm10          0.181950  1.40425   -1.27576  6.974e-01   0.611185
## Sapcd2        -0.213268  1.81356   -0.50012 -4.726e-01   0.595930
## Il1rn         -0.783610  1.57191   -0.83072  1.086e-01   0.109658
## Dut           -0.177034  1.53238   -1.11646  6.816e-01   0.455594
## Hdc           -0.980179  1.08510    0.37293 -7.364e-01   0.553242
## Zbp1          -0.831118  1.02377   -0.77614  4.782e-01   0.711561
## Car1           0.377499  0.56665   -1.30196  9.891e-01   0.451511
## Procr         -0.941462  1.73238   -0.93128 -4.201e-02   0.324809
## Il21          -0.323217  2.14288   -0.61591 -3.609e-01   0.680726
## Ccdc109b      -1.593039  2.06912   -1.16586  4.413e-01   0.798005
## Ifi44         -0.864554  1.08849   -0.53135 -1.224e-01   0.681941
## Gbp3          -0.984722  1.34242   -0.93939  2.251e-01   0.704083
## Gbp2          -0.869098  1.01728   -0.86085  5.565e-01   0.819337
## Tnc           -1.855952  1.48195   -0.06680  1.511e-01  -0.294146
## Smpdl3b       -0.335938  1.60408   -0.39843  1.685e-01   0.234765
## Htra3          0.750375 -0.47449    0.81832 -7.755e-01  -0.770862
## Gbp9          -1.058040  0.50028   -0.78874  5.865e-01   0.918671
## Cxcl9         -0.953420  1.01123   -0.83402  4.837e-01   0.776425
## Oasl2         -1.045235  1.14491   -0.71788  4.294e-01   0.488824
## Hsph1          0.612808  0.89730   -1.31289 -8.189e-01   0.981220
## Asns          -0.004198  0.70026   -1.17743  1.106e+00   0.720859
## Usp18         -0.995894  0.52719   -0.95683  1.660e-01   0.523158
## Bcl2l14       -1.223246  0.98889   -0.93078  8.014e-01   0.864689
## Ift122        -0.889688 -0.41223   -0.08846 -8.245e-01  -0.259069
## Tmem159        0.093612 -0.14953    0.04468 -1.646e-01  -0.558897
## Gpt2          -0.473849  2.02750   -1.01325 -1.934e-01  -0.362581
## Mt2           -0.288724  1.34411   -1.23175  6.571e-01   0.495258
## Mt1           -0.012761  1.38858   -0.63210  6.354e-01   0.277525
## Ctrl          -0.658739 -0.57350    1.21071 -6.837e-01   0.311691
## Psmb10        -0.757977  1.12663   -0.85191  3.677e-01   0.553877
## Chek1         -0.673636  1.08430   -0.97760  6.786e-01   0.164845
## Stra6         -0.147844  0.39770   -0.54577  5.550e-01   1.540750
## Ptgs2         -0.911831  1.85886   -0.84814  1.685e-01   0.241010
## Oas3          -0.578230  1.05614   -0.97332  6.385e-01   0.427818
## Oas2          -0.887888  0.99983   -0.96661 -9.448e-02   0.447169
## Rtp4          -1.246178  0.77429   -0.79808  4.010e-01   0.630642
## Apol6         -1.018900  1.30028   -0.97244  4.166e-01   0.663266
## Recql4         0.025673  1.11144   -1.31963  7.620e-01   0.474506
## Pla2g4c       -0.007859  1.19505   -1.46692  1.322e+00   0.283299
## Tmem132c       1.363899 -1.56343    0.81085  5.905e-01  -0.745409
## Lif           -0.909203  0.65491   -0.79398 -1.727e-01   0.514548
## Parp14        -0.954581  0.88621   -0.81028  3.805e-01   0.786591
## Gbp8          -0.981757  1.44380   -0.92791  2.125e-01   0.841298
## Ifit1         -1.094992  0.82679   -1.01688  4.576e-01   0.505875
## Cxcl10        -0.866544  1.32519   -0.97541  4.586e-01   0.841171
## Ubd           -0.869986  1.51230   -0.88682  3.505e-01   0.744957
## Ccl2          -0.754913  1.55068   -0.93215  3.435e-02   0.283653
## Isg15         -0.962480  0.94825   -1.07605  5.283e-01   0.482945
## Npy1r          0.856765 -1.03243    0.76388 -1.345e+00  -0.456215
## Tmem255a       0.403720 -2.03040    0.77634 -3.645e-01  -0.255565
## Tap1          -1.042218  1.11291   -0.41769  4.197e-01   0.636701
## Dtl            0.049414  1.05751   -1.29251  9.428e-01   0.741391
## Nme1          -0.210952  1.56903   -0.92397 -3.549e-02   0.438094
## Fam13a         0.949765 -1.60113    0.57566 -5.649e-01  -0.554482
## Tgm2          -0.898778  1.58519   -0.86010  2.497e-01   0.497070
## Rmi2          -1.035042  1.16238   -0.71838  1.982e-01   0.534950
## Socs1         -0.887805  1.18343   -0.93114  3.351e-01   0.802524
## Fanci         -0.345428  1.13240   -1.01187  1.019e+00   0.544495
## Batf2         -1.189306  1.66743   -0.63763 -1.573e-01   0.549955
## Stat2         -0.992289  0.79403   -0.78105  3.176e-01   0.657312
## Gbp7          -0.853470  1.18854   -0.94157  5.504e-01   0.818673
## Gbp2b         -0.765272  1.83051   -0.75179 -6.238e-02   0.469066
## Btnl9          0.820649 -1.34924    0.91301  2.154e-01  -0.690834
## Olfr56        -0.891618  1.35965   -0.86090  7.018e-01   0.613674
## Il7            0.840197 -1.28984    1.07927 -6.064e-01  -0.390470
## Xaf1          -0.865759  0.58455   -1.09198  6.114e-01   0.599121
## Serpina3g     -0.879204  1.35672   -0.59810  4.281e-01   0.784919
## Prelp          0.802561 -1.27807    0.96084 -4.989e-01  -0.924232
## Abca9          0.803707 -1.22834    0.78374 -3.316e-01  -0.306130
## Oasl1         -0.851660  0.63817   -1.56568  3.186e-01   0.402184
## Abca8a         0.352928 -1.45348    1.32224  1.071e-01  -0.345263
## Bag2           0.220944  1.05200   -1.93241  5.976e-01   0.839645
## Cilp           1.336798 -1.32341    0.90760 -1.003e-01  -0.305794
## Maff          -0.677340  0.96964   -0.46923  1.081e-01   0.849017
## Mmp3          -0.648826  1.66029   -0.59866  4.755e-01   0.084453
## Phf11a        -1.830497  1.15931   -0.29327  2.396e-01   0.569664
## Gvin1         -0.955279  0.89989   -0.69813  5.001e-01   0.885885
## Ifit2         -1.204218  1.00655   -1.13848  3.164e-01   0.509993
## Fam26f        -0.938394  1.53444   -0.76138  1.695e-01   0.643833
## Olfml2a        0.817982 -1.20734    1.07106  2.031e-01  -1.215609
## Bst2          -0.900294  0.95863   -0.87153  7.102e-02   0.620794
## Irgm1         -0.892476  1.08008   -0.81518  5.050e-01   0.811026
## Kcne4         -0.337988  1.46625   -0.50678  1.604e-01   0.732191
## Gm12185       -0.549681  1.13493   -0.71248  5.456e-01   0.687659
## Zg16          -0.391825 -0.52311    1.15738 -3.676e-01   0.147305
## Apol10b       -1.515528  1.16767   -0.85339  4.337e-01   0.514894
## Mmp13         -0.880654  1.59238   -0.96483  4.983e-02   0.523700
## Kcnj16         0.863524 -1.63410    0.89127 -3.040e-01  -0.455971
## Fpr2          -1.306588  1.74401   -0.64784  5.204e-02   0.167446
## Epha3          1.027730 -0.50163    0.38404 -9.509e-01  -0.614626
## Oas1a         -0.832728  1.14260   -0.79335  6.539e-02   0.535767
## Socs3         -0.904271  1.78769   -0.44327  3.435e-02   0.504529
## Slamf8        -1.203773  1.52135   -0.73618  4.839e-02   0.621533
## Iigp1         -0.906253  1.13339   -0.72499  4.750e-01   0.830811
## Ifi205        -1.107910  1.46718   -0.79222  2.290e-02   0.571987
## Ifng          -0.836756  1.96762   -0.50844  1.676e-01   0.404777
## Cebpb         -0.672271  1.43212   -0.56301 -7.682e-01   0.215301
## Gm5431        -1.133689  0.93739   -1.11368 -2.948e-02   0.631682
## Fcgr4         -0.806943  1.36318   -0.80864  4.307e-01   0.758604
## Pla2g16       -0.974407  1.18193   -0.78044  5.912e-01   0.773061
## Obscn          0.072025 -0.88914    0.95936 -2.589e-01  -1.358610
## Serpina10     -0.351936  0.54319   -0.96834  1.098e+00   1.227528
## Tubb3         -0.975045  1.77056   -0.71086  8.528e-02   0.644707
## Ifit3b        -1.349914  0.24718   -1.28444  4.602e-01   0.231869
## Serpina3f     -0.773189  1.25229   -0.73758  4.437e-01   0.803032
## Cenpm         -0.459872  1.28051   -0.85345  8.435e-01   0.143869
## Phf11d        -0.845480  1.18415   -0.74702 -1.174e-01   0.231848
## Gm4841        -0.681395  1.53650   -0.68724  9.993e-02   0.592233
## Irgm2         -0.889494  0.92105   -0.79721  5.050e-01   0.956932
## Rnf213        -0.900257  0.63563   -1.03198  3.756e-01   0.545998
## Cited4         0.185186  0.13768   -1.33660  7.802e-01   0.597270
## Ccl19         -0.323624 -0.35228   -0.57249  3.249e-01   1.052737
## Ifi204        -0.982574  1.40355   -0.63603  8.409e-02   0.584826
## Pydc4         -1.061275  0.21332   -0.99605  5.825e-01   0.678454
## Gm4951        -0.973809  1.43437   -0.71167  2.044e-01   0.787029
## Nlrc5         -0.848777  0.59236   -0.51083  5.697e-01   0.937017
## Amy2a5         0.324230 -0.90723    1.63292 -9.072e-01   1.304377
## Ifit3         -1.199485  0.69616   -0.97489  4.133e-01   0.487626
## Grem1          1.594544 -0.95475    0.97297 -1.082e+00  -0.437600
## Ly6a          -1.032006  1.50690   -0.63478  7.940e-05   0.530562
## Aunip         -0.189519  1.41978   -1.09190  8.956e-01   0.734317
## Gm4070        -0.878025  0.98788   -0.54753  5.350e-01   0.917653
## Igtp          -0.744467  1.06024   -0.76515  5.311e-01   0.805203
## Ifi47         -0.852390  1.07231   -0.87706  4.728e-01   0.812775
## Tgtp2         -0.785673  0.89281   -0.70569  5.222e-01   0.866434
## Tgtp1         -0.785544  1.05646   -0.83481  5.285e-01   0.803172
## Ifit1bl1      -1.075656  0.66808   -1.22487  4.364e-01   0.693912
## Gm43302       -0.717391  1.02819   -0.74889  5.634e-01   0.770269
## Gbp4          -0.891694  1.08806   -0.86203  4.910e-01   0.870797
## Gm12216       -1.252892  0.53100   -0.11690  5.745e-01   0.584697
## Ctsf           1.148920 -1.43884    0.48143  8.033e-01  -0.023603
## Cfb           -0.823057  1.60604   -0.99327  2.395e-02   0.543718
## Hspa1b         0.350478  1.01156   -1.37871 -6.504e-01   0.971683
## F830016B08Rik -0.707048  1.58083   -0.70113  1.622e-01   0.723027
## Gm17334       -0.892454  0.50628   -0.84434  5.693e-01   0.844871
## Gm20390       -0.427456  0.99891   -1.00992 -7.440e-02   0.828203
## Phf11b        -1.119385  1.09596   -0.92080  3.704e-01   0.470474
## Hspa1a         0.212451  1.05536   -1.02463 -8.770e-01   1.110681
## Gal3st2        1.046352 -0.48177    0.05941 -4.989e-01  -0.405616
## Hist1h3g       0.181800  1.35193   -1.15875  6.531e-01   0.637411
## Gbp6          -0.753312  1.10021   -0.76349  4.905e-01   0.773345
## Gbp10         -1.014010  1.08678   -0.81103  4.556e-01   0.838734
## Gbp5          -0.952509  1.28525   -0.89710  3.691e-01   0.859556
## Chaf1a        -0.176858  1.37921   -1.09693  1.018e+00   0.450705
## Atp1a2         0.181104 -0.75217    0.41697 -8.281e-01  -0.462139
## Ehf            0.432429 -0.41290    0.82425 -9.707e-01  -0.972484
## Mybpc1         0.315803 -1.96586    0.54364 -4.155e-01  -0.282577
## Fos            0.448721  0.57234   -1.12123  9.476e-01   0.060094
## Trip13        -0.859274  1.67227   -0.44720  4.240e-01   0.381154
## Dhfr          -0.152086  1.32441   -1.32108  7.341e-01   0.702616
## Shcbp1        -0.164222  1.56265   -0.87639  8.685e-01   0.517160
## Spata24       -0.782036  0.73310   -0.58593  7.655e-01   1.147471
## Lox            1.021256 -0.26747    0.71746 -7.689e-01  -1.635197
## Msr1          -0.628590  1.94709    0.08279 -5.951e-01   0.711963
## Il2ra         -0.526412  1.05676   -0.75571  3.495e-01   1.173707
## Rad51         -0.146919  1.24438   -0.83597  7.568e-01   0.684086
## Slc7a11        0.368638  0.84383   -0.40635  7.593e-01   1.193928
## Extl2         -0.541449 -0.46021    3.04918 -3.271e-01  -0.189642
## Auts2          0.274232 -0.55030    0.69715 -5.278e-01  -1.422362
## Klra2         -1.170516  0.96726   -0.71820  3.961e-01   0.904268
## Bcat1         -0.501152  1.26607   -0.65341  1.643e+00   0.310272
## Pcsk6         -0.238064 -0.03419    0.03606 -3.174e-01  -0.628716
## Cd209a         0.228940 -2.18782    0.17003 -3.662e-01  -0.059820
## Prrg3         -0.472167 -0.70196    0.50692 -9.694e-01  -1.505807
## Lrr1          -0.357068  0.67812   -1.17340  1.302e+00   1.105790
## Fxyd1         -0.262604 -0.87770    0.87477 -7.624e-01  -1.083577
## Eme1          -0.299715  1.74818   -0.75478  7.199e-01   0.353452
## C130074G19Rik  0.683217 -0.97896    0.35017 -9.206e-01  -0.777299
## Tnip3         -0.114057  2.46236   -0.40215  3.027e-01   0.052278
## Mab21l3        0.104970  0.35987    0.01534  5.937e-01   1.333302
## Ifitm10       -0.662135 -0.33363    0.38555 -8.489e-01  -0.539233
## AI464131       0.455373 -1.26007    0.76943 -7.626e-01  -1.173249
## Sned1          1.134252 -1.60853    0.56954 -6.307e-01  -0.391010
## Bex4           0.464715  0.52568   -1.03967  1.295e+00   0.799698
## Vstm4          0.827827 -1.42977    0.62138 -6.613e-01  -0.725137
## Rnd1          -0.532473  1.63012   -0.85072  1.734e+00   0.777060
## Sphk1          0.408029  1.11187   -1.35115  1.139e+00   0.381226
## Efcc1          1.058547  0.39643    0.43205 -1.141e+00  -0.490886
## Lilr4b        -0.646614  2.20780    0.02708  8.205e-02   0.280375
## Gm21887       -0.179950  0.84277   -1.19288 -1.096e+00  -0.906416
##               rtmt.d4.r4 naive.r1 naive.r2 naive.r3 naive.r4
## Cdc45            0.07413  -1.6194  -0.7630 -0.34559 -1.65936
## Slfn4            0.61738  -1.5390  -0.9195 -0.76606 -0.08473
## Mx1              0.50182  -1.1570  -0.9840 -0.98250 -0.72057
## Il12rb1          0.76747  -1.0811  -0.6705 -0.93382 -1.32973
## Gnb1l            0.17819  -1.2392  -1.0720  0.08889 -1.95287
## Lgals9           0.29583  -1.2500  -1.0921 -0.88225 -1.05533
## Timp1           -0.32096  -0.5555  -1.5640 -0.92957 -1.03549
## Tubb6            0.45478  -1.4114  -0.8273 -1.09900 -1.18500
## Peg3            -0.61071   1.5581   1.0076  1.14894  1.47487
## Syce2            0.19576  -1.6606  -1.0240 -0.38806 -1.79073
## Abca13           0.41443  -1.6228  -1.1460 -0.66593 -1.37418
## Ccl24            0.54385  -0.9302  -0.7829 -0.89901 -1.13592
## Thop1            0.06361  -1.4786  -0.9152 -1.25065 -1.63174
## Hspb1            0.89143  -0.1887  -0.4422 -0.11224  0.14580
## Spo11            0.60087  -1.3717  -0.6103 -1.93679 -0.85502
## Srm              0.27215  -1.1036  -0.8061 -1.44517 -1.32488
## Atp7b           -0.23964  -1.4843  -0.8097 -0.36277 -2.03746
## Cd163           -0.46616   1.1942   0.9002  1.17049  1.13081
## Oit3            -0.29417   1.5397   1.0455  0.63696  1.09085
## Mlkl             0.47862  -1.2658  -1.0122 -0.96278 -0.69034
## Enkd1            0.63258  -0.9648  -1.1534 -0.96577 -1.21695
## Gzmb             0.29756  -1.0584  -0.9005 -0.69545 -0.65175
## Cd274            0.76945  -1.1458  -1.0297 -1.22342 -0.95679
## Dhx58            0.46664  -1.2542  -0.8743 -1.18724 -0.65387
## Irf1             0.84299  -1.1644  -1.1860 -1.41010 -1.06426
## Pdk4             0.23024   1.0109   1.1093  0.20824  1.78061
## Pkib             0.61008  -1.0573  -1.5047 -1.22970 -1.06373
## Dram1            0.52756  -1.4900  -1.0881 -1.05930 -0.87603
## Ppa1             0.49479  -1.4482  -0.8813 -1.17583 -0.98363
## Nefh             0.35337  -1.1116  -1.3706 -1.06019 -1.03791
## Upp1             0.31927  -1.2481  -0.7999 -1.06116 -1.04748
## Igfbp3          -0.31544   1.2759   1.1092  0.88959  1.32788
## Nampt            0.57207  -1.3047  -1.0810 -1.05394 -0.96846
## Cmpk2            0.24370  -1.5952  -1.1642 -0.15998 -1.32646
## Serpina3n        1.04189  -0.8520  -0.8452 -2.05278 -1.20708
## Wars             0.85047  -0.8876  -0.9233 -1.38659 -1.06270
## Hsp90aa1         0.56269  -1.2562  -0.7757 -0.97488 -1.41583
## Thbs4            1.27212  -1.2663  -1.7183 -1.02725 -0.91099
## Plau             0.14834  -0.9075  -0.9656 -0.91947 -0.85331
## Pnp              0.01527  -1.4629  -1.1618 -0.23253 -1.63808
## Gdf10           -0.16489   1.2460   1.1421  0.83856  1.13280
## Scara5          -0.44799   1.4577   0.5862  0.96648  1.42122
## Acod1            0.20686  -0.9823  -1.0414 -1.04615 -0.85162
## Has2             0.53626  -1.3805  -1.1279 -1.03423 -1.06867
## Vdr              0.64547  -1.3254  -1.3883 -0.90670 -1.09787
## Ly6c2            0.27535  -1.3443  -1.0029 -1.13349 -0.87563
## Ly6i             0.61963  -1.0783  -1.0850 -0.99250 -0.80897
## Parp9            0.59355  -1.1787  -1.1729 -1.10603 -1.08483
## Cela1           -1.11073  -0.7957   0.3682 -0.53358 -1.07854
## Cdkn1a           0.32336  -1.0313  -1.2776 -1.25114 -1.01790
## Fam132a         -0.25455  -1.5462  -0.8105 -0.52259 -1.98331
## Ms4a6d           0.29334  -1.0913  -0.9665 -0.91502 -0.51754
## Il33             0.77708  -0.8687  -1.2257 -1.69154 -1.22913
## Ifitm3           0.61676  -1.2058  -0.9200 -1.06040 -0.76977
## Irf7             0.29182  -1.4153  -1.0967 -0.86143 -0.84102
## Homer2           0.35543  -1.5563  -0.6527 -0.76140 -1.37708
## Hk3              0.78957  -1.3055  -1.0252 -1.08819 -0.91376
## Il1rl1          -0.23979  -1.6759  -1.0651 -0.17990 -1.72283
## Stat1            1.00404  -1.2473  -1.1704 -1.28649 -0.87188
## Steap3          -0.13308  -1.5759  -1.0646 -0.41645 -1.95819
## Mnda             0.64497  -1.3384  -1.1398 -1.16680 -0.77313
## Xcl1             0.73343  -1.3089  -0.8131 -1.38023 -0.96723
## Atf3             0.45063  -1.1379  -1.4023 -1.50617 -0.77312
## Mcm10           -0.13187  -1.3778  -1.1804 -0.14503 -1.68025
## Sapcd2           0.22612  -1.8017  -1.1773 -0.84726 -1.00433
## Il1rn            0.13336  -0.9807  -1.3421 -1.02763 -0.67688
## Dut              0.14751  -1.4590  -0.8835 -1.04754 -1.23174
## Hdc             -0.05281  -1.4224  -1.1171 -1.20963 -0.94984
## Zbp1             0.75059  -1.2165  -1.0606 -1.42137 -1.01553
## Car1            -0.13123  -1.6734  -0.8503 -0.06165 -2.05107
## Procr            0.30274  -0.6950  -1.0323 -1.19941 -0.80580
## Il21             0.41086  -1.1010  -0.9301 -1.21961 -1.18694
## Ccdc109b         0.46594  -0.7909  -1.2526 -1.06621 -0.84210
## Ifi44            0.60532  -1.4285  -0.9927 -0.98632 -0.71627
## Gbp3             0.83409  -1.2477  -0.9285 -1.10259 -0.84008
## Gbp2             0.73044  -1.2056  -1.1229 -1.27494 -0.99891
## Tnc              1.14544  -0.7693  -0.8696 -0.55021 -1.11784
## Smpdl3b          0.82714  -1.5101  -1.1926 -1.20627 -0.83326
## Htra3           -0.06192   1.2215   1.3211  0.68414  1.28473
## Gbp9             0.82233  -1.2133  -1.1416 -1.26963 -0.87372
## Cxcl9            0.67016  -1.0042  -1.3495 -1.35403 -1.06587
## Oasl2            0.57542  -1.3696  -1.1705 -1.03251 -0.61133
## Hsph1            1.01817  -0.6184  -0.1929 -1.69022 -1.82955
## Asns            -0.22806  -1.6345  -0.9565 -0.30537 -1.97332
## Usp18            0.39134  -1.1548  -1.0552 -0.92030 -1.10476
## Bcl2l14          0.55921  -0.9517  -0.9464 -1.30618 -0.92888
## Ift122          -0.59419   2.6481   1.4444  1.21326  0.50446
## Tmem159         -0.40675   0.3795   3.6012 -0.46798  0.15955
## Gpt2             1.09159  -0.9695  -1.0016 -1.36310 -0.44331
## Mt2             -0.08671  -1.6043  -0.8950 -0.46683 -1.70919
## Mt1             -0.02733  -1.7511  -0.9465 -0.81545 -1.95169
## Ctrl            -0.45987  -0.9124   0.4040 -0.61492 -0.73229
## Psmb10           0.55859  -1.2617  -1.1801 -1.11692 -1.14153
## Chek1            0.31643  -1.5929  -0.3809 -0.75943 -1.65882
## Stra6            0.98767  -0.9837  -0.8941 -1.91602 -1.16585
## Ptgs2            0.15091  -1.0518  -0.8595 -0.86511 -0.89542
## Oas3             0.16974  -1.6267  -1.3017 -0.06213 -1.24305
## Oas2             0.56035  -1.3638  -1.0233 -1.05796 -0.56764
## Rtp4             0.62718  -1.3826  -1.0706 -1.01898 -0.45378
## Apol6            0.60667  -0.8674  -1.3543 -1.03983 -0.72572
## Recql4          -0.14671  -1.4034  -1.1867 -0.79180 -1.49906
## Pla2g4c          0.27258  -1.4053  -0.9455 -0.31723 -1.59205
## Tmem132c        -0.51578   1.2824   0.8078  0.49766  1.44597
## Lif              0.39665  -1.1196  -1.2966 -0.66979 -1.18530
## Parp14           0.87142  -1.2835  -1.0071 -1.09373 -0.87941
## Gbp8             0.87504  -1.2398  -1.0863 -1.08047 -0.92009
## Ifit1            0.39590  -1.1479  -1.1623 -0.75274 -0.88864
## Cxcl10           0.79058  -1.1633  -1.1775 -1.05589 -1.05486
## Ubd              0.87262  -1.0891  -1.1517 -1.06557 -1.12908
## Ccl2             0.10524  -1.0354  -1.0024 -0.95414 -0.93838
## Isg15            0.12608  -1.4408  -1.0359 -0.10274 -1.26115
## Npy1r           -0.15514   1.2583   1.3535  0.87210  1.08536
## Tmem255a         0.35629   0.9568   1.4593  0.83406  1.31550
## Tap1             0.89998  -1.1954  -1.0848 -1.43788 -1.13448
## Dtl             -0.14739  -1.4596  -1.0282 -0.22764 -1.86650
## Nme1             0.55307  -1.6221  -0.4167 -1.36678 -1.45854
## Fam13a           0.27119   1.5896   0.8121  0.66748  1.52986
## Tgm2             0.47398  -1.0616  -1.3045 -1.06941 -0.92349
## Rmi2             0.32075  -1.2848  -1.0688 -0.97693 -1.19225
## Socs1            0.71165  -1.2287  -1.1762 -1.11367 -1.01144
## Fanci           -0.53511  -1.5756  -0.9854 -0.55958 -1.55777
## Batf2            0.88766  -1.1021  -0.8736 -0.99783 -1.06414
## Stat2            0.76218  -1.2464  -1.1446 -1.17238 -0.77574
## Gbp7             0.70284  -1.3096  -1.0998 -1.10660 -1.04820
## Gbp2b            0.69359  -1.1623  -0.9022 -1.03637 -0.84439
## Btnl9           -0.14543   1.3836   0.6193  1.13234  0.99429
## Olfr56           0.32549  -1.3365  -1.0244 -0.90265 -0.92295
## Il7             -0.71947   0.9559   1.3011  1.19343  1.10287
## Xaf1             0.61136  -1.3447  -1.2951 -0.94235 -0.63765
## Serpina3g        0.86113  -1.2826  -1.2239 -1.25348 -0.91025
## Prelp           -0.14015   1.3848   1.1701  0.88201  1.24753
## Abca9            0.06618   1.0877   0.9860  0.96226  0.97186
## Oasl1            0.62759  -1.2070  -0.9619 -0.90571 -0.83367
## Abca8a          -0.73918   0.9433   1.2152  1.08025  0.99856
## Bag2             0.11954  -0.7837  -1.0599 -0.30615 -2.00127
## Cilp             0.23705   0.9762   1.2047  1.04423  0.81821
## Maff             0.59905  -0.8081  -1.6700 -1.52001 -1.23018
## Mmp3            -0.22255  -0.6536  -1.0613 -1.07344 -1.33884
## Phf11a           0.31035  -1.1315  -0.8452 -1.05911 -0.41580
## Gvin1            0.90452  -1.3075  -1.1218 -1.34693 -1.00690
## Ifit2            0.52205  -1.1878  -0.8538 -1.05273 -0.74415
## Fam26f           0.64629  -1.0649  -1.1965 -1.23567 -0.82792
## Olfml2a         -0.36764   1.2699   0.9182  0.97592  1.32334
## Bst2             0.59732  -1.3310  -1.0721 -1.13289 -0.72761
## Irgm1            0.72175  -1.3040  -1.1603 -1.18830 -1.04998
## Kcne4            0.64203  -0.8233  -1.5646 -1.62724 -1.01248
## Gm12185          0.74808  -0.8760  -1.2622 -1.13329 -1.02433
## Zg16            -0.74995  -0.8053   0.5071 -0.39887 -1.07585
## Apol10b          0.92167  -1.4750  -1.0621 -0.86759 -0.44850
## Mmp13            0.39703  -0.9167  -1.1401 -1.02950 -0.80970
## Kcnj16          -0.49097   0.8888   1.1365  1.14131  1.07252
## Fpr2             0.12155  -0.9746  -1.1954 -0.60020 -0.51050
## Epha3            0.26245   1.2907   0.3413  1.46427  1.49063
## Oas1a            0.35262  -1.5023  -1.2965 -0.94415 -0.53434
## Socs3            0.48940  -1.1679  -1.1384 -1.49068 -0.97972
## Slamf8           0.64971  -0.8319  -0.8786 -1.21659 -0.87647
## Iigp1            0.87728  -1.2446  -1.2356 -1.22689 -0.90078
## Ifi205           0.76619  -1.1370  -0.9502 -1.03566 -0.94198
## Ifng             0.69183  -1.0947  -1.1365 -1.32302 -0.93162
## Cebpb            0.44432  -1.4832  -1.2045 -1.69883 -0.36823
## Gm5431           0.67769  -1.1667  -0.9390 -0.94815 -0.23280
## Fcgr4            0.97157  -1.3463  -0.9625 -1.12069 -1.02943
## Pla2g16          0.37697  -1.2366  -1.2472 -0.39834 -1.57024
## Obscn           -0.84536   1.1708   1.2898  1.41950  0.86908
## Serpina10        1.26524  -1.4282  -1.3186 -0.82057 -0.80739
## Tubb3            0.15050  -0.8346  -0.9727 -1.02798 -0.95786
## Ifit3b           0.58405  -1.0485  -0.7553 -1.01988 -0.16786
## Serpina3f        0.91590  -1.3007  -1.1587 -1.26469 -0.93370
## Cenpm            0.02292  -1.2452  -0.9468 -0.55442 -1.87034
## Phf11d           0.49623  -1.5435  -0.6092 -1.19003 -0.64720
## Gm4841           1.03446  -1.3058  -1.0366 -1.17277 -0.74209
## Irgm2            0.93502  -1.2739  -1.1160 -1.25320 -0.89448
## Rnf213           0.60130  -1.3174  -0.9378 -1.06848 -0.80623
## Cited4           0.04427  -1.9713  -0.7045 -0.54838 -1.51318
## Ccl19            1.04876  -1.1011  -1.1081 -1.68594 -0.82553
## Ifi204           0.80633  -1.4841  -0.8835 -1.04969 -0.86665
## Pydc4            0.77121  -1.2626  -0.8754 -1.32879 -0.69985
## Gm4951           0.98008  -1.1234  -1.1073 -1.32299 -0.68756
## Nlrc5            0.99509  -1.2375  -0.9388 -1.69600 -0.70404
## Amy2a5          -0.44902  -0.6587  -0.5149 -0.51797 -0.90723
## Ifit3            0.61282  -1.1321  -0.9548 -0.90939 -0.60721
## Grem1           -0.17759   1.2231   0.8277  0.47064  1.22696
## Ly6a             0.58593  -1.3037  -0.9469 -1.21078 -0.83694
## Aunip           -0.39487  -1.2526  -1.0391 -0.24653 -1.84023
## Gm4070           0.91256  -1.4606  -1.1192 -1.38484 -0.91970
## Igtp             0.80685  -1.2773  -1.1470 -1.31188 -1.12330
## Ifi47            0.69189  -1.2341  -1.0679 -1.29387 -1.09786
## Tgtp2            0.81734  -1.2873  -1.3296 -1.16488 -1.04485
## Tgtp1            0.72010  -1.2063  -1.1000 -1.32352 -1.09182
## Ifit1bl1         0.68603  -1.2510  -0.7526 -1.23397 -0.82687
## Gm43302          0.72808  -0.8405  -1.4637 -1.34114 -0.28926
## Gbp4             0.76470  -1.1120  -1.1569 -1.39501 -1.00718
## Gm12216          1.26385  -1.0349  -1.0772 -1.30314 -0.89154
## Ctsf            -0.74000   0.6481   0.9201  1.51501  0.74146
## Cfb              0.38586  -1.1689  -0.9646 -1.16375 -0.88156
## Hspa1b           1.22573  -0.7843  -0.7462 -1.63254 -1.09634
## F830016B08Rik    0.97024  -1.2937  -1.0528 -1.19696 -0.76365
## Gm17334          0.97575  -1.2675  -0.8550 -1.21474 -1.09393
## Gm20390         -0.11408  -1.5309  -0.7808 -1.31903 -1.11067
## Phf11b           0.56462  -1.1420  -1.0754 -1.15840 -0.92829
## Hspa1a           1.43175  -0.3705  -0.3775 -1.93261 -1.14881
## Gal3st2         -0.13449   1.5316   1.7381  0.96561  0.74694
## Hist1h3g        -0.45724  -1.6599  -1.1246 -0.05079 -1.70959
## Gbp6             0.82273  -1.2866  -1.1679 -1.34801 -1.02133
## Gbp10            0.84896  -1.0817  -0.9291 -1.35531 -1.10793
## Gbp5             0.79598  -1.1051  -1.1294 -1.26613 -0.94989
## Chaf1a          -0.10970  -1.5445  -1.2244 -0.40394 -1.31231
## Atp1a2          -0.50819   1.2078   1.9963  0.61195  1.14353
## Ehf             -0.98069   0.9284   0.8346  1.15182  1.35835
## Mybpc1          -0.36744   0.8184   1.5173  0.81827  1.31044
## Fos              1.24245  -1.0351  -0.7014 -2.04499 -0.40070
## Trip13           0.39889  -1.2337  -1.0661 -0.58439 -1.08260
## Dhfr             0.01912  -1.2418  -1.0036 -0.55965 -1.42117
## Shcbp1          -0.14928  -1.8142  -0.9970  0.09238 -1.25222
## Spata24         -0.10843  -1.0782  -1.2558 -1.17524 -1.35717
## Lox             -1.22895   1.4550   0.8430  0.17276  1.34394
## Msr1             0.45303  -0.7525  -1.5749 -0.74526 -0.83604
## Il2ra            0.52964  -1.1678  -1.0811 -1.11751 -1.09728
## Rad51            0.05930  -2.1641  -0.9101 -0.14311 -1.35914
## Slc7a11          0.64231  -1.3491  -1.6647 -1.48703 -0.77641
## Extl2           -0.18253  -0.4183  -0.3036 -0.43579 -0.21239
## Auts2           -1.36782   2.3052   0.7540  1.08569 -0.32964
## Klra2            1.16963  -1.4428  -0.8560 -0.81331 -0.82834
## Bcat1            0.43330  -0.3029  -0.5659 -1.96738 -1.34010
## Pcsk6           -1.40885   1.0481   1.3035  1.75103  0.48382
## Cd209a           0.13898   1.2850   0.8248  0.88730  1.17871
## Prrg3           -0.64596   0.6703   1.2026  0.15618  2.41701
## Lrr1             0.47358  -1.4689  -0.6389 -0.37655 -1.27892
## Fxyd1           -0.90150   1.2605   1.5475  1.31142  1.48480
## Eme1             0.10749  -1.4311  -0.4709 -0.72519 -1.65257
## C130074G19Rik   -0.76649   1.4768   1.3911  0.99838  1.09465
## Tnip3            0.67044  -0.9128  -0.5357 -0.93379 -0.89492
## Mab21l3          1.36306  -1.8109  -1.8055 -0.90818 -0.58602
## Ifitm10         -0.30442   1.3470   0.6284  0.84261  1.55555
## AI464131        -0.13962   1.3447   1.4311  1.15872  1.08626
## Sned1           -0.46464   1.1014   0.9770  0.87106  1.13713
## Bex4            -0.67184  -1.2153  -0.6013  0.08301 -2.42381
## Vstm4           -0.41348   1.0804   1.1835  0.92804  1.29961
## Rnd1            -0.12491  -0.3828  -1.7156 -1.52187 -0.42426
## Sphk1           -0.38133  -1.0482  -1.2942 -0.08330 -1.71014
## Efcc1           -0.68712   1.3292   1.5965  0.64671  0.82220
## Lilr4b           0.36215  -1.2709  -0.7068 -1.07107 -0.92873
## Gm21887         -1.46189   0.6220   1.0383 -0.14799 -1.58216
##     heat.list day delivery rep
## 13   naive.r1   0    naive   1
## 14   naive.r2   0    naive   2
## 15   naive.r3   0    naive   3
## 16   naive.r4   0    naive   4
## 1   sbp.d4.r1   4      sbp   1
## 2   sbp.d4.r2   4      sbp   2
## 3   sbp.d4.r3   4      sbp   3
## 4   sbp.d4.r4   4      sbp   4
## 9  rtmt.d4.r1   4     rtmt   1
## 10 rtmt.d4.r2   4     rtmt   2
## 11 rtmt.d4.r3   4     rtmt   3
## 12 rtmt.d4.r4   4     rtmt   4
## 5    mt.d4.r1   4       mt   1
## 6    mt.d4.r2   4       mt   2
## 7    mt.d4.r3   4       mt   3
## 8    mt.d4.r4   4       mt   4

4.5 Day 3

##               sbp.d3.r1  sbp.d3.r2  sbp.d3.r3  sbp.d3.r4  mt.d3.r1
## Cdc45          -1.00289 -0.9543746  0.0752548  3.117e-01  0.275581
## Il12rb1        -0.71030 -0.4064072 -0.5086540  3.218e-01  1.854990
## Gnb1l           1.55396 -0.3553318  0.0670669  5.470e-01  0.976381
## Lgals9         -1.01407 -0.4723919 -0.3631331 -1.823e-01  1.535581
## Uhrf1          -1.45653 -1.0468761  0.3042956  2.772e-01  0.390601
## Hpn            -0.21310  0.0594541 -0.1899847  1.327e+00  0.596095
## Chaf1a         -1.05359 -1.6558046  0.2576024  3.609e-02  0.766204
## Syce2          -1.76805 -0.6048044  0.4400295  2.378e-01  0.253602
## Abca13         -0.86074 -0.0273248  0.2204630 -8.163e-01  0.656730
## Ccl24          -0.76581 -0.2227142 -0.3160276  2.586e-01  1.706524
## Mcm5           -1.14410 -1.2937953  0.3271767  1.712e-01  0.663787
## Atp7b          -1.78449 -1.0921680  0.3869646  1.073e+00  0.384352
## Gmnn           -1.42098 -1.2075595  0.2040709  2.961e-01  0.483828
## Pole           -0.85129 -1.5891897  0.7676668  4.916e-01  0.701145
## Mlkl           -1.07410 -0.9810406 -0.2464786 -2.026e-01  1.776857
## Hmgb3          -1.29513 -1.4495216  0.5456203  7.807e-01 -0.060613
## Gzmb           -0.71666 -0.3397392 -0.3505251 -3.481e-01  1.397225
## Cdc6           -1.30883 -1.5283558  0.7233319  5.615e-01  0.298404
## Mapt            1.10938  0.7481967 -0.2006224 -1.096e-01 -1.171245
## Irf1           -0.04168 -0.6801739 -0.0135482 -2.615e-01  2.260363
## Slfn3          -0.68404 -0.5986075 -0.2762956 -1.253e-01  0.591418
## Mtfr2          -1.35398 -0.5747404  0.2891889  1.469e-01  0.557148
## Ppa1           -0.48933 -1.1100524 -0.4586197 -1.466e-01  1.804495
## Nefh           -1.06419 -1.0284110  0.6824476 -7.159e-01  1.578295
## Upp1           -0.21553 -1.1712954 -0.0752641 -6.862e-01  1.091924
## Nampt          -0.74490 -0.5359029 -0.5035724 -3.448e-01  1.985799
## Cmpk2          -1.63372 -0.6173777  0.0007689 -1.057e-01  1.084928
## Fam64a         -0.20921 -0.7796740  0.3505722 -6.396e-01  0.410831
## Top2a          -1.39592 -1.1440559  0.2786360  1.148e-01  0.202262
## Serpina3n       0.26055 -1.5965745  0.1889259 -4.375e-01  1.334625
## Wars           -0.60440 -0.7587759 -0.4292658 -3.401e-01  2.247650
## Hsp90aa1       -0.38926 -0.0755808 -0.2240133 -4.443e-01  1.364269
## Thbs4           0.38389 -0.8511855  0.3247845 -1.524e+00  1.819246
## Dhfr           -1.41887 -1.1750158  0.3808530  2.773e-02  0.581167
## Cenpk          -1.38170 -1.0986446  0.2621448  3.046e-01  0.318094
## Fam107a         0.25605 -0.3036187  0.0399632 -7.762e-01 -1.792481
## Pnp            -1.55214 -0.8919229  0.2500491  2.444e-01  0.770789
## Pbk            -1.17841 -1.1649409  0.4834809  3.550e-01 -0.393413
## Acod1          -0.86683 -0.3098034 -0.4326139 -6.158e-01  1.236949
## Shcbp1         -1.14169 -0.8573537  0.1908737  1.223e-01 -0.046310
## Has2            0.13095 -0.8358193 -0.0134468  1.198e-01  2.140002
## Dscc1          -0.98879 -1.3715182 -0.0484118 -2.119e-01  0.946107
## Vdr            -0.22362  0.2691464 -0.3892628 -1.819e-01  2.327556
## Ly6c2          -1.46122 -0.6607925 -0.4063723 -3.590e-01  1.761084
## Ly6i           -0.97716  0.0071066 -0.1020800 -1.904e-01  1.336305
## Chaf1b         -2.17405 -0.7770393  0.0515944  3.405e-01  0.074414
## Fam132a        -1.68375 -1.3696487  0.2687599  1.108e+00  0.391989
## Il33           -0.10394 -1.3317229  0.2761683 -2.133e-01  1.579421
## Irf7           -1.35219  0.1798835 -0.2644601 -6.047e-01  1.833537
## Tyms           -1.77099 -1.0887653  0.7368132  3.028e-02  0.474949
## Hk3            -1.18821 -0.4110442 -0.4875521  9.657e-05  2.161583
## Il1rl1         -1.55286 -0.9035323  0.3345335  5.701e-01 -0.271914
## Stat1          -0.41693 -0.8610771 -0.1194334 -2.275e-01  2.267506
## Steap3         -1.82951 -0.7261806  0.4067175  7.643e-01  0.175985
## Ube2t          -0.85756 -0.5934756 -0.0506598  4.580e-01  0.184505
## Mnda           -0.95894 -0.1714864 -0.4285407 -4.243e-01  1.826391
## Xcl1           -0.28931 -0.0585939 -0.8414515  4.657e-01  2.237966
## Atf3           -0.48937 -0.3014441 -0.3140809  1.478e-02  2.154716
## Mcm10          -0.94287 -1.1070162  0.3978430  2.352e-01  0.356999
## Il2ra          -0.51224 -1.4114145 -0.3334503 -3.302e-01  1.931852
## Sapcd2         -0.91115  0.4272891 -0.4924481 -6.617e-01  0.768569
## Il1rn          -0.85183 -0.7007480 -0.8517246  5.051e-03  1.621651
## Gatm           -1.49749 -0.9076623 -0.1398564  4.990e-01  1.263968
## Dut            -1.20949 -0.6782561  0.0307049  1.007e-01  0.514098
## Rad51          -1.09690 -1.3836008  0.3367755  6.701e-01 -0.106635
## Bub1           -1.30941 -0.9909382  0.0045892 -5.834e-02  0.078454
## Gins1          -1.44117 -1.1854432  0.5466238 -1.382e-01  0.720197
## Aurka          -1.34862 -1.0566779  0.4406829  3.657e-01  0.139031
## Zbp1           -0.92464 -0.5262233 -0.2729190 -2.916e-01  2.097357
## Car1           -1.65769 -0.9343186  0.4031853  8.217e-01  0.230684
## Il21            0.43831 -1.8180389 -1.0796405 -1.749e-01  0.273484
## Ifi44          -0.77926 -0.0001395 -0.7315818 -9.532e-01  1.491352
## Gbp3           -0.88664 -0.6712987 -0.2374000 -4.172e-01  1.937856
## Gbp2           -0.50516 -0.9238856 -0.0576186 -3.433e-01  2.042873
## Smpdl3b        -1.06361  0.1740358 -0.5194535 -1.871e-01  0.565169
## Htra3           0.12733  0.4356402  0.8102531  6.929e-02 -1.822514
## Cxcl9          -0.37100 -0.8767183 -0.0284235 -2.502e-02  2.015951
## Oasl2          -1.34190 -0.2132220 -0.5621882 -3.182e-01  1.720325
## Hsph1           0.16515  0.6325867  0.7455875 -1.020e+00  1.177829
## Tfr2           -1.83576 -0.6240264  0.5734727  8.912e-01 -0.184161
## Asns           -1.36597 -1.3977339  0.3686386  7.715e-01  0.192291
## Klrg1          -1.41493  0.1836429  0.2334399  6.082e-01 -0.067726
## Klra2          -0.73842 -0.2611060 -0.6375168 -1.572e-01  2.175731
## Bcat1           0.15176 -0.9067816 -0.9060016 -3.008e-01  0.305607
## Rad51ap1       -1.27361 -1.5774871 -0.3361952  2.506e-01  0.241840
## Ddias          -1.48161 -0.8405708  0.6457222  1.457e-01 -0.214918
## Sult1a1         0.72536  0.2374594  0.5657610  2.598e-01 -1.560371
## Plk1           -1.43550 -1.2285185  0.7182481  1.770e-01  0.089648
## Tmem159         0.12579 -0.2278823 -0.2562193 -7.996e-02 -0.319576
## Cenpi          -1.24731 -0.0368463  0.3414692  1.434e-01  0.244247
## Adgrg2          0.52026  1.2016435 -0.4920495  6.254e-01 -0.784241
## Cenpn          -1.20507 -1.0345641  0.4031434  6.194e-01 -0.121804
## Mt2            -1.27263 -0.8941914  0.1020056  6.508e-01  0.530698
## Mt1            -1.04776 -1.0043137  0.0584651  3.511e-01 -0.269869
## Chek1          -0.88986 -0.6741015 -0.1908342  2.547e-01  0.515225
## Mns1           -1.37462 -0.8899928  0.3589302  4.179e-01  0.298200
## Ptgs2          -0.19165 -0.6570809 -0.0876610 -4.960e-01  1.968098
## Traip          -1.37885 -0.5630436  0.0349635  5.664e-01  0.648270
## Oas3           -1.91476 -0.3990022 -0.0121213 -2.179e-01  1.152500
## C330027C09Rik  -1.16994 -0.8782777 -0.2656930  3.509e-02  0.078874
## Rtp4           -1.21235 -0.2964659 -0.2556362 -8.037e-01  1.860852
## Apol6          -0.04127 -0.9885300 -0.4842109 -3.301e-01  2.301384
## Recql4         -1.54652 -0.7012294  0.6027529  6.960e-01  0.128916
## Pla2g4c        -1.40441 -0.9565463  0.6493394 -1.976e-02 -0.365706
## Polq           -1.26465 -0.9668482  0.6109785  3.391e-01  0.357374
## Kif4           -1.08457 -1.1317647  0.7648339  1.393e-01 -0.265661
## Tmem132c        0.69788 -0.1559072 -0.0480812  9.726e-01 -0.835057
## Brip1          -1.42293 -1.2627885  0.2490738  2.477e-01  1.263177
## Lif            -1.14646 -1.1120827 -0.3910535  1.274e-01  2.167115
## Gbp8           -0.48163 -0.8147731 -0.2694757 -5.647e-01  2.330641
## Ifit1          -1.21707 -0.1833553 -0.5365811 -5.498e-01  1.752630
## BC030867       -0.90525 -1.4243718  0.8272917  7.708e-01  0.976695
## Cxcl10         -0.44722  0.0350729 -0.2466375 -5.790e-01  2.201292
## Ubd            -0.24976 -1.0026379 -0.2146225 -3.575e-01  1.995293
## Ccl2           -0.80095  0.1111142  0.0521684 -8.818e-01  2.252411
## Fignl1         -1.71510 -1.1753562  0.5885354  3.625e-01  0.347464
## Isg15          -1.53321 -0.4902026 -0.1224560 -3.188e-01  1.179919
## Kif15          -1.35644 -1.0842821  0.4249608  2.711e-01  0.136300
## Dtl            -1.40218 -1.3326195  0.5075110  4.801e-01  0.298041
## Fam13a         -0.03714 -0.1741327 -0.3132962  1.537e-01 -1.722014
## Rmi2           -0.84074 -0.5231555 -0.5744709 -2.551e-01  1.707813
## Socs1          -0.11213 -0.6825090 -0.2050275 -1.534e-01  2.095512
## Eme1           -0.51163 -0.8525594  0.7482065 -2.126e-01  0.105595
## Fanci          -1.21773 -1.1472294  0.5620480  8.421e-02  0.333645
## Batf2          -0.16921 -0.9721780  0.1610371 -2.493e-01  2.091295
## 2810417H13Rik  -1.10025 -1.4852675  0.0486063 -5.694e-02  0.563593
## Gbp7           -0.50249 -0.8251562 -0.2255678 -3.992e-01  1.987120
## Gbp2b          -0.39266 -0.5040570 -0.5420351 -2.641e-01  1.695925
## Olfr56         -0.45117 -0.6631033 -0.4735225 -4.961e-01  2.145524
## Il7             0.10487  0.2571932  0.0715595  6.221e-01 -2.373964
## Pklr           -1.93386 -0.7398195  0.4774436  8.428e-01  0.192008
## Serpina3g      -0.40789 -0.8767089 -0.3607608 -2.230e-01  1.930449
## Abca8a          0.45454  0.9503977 -0.1696940  9.756e-01 -2.128444
## Mmp3            0.31443 -1.4635032  0.3574032 -2.083e-01  1.272588
## Tnip3          -0.27225 -1.4315818  0.8266180 -1.649e-01  1.085385
## Gvin1          -0.64146 -0.6856696 -0.1817729 -4.199e-01  2.149411
## Ifit2          -0.67272 -0.2264693 -0.5228728 -3.695e-01  2.183581
## Fam26f         -0.44412 -0.5574813 -0.3497197 -4.849e-01  2.192473
## Irgm1          -0.52926 -0.6339817 -0.1458111 -5.041e-01  2.081960
## Kcne4          -0.44250 -0.9762106 -0.0025052  7.724e-02  1.677406
## Bex4           -1.51878 -0.6122834  0.2010267  7.973e-01 -0.017790
## Ccr4           -0.14841 -1.0988341 -0.1596822 -9.610e-01  1.877540
## Ckap2l         -1.21117 -1.2239403  0.4737405  9.106e-02 -0.003965
## Gm12185        -0.54444 -0.6648030 -0.7385737 -4.661e-02  1.974257
## 2610318N02Rik  -0.09738 -0.4097538 -0.2899462 -1.141e+00  1.173903
## Tcf19          -1.38498 -1.1400293  0.2665928  2.252e-02  0.520630
## Mmp13          -0.48194 -0.2877189 -0.1700527 -1.016e-01  1.724102
## Socs3          -0.04058 -1.2798197 -0.4986069 -7.999e-01  1.550335
## Slamf8         -0.42047 -0.7902629 -0.3863071 -2.559e-01  1.869153
## Iigp1          -0.36252 -0.6872299 -0.2457011 -1.748e-01  2.049824
## Ifng            0.07376 -0.9021854  0.2915040  2.460e-01  1.517490
## Fam72a         -0.62949 -0.8442533  0.2023889 -3.293e-02  1.573291
## Fcgr4          -0.94423 -0.3096028 -0.4982612 -1.272e-01  1.868332
## Obscn           0.65461  0.5140171 -0.0676935 -2.992e-01 -1.711907
## Sphk1          -1.37019 -1.2492449  0.3345496  9.431e-01  0.462712
## Serpina10      -0.07571  0.0187480 -0.0847875 -2.967e-01  1.321082
## Tubb3          -0.12107 -0.2129766 -0.4685152 -1.485e-01  1.278633
## Serpina3f      -0.40051 -1.0264934 -0.2823183 -3.487e-02  1.924086
## Zbtb16          0.82723  0.1441139  0.5824573 -3.262e-01 -1.580232
## Gm4841         -0.28783 -0.0692659 -0.3161695 -3.413e-01  1.434346
## Slfn9          -0.97018 -0.7514766 -0.4617539 -6.946e-01  1.701956
## Irgm2          -0.39814 -0.6511341 -0.1289512 -3.698e-01  2.224527
## Cited4         -1.88399 -0.4292520  0.2424331  4.656e-01 -0.108271
## Gm4951         -0.67247 -0.3190204 -0.2726685 -2.298e-01  1.976740
## Nlrc5          -0.48614 -0.6057065 -0.0474994 -5.599e-01  2.165702
## Amy2a5         -0.53783 -0.2549223 -0.3718040 -3.712e-01  2.793867
## Spc24          -1.36285 -0.9347684  0.3403295  3.211e-01  0.359547
## Ifit3          -1.43473 -0.0709558 -0.5106886 -5.951e-01  2.181392
## Cenpw          -1.00811 -0.6630699  0.1882173 -3.732e-01  0.592144
## Ly6a           -1.15459 -0.7084434 -0.5718676 -2.514e-01  1.758362
## Aunip          -1.33181 -1.4549967  0.2577256  2.999e-01  0.261119
## Gm4070         -0.64333 -0.5960155 -0.3717842 -3.432e-01  2.054069
## Igtp           -0.42725 -0.7499942 -0.0413580 -2.965e-01  2.006078
## Ifi47          -0.50169 -0.5892356 -0.1792620 -4.135e-01  2.120739
## Tgtp2          -0.38427 -0.9124103  0.0195377 -1.969e-01  2.110313
## Tgtp1          -0.15871 -1.0754947  0.0794456 -3.127e-01  1.862872
## Ifit1bl1       -1.18839 -0.6541509 -0.1407076 -9.688e-01  1.924738
## Gm43302        -0.37582 -0.2747891 -0.0374983  3.178e-01  1.725787
## Gbp4           -0.20767 -0.7430294 -0.1312915 -3.214e-01  2.199508
## Hspa1b          0.42688  0.7733723  0.8755168 -1.016e+00  1.515016
## F830016B08Rik  -0.27087 -0.4694319 -0.3416594 -4.328e-01  2.038845
## Gm17334         0.06181 -0.6960358  0.2581659 -6.211e-01  2.584261
## Apol11b        -1.71055 -0.6369424  0.2438432  1.905e-01 -0.147812
## Hist1h3g       -1.23856 -1.3211616  0.6907071  3.091e-01  0.246747
## Gbp6           -0.43949 -0.9328082 -0.1654602 -3.678e-01  2.108544
## Gbp10          -0.02519 -0.4840985 -0.1648056 -6.319e-01  2.001543
## Gbp5           -0.47147 -0.7491704 -0.1976365 -3.193e-01  2.172689
## Cela3b         -0.61078 -0.6107764 -0.6107764 -6.108e-01  2.004383
## Ctrb1          -0.60760 -0.6076009 -0.6076009 -6.076e-01  2.015430
## Ttc41          -1.46099 -1.6013120 -1.3519021 -1.014e+00  0.745419
## Reg1           -0.54528 -0.5452801 -0.5452801 -5.453e-01  2.188136
## Amy2a3         -0.55514 -0.5551352 -0.5551352 -5.551e-01  1.826532
## Amy2a2         -0.55514 -0.5551352 -0.5551352 -5.551e-01  1.826532
## Amy2a4         -0.55514 -0.5551352 -0.5551352 -5.551e-01  1.826532
##               mt.d3.r2  mt.d3.r3  mt.d3.r4 rtmt.d3.r1 rtmt.d3.r2
## Cdc45           2.7686  0.953591 -0.164198   -0.58268   0.291730
## Il12rb1         2.5736 -1.076768  0.552904   -0.58407  -0.340362
## Gnb1l           1.2161  0.474695  0.806773   -1.46327  -0.500138
## Lgals9          3.0787 -0.079506  0.447807   -0.27620  -0.375688
## Uhrf1           2.3403  0.875433  0.079860   -0.63322   0.368488
## Hpn             2.3949  0.689898  0.629650   -0.92648  -0.746571
## Chaf1a          2.5046  1.137741  0.250588   -0.61629   0.287068
## Syce2           2.3288  0.481176  0.525607   -0.85878   0.269227
## Abca13          3.0530  0.477156  0.110873   -0.30278  -1.013422
## Ccl24           3.0389 -0.269399  0.157679   -0.64983  -0.198010
## Mcm5            2.5044  0.929374  0.039050   -0.84326   0.323713
## Atp7b           2.0126  1.035988  0.323879   -0.39616   0.012069
## Gmnn            2.5386  1.034703 -0.103041   -0.80925   0.283671
## Pole            2.5043  0.661853  0.354163   -0.71032   0.150761
## Mlkl            2.7480 -0.309518  0.594939   -0.50333  -0.047344
## Hmgb3           2.2090  1.108608 -0.006397   -0.42252   0.277808
## Gzmb            3.1713  0.133046  0.441237   -0.31067  -0.256882
## Cdc6            1.9538  1.160990 -0.304418   -0.56585   0.492453
## Mapt           -2.2042 -0.304587 -1.185139    0.07672   1.226192
## Irf1            2.1067 -0.224233  0.931837   -0.24959  -0.004875
## Slfn3           2.9990  0.890913 -0.004291   -0.95382  -0.209273
## Mtfr2           2.6026  0.839028 -0.100782   -0.84760  -0.048190
## Ppa1            2.7060  0.372706  0.361423   -0.82073  -0.222125
## Nefh            2.4197 -0.038019  0.605404   -0.40660   0.241903
## Upp1            2.7580  1.370749 -0.022434    0.44551  -0.644952
## Nampt           2.7790 -0.363082  0.600973   -0.44007  -0.208209
## Cmpk2           2.6801  0.352191  0.282035   -0.53997  -0.242702
## Fam64a          2.7652  0.178015  1.162508   -0.61981   0.084129
## Top2a           2.5048  1.025599 -0.250520   -0.75839   0.252835
## Serpina3n       1.1613 -0.058972  0.903541   -0.17404   0.704090
## Wars            2.4773  0.229689  0.524679   -0.69569  -0.321589
## Hsp90aa1        2.6072  0.570175  0.746129   -1.12840  -0.443833
## Thbs4           1.3786  0.296440  1.188475   -0.11178   0.520236
## Dhfr            2.8058  0.712411  0.013888   -0.83318   0.162322
## Cenpk           2.2383  1.269715 -0.202771   -0.94153   0.376234
## Fam107a        -1.6384 -0.385973 -0.625301    0.66848   1.008882
## Pnp             2.5655  0.912305  0.063519   -0.78155   0.015912
## Pbk             2.3913  1.352903 -0.400163   -0.67602  -0.008990
## Acod1           3.3396  0.036946  0.013383   -0.46663  -0.470184
## Shcbp1          2.5755  0.973283 -0.031361   -0.93982   0.368477
## Has2            2.2706  0.144254  0.871495   -0.40161  -0.279053
## Dscc1           2.5179  0.951262  0.030162   -0.51895   0.252828
## Vdr             2.0940 -0.091803  0.551569   -0.53385  -0.522744
## Ly6c2           2.6618  0.257896  0.647776   -0.29741  -0.162758
## Ly6i            3.1760 -0.838547  0.407722   -0.10014  -0.383442
## Chaf1b          2.3605  1.274233 -0.083028   -0.54301   0.298719
## Fam132a         1.8653  1.149166  0.149160   -0.32526   0.493334
## Il33            1.4185  0.379330  0.823633    0.10004   0.403493
## Irf7            2.6683 -0.215551  0.525919   -0.33519  -0.072428
## Tyms            2.3916  0.894091 -0.124710   -0.45376   0.326383
## Hk3             2.6309  0.061971  0.330049   -0.35722  -0.290712
## Il1rl1          2.1701  1.297563  0.321817   -0.18428   0.493657
## Stat1           2.0737 -0.168815  1.124818   -0.47947  -0.124354
## Steap3          2.1134  1.081864  0.169041   -0.94429   0.382484
## Ube2t           2.4425  1.659537 -0.545765   -0.41897   0.047728
## Mnda            2.7080  0.191417  0.742129   -0.35500  -0.096592
## Xcl1            2.2621  0.407617  0.638778   -0.57028  -0.461928
## Atf3            2.6022 -0.548799  0.242312   -0.49613  -0.370588
## Mcm10           2.7083  0.728778 -0.170520   -0.70408   0.336755
## Il2ra           2.3366 -0.014804  1.200035   -0.02014  -0.276456
## Sapcd2          2.8653  0.757800 -0.518837   -0.08968   0.675548
## Il1rn           2.9048 -0.001937  0.354683   -0.55927   0.256328
## Gatm            2.6607  0.795657  0.080566   -0.22382  -0.147851
## Dut             2.9460  0.601031  0.113484   -0.69845   0.195462
## Rad51           2.2843  1.428579 -0.062747   -0.69909   0.272982
## Bub1            2.7050  0.752565  0.107775   -0.77538   0.413564
## Gins1           2.6744  0.895309 -0.462186   -0.34947   0.107700
## Aurka           2.1265  1.034914  0.064867   -0.48874   0.312963
## Zbp1            2.4239 -0.197859  0.875277   -0.30592  -0.128990
## Car1            1.8829  0.992393  0.330627   -0.19830   0.322244
## Il21            2.4839  0.340975 -0.296810    0.27697   0.896349
## Ifi44           2.8104 -0.685207  0.662927   -0.62614  -0.284237
## Gbp3            2.7409  0.065236  0.727836   -0.33404  -0.217552
## Gbp2            2.4946 -0.053584  0.869671   -0.51126  -0.218359
## Smpdl3b         2.8222  0.062798  0.292718   -0.02509   0.534578
## Htra3          -2.5121  0.350984 -0.663193   -0.19286   0.522127
## Cxcl9           2.3857 -0.182441  0.868163   -0.41061  -0.112345
## Oasl2           2.7912 -0.164739  0.512111   -0.35931  -0.382802
## Hsph1           1.1493 -0.068182  0.900389   -0.54528   0.184484
## Tfr2            1.8639  1.176114  0.363170   -0.48258   0.051434
## Asns            2.1348  1.039297  0.295367   -0.73330   0.396246
## Klrg1           2.4452  1.568741  0.727691   -0.41231  -0.251204
## Klra2           2.4290 -0.865934  0.878450    0.02249  -0.640574
## Bcat1           2.4753 -0.098399  0.632705    0.60207   0.499142
## Rad51ap1        2.4349  0.950596 -0.321251   -0.33550   1.125974
## Ddias           2.5995  0.758656 -0.522305    0.01177   0.510731
## Sult1a1        -2.2468 -1.045769 -0.950526   -0.32619   0.706247
## Plk1            2.1288  1.063644 -0.056757   -1.09496   0.254891
## Tmem159        -0.1782 -0.643234 -0.581866   -0.69936  -0.274096
## Cenpi           2.5422  1.271020 -0.610972   -0.79845   0.274050
## Adgrg2         -2.1778 -1.048788 -1.056594    0.05438  -0.485290
## Cenpn           2.5793  1.105152  0.561522   -0.93169   0.108836
## Mt2             2.6096  0.724482  0.148087   -0.23041   0.142247
## Mt1             1.9903  1.671717  0.224223    0.28013   0.137944
## Chek1           2.7299  0.937657  0.725329   -0.48239  -0.053284
## Mns1            2.5320  1.114919  0.024179   -0.77366   0.258865
## Ptgs2           2.7397 -0.330703  0.734762   -0.82001  -0.422101
## Traip           2.4584  0.953007 -0.678935   -0.39022   0.107438
## Oas3            2.4689  0.323464  0.418157   -0.86568  -0.263718
## C330027C09Rik   2.7462  1.155597  0.313821   -0.46595   0.081963
## Rtp4            2.4438 -0.875385  0.576789   -0.02748   0.075464
## Apol6           2.3595 -0.442341  0.794016   -0.44118  -0.139892
## Recql4          2.3153  1.125417  0.641648   -0.52491   0.056124
## Pla2g4c         1.9938  0.901597  0.353723   -0.79187   1.037389
## Polq            2.5793  0.973621 -0.078759   -0.78514  -0.092550
## Kif4            2.3010  1.373400 -0.232469   -0.87180   0.226623
## Tmem132c       -2.8644 -0.499600 -0.259678    0.93347   0.445327
## Brip1           2.8211  0.330925  0.137768   -0.74411  -0.425834
## Lif             2.0477  0.052473 -0.047974   -0.19381  -0.004560
## Gbp8            2.2828  0.203582  1.016935   -0.69974  -0.457066
## Ifit1           2.7656 -0.335793  0.681921   -0.37479  -0.915192
## BC030867        2.2569  1.257637 -0.484386   -0.49158   0.177234
## Cxcl10          2.4888 -0.146602  0.879415   -0.54755  -0.609523
## Ubd             2.6532 -0.384951  0.840145   -0.46507  -0.182481
## Ccl2            2.5033 -0.004581  0.109771   -0.20452   0.165752
## Fignl1          2.3175  0.999063 -0.033184   -0.72053   0.335775
## Isg15           2.7991  0.458569  0.188426   -0.79260  -0.425053
## Kif15           2.4801  0.928872 -0.108923   -0.71964   0.306614
## Dtl             2.2222  1.097948 -0.024945   -0.75449   0.455194
## Fam13a         -2.5762 -0.107135  0.048714    0.62964   0.732363
## Rmi2            2.5449  0.731287  0.826189   -0.81620  -0.045244
## Socs1           2.3692 -0.319510  0.722157   -0.46225  -0.139974
## Eme1            3.0392  0.200371 -0.050561   -0.11709  -0.228893
## Fanci           2.5998  0.851071 -0.454448   -0.50985   0.444106
## Batf2           2.7229 -0.242601  0.328110   -0.43138  -0.355729
## 2810417H13Rik   2.7847  0.807164 -0.250661   -0.64124   0.324712
## Gbp7            2.6198  0.193883  0.724066   -0.51049  -0.278370
## Gbp2b           3.1072 -0.013268  0.301389   -0.51164  -0.367664
## Olfr56          2.6168 -0.347577  0.620291   -0.44356  -0.683426
## Il7            -2.0349 -0.957747 -0.229144   -0.13059   0.614501
## Pklr            1.8104  1.010565  0.246308   -0.57845   0.420421
## Serpina3g       2.6223 -0.005927  0.805545   -0.43931  -0.256719
## Abca8a         -2.0999  0.206659 -0.741875    0.52723  -0.409900
## Mmp3            2.6937 -0.076854  0.318665   -0.02844  -0.329797
## Tnip3           2.8173  0.089704  0.357761    0.21010  -0.483921
## Gvin1           2.3254  0.013011  0.942489   -0.50211  -0.195635
## Ifit2           2.5778 -0.678576  0.753958   -0.47238  -0.335979
## Fam26f          2.6196 -0.265466  0.484169   -0.01992  -0.129366
## Irgm1           2.5288 -0.276245  0.794389   -0.42976  -0.097818
## Kcne4           2.0573  0.267466  0.273232    0.09591   0.749329
## Bex4            1.7712  0.788949  0.548136   -0.39380   0.633041
## Ccr4            2.1556  1.323913  0.589395   -0.79258   0.108802
## Ckap2l          2.4065  0.974020  0.001918   -0.77831   0.266743
## Gm12185         2.7069 -0.566605  0.697852   -0.49241  -0.054193
## 2610318N02Rik   2.7528  0.572906  0.706081   -0.49466  -0.464282
## Tcf19           2.6886  1.064235 -0.445450   -0.53542   0.472381
## Mmp13           2.8842  0.105056  0.009471    0.52625  -0.691738
## Socs3           2.1091  0.426462  1.220665    0.20833   0.134046
## Slamf8          2.8070 -0.390780  0.770442   -0.34992  -0.266401
## Iigp1           2.4812  0.049682  0.955016   -0.53453  -0.307544
## Ifng            2.8313 -0.063815  0.560223   -0.24599  -0.455004
## Fam72a          2.8344  0.415211 -0.318212   -0.45477  -0.470784
## Fcgr4           2.8290 -0.141033  0.577799   -0.50787  -0.472121
## Obscn          -2.3546 -1.219315  0.776089    0.29463  -0.143063
## Sphk1           1.9638  1.221061  0.019515   -0.74444   0.290327
## Serpina10       1.2531  0.769898  1.077050    0.13286  -0.178743
## Tubb3           3.2035 -1.232264 -0.349231   -0.60424  -0.290714
## Serpina3f       2.5057  0.018319  0.919613   -0.49622  -0.204962
## Zbtb16         -1.9050 -1.087589 -0.468226    0.15142  -0.015161
## Gm4841          3.0887  0.095771  0.531771   -0.93995  -0.470125
## Slfn9           2.9638 -0.284473  0.446404   -0.02961  -0.441787
## Irgm2           2.2371 -0.129021  1.108241   -0.53638  -0.090245
## Cited4          1.7639  1.323357  0.335191   -1.10068   0.170908
## Gm4951          2.6633 -0.255952  0.855295   -0.72892  -0.743011
## Nlrc5           1.8521 -0.165018  1.217037   -0.69180   0.026506
## Amy2a5          0.5799 -0.702566 -0.247129   -0.31277   2.065251
## Spc24           2.6809  1.024700 -0.469583   -0.91565   0.483070
## Ifit3           2.2890 -0.677419  0.843483   -0.17101  -0.526784
## Cenpw           2.7348  1.159627 -0.101339   -1.18858  -0.037293
## Ly6a            2.7469 -0.165911  0.550486   -0.55403  -0.100067
## Aunip           2.3373  0.835925 -0.221405    0.15407   0.260086
## Gm4070          2.1912  0.237747  1.171481   -0.64216  -0.070065
## Igtp            2.3807 -0.099418  0.919335   -0.46441   0.017644
## Ifi47           2.4870 -0.286730  0.795527   -0.33857  -0.145566
## Tgtp2           2.2149 -0.056165  1.077176   -0.38575  -0.022077
## Tgtp1           2.3200 -0.006929  1.001503   -0.39430  -0.017066
## Ifit1bl1        2.4423 -0.327851  1.048851   -0.64823  -0.177728
## Gm43302         2.0088 -1.204474  1.126086   -1.14996  -0.068284
## Gbp4            2.2638 -0.325485  0.938627   -0.35195  -0.185696
## Hspa1b          1.4089 -0.864508  0.750156   -0.81001   0.339292
## F830016B08Rik   2.5825 -0.354422  0.962983   -0.56018  -0.345207
## Gm17334         1.8871 -0.302339  0.450915   -0.02210   0.018524
## Apol11b         2.5969  1.077515 -0.264395   -0.59449  -0.117360
## Hist1h3g        2.1504  1.086918 -0.366269   -0.48647   0.352488
## Gbp6            2.1665  0.023186  1.083833   -0.31630   0.035075
## Gbp10           2.3891 -0.031070  1.058741   -0.47784  -0.731692
## Gbp5            2.4981 -0.191480  0.873413   -0.34645  -0.274282
## Cela3b          1.2612 -0.340819 -0.344348   -0.35985   2.027239
## Ctrb1           1.2274 -0.607601 -0.607601   -0.43232   1.982522
## Ttc41          -0.7179  1.553751 -0.135726    0.74446  -0.187929
## Reg1            1.1858 -0.545280 -0.545280   -0.54528   1.912841
## Amy2a3          1.5007 -0.555135 -0.555135   -0.55514   1.945135
## Amy2a2          1.5007 -0.555135 -0.555135   -0.55514   1.945135
## Amy2a4          1.5007 -0.555135 -0.555135   -0.55514   1.945135
##               rtmt.d3.r3 rtmt.d3.r4 naive.r1 naive.r2 naive.r3 naive.r4
## Cdc45           0.459602   0.092274 -1.29874 -0.20455  0.32879 -1.34976
## Il12rb1         0.509004  -0.090266 -0.65098  0.02409 -0.40883 -1.05969
## Gnb1l           0.784217  -0.955586 -0.99640 -0.81805  0.42012 -1.75754
## Lgals9         -0.362176   0.079259 -0.78750 -0.53892 -0.20846 -0.48099
## Uhrf1           0.446615   0.525867 -1.39218 -0.31073  0.58175 -1.35089
## Hpn            -0.680739   0.472066 -0.08188 -0.70727 -1.04730 -1.57607
## Chaf1a         -0.147917   0.363051 -1.05130 -0.65874  0.34730 -0.76659
## Syce2           0.690147   0.792616 -1.16836 -0.49348  0.18076 -1.30637
## Abca13         -0.198200   0.135753 -1.17230 -0.25000  0.67849 -0.69136
## Ccl24          -0.717008  -0.366028 -0.40358 -0.17440 -0.35510 -0.72376
## Mcm5            0.200370   0.579699 -1.31756 -0.41785  0.32418 -1.04639
## Atp7b          -0.174530   0.621286 -0.93840 -0.20548  0.28013 -1.53936
## Gmnn            0.060002   0.464496 -1.08249 -0.52797  0.66927 -0.88343
## Pole           -0.373116   0.378825 -0.95145 -0.34197  0.12755 -1.32053
## Mlkl           -0.642525   0.246009 -0.79560 -0.38709 -0.30749  0.13132
## Hmgb3           0.209089   0.542581 -1.17782 -0.42210  0.49969 -1.33901
## Gzmb           -0.349098  -0.635317 -0.89298 -0.59737 -0.21362 -0.13182
## Cdc6            0.329241   0.573332 -1.09129 -0.34526  0.52690 -1.47590
## Mapt            0.639072  -0.183060  1.77986 -0.36610 -0.21540  0.36050
## Irf1            0.110553  -0.048477 -0.90736 -0.94037 -1.28377 -0.75389
## Slfn3           0.462418   0.263677 -1.37806 -0.47640  0.22645 -0.72780
## Mtfr2          -0.112191   0.862531 -1.23594 -0.38625  0.56884 -1.20654
## Ppa1           -0.036365   0.257652 -1.04803 -0.18989 -0.63576 -0.34483
## Nefh            0.326383   0.497162 -0.72742 -1.09244 -0.65488 -0.62347
## Upp1           -0.720479  -0.189676 -0.85377 -0.06297 -0.52391 -0.49977
## Nampt           0.069016  -0.093832 -0.88170 -0.51568 -0.47144 -0.33157
## Cmpk2           0.205193   0.280893 -1.15616 -0.57513  0.77850 -0.79386
## Fam64a         -0.267036   0.073441 -0.38026 -0.25914  0.11144 -1.98143
## Top2a           0.372325   0.325690 -0.86457 -0.39107  0.95932 -1.23185
## Serpina3n       1.327506   0.513959 -0.56702 -0.55886 -2.00831 -0.99326
## Wars            0.021719  -0.142407 -0.26214 -0.32048 -1.07783 -0.54838
## Hsp90aa1        0.058283   0.635059 -1.03295 -0.34990 -0.63307 -1.25990
## Thbs4           0.395788   0.130129 -1.03345 -1.61400 -0.72639 -0.57705
## Dhfr            0.061901   0.579111 -0.72824 -0.40201  0.20595 -0.97380
## Cenpk           0.481137   0.399440 -0.99647 -0.20742  0.62996 -1.45115
## Fam107a         1.417934   0.510774  0.62930  0.93590 -1.15399  1.20872
## Pnp             0.164347   0.336131 -0.94513 -0.57146  0.58182 -1.16255
## Pbk             0.466675   0.633816 -1.03463 -0.17855  0.58208 -1.23013
## Acod1          -0.155178  -0.160167 -0.29102 -0.39901 -0.40777 -0.05192
## Shcbp1          0.310848   0.524267 -1.51954 -0.51745  0.81838 -0.83038
## Has2           -0.178612  -0.474346 -1.25411 -0.83183 -0.67536 -0.73293
## Dscc1          -0.123749   0.752783 -0.89985 -0.92459  0.62698 -0.99022
## Vdr            -0.242347   0.517366 -1.16339 -1.27981 -0.38854 -0.74232
## Ly6c2          -0.277478   0.196752 -0.89685 -0.33266 -0.54842 -0.12230
## Ly6i           -0.470717  -0.213341 -0.56447 -0.57624 -0.41510 -0.09549
## Chaf1b          0.357500   0.495203 -0.89976 -0.20981  0.25188 -0.81785
## Fam132a         0.219649   0.448125 -1.03640 -0.24018  0.07138 -1.50948
## Il33            0.979336   0.493215 -0.68210 -1.16317 -1.79101 -1.16785
## Irf7           -0.364956   0.038237 -1.11866 -0.58166 -0.18524 -0.15084
## Tyms            0.280236  -0.035424 -0.89158 -0.09646  0.65140 -1.32409
## Hk3            -0.225815  -0.286179 -0.82475 -0.39578 -0.49212 -0.22519
## Il1rl1         -0.311045   0.792026 -1.25327 -0.58407  0.38585 -1.30471
## Stat1           0.225071   0.023895 -0.98338 -0.86868 -1.04181 -0.42361
## Steap3          0.085667   0.851254 -0.95136 -0.44551  0.19575 -1.32960
## Ube2t          -0.450943   0.413908 -1.01757 -0.17989  0.55711 -1.64846
## Mnda           -0.168467  -0.183559 -1.04530 -0.72684 -0.77014 -0.13882
## Xcl1           -0.846750  -0.743272 -0.76175 -0.21399 -0.84057 -0.38426
## Atf3            0.224282  -0.314127 -0.49388 -0.91661 -1.08270  0.08948
## Mcm10           0.110297   0.531487 -0.98311 -0.72908  0.60340 -1.37235
## Il2ra           0.155180  -0.056444 -0.74143 -0.61731 -0.66940 -0.64043
## Sapcd2         -0.642482   0.099905 -1.56626 -0.51859  0.03511 -0.22843
## Il1rn          -0.075824  -0.407813 -0.38053 -0.97259 -0.45741  0.11712
## Gatm           -0.104180   0.288075 -1.08818 -0.74848 -0.07219 -0.65822
## Dut             0.295286   0.747005 -1.18231 -0.34264 -0.58193 -0.85069
## Rad51          -0.109177   0.389192 -1.55893 -0.23360  0.57697 -0.70819
## Bub1            0.319793   0.558537 -1.38011 -0.09396  0.62250 -0.95465
## Gins1           0.083721   0.471973 -1.02476 -0.53258  0.42892 -0.79502
## Aurka           0.406374   0.475066 -1.17213 -0.51125  0.91828 -1.70702
## Zbp1            0.205781   0.037554 -0.80623 -0.56696 -1.12079 -0.49769
## Car1            0.158517   0.750020 -1.32684 -0.44442  0.40109 -1.73178
## Il21            0.810342   0.585934 -0.67205 -0.42550 -0.84322 -0.79608
## Ifi44          -0.422060   0.605297 -0.87755 -0.21374 -0.20407  0.20726
## Gbp3           -0.183237  -0.467493 -0.86876 -0.34959 -0.63278 -0.20586
## Gbp2            0.222764  -0.088564 -0.81852 -0.68851 -0.92739 -0.49376
## Smpdl3b         0.248095   0.783910 -1.52612 -0.93518 -0.96061 -0.26635
## Htra3          -0.006936  -0.486901  0.97686  1.12010  0.20410  1.06779
## Cxcl9           0.388267  -0.248794 -0.54832 -1.10016 -1.10740 -0.64685
## Oasl2          -0.286728   0.234928 -0.86555 -0.58373 -0.38827  0.20817
## Hsph1           0.097867   1.072681 -0.55298 -0.03054 -1.86889 -2.03994
## Tfr2           -0.012446   0.738359 -1.16995 -0.03128  0.36007 -1.67751
## Asns            0.099891   0.808108 -1.06717 -0.39276  0.25497 -1.40419
## Klrg1          -0.803708  -0.419447 -1.16022 -1.00421 -0.37061  0.13748
## Klra2          -0.092541  -0.538324 -0.98725 -0.22603 -0.17062 -0.19012
## Bcat1          -0.514881   0.934677  0.22711 -0.10843 -1.89671 -1.09632
## Rad51ap1        0.077996   0.395995 -0.60025 -0.47680  0.56824 -1.12505
## Ddias           0.297556   0.183508 -0.69669 -0.70850  0.75131 -1.43985
## Sult1a1         0.789541  -0.110701  1.06047  1.27698 -0.11643  0.73513
## Plk1            0.220076   0.815401 -0.72919 -0.42968  0.84737 -1.34044
## Tmem159        -0.177576  -0.341254  0.37640  3.58831 -0.46845  0.15716
## Cenpi          -0.064327  -0.036193 -1.02805 -0.25684  0.78918 -1.52664
## Adgrg2          0.176596   0.070281  0.58802  1.98654  0.11602  0.70559
## Cenpn           0.196166   0.163283 -0.39303 -0.78721  0.14613 -1.40951
## Mt2            -0.457363   0.651346 -1.27325 -0.30076  0.28631 -1.41701
## Mt1            -0.327014   1.263396 -1.28063 -0.34302 -0.19029 -1.51436
## Chek1           0.117865  -0.044331 -1.39570  0.21877 -0.28543 -1.48347
## Mns1           -0.279474   0.393929 -0.95009 -0.13555  0.49105 -1.48663
## Ptgs2          -0.641776  -0.804770 -0.50885 -0.13364 -0.14455 -0.20371
## Traip           0.933496   0.092697 -1.39445 -0.41523  0.21712 -1.19110
## Oas3            0.230150   0.232127 -0.99272 -0.58968  0.94727 -0.51698
## C330027C09Rik   0.140756   0.188937 -1.13192 -0.27189  0.72539 -1.28291
## Rtp4            0.161608   0.338089 -1.11419 -0.63365 -0.55414  0.31633
## Apol6          -0.559095  -0.478679 -0.16803 -0.99341 -0.46031  0.07219
## Recql4          0.192785   0.550021 -1.11462 -0.84184 -0.34482 -1.23497
## Pla2g4c         0.742873   0.762590 -1.17691 -0.56730  0.26579 -1.42459
## Polq            0.199317   0.425079 -1.04607 -0.57003  0.59410 -1.27482
## Kif4            0.415991   0.267649 -0.79486 -0.55716  0.83897 -1.38949
## Tmem132c        0.020029  -0.963849  0.94078  0.41851  0.07725  1.12073
## Brip1           0.141917   0.067101 -0.67021 -0.12931 -0.01312 -0.59050
## Lif             0.858607   0.407320 -0.77052 -1.04173 -0.08119 -0.87121
## Gbp8           -0.109612  -0.434592 -0.71269 -0.50679 -0.49899 -0.28391
## Ifit1           0.039307   0.094383 -0.52846 -0.54867  0.02275 -0.16684
## BC030867       -0.825893  -0.093687 -0.62178 -0.38751  0.18242 -1.21457
## Cxcl10         -0.091452  -0.267321 -0.74954 -0.77277 -0.57434 -0.57266
## Ubd             0.070546  -0.189957 -0.59163 -0.70696 -0.54834 -0.66526
## Ccl2           -0.403856  -0.107716 -0.80079 -0.73637 -0.64230 -0.61156
## Fignl1          0.257370   0.429038 -0.91116 -0.48155  0.58959 -1.19005
## Isg15           0.142950  -0.091489 -0.86289 -0.34555  0.84661 -0.63333
## Kif15           0.288226   0.481262 -0.97082 -0.31708  0.72154 -1.48180
## Dtl             0.337004   0.566645 -0.96200 -0.48215  0.40842 -1.41464
## Fam13a          0.476594  -0.117903  1.46425  0.20467 -0.02962  1.36749
## Rmi2           -0.202210   0.315440 -0.96987 -0.61563 -0.46494 -0.81807
## Socs1           0.322719   0.230323 -1.08409 -0.99252 -0.88345 -0.70505
## Eme1            0.254355   0.329750 -1.20702  0.20465 -0.16921 -1.53254
## Fanci           0.646460   0.521284 -1.17725 -0.45199  0.07120 -1.15532
## Batf2          -0.183926  -0.780403 -0.65533 -0.22221 -0.45766 -0.58337
## 2810417H13Rik   0.517229   0.601476 -1.01789 -0.30759 -0.07432 -0.71336
## Gbp7            0.021727   0.053613 -0.97809 -0.65030 -0.66090 -0.56967
## Gbp2b          -0.551785  -0.337012 -0.66742 -0.27967 -0.47969 -0.19355
## Olfr56          0.238211  -0.561073 -0.85572 -0.33844 -0.13673 -0.17038
## Il7             0.242342   0.308049  0.58490  1.13663  0.96448  0.81975
## Pklr           -0.268162   1.135252 -1.27032 -0.16723  0.17671 -1.35404
## Serpina3g       0.163083  -0.045116 -0.91220 -0.81743 -0.86521 -0.31111
## Abca8a         -0.622820  -0.058445  0.59047  1.03265  0.81320  0.68039
## Mmp3            0.452743  -0.968619  0.18504 -0.64342 -0.66815 -1.20745
## Tnip3           0.260457  -0.659605 -0.83818 -0.11467 -0.87839 -0.80383
## Gvin1           0.275387   0.064986 -0.94332 -0.68183 -0.99880 -0.52015
## Ifit2          -0.190117  -0.128459 -0.86382 -0.30139 -0.63637 -0.11665
## Fam26f         -0.010906  -0.520167 -0.60080 -0.82408 -0.89047 -0.19880
## Irgm1           0.195597   0.044562 -0.95618 -0.73325 -0.77672 -0.56216
## Kcne4           0.367082   0.195683 -0.39862 -1.57186 -1.67095 -0.69804
## Bex4            0.188132   0.656148 -0.95705 -0.27059  0.49434 -2.30797
## Ccr4           -0.354552  -0.086103 -0.59686 -1.00233 -0.58580 -0.26907
## Ckap2l          0.311283   0.374884 -1.09321 -0.31612  1.04973 -1.32321
## Gm12185        -0.038688   0.012158 -0.27028 -0.83783 -0.64843 -0.48830
## 2610318N02Rik   0.304855   0.516467 -0.77556 -0.91651 -1.14194 -0.29556
## Tcf19           0.379622   0.062490 -1.17958 -0.59384  0.37979 -0.57759
## Mmp13          -0.186863  -0.965214 -0.48109 -0.90954 -0.69745 -0.27592
## Socs3           0.360284   0.257935 -0.86943 -0.82139 -1.39370 -0.56371
## Slamf8          0.006450  -0.749494 -0.26469 -0.34168 -0.89902 -0.33815
## Iigp1           0.033814  -0.134776 -0.92185 -0.90814 -0.89485 -0.39759
## Ifng           -0.082807  -0.500045 -0.77459 -0.84180 -1.14119 -0.51279
## Fam72a          0.600124  -0.781319 -0.77425  0.11931 -0.62231 -0.81635
## Fcgr4          -0.089999   0.033168 -0.89397 -0.33133 -0.56323 -0.42943
## Obscn          -0.305386   0.486988  0.81930  0.99560  1.18767  0.37231
## Sphk1          -0.038967   0.749755 -0.66283 -0.96324  0.51524 -1.47108
## Serpina10       1.429452  -0.059148 -1.81967 -1.65812 -0.92438 -0.90495
## Tubb3           0.360257   0.035988 -0.17644 -0.40275 -0.49329 -0.37838
## Serpina3f       0.120927   0.040981 -0.98169 -0.76222 -0.92601 -0.41431
## Zbtb16          1.361853   1.098623  0.78240  0.01597 -0.91703  1.33530
## Gm4841         -0.368568  -0.236157 -0.88905 -0.48915 -0.69137 -0.05165
## Slfn9          -0.053100  -0.090243 -0.70508 -0.21867 -0.22307 -0.18813
## Irgm2           0.026272  -0.098564 -1.00962 -0.77069 -0.97829 -0.43532
## Cited4          0.539771   1.147472 -1.47865 -0.09099  0.08002 -0.97683
## Gm4951         -0.108618  -0.360360 -0.54581 -0.52162 -0.84529  0.10822
## Nlrc5           0.475963   0.002039 -0.93469 -0.49067 -1.61614 -0.14170
## Amy2a5         -0.537507  -0.470566 -0.41846 -0.25408 -0.25765 -0.70257
## Spc24           0.030115  -0.115061 -0.95167  0.10952  0.50007 -1.09974
## Ifit3          -0.630448   0.065348 -0.52560 -0.26862 -0.20284  0.23501
## Cenpw           0.227473   0.545559 -1.23404 -0.74658  0.36236 -0.45793
## Ly6a            0.169417   0.268749 -0.87970 -0.28358 -0.72449 -0.09977
## Aunip           0.427482   0.905262 -0.86399 -0.61892  0.29059 -1.53832
## Gm4070          0.272322  -0.004467 -1.15856 -0.66743 -1.04953 -0.38036
## Igtp            0.294635   0.066821 -0.99582 -0.79911 -1.04796 -0.76334
## Ifi47           0.225511   0.006283 -0.88933 -0.63123 -0.98217 -0.67778
## Tgtp2           0.223826  -0.146924 -1.00101 -1.06156 -0.82540 -0.65328
## Tgtp1           0.365577   0.068464 -0.97224 -0.81190 -1.14904 -0.79955
## Ifit1bl1       -0.025387   0.073779 -0.66748  0.02830 -0.64377 -0.07544
## Gm43302         0.366769   0.108576 -0.42543 -1.34102 -1.16095  0.38435
## Gbp4            0.298218  -0.037158 -0.76093 -0.83191 -1.20857 -0.59506
## Hspa1b         -0.166636   0.863116 -0.61031 -0.55413 -1.86057 -1.07026
## F830016B08Rik  -0.208012  -0.077294 -0.99380 -0.59106 -0.83204 -0.10751
## Gm17334         0.078265  -0.087213 -1.15471 -0.50355 -1.07138 -0.88066
## Apol11b         0.507129  -0.022970 -0.29663 -0.64698  1.01316 -1.19087
## Hist1h3g        0.736136   0.438499 -1.25292 -0.63627  0.60073 -1.31013
## Gbp6            0.255779   0.092683 -1.00881 -0.82791 -1.10237 -0.60468
## Gbp10           0.197831   0.032767 -0.72385 -0.47700 -1.16632 -0.76620
## Gbp5           -0.006087  -0.199676 -0.68479 -0.72466 -0.94913 -0.43002
## Cela3b         -0.610776  -0.610776 -0.61078  1.24916 -0.61078 -0.61078
## Ctrb1          -0.607601  -0.428566 -0.42875  1.34725 -0.42216 -0.60760
## Ttc41          -0.134901   0.804719  1.34954  0.24518  0.32493  0.83655
## Reg1           -0.545280  -0.545280 -0.54528  1.25663 -0.54528 -0.54528
## Amy2a3         -0.555135  -0.555135 -0.55514  1.38927 -0.55514 -0.55514
## Amy2a2         -0.555135  -0.555135 -0.55514  1.38927 -0.55514 -0.55514
## Amy2a4         -0.555135  -0.555135 -0.55514  1.38927 -0.55514 -0.55514
##     heat.list day delivery rep
## 13   naive.r1   0    naive   1
## 14   naive.r2   0    naive   2
## 15   naive.r3   0    naive   3
## 16   naive.r4   0    naive   4
## 1   sbp.d3.r1   3      sbp   1
## 2   sbp.d3.r2   3      sbp   2
## 3   sbp.d3.r3   3      sbp   3
## 4   sbp.d3.r4   3      sbp   4
## 9  rtmt.d3.r1   3     rtmt   1
## 10 rtmt.d3.r2   3     rtmt   2
## 11 rtmt.d3.r3   3     rtmt   3
## 12 rtmt.d3.r4   3     rtmt   4
## 5    mt.d3.r1   3       mt   1
## 6    mt.d3.r2   3       mt   2
## 7    mt.d3.r3   3       mt   3
## 8    mt.d3.r4   3       mt   4

4.6 Ifng

## [1] "ENSMUSG00000055170"

## [1] 843
## [1] 855
## [1] 766

4.7 Heatmap of ISGs unique to MT and RTMT

##           sbp.d6.r1 sbp.d6.r2 sbp.d6.r3 sbp.d6.r4 mt.d6.r1 mt.d6.r2
## B3gnt8    -0.068448  0.216193  0.007990  -0.57523 -0.68598 -0.82295
## Ccrl2      0.103731  0.355740  0.359574  -0.06783  0.36246  0.27072
## Epb41l1    0.304218 -0.860643  0.105673  -0.97897 -0.77185 -1.28460
## Eya1      -0.208376  0.225788 -0.081829  -0.11969 -0.25338 -0.01342
## Igfbp4    -0.825054 -0.487663 -0.940250  -0.23272  0.04256  0.37101
## Lox       -0.067240 -1.971500 -0.696712  -0.24098  1.10214  0.96383
## Oaf        0.743467 -0.677860 -0.115009   0.25231  1.75428  0.36168
## Pola2      0.385802  0.734549  0.339242   0.18755  0.75815  0.42683
## Acpp       0.293898 -0.152581  0.054735  -0.11824 -1.41588 -0.25106
## Adamtsl4   0.441989 -0.186479 -1.062666   0.60908 -1.52635 -0.17512
## Agpat9     0.173475 -0.096227  0.791701   0.20059 -1.63511 -0.48557
## AI607873   0.108824  0.195724  0.472340   0.41240  0.26028  0.47222
## Ank        0.080367 -0.342630 -0.258593  -0.66890 -0.96959 -0.97788
## Aox1      -1.342519  0.051220  0.182260   0.30563 -0.33386 -0.67756
## B2m        0.358161  0.279908  0.429032   0.52719  0.55250  0.65481
## Basp1      0.072513 -0.072171  0.284211   0.21118  0.72323  0.79703
## Bcl2a1b    0.054528  0.181623  0.198186  -0.04103  0.22173  0.72975
## Blvra      0.765710 -0.145010  0.016556  -0.02292  0.89534  0.96906
## Brwd1     -0.589696 -0.429789 -0.242214  -0.27882 -0.99232 -0.52502
## C1rl      -0.391445  0.243637 -0.165320   0.51652  0.96067  0.87028
## Casp12    -0.117099  0.647364  0.430509   0.53670  0.94380  0.64570
## Ccdc125   -0.171015 -0.435226  0.163099  -0.07484 -0.65996 -0.86642
## Cfh       -0.376435 -0.009423 -0.354583  -0.28383 -0.74368 -0.60008
## Cish      -0.088582  0.533734 -0.515993   0.26389  0.23010  0.99768
## Clic4      0.418385  0.250312  0.314014   0.36999  0.45057  0.46998
## Csrp1      0.311618  0.203074  0.264403   0.59433  0.54692  0.66599
## Ctla2b    -0.093533  0.006361 -0.568235   0.24648  1.11660  1.01564
## Ctsd       0.096685 -0.217004  0.271347   0.05289  0.96476  0.93651
## Cttnbp2nl  0.036532 -0.070586  0.147890   0.30394  0.76699  0.86733
## Dnase1l3   0.143341 -0.002492  0.013074   0.21613  0.67673  0.85256
## Eepd1     -0.114446 -0.148122 -0.570796  -0.37894 -0.66331 -0.61803
## Fam162a    0.656002 -0.315084  0.551854   0.11972  0.77598  0.39468
## Fam214a   -0.336903 -0.500910 -0.012488  -0.69783 -0.06457 -0.89470
## Fas        0.019560  0.196372  0.019069   0.53570  0.59400  0.38769
## Fblim1    -0.179557 -0.252501  0.133833   0.35290  1.45217  0.78371
## Fbxl20    -0.119433 -0.256183 -0.199434  -0.37133 -0.93250 -0.65309
## Fcgr3      0.059735 -0.350111  0.189398   0.04490  1.13705  0.99473
## Fgf2      -0.825406 -0.273888  0.805424   0.27347 -0.68333 -0.60367
## Fry       -0.169645 -0.044576  0.149844   0.28219 -1.00866 -0.52716
## Gca       -0.408708  0.196835 -0.294657  -0.89241  1.64169  0.17573
## Gnb4      -0.109532  0.291090  0.047257   0.20946  0.24338  0.77939
## Gpnmb     -0.384956 -1.142113  0.003326   0.72635 -0.40280  0.95238
## Gsr        0.366322  0.295519  0.285841   0.51252  0.68960  0.52267
## Id2        0.176781  0.023377  0.450923   0.50561  0.22054  0.81812
## Ier3       0.032120 -0.567241  0.177572  -0.22154  0.54460  0.81921
## Insr      -0.350611 -0.311431 -0.155202  -0.32668 -0.55959 -0.61032
## L1cam     -0.792212  0.170780  0.092717   0.16730 -1.59554 -0.54391
## Ly75       0.239449  0.169868  0.140238   0.25730  0.65251  0.60689
## Mab21l3   -0.227400 -0.418116 -0.270087  -0.18287  0.24608  1.10150
## Map2k6    -0.181955  0.061798 -0.122101  -0.35565 -0.93567 -0.47382
## Matn2     -0.165827 -0.452114 -0.188527  -0.01037 -0.18867 -0.27899
## Metrnl    -0.093432  0.140604  0.216662   0.12641  0.55787  0.81905
## Nifk       0.657968  0.453728  0.411428   0.48073  0.73288  0.39412
## Mrps34     0.562970  0.337623  0.483235  -0.17415  0.98932  0.60277
## Mylip     -0.392342 -0.228153 -0.191603  -0.58269 -0.63558 -0.55508
## Myo1f      0.244002  0.310985  0.090381   0.61004  0.35441  0.67959
## Nabp1      0.009371 -0.306950 -0.082334  -0.13875  0.67435  0.90274
## Nlrp10    -0.559423  0.064624  0.556405  -0.91394 -0.67258 -1.36596
## Nod1      -0.175392 -0.021001  0.286739   0.20398  0.71820  0.59972
## Nos2      -0.410736 -0.834258 -1.066556   0.17268 -0.05019  0.58656
## Nr1h3     -0.139151  0.035889  0.137890   0.20694  0.80149  0.81564
## Parp10     0.396646  0.286746  0.621691   0.23909  0.56896  0.55205
## Phxr4     -0.608728  0.070346 -0.593876  -0.03455 -1.33935 -0.31520
## Pla2g4a   -0.032111  0.014100 -0.096796   0.09352  0.71192  0.69907
## Pnpt1      0.511881  0.397341  0.697635   0.37021  0.49421  0.26745
## Prune2     0.636161 -0.084140 -0.347718   0.38979 -0.05354  0.78542
## Pxdc1     -0.175717  0.447687 -0.484176  -0.43304 -0.60863 -0.76335
## Rab19      0.054549  0.677060  0.737528  -0.08461  0.25095  0.56883
## Ralgds     0.153852  0.008135  0.172480   0.13241 -0.19796  0.57540
## Rangap1    0.366060  0.421082  0.219512   0.44846  0.81322  0.49480
## Rasal2    -0.508312  0.101306 -0.338181  -0.64536 -0.83680 -0.39273
## Rora      -0.526267 -0.297645 -0.247467  -0.20906 -0.98958 -0.11729
## Sap30     -0.146863  0.269187 -0.068467   0.75680  0.72282  0.73539
## Sdc3       0.192417 -0.097863  0.165791   0.34313  1.10182  0.86510
## Sdc4       0.177226  0.003971  0.170796   0.33308  0.10794  0.47878
## Serpinb6b  0.264923  0.113999  0.214410   0.31921  0.59259  0.82522
## Slc2a6     0.057992 -0.146768  0.045767   0.07957  0.03710  0.53347
## Specc1     0.963486 -0.145926 -0.269338  -0.49539 -0.24902 -0.83173
## Stk39      0.132417  0.388930 -0.006416   0.83877 -0.01709  0.47649
## Tfec       0.026965 -0.184640  0.180969  -0.31362  0.96342  1.09857
## Tmem191c   0.350134 -0.556451 -0.321022  -0.01527 -0.44122 -0.44279
## Tmod1      0.825343  0.048555  0.407916  -0.44207  0.20244 -0.92295
## Xylt1      0.524417 -0.232340 -0.468489  -1.11818 -1.52079 -0.77060
##           mt.d6.r3 mt.d6.r4 rtmt.d6.r1 rtmt.d6.r2 rtmt.d6.r3 rtmt.d6.r4
## B3gnt8     -0.7910 -0.17029  -0.828974  -1.316003    -0.9205   -0.11885
## Ccrl2       0.3123  0.16238   0.448964   1.635882     0.7333    0.85335
## Epb41l1     0.5893  0.09446  -0.846986  -1.333715    -0.4710    0.16631
## Eya1        0.0816 -1.28874  -0.529355  -1.312371    -1.0007   -0.78434
## Igfbp4     -0.4968 -0.83448  -0.970779  -0.813677    -0.3595   -0.53327
## Lox        -1.1061  0.52659  -0.643685  -1.303332     0.7762   -0.27157
## Oaf         0.7998  1.31655   0.174018   0.384023     0.3247    0.21034
## Pola2       0.3749  0.57476   0.721367   0.497285     0.6604    0.76020
## Acpp       -0.7446 -0.50001  -0.333528  -0.312014    -1.6467   -0.56569
## Adamtsl4   -0.5914  0.62138  -0.667320  -0.438321    -0.9219   -0.88326
## Agpat9     -0.7930  0.25757  -0.940459  -0.387573    -1.4476   -0.53161
## AI607873    0.5441  0.57537   1.073519   0.906621     0.8962    0.51827
## Ank        -0.6188 -0.59144  -0.287606   0.145195    -0.5887   -0.96494
## Aox1       -1.0292 -0.61181   0.090929  -0.532648    -1.1462   -0.82153
## B2m         0.4604  0.63400   0.637036   0.682516     0.7714    0.64718
## Basp1       1.2428  0.73982   0.659180   0.458385     0.6829    0.49711
## Bcl2a1b     0.9150  0.38959   0.674020   1.096771     0.7554    1.10142
## Blvra       0.7992  1.08616   0.380117   0.396298     0.6767    0.40037
## Brwd1      -0.1403 -0.79800  -0.464915  -0.222922    -0.9813   -0.77798
## C1rl       -0.1119  0.79247   0.940861   0.449145     0.9660    0.94280
## Casp12      0.4329  0.36837   0.844930   0.104185     1.4035   -0.01445
## Ccdc125    -0.8603 -1.06032  -0.623845  -0.203610    -0.6435   -0.83654
## Cfh        -0.3760 -0.83769  -0.636810  -0.819704    -0.4008   -0.96077
## Cish        0.9487 -0.06136   0.653375   0.993235     0.7360    0.98929
## Clic4       0.3593  0.56944   0.686170   1.078215     0.8016    0.74548
## Csrp1       0.4287  0.72752   0.599589   0.577970     0.9484    0.68856
## Ctla2b      1.3033  0.46063   0.749699   0.478116     0.9090    0.25226
## Ctsd        0.5422  0.67052   0.419618   0.595659     1.2071    0.71816
## Cttnbp2nl   0.7944  0.57882   0.745086   0.616451     1.1291    0.42197
## Dnase1l3    1.1550  0.62318   0.495358   0.623121     0.9478    0.54850
## Eepd1      -0.2661 -0.88489  -0.654193   0.157954    -1.1610   -0.76567
## Fam162a     0.7675  0.76272   0.462685   0.860402     0.2519    1.03361
## Fam214a    -0.8193 -0.56867  -0.672144  -0.866074    -0.3632   -0.65144
## Fas         0.4084  0.53446   0.723333   0.863447     0.8061    1.22994
## Fblim1      0.6797  0.42364   0.776845   0.783294     0.7699    0.35457
## Fbxl20     -0.8650 -0.58648  -0.476061  -0.499448    -0.9132   -0.63298
## Fcgr3       1.1401  0.88930   0.689034   0.453849     0.7534    0.06396
## Fgf2       -1.2077 -0.67732   0.103702  -1.115532    -0.4438   -0.88446
## Fry        -0.9161 -1.09477  -0.382675  -0.449469    -1.0281   -0.78006
## Gca         0.8700 -0.46647   0.344741   0.979535     1.3960    0.88880
## Gnb4        1.1406  0.27127   0.898090   0.944983     1.0354    0.49276
## Gpnmb      -0.1126  0.79567   0.696414   0.909600     1.5078    1.19806
## Gsr         0.5689  0.71397   1.099984   0.579650     0.5073    0.41548
## Id2         0.5989  0.70328   0.860023   0.337549     0.7737    0.98082
## Ier3        0.6572  0.40864   0.264675   0.957404     1.2500    1.38727
## Insr       -0.6954 -0.54238  -0.510962  -0.598217    -0.7369   -1.12639
## L1cam      -0.8351 -0.36927  -0.376009  -0.386019    -0.3124   -1.04792
## Ly75        0.8009  0.40265   0.550795   0.765636     0.9796    0.88721
## Mab21l3     1.0504  0.73441   0.724708   1.211621     0.8952    0.73488
## Map2k6     -0.1728 -0.67146  -1.052422  -0.971408    -0.1400   -1.17653
## Matn2      -1.1625 -0.16110  -0.896315  -1.219159    -0.7401   -0.74106
## Metrnl      0.6052  0.77180   0.986297   0.729171     0.9168    0.55117
## Nifk        0.5070  0.50504   0.642438   0.712170     0.6432    0.52672
## Mrps34      0.1333  0.77814   0.837998   0.685784     0.8981    0.15048
## Mylip      -0.3565 -0.71419  -0.678916  -0.792171    -0.7844   -0.64947
## Myo1f       0.6498  0.64606   0.648957   0.410100     0.7891    1.02383
## Nabp1       1.1392  0.55361   0.643676   0.541619     1.0148    1.02916
## Nlrp10     -0.6356 -0.78102   0.003491  -0.144072    -1.1335   -0.17464
## Nod1        1.0160  0.50885   0.699875   0.490361     0.8509    1.06135
## Nos2        0.8612 -0.01503   0.722548   1.508476     1.1758    1.44309
## Nr1h3       1.0003  0.73498   0.520767   0.607772     0.9418    0.66533
## Parp10      0.4417  0.47637   0.777154   1.161164     0.2757    0.68701
## Phxr4      -0.5883 -0.51002   0.010499  -0.793528    -0.6432   -0.85899
## Pla2g4a     0.7833  0.66823   0.891342   0.628951     1.0184    0.75923
## Pnpt1       0.4576  0.87229   0.656027   0.853070     0.4898    0.48371
## Prune2      0.9826  0.89178   0.887909   0.340584     0.8816    0.83987
## Pxdc1      -0.5438 -0.69584  -0.830835  -0.876979    -0.9406   -0.39166
## Rab19       0.7797  0.55306   0.503343   0.371410     0.7878    1.11829
## Ralgds      0.5179  0.87060   0.717045   0.827697     1.2072    1.13189
## Rangap1     0.4475  0.49546   0.641972   0.930298     0.5496    0.71012
## Rasal2     -0.6602 -0.33915  -0.597364  -0.891925    -0.7575   -0.53018
## Rora       -0.9284 -0.76948  -0.504869  -0.510683    -0.6751   -0.64612
## Sap30       0.7490  0.73631   0.904453   0.517960     0.5927    0.55417
## Sdc3        0.8211  0.93411   0.352123   0.493606     0.8581    0.25711
## Sdc4        0.8079  0.49586   0.920945   1.071935     1.0467    0.71483
## Serpinb6b   0.8806  0.54167   0.547696   0.348336     0.9535    0.86398
## Slc2a6      0.2687  0.33828   0.779988   1.410183     1.0884    1.36015
## Specc1     -1.2632  0.39268  -0.116618   0.857969    -1.2188   -0.57953
## Stk39       1.0461  0.24295   0.754990   0.402048     1.1103    0.78443
## Tfec        1.2872  0.83142   0.428181  -0.006777     1.0525    0.51545
## Tmem191c   -0.9028 -0.78291  -0.837828  -1.240250    -0.4435   -0.25706
## Tmod1      -0.8753  0.31478  -0.643039   0.604897    -1.1996   -0.70547
## Xylt1      -0.4754 -0.08086  -0.730239  -0.085410    -0.5249   -0.48195
##           naive.r1 naive.r2  naive.r3 naive.r4
## B3gnt8      1.9985   1.3553  1.406039   1.3141
## Ccrl2      -1.7853  -1.7764  0.009435  -1.9784
## Epb41l1     1.3415   0.6538  1.328507   1.9640
## Eya1        2.3215   1.8668  0.718854   0.3776
## Igfbp4      2.0851   1.1768  0.998637   1.8201
## Lox         1.4300   0.5792 -0.352401   1.2756
## Oaf        -1.5235  -1.0541 -1.146285  -1.8045
## Pola2      -1.6836  -1.7978 -0.851530  -2.0881
## Acpp        1.5546   1.7153  0.726536   1.6952
## Adamtsl4    2.0846   0.2388  1.720830   0.7361
## Agpat9      1.8742   0.4719  1.658180   0.8895
## AI607873   -1.9273  -1.4965 -1.732230  -1.2799
## Ank         1.4169   1.2387  2.425480   0.9624
## Aox1        1.1820   1.7848  1.445940   1.4527
## B2m        -1.7585  -1.5057 -1.858294  -1.5117
## Basp1      -1.7731  -1.7197 -1.737220  -1.0661
## Bcl2a1b    -1.7098  -1.4571 -1.674111  -1.4360
## Blvra      -1.7009  -1.7418 -1.126556  -1.6483
## Brwd1       1.5488   1.4706  1.992497   1.4314
## C1rl       -1.3876  -1.2517 -1.884837  -1.4896
## Casp12     -1.3274  -1.6871 -1.638162  -1.5737
## Ccdc125     1.7043   1.1455  1.511976   1.9107
## Cfh         1.8835   1.9584  1.078405   1.4795
## Cish       -1.6693  -1.8128 -0.392966  -1.8050
## Clic4      -1.7354  -1.8793 -1.258302  -1.6405
## Csrp1      -1.6193  -1.9585 -1.589163  -1.3901
## Ctla2b     -1.6379  -1.4570 -1.211753  -1.5697
## Ctsd       -1.6687  -1.5870 -1.486900  -1.5158
## Cttnbp2nl  -1.6759  -1.7964 -1.579803  -1.2858
## Dnase1l3   -1.6796  -1.7684 -1.737774  -1.1065
## Eepd1       1.9481   2.1669  0.842030   1.1105
## Fam162a    -1.6629  -1.3982 -1.407113  -1.8538
## Fam214a     1.7966   1.8486  1.308104   1.4950
## Fas        -1.3156  -1.3424 -1.997551  -1.6625
## Fblim1     -1.1200  -1.7292 -1.579255  -1.6502
## Fbxl20      1.7201   1.4169  1.632626   1.7355
## Fcgr3      -1.5956  -1.4986 -1.437607  -1.5336
## Fgf2        2.1701   1.3050  0.963444   1.0939
## Fry         1.6436   0.9888  2.038534   1.2982
## Gca        -1.3258  -1.1421 -1.819409  -0.1438
## Gnb4       -1.5316  -1.6612 -1.383120  -1.6682
## Gpnmb      -1.6910  -0.9635 -0.654898  -1.4376
## Gsr        -1.7371  -1.3414 -1.682459  -1.7967
## Id2        -1.4123  -1.4765 -1.849889  -1.7108
## Ier3       -1.3535  -1.8923 -0.999729  -1.4644
## Insr        1.5722   1.5630  1.915661   1.4734
## L1cam       2.0022   0.9004  1.307733   1.6173
## Ly75       -1.6063  -1.5564 -1.943771  -1.3466
## Mab21l3    -1.7726  -1.7689 -1.141956  -0.9169
## Map2k6      1.2437   1.7107  1.807943   1.4297
## Matn2       1.3859   1.9394  1.323482   1.5561
## Metrnl     -1.6272  -1.9134 -1.145544  -1.6414
## Nifk       -1.8136  -1.5792 -1.654899  -1.6198
## Mrps34     -2.1414  -1.4194 -1.475840  -1.2489
## Mylip       1.6715   1.5088  1.971397   1.4094
## Myo1f      -1.9401  -1.6156 -1.761002  -1.1405
## Nabp1      -1.4782  -1.5238 -1.854080  -1.1244
## Nlrp10      1.0604   1.6866  1.936251   1.0730
## Nod1       -1.8259  -1.5433 -1.797454  -1.0728
## Nos2       -1.9416  -1.1520 -0.600398  -0.3996
## Nr1h3      -1.6828  -1.3710 -1.741572  -1.5344
## Parp10     -1.5832  -1.9098 -1.758573  -1.2327
## Phxr4       1.9367   1.7022  1.125632   1.4403
## Pla2g4a    -2.0821  -1.4488 -1.682049  -0.9262
## Pnpt1      -1.9467  -1.7412 -1.189353  -1.6740
## Prune2     -1.6849  -1.3417 -1.439458  -1.6842
## Pxdc1       1.9291   1.4120  1.350446   1.6054
## Rab19      -1.8998  -1.7292 -1.668716  -1.0202
## Ralgds     -1.9429  -1.4765 -1.383521  -1.3137
## Rangap1    -1.7191  -1.7203 -1.169684  -1.9289
## Rasal2      2.2183   1.3756  1.555519   1.2470
## Rora        1.0965   1.6267  1.898703   1.8001
## Sap30      -1.9708  -1.3715 -1.167627  -1.8135
## Sdc3       -1.6772  -1.7061 -1.760742  -1.1424
## Sdc4       -1.5381  -1.7116 -1.691607  -1.3886
## Serpinb6b  -1.7461  -1.7143 -1.710441  -1.2953
## Slc2a6     -1.4031  -1.1077 -1.468728  -1.8734
## Specc1      0.9114   0.3254  2.626245  -0.9077
## Stk39      -0.9825  -1.6005 -2.149310  -1.4215
## Tfec       -1.3407  -1.6908 -1.221610  -1.6265
## Tmem191c    2.4960   1.2183  0.915953   1.2608
## Tmod1       0.2292   0.9768  2.561455  -1.3830
## Xylt1       1.3623   1.3019  1.739903   1.5606
##     heat.list day delivery rep
## 13   naive.r1   0    naive   1
## 14   naive.r2   0    naive   2
## 15   naive.r3   0    naive   3
## 16   naive.r4   0    naive   4
## 1   sbp.d6.r1   6      sbp   1
## 2   sbp.d6.r2   6      sbp   2
## 3   sbp.d6.r3   6      sbp   3
## 4   sbp.d6.r4   6      sbp   4
## 9  rtmt.d6.r1   6     rtmt   1
## 10 rtmt.d6.r2   6     rtmt   2
## 11 rtmt.d6.r3   6     rtmt   3
## 12 rtmt.d6.r4   6     rtmt   4
## 5    mt.d6.r1   6       mt   1
## 6    mt.d6.r2   6       mt   2
## 7    mt.d6.r3   6       mt   3
## 8    mt.d6.r4   6       mt   4

4.8 ISGs SBP and RTMT Day 4

##           sbp.d4.r1 sbp.d4.r2 sbp.d4.r3 sbp.d4.r4 mt.d4.r1 mt.d4.r2
## Apol10b     1.03776 -0.816034 -0.113547   1.29597  0.76460   1.0155
## Apol6       1.00453 -1.349732  0.286550   1.13368  0.71920   1.1975
## Asns        0.48705 -0.073036  0.694714   0.20845  1.11489   1.3200
## Aunip       0.18854 -0.481171  0.364887   0.20923  1.29080   1.4327
## Batf2       0.98472 -1.143042  0.143331   0.91025  0.94469   1.0770
## Bcl2l14     0.91542 -1.140906  0.210147   1.36929  0.70080   1.0182
## Ccl2        1.49558 -1.167034  0.176797   0.82728  0.82980   1.4810
## Cd163      -1.10995  0.795306  0.476639  -0.14125 -1.18887  -1.8810
## Cd274       1.12193 -1.179835  0.105092   0.92930  0.91991   1.1795
## Cdc45       0.29059 -0.457178  0.386845   0.06097  1.42695   1.6049
## Chaf1a      0.30067 -0.769839  0.392644   0.30398  1.32043   1.4725
## Cmpk2       0.72938 -1.007336  0.033653   0.77961  1.36763   1.4389
## Cxcl10      0.90099 -1.193210  0.343507   0.93279  0.86244   1.0315
## Cxcl9       1.05372 -0.945375  0.506726   1.01699  0.89947   1.0880
## Dtl         0.12084 -0.175633  0.431137   0.11417  1.25523   1.4850
## Fam132a     0.28185 -0.549356  0.732392   0.27567  0.83165   1.5145
## Fam13a     -0.73472  0.318186 -0.407615  -0.24561 -0.93582  -1.6695
## Fam26f      0.86780 -1.165909  0.186357   0.94466  0.88510   1.3127
## Fanci       0.10139 -0.059405  0.623711   0.29723  1.33428   1.5773
## Fcgr4       0.62328 -1.011918 -0.225667   0.68885  1.04555   1.4304
## Fos         0.73996 -0.890952 -0.628006   1.38039  1.03002   0.4007
## Gbp11       0.89572 -1.071483  0.373509   1.16661  0.92032   1.1054
## Gbp2        0.99380 -1.177887  0.337606   0.96698  0.96656   1.1217
## Gbp3        0.81259 -1.201132  0.068073   0.87907  1.02476   1.3539
## Gbp4        1.04234 -1.080395  0.377900   1.00781  0.85607   1.0066
## Gbp2b       0.30655 -1.027049 -0.321036   0.78955  1.17702   1.6065
## Gm43302     1.01533 -1.778251  0.449231   0.91562  0.82423   0.8847
## Gbp7        0.85013 -1.138314  0.342306   0.92492  0.96141   1.1584
## Gm12185     0.99805 -1.667083  0.066933   1.04448  0.93344   1.0658
## Gm12250     0.85159 -1.234870  0.479825   0.89913  0.97399   1.0634
## Ifit1bl1    1.13505 -0.989998  0.257895   1.30445  1.18256   0.9905
## Gm17334     1.10707 -1.353709  0.674703   1.07158  0.92026   0.8520
## Gm1966      1.11996 -1.060158  0.688260   1.11701  0.80220   0.7133
## Gm4070      0.91335 -1.136502  0.420128   0.94592  0.89719   0.9168
## Gm4841      0.81527 -1.295282 -0.040600   0.42295  1.14127   1.3192
## Gm4951      0.81488 -1.234608  0.013269   0.80701  0.87687   1.2435
## Gvin1       1.00099 -1.086952  0.465908   0.99267  0.92467   0.9488
## Has2        0.91311 -1.224948  0.915842   0.99442  0.80314   1.0511
## Hk3         1.12793 -0.872360 -0.325371   0.74125  0.95288   1.3378
## Hspa1a      0.48363 -0.908298  0.778535   1.27664 -0.03809   0.3284
## Hspa1b      0.61352 -0.789308  0.909800   1.43552  0.27064   0.2888
## Htra3      -1.48010  0.470597 -0.042283   0.05870 -1.33432  -1.6700
## Ifi204      0.76552 -1.018608 -0.214208   0.99180  1.09421   1.4051
## Ifi44       1.13300 -1.381491 -0.026858   0.99913  1.22803   1.3145
## Ifi47       0.90741 -1.056951  0.371256   0.89286  1.02451   1.2343
## Ifit1       1.05604 -1.123221  0.068788   1.12948  1.30848   1.4377
## Ifit2       0.89751 -0.981553  0.030689   1.22376  1.25119   1.4046
## Ifit3       1.23631 -1.372506  0.060631   1.47269  1.16271   1.0082
## Igfbp3     -0.89670  0.680872 -0.214557  -0.40061 -1.36989  -1.4041
## Igtp        0.92219 -1.134176  0.432706   0.93878  0.94434   1.0619
## Iigp1       0.93233 -1.217259  0.307809   0.82924  0.95199   1.1185
## Il12rb1     1.06223 -1.135382  0.369164   1.16063  0.75893   1.1364
## Il1rn       1.23948 -1.059147  0.078629   0.74793  1.29698   1.4143
## Il2ra       0.85018 -1.356766 -0.087927   0.73620  1.09820   1.3964
## Irf1        0.99728 -1.085325  0.570774   0.93881  0.84365   0.8671
## Irf7        1.05983 -1.145092  0.044739   1.25236  1.25574   1.3267
## Acod1       1.18149 -1.170482 -0.238035   0.67834  1.14662   1.5274
## Irgm1       0.91390 -1.124964  0.500989   0.91583  0.97178   1.1148
## Irgm2       0.96174 -1.308185  0.504834   1.05715  0.80754   0.8832
## Klra2       0.66349 -1.063303 -0.537462   0.86296  1.35237   1.1138
## Lgals9      0.84508 -1.053011  0.002111   0.67343  1.24232   1.5314
## Lif         1.77466 -0.862010  0.273900   1.28570  1.17669   0.9321
## Lox         0.51496  0.321303 -0.400533   0.44267 -1.22769  -1.3037
## Lrr1        0.04010 -1.009574  0.301811  -0.46203  1.18295   1.6805
## Ly6a        0.88952 -0.934586 -0.028186   0.71615  1.18536   1.5134
## Ly6i        0.76683 -0.802923 -0.216967   0.59075  1.61952   1.4533
## Mab21l3     0.68114 -0.901954 -0.268002   1.28921  0.21314   0.3269
## Maff        0.79434 -0.480629  0.246418   1.55260  0.56564   1.1707
## Mcm10       0.11223 -0.595281  0.377333   0.27684  1.19734   1.5279
## Mlkl        1.05418 -1.148228 -0.067274   0.60857  1.12065   1.4708
## Mmp13       1.32474 -1.014366 -0.271173   0.62663  1.08155   1.4311
## Mnda        0.88635 -1.000911  0.083907   0.88935  1.25705   1.2323
## Mt2         0.89289 -0.348047  0.266479   0.44858  1.18401   1.3422
## Mx1         1.19209 -1.165385 -0.137339   1.57510  1.29992   1.0814
## Nampt       0.98576 -1.071585  0.160113   0.81723  1.12575   1.2952
## Nlrc5       1.15455 -1.352565  0.416473   1.07208  0.80291   0.7484
## Oas3        0.87187 -0.970831 -0.001516   0.97132  1.24113   1.3810
## Oasl2       0.99833 -1.195324 -0.023732   0.97732  1.23151   1.3204
## Oit3       -1.24218  0.820377  0.092339  -0.65642 -1.15377  -1.3070
## Parp9       0.97593 -1.175965  0.186061   1.08205  1.18372   1.2394
## Pla2g16     0.78728 -0.959697  0.242036   0.71366  1.17702   1.3237
## Ppa1        0.91259 -1.014504  0.247976   0.82903  1.15320   1.3571
## Ptgs2       0.77606 -1.057363 -0.130562   0.51766  1.09303   1.8137
## Rad51       0.02524 -0.339290  0.030304   0.22045  1.42345   1.4547
## Rnd1        0.53783 -0.564769 -0.247837  -0.01324  0.91532   0.7838
## Rtp4        1.01717 -1.169042  0.002673   1.10002  1.27483   1.3115
## Serpina3f   0.91729 -1.252431  0.310579   0.86715  0.85791   1.0531
## Serpina3g   0.83066 -1.189721  0.215231   0.77767  0.94263   1.1401
## Serpina3n   1.01127 -1.332723  0.605127   0.73233  0.82057   0.2346
## Shcbp1     -0.01474 -0.333766  0.106546  -0.51305  1.30047   1.6672
## Slamf8      1.00458 -1.239395 -0.078989   0.79517  1.04247   1.3787
## Slc7a11     0.76307 -1.386573  0.487031   0.54867  0.89494   0.5684
## Smpdl3b     0.48318 -0.890244 -0.404693   0.67668  1.51393   1.2633
## Socs1       0.95992 -1.142510  0.524817   1.20140  0.82028   0.9523
## Socs3       0.85233 -0.798917  0.289839   0.82483  0.94066   1.1995
## Sphk1       0.19325 -0.632061  0.515193   0.04248  1.12605   1.5829
## Stat1       1.13334 -1.331103  0.619904   1.14155  0.77714   0.6847
## Steap3      0.21168 -0.238498  1.101176   0.24713  0.97638   1.2479
## Syce2       0.10832 -0.349306  0.317246   0.27733  1.15952   1.3915
## Tap1        1.09983 -1.031130  0.284708   1.04099  0.89021   0.9586
## Tgtp1       0.90338 -1.178443  0.464837   0.96074  0.99680   1.0865
## Tgtp2       0.91222 -1.215213  0.619528   1.04694  0.85070   1.0050
## Tnip3      -0.18024 -0.721296 -0.854107  -0.53105  0.79585   1.7965
## Trip13      0.13159 -1.028545 -0.060589   0.06481  1.40524   1.8844
## Tubb3       0.72746 -1.082102 -0.222711   0.48282  1.24596   1.6766
## Ubd         0.83632 -1.129633  0.206517   0.64205  0.91771   1.2389
## Upp1        1.14027 -0.767930 -0.352334   0.30393  1.17134   1.4671
## Vdr         1.48845 -1.036752 -0.163986   1.06956  0.82540   0.8188
## Wars        1.15344 -1.233468  0.164411   1.04848  0.70608   0.9918
## Xaf1        1.07479 -1.048458  0.056383   1.09352  1.36613   1.2288
## Zbp1        1.00323 -1.124500  0.327676   0.94627  1.08861   1.1158
## Abca9      -1.33690  0.782809  0.164748  -0.12984 -1.33285  -1.9433
## Apol10b     1.03776 -0.816034 -0.113547   1.29597  0.76460   1.0155
## Apol6       1.00453 -1.349732  0.286550   1.13368  0.71920   1.1975
## Asns        0.48705 -0.073036  0.694714   0.20845  1.11489   1.3200
## Aunip       0.18854 -0.481171  0.364887   0.20923  1.29080   1.4327
## Bag2       -0.33954  0.281124  0.969122   0.54000  1.17247   0.6306
## Batf2       0.98472 -1.143042  0.143331   0.91025  0.94469   1.0770
## Bcl2l14     0.91542 -1.140906  0.210147   1.36929  0.70080   1.0182
## Bst2        1.28625 -1.124898  0.138624   1.28801  1.02082   1.1789
## Ccl19       1.28658 -0.999250  0.913894   1.50586  0.59050   0.2452
## Ccl2        1.49558 -1.167034  0.176797   0.82728  0.82980   1.4810
## Cd163      -1.10995  0.795306  0.476639  -0.14125 -1.18887  -1.8810
## Cd274       1.12193 -1.179835  0.105092   0.92930  0.91991   1.1795
## Cdc45       0.29059 -0.457178  0.386845   0.06097  1.42695   1.6049
## Cdkn1a      0.98153 -1.089294  0.385626   0.90999  1.00818   0.7798
## Cebpb       1.32761  0.051947  0.579625   1.19062  0.80881   0.7078
## Cela1       2.73261 -0.339340  1.106106  -0.83951  0.25630  -0.3781
## Cmpk2       0.72938 -1.007336  0.033653   0.77961  1.36763   1.4389
## Ctrl        2.75002 -0.875962  1.166097  -0.26965  0.36990  -0.4313
## Ctsf       -1.65682  0.574440 -0.352806  -1.49737 -0.57097  -0.5524
## Cxcl10      0.90099 -1.193210  0.343507   0.93279  0.86244   1.0315
## Cxcl9       1.05372 -0.945375  0.506726   1.01699  0.89947   1.0880
## Dhx58       1.13207 -0.989423  0.211480   1.45103  1.44409   1.0801
## Dram1       1.10409 -1.095168  0.182509   0.69236  1.05268   1.2258
## Dtl         0.12084 -0.175633  0.431137   0.11417  1.25523   1.4850
## Fam132a     0.28185 -0.549356  0.732392   0.27567  0.83165   1.5145
## Fam13a     -0.73472  0.318186 -0.407615  -0.24561 -0.93582  -1.6695
## Fam26f      0.86780 -1.165909  0.186357   0.94466  0.88510   1.3127
## Fanci       0.10139 -0.059405  0.623711   0.29723  1.33428   1.5773
## Fcgr4       0.62328 -1.011918 -0.225667   0.68885  1.04555   1.4304
## Fpr2        1.37318 -0.560716 -0.694596   0.19330  1.28403   1.5549
## Gbp11       0.89572 -1.071483  0.373509   1.16661  0.92032   1.1054
## Gbp2        0.99380 -1.177887  0.337606   0.96698  0.96656   1.1217
## Gbp3        0.81259 -1.201132  0.068073   0.87907  1.02476   1.3539
## Gbp4        1.04234 -1.080395  0.377900   1.00781  0.85607   1.0066
## Gbp2b       0.30655 -1.027049 -0.321036   0.78955  1.17702   1.6065
## Gm43302     1.01533 -1.778251  0.449231   0.91562  0.82423   0.8847
## Gbp7        0.85013 -1.138314  0.342306   0.92492  0.96141   1.1584
## Gbp8        0.81905 -1.152177  0.445368   1.10899  0.64030   1.0021
## Gbp9        1.16360 -1.133796  0.465062   1.25519  0.89506   0.8722
## Gm12185     0.99805 -1.667083  0.066933   1.04448  0.93344   1.0658
## Gm12250     0.85159 -1.234870  0.479825   0.89913  0.97399   1.0634
## Ifit1bl1    1.13505 -0.989998  0.257895   1.30445  1.18256   0.9905
## Gm17334     1.10707 -1.353709  0.674703   1.07158  0.92026   0.8520
## Gm1966      1.11996 -1.060158  0.688260   1.11701  0.80220   0.7133
## Gm4070      0.91335 -1.136502  0.420128   0.94592  0.89719   0.9168
## Gm4841      0.81527 -1.295282 -0.040600   0.42295  1.14127   1.3192
## Gm4951      0.81488 -1.234608  0.013269   0.80701  0.87687   1.2435
## Gm5431      1.04700 -1.396070  0.136661   1.43737  1.37980   0.7119
## Gvin1       1.00099 -1.086952  0.465908   0.99267  0.92467   0.9488
## Has2        0.91311 -1.224948  0.915842   0.99442  0.80314   1.0511
## Hdc         1.80578  0.009917  0.386176  -0.08847  1.35957   0.9842
## Hk3         1.12793 -0.872360 -0.325371   0.74125  0.95288   1.3378
## Hspa1a      0.48363 -0.908298  0.778535   1.27664 -0.03809   0.3284
## Hspa1b      0.61352 -0.789308  0.909800   1.43552  0.27064   0.2888
## Hsph1       0.53106 -0.377984  0.946192   1.09108  0.37917   0.3839
## Htra3      -1.48010  0.470597 -0.042283   0.05870 -1.33432  -1.6700
## Ifit3b      1.45008 -1.082114  0.067267   1.68560  1.13077   0.8509
## Ifi204      0.76552 -1.018608 -0.214208   0.99180  1.09421   1.4051
## Ifi205      0.79040 -0.964714 -0.255414   1.02178  1.17295   1.3717
## Ifi44       1.13300 -1.381491 -0.026858   0.99913  1.22803   1.3145
## Ifi47       0.90741 -1.056951  0.371256   0.89286  1.02451   1.2343
## Ifit1       1.05604 -1.123221  0.068788   1.12948  1.30848   1.4377
## Ifit2       0.89751 -0.981553  0.030689   1.22376  1.25119   1.4046
## Ifit3       1.23631 -1.372506  0.060631   1.47269  1.16271   1.0082
## Ifitm3      1.01641 -1.088033  0.105500   0.99060  1.29050   1.4712
## Igfbp3     -0.89670  0.680872 -0.214557  -0.40061 -1.36989  -1.4041
## Igtp        0.92219 -1.134176  0.432706   0.93878  0.94434   1.0619
## Iigp1       0.93233 -1.217259  0.307809   0.82924  0.95199   1.1185
## Il12rb1     1.06223 -1.135382  0.369164   1.16063  0.75893   1.1364
## Il1rn       1.23948 -1.059147  0.078629   0.74793  1.29698   1.4143
## Irf1        0.99728 -1.085325  0.570774   0.93881  0.84365   0.8671
## Irf7        1.05983 -1.145092  0.044739   1.25236  1.25574   1.3267
## Acod1       1.18149 -1.170482 -0.238035   0.67834  1.14662   1.5274
## Irgm1       0.91390 -1.124964  0.500989   0.91583  0.97178   1.1148
## Irgm2       0.96174 -1.308185  0.504834   1.05715  0.80754   0.8832
## Isg15       0.92855 -0.871457 -0.027270   0.74450  1.46716   1.5521
## Lgals9      0.84508 -1.053011  0.002111   0.67343  1.24232   1.5314
## Lif         1.77466 -0.862010  0.273900   1.28570  1.17669   0.9321
## Ly6a        0.88952 -0.934586 -0.028186   0.71615  1.18536   1.5134
## Ly6c2       0.57432 -0.605606 -0.236691   0.75639  1.33931   1.6132
## Ly6i        0.76683 -0.802923 -0.216967   0.59075  1.61952   1.4533
## Maff        0.79434 -0.480629  0.246418   1.55260  0.56564   1.1707
## Mcm10       0.11223 -0.595281  0.377333   0.27684  1.19734   1.5279
## Mlkl        1.05418 -1.148228 -0.067274   0.60857  1.12065   1.4708
## Mmp13       1.32474 -1.014366 -0.271173   0.62663  1.08155   1.4311
## Mnda        0.88635 -1.000911  0.083907   0.88935  1.25705   1.2323
## Mt1         0.63667 -0.195293  0.878876   0.42787  0.74631   1.3410
## Mt2         0.89289 -0.348047  0.266479   0.44858  1.18401   1.3422
## Mx1         1.19209 -1.165385 -0.137339   1.57510  1.29992   1.0814
## Nampt       0.98576 -1.071585  0.160113   0.81723  1.12575   1.2952
## Nlrc5       1.15455 -1.352565  0.416473   1.07208  0.80291   0.7484
## Nme1        0.83969 -0.530162  0.087741   0.79937  0.90031   1.3774
## Oas1a       0.99076 -1.062589  0.142968   1.06517  1.40385   1.2668
## Oas2        1.09054 -1.062892  0.025462   1.35882  1.33479   1.2076
## Oas3        0.87187 -0.970831 -0.001516   0.97132  1.24113   1.3810
## Oasl1       1.05731 -0.896736  0.391074   1.25924  1.21285   1.3153
## Oasl2       0.99833 -1.195324 -0.023732   0.97732  1.23151   1.3204
## Oit3       -1.24218  0.820377  0.092339  -0.65642 -1.15377  -1.3070
## Parp14      1.03112 -1.364133  0.205950   1.23124  1.07410   0.9255
## Parp9       0.97593 -1.175965  0.186061   1.08205  1.18372   1.2394
## Phf11a      0.95654 -1.131772 -0.074513   0.99265  1.32360   1.2300
## Phf11d      1.37848 -0.947565 -0.319705   1.25397  1.12338   1.2991
## Pkib        1.35191 -0.325030  0.582697   1.05500  0.71519   0.6623
## Pla2g16     0.78728 -0.959697  0.242036   0.71366  1.17702   1.3237
## Plau        1.55637 -0.958332 -0.607275   0.29082  1.11634   1.6484
## Pnp         0.55022 -0.616947  0.310654   0.45014  1.33056   1.5180
## Ppa1        0.91259 -1.014504  0.247976   0.82903  1.15320   1.3571
## Procr       1.25593 -1.063133 -0.076071   0.81675  0.81695   1.5369
## Psmb10      1.02687 -0.979829  0.175241   1.08019  1.04707   1.3538
## Ptgs2       0.77606 -1.057363 -0.130562   0.51766  1.09303   1.8137
## Pydc4       1.30346 -1.069764  0.473443   1.40309  1.08289   0.7854
## Rnf213      1.29889 -1.202722  0.231809   1.37594  1.18118   1.0185
## Rtp4        1.01717 -1.169042  0.002673   1.10002  1.27483   1.3115
## Serpina3f   0.91729 -1.252431  0.310579   0.86715  0.85791   1.0531
## Serpina3g   0.83066 -1.189721  0.215231   0.77767  0.94263   1.1401
## Serpina3n   1.01127 -1.332723  0.605127   0.73233  0.82057   0.2346
## Slamf8      1.00458 -1.239395 -0.078989   0.79517  1.04247   1.3787
## Slfn4       1.70335 -1.130757 -0.279779   0.05441  1.41159   1.5578
## Smpdl3b     0.48318 -0.890244 -0.404693   0.67668  1.51393   1.2633
## Socs1       0.95992 -1.142510  0.524817   1.20140  0.82028   0.9523
## Socs3       0.85233 -0.798917  0.289839   0.82483  0.94066   1.1995
## Srm         1.01350 -0.725811  0.638081   0.85061  1.09814   1.2296
## Stat1       1.13334 -1.331103  0.619904   1.14155  0.77714   0.6847
## Stat2       1.33710 -1.202606  0.261623   1.35305  0.98519   0.8470
## Steap3      0.21168 -0.238498  1.101176   0.24713  0.97638   1.2479
## Syce2       0.10832 -0.349306  0.317246   0.27733  1.15952   1.3915
## Tap1        1.09983 -1.031130  0.284708   1.04099  0.89021   0.9586
## Tgm2        1.58276 -0.831931  0.002498   0.72144  0.62253   1.2146
## Tgtp1       0.90338 -1.178443  0.464837   0.96074  0.99680   1.0865
## Tgtp2       0.91222 -1.215213  0.619528   1.04694  0.85070   1.0050
## Timp1       0.89215 -1.175029 -0.070954   1.14393  1.14244   1.4490
## Tmem255a   -0.80715  0.327191 -0.071823  -0.42855 -0.83909  -1.6321
## Tnc         1.08054 -0.828081  0.053570   1.48362 -0.03159   0.9873
## Tubb3       0.72746 -1.082102 -0.222711   0.48282  1.24596   1.6766
## Tubb6       1.06900 -0.619923 -0.098152   0.71772  1.11298   0.9687
## Ubd         0.83632 -1.129633  0.206517   0.64205  0.91771   1.2389
## Upp1        1.14027 -0.767930 -0.352334   0.30393  1.17134   1.4671
## Usp18       1.13992 -0.864288  0.153537   1.50609  1.39331   1.2515
## Vdr         1.48845 -1.036752 -0.163986   1.06956  0.82540   0.8188
## Wars        1.15344 -1.233468  0.164411   1.04848  0.70608   0.9918
## Xaf1        1.07479 -1.048458  0.056383   1.09352  1.36613   1.2288
## Zbp1        1.00323 -1.124500  0.327676   0.94627  1.08861   1.1158
##            mt.d4.r3 mt.d4.r4 rtmt.d4.r1 rtmt.d4.r2 rtmt.d4.r3 rtmt.d4.r4
## Apol10b   -1.515528   1.1677   -0.85339  0.4337289   0.514894    0.92167
## Apol6     -1.018900   1.3003   -0.97244  0.4166140   0.663266    0.60667
## Asns      -0.004198   0.7003   -1.17743  1.1062550   0.720859   -0.22806
## Aunip     -0.189519   1.4198   -1.09190  0.8956344   0.734317   -0.39487
## Batf2     -1.189306   1.6674   -0.63763 -0.1572878   0.549955    0.88766
## Bcl2l14   -1.223246   0.9889   -0.93078  0.8013715   0.864689    0.55921
## Ccl2      -0.754913   1.5507   -0.93215  0.0343500   0.283653    0.10524
## Cd163      0.730019  -1.3164    0.48783 -0.5025186  -0.279315   -0.46616
## Cd274     -1.012018   1.2483   -0.81090  0.4174181   0.667570    0.76945
## Cdc45     -0.310313   1.3344   -1.15709  0.5578545   0.575281    0.07413
## Chaf1a    -0.176858   1.3792   -1.09693  1.0183176   0.450705   -0.10970
## Cmpk2     -0.536109   0.7886   -1.06877  0.8310213   0.645585    0.24370
## Cxcl10    -0.866544   1.3252   -0.97541  0.4585692   0.841171    0.79058
## Cxcl9     -0.953420   1.0112   -0.83402  0.4837435   0.776425    0.67016
## Dtl        0.049414   1.0575   -1.29251  0.9428173   0.741391   -0.14739
## Fam132a    0.305220   0.9889   -0.94519  1.2431722   0.438224   -0.25455
## Fam13a     0.949765  -1.6011    0.57566 -0.5649456  -0.554482    0.27119
## Fam26f    -0.938394   1.5344   -0.76138  0.1694839   0.643833    0.64629
## Fanci     -0.345428   1.1324   -1.01187  1.0193084   0.544495   -0.53511
## Fcgr4     -0.806943   1.3632   -0.80864  0.4306558   0.758604    0.97157
## Fos        0.448721   0.5723   -1.12123  0.9476391   0.060094    1.24245
## Gbp11     -0.882095   1.2295   -0.65231  0.3933427   0.702450    0.45346
## Gbp2      -0.869098   1.0173   -0.86085  0.5564883   0.819337    0.73044
## Gbp3      -0.984722   1.3424   -0.93939  0.2251070   0.704083    0.83409
## Gbp4      -0.891694   1.0881   -0.86203  0.4909837   0.870797    0.76470
## Gbp2b     -0.765272   1.8305   -0.75179 -0.0623803   0.469066    0.69359
## Gm43302   -0.717391   1.0282   -0.74889  0.5634416   0.770269    0.72808
## Gbp7      -0.853470   1.1885   -0.94157  0.5504144   0.818673    0.70284
## Gm12185   -0.549681   1.1349   -0.71248  0.5456387   0.687659    0.74808
## Gm12250   -0.856067   1.1037   -0.72964  0.4573584   0.920532    0.75487
## Ifit1bl1  -1.075656   0.6681   -1.22487  0.4363658   0.693912    0.68603
## Gm17334   -0.892454   0.5063   -0.84434  0.5692591   0.844871    0.97575
## Gm1966    -1.074622   0.4266   -0.74691  0.6393753   1.025932    0.98268
## Gm4070    -0.878025   0.9879   -0.54753  0.5349880   0.917653    0.91256
## Gm4841    -0.681395   1.5365   -0.68724  0.0999311   0.592233    1.03446
## Gm4951    -0.973809   1.4344   -0.71167  0.2043559   0.787029    0.98008
## Gvin1     -0.955279   0.8999   -0.69813  0.5001008   0.885885    0.90452
## Has2      -0.610477   1.0763   -1.06235  0.6753655   0.543603    0.53626
## Hk3       -1.094223   1.4820   -0.66618  0.3628932   0.496527    0.78957
## Hspa1a     0.212451   1.0554   -1.02463 -0.8769896   1.110681    1.43175
## Hspa1b     0.350478   1.0116   -1.37871 -0.6503782   0.971683    1.22573
## Htra3      0.750375  -0.4745    0.81832 -0.7754773  -0.770862   -0.06192
## Ifi204    -0.982574   1.4036   -0.63603  0.0840915   0.584826    0.80633
## Ifi44     -0.864554   1.0885   -0.53135 -0.1224125   0.681941    0.60532
## Ifi47     -0.852390   1.0723   -0.87706  0.4727541   0.812775    0.69189
## Ifit1     -1.094992   0.8268   -1.01688  0.4576419   0.505875    0.39590
## Ifit2     -1.204218   1.0066   -1.13848  0.3163863   0.509993    0.52205
## Ifit3     -1.199485   0.6962   -0.97489  0.4132760   0.487626    0.61282
## Igfbp3     1.053224  -1.4273    0.70590 -0.5624834  -0.451546   -0.31544
## Igtp      -0.744467   1.0602   -0.76515  0.5310537   0.805203    0.80685
## Iigp1     -0.906253   1.1334   -0.72499  0.4750411   0.830811    0.87728
## Il12rb1   -1.181724   1.1546   -1.06682  0.3788204   0.610855    0.76747
## Il1rn     -0.783610   1.5719   -0.83072  0.1085717   0.109658    0.13336
## Il2ra     -0.526412   1.0568   -0.75571  0.3494787   1.173707    0.52964
## Irf1      -0.823543   1.0429   -0.82359  0.5510743   0.902654    0.84299
## Irf7      -0.939432   1.1033   -0.74887  0.3925371   0.320814    0.29182
## Acod1     -0.590357   1.5432   -1.06905  0.2184818   0.487029    0.20686
## Irgm1     -0.892476   1.0801   -0.81518  0.5050357   0.811026    0.72175
## Irgm2     -0.889494   0.9211   -0.79721  0.5050466   0.956932    0.93502
## Klra2     -1.170516   0.9673   -0.71820  0.3960998   0.904268    1.16963
## Lgals9    -0.794993   1.3216   -0.99404  0.6316929   0.578267    0.29583
## Lif       -0.909203   0.6549   -0.79398 -0.1727414   0.514548    0.39665
## Lox        1.021256  -0.2675    0.71746 -0.7688537  -1.635197   -1.22895
## Lrr1      -0.357068   0.6781   -1.17340  1.3024910   1.105790    0.47358
## Ly6a      -1.032006   1.5069   -0.63478  0.0000794   0.530562    0.58593
## Ly6i      -1.192581   1.4295   -0.68550 -0.1716454   0.554884    0.61963
## Mab21l3    0.104970   0.3599    0.01534  0.5936615   1.333302    1.36306
## Maff      -0.677340   0.9696   -0.46923  0.1081148   0.849017    0.59905
## Mcm10      0.181950   1.4042   -1.27576  0.6973745   0.611185   -0.13187
## Mlkl      -0.830465   1.6766   -0.89967  0.0128802   0.454472    0.47862
## Mmp13     -0.880654   1.5924   -0.96483  0.0498276   0.523700    0.39703
## Mnda      -1.012634   1.3678   -0.75733  0.2750600   0.552248    0.64497
## Mt2       -0.288724   1.3441   -1.23175  0.6571230   0.495258   -0.08671
## Mx1       -1.020438   0.5063   -0.98726  0.3432440   0.654637    0.50182
## Nampt     -0.950558   1.2856   -0.88519  0.3382774   0.735376    0.57207
## Nlrc5     -0.848777   0.5924   -0.51083  0.5697001   0.937017    0.99509
## Oas3      -0.578230   1.0561   -0.97332  0.6385077   0.427818    0.16974
## Oasl2     -1.045235   1.1449   -0.71788  0.4294215   0.488824    0.57542
## Oit3       1.242761  -0.9736    0.63985 -1.0238144  -0.457304   -0.29417
## Parp9     -0.828880   0.9243   -0.84754  0.5254683   0.684355    0.59355
## Pla2g16   -0.974407   1.1819   -0.78044  0.5912197   0.773061    0.37697
## Ppa1      -0.730950   1.1875   -1.01527  0.2145155   0.852959    0.49479
## Ptgs2     -0.911831   1.8589   -0.84814  0.1685095   0.241010    0.15091
## Rad51     -0.146919   1.2444   -0.83597  0.7567505   0.684086    0.05930
## Rnd1      -0.532473   1.6301   -0.85072  1.7344075   0.777060   -0.12491
## Rtp4      -1.246178   0.7743   -0.79808  0.4009643   0.630642    0.62718
## Serpina3f -0.773189   1.2523   -0.73758  0.4437319   0.803032    0.91590
## Serpina3g -0.879204   1.3567   -0.59810  0.4281183   0.784919    0.86113
## Serpina3n -0.310043   0.4155   -0.23049  0.7463056   1.222651    1.04189
## Shcbp1    -0.164222   1.5627   -0.87639  0.8685367   0.517160   -0.14928
## Slamf8    -1.203773   1.5213   -0.73618  0.0483946   0.621533    0.64971
## Slc7a11    0.368638   0.8438   -0.40635  0.7593127   1.193928    0.64231
## Smpdl3b   -0.335938   1.6041   -0.39843  0.1684796   0.234765    0.82714
## Socs1     -0.887805   1.1834   -0.93114  0.3351023   0.802524    0.71165
## Socs3     -0.904271   1.7877   -0.44327  0.0343458   0.504529    0.48940
## Sphk1      0.408029   1.1119   -1.35115  1.1393206   0.381226   -0.38133
## Stat1     -0.805112   0.6932   -0.79048  0.5988993   0.850025    1.00404
## Steap3     0.411938   0.9859   -1.12532  0.9643731   0.365527   -0.13308
## Syce2     -0.058199   1.2481   -1.10912  0.8384590   0.843710    0.19576
## Tap1      -1.042218   1.1129   -0.41769  0.4196578   0.636701    0.89998
## Tgtp1     -0.785544   1.0565   -0.83481  0.5284628   0.803172    0.72010
## Tgtp2     -0.785673   0.8928   -0.70569  0.5221855   0.866434    0.81734
## Tnip3     -0.114057   2.4624   -0.40215  0.3026635   0.052278    0.67044
## Trip13    -0.859274   1.6723   -0.44720  0.4240324   0.381154    0.39889
## Tubb3     -0.975045   1.7706   -0.71086  0.0852845   0.644707    0.15050
## Ubd       -0.869986   1.5123   -0.88682  0.3505216   0.744957    0.87262
## Upp1      -0.937719   1.8717   -0.48427 -0.0507237   0.476065    0.31927
## Vdr       -0.232632   1.5016   -0.73483  0.0874288   0.449741    0.64547
## Wars      -1.064358   1.1535   -0.82411  0.4137854   0.900180    0.85047
## Xaf1      -0.865759   0.5846   -1.09198  0.6113997   0.599121    0.61136
## Zbp1      -0.831118   1.0238   -0.77614  0.4782392   0.711561    0.75059
## Abca9      0.803707  -1.2283    0.78374 -0.3316173  -0.306130    0.06618
## Apol10b   -1.515528   1.1677   -0.85339  0.4337289   0.514894    0.92167
## Apol6     -1.018900   1.3003   -0.97244  0.4166140   0.663266    0.60667
## Asns      -0.004198   0.7003   -1.17743  1.1062550   0.720859   -0.22806
## Aunip     -0.189519   1.4198   -1.09190  0.8956344   0.734317   -0.39487
## Bag2       0.220944   1.0520   -1.93241  0.5975825   0.839645    0.11954
## Batf2     -1.189306   1.6674   -0.63763 -0.1572878   0.549955    0.88766
## Bcl2l14   -1.223246   0.9889   -0.93078  0.8013715   0.864689    0.55921
## Bst2      -0.900294   0.9586   -0.87153  0.0710206   0.620794    0.59732
## Ccl19     -0.323624  -0.3523   -0.57249  0.3248564   1.052737    1.04876
## Ccl2      -0.754913   1.5507   -0.93215  0.0343500   0.283653    0.10524
## Cd163      0.730019  -1.3164    0.48783 -0.5025186  -0.279315   -0.46616
## Cd274     -1.012018   1.2483   -0.81090  0.4174181   0.667570    0.76945
## Cdc45     -0.310313   1.3344   -1.15709  0.5578545   0.575281    0.07413
## Cdkn1a    -0.692249   1.9039   -0.67637  0.3053204   0.438114    0.32336
## Cebpb     -0.672271   1.4321   -0.56301 -0.7681995   0.215301    0.44432
## Cela1     -0.285088  -0.5006    1.20263 -0.0309173   0.226227   -1.11073
## Cmpk2     -0.536109   0.7886   -1.06877  0.8310213   0.645585    0.24370
## Ctrl      -0.658739  -0.5735    1.21071 -0.6837133   0.311691   -0.45987
## Ctsf       1.148920  -1.4388    0.48143  0.8033281  -0.023603   -0.74000
## Cxcl10    -0.866544   1.3252   -0.97541  0.4585692   0.841171    0.79058
## Cxcl9     -0.953420   1.0112   -0.83402  0.4837435   0.776425    0.67016
## Dhx58     -0.951706   0.7167   -1.16609  0.2683128   0.306345    0.46664
## Dram1     -0.924243   1.4849   -0.59305  0.1947324   0.661235    0.52756
## Dtl        0.049414   1.0575   -1.29251  0.9428173   0.741391   -0.14739
## Fam132a    0.305220   0.9889   -0.94519  1.2431722   0.438224   -0.25455
## Fam13a     0.949765  -1.6011    0.57566 -0.5649456  -0.554482    0.27119
## Fam26f    -0.938394   1.5344   -0.76138  0.1694839   0.643833    0.64629
## Fanci     -0.345428   1.1324   -1.01187  1.0193084   0.544495   -0.53511
## Fcgr4     -0.806943   1.3632   -0.80864  0.4306558   0.758604    0.97157
## Fpr2      -1.306588   1.7440   -0.64784  0.0520389   0.167446    0.12155
## Gbp11     -0.882095   1.2295   -0.65231  0.3933427   0.702450    0.45346
## Gbp2      -0.869098   1.0173   -0.86085  0.5564883   0.819337    0.73044
## Gbp3      -0.984722   1.3424   -0.93939  0.2251070   0.704083    0.83409
## Gbp4      -0.891694   1.0881   -0.86203  0.4909837   0.870797    0.76470
## Gbp2b     -0.765272   1.8305   -0.75179 -0.0623803   0.469066    0.69359
## Gm43302   -0.717391   1.0282   -0.74889  0.5634416   0.770269    0.72808
## Gbp7      -0.853470   1.1885   -0.94157  0.5504144   0.818673    0.70284
## Gbp8      -0.981757   1.4438   -0.92791  0.2125342   0.841298    0.87504
## Gbp9      -1.058040   0.5003   -0.78874  0.5865367   0.918671    0.82233
## Gm12185   -0.549681   1.1349   -0.71248  0.5456387   0.687659    0.74808
## Gm12250   -0.856067   1.1037   -0.72964  0.4573584   0.920532    0.75487
## Ifit1bl1  -1.075656   0.6681   -1.22487  0.4363658   0.693912    0.68603
## Gm17334   -0.892454   0.5063   -0.84434  0.5692591   0.844871    0.97575
## Gm1966    -1.074622   0.4266   -0.74691  0.6393753   1.025932    0.98268
## Gm4070    -0.878025   0.9879   -0.54753  0.5349880   0.917653    0.91256
## Gm4841    -0.681395   1.5365   -0.68724  0.0999311   0.592233    1.03446
## Gm4951    -0.973809   1.4344   -0.71167  0.2043559   0.787029    0.98008
## Gm5431    -1.133689   0.9374   -1.11368 -0.0294804   0.631682    0.67769
## Gvin1     -0.955279   0.8999   -0.69813  0.5001008   0.885885    0.90452
## Has2      -0.610477   1.0763   -1.06235  0.6753655   0.543603    0.53626
## Hdc       -0.980179   1.0851    0.37293 -0.7364492   0.553242   -0.05281
## Hk3       -1.094223   1.4820   -0.66618  0.3628932   0.496527    0.78957
## Hspa1a     0.212451   1.0554   -1.02463 -0.8769896   1.110681    1.43175
## Hspa1b     0.350478   1.0116   -1.37871 -0.6503782   0.971683    1.22573
## Hsph1      0.612808   0.8973   -1.31289 -0.8189453   0.981220    1.01817
## Htra3      0.750375  -0.4745    0.81832 -0.7754773  -0.770862   -0.06192
## Ifit3b    -1.349914   0.2472   -1.28444  0.4602188   0.231869    0.58405
## Ifi204    -0.982574   1.4036   -0.63603  0.0840915   0.584826    0.80633
## Ifi205    -1.107910   1.4672   -0.79222  0.0228990   0.571987    0.76619
## Ifi44     -0.864554   1.0885   -0.53135 -0.1224125   0.681941    0.60532
## Ifi47     -0.852390   1.0723   -0.87706  0.4727541   0.812775    0.69189
## Ifit1     -1.094992   0.8268   -1.01688  0.4576419   0.505875    0.39590
## Ifit2     -1.204218   1.0066   -1.13848  0.3163863   0.509993    0.52205
## Ifit3     -1.199485   0.6962   -0.97489  0.4132760   0.487626    0.61282
## Ifitm3    -1.101613   1.0059   -1.02295  0.1547487   0.517000    0.61676
## Igfbp3     1.053224  -1.4273    0.70590 -0.5624834  -0.451546   -0.31544
## Igtp      -0.744467   1.0602   -0.76515  0.5310537   0.805203    0.80685
## Iigp1     -0.906253   1.1334   -0.72499  0.4750411   0.830811    0.87728
## Il12rb1   -1.181724   1.1546   -1.06682  0.3788204   0.610855    0.76747
## Il1rn     -0.783610   1.5719   -0.83072  0.1085717   0.109658    0.13336
## Irf1      -0.823543   1.0429   -0.82359  0.5510743   0.902654    0.84299
## Irf7      -0.939432   1.1033   -0.74887  0.3925371   0.320814    0.29182
## Acod1     -0.590357   1.5432   -1.06905  0.2184818   0.487029    0.20686
## Irgm1     -0.892476   1.0801   -0.81518  0.5050357   0.811026    0.72175
## Irgm2     -0.889494   0.9211   -0.79721  0.5050466   0.956932    0.93502
## Isg15     -0.962480   0.9483   -1.07605  0.5283167   0.482945    0.12608
## Lgals9    -0.794993   1.3216   -0.99404  0.6316929   0.578267    0.29583
## Lif       -0.909203   0.6549   -0.79398 -0.1727414   0.514548    0.39665
## Ly6a      -1.032006   1.5069   -0.63478  0.0000794   0.530562    0.58593
## Ly6c2     -0.773501   1.7278   -0.72194 -0.0707689   0.478594    0.27535
## Ly6i      -1.192581   1.4295   -0.68550 -0.1716454   0.554884    0.61963
## Maff      -0.677340   0.9696   -0.46923  0.1081148   0.849017    0.59905
## Mcm10      0.181950   1.4042   -1.27576  0.6973745   0.611185   -0.13187
## Mlkl      -0.830465   1.6766   -0.89967  0.0128802   0.454472    0.47862
## Mmp13     -0.880654   1.5924   -0.96483  0.0498276   0.523700    0.39703
## Mnda      -1.012634   1.3678   -0.75733  0.2750600   0.552248    0.64497
## Mt1       -0.012761   1.3886   -0.63210  0.6353905   0.277525   -0.02733
## Mt2       -0.288724   1.3441   -1.23175  0.6571230   0.495258   -0.08671
## Mx1       -1.020438   0.5063   -0.98726  0.3432440   0.654637    0.50182
## Nampt     -0.950558   1.2856   -0.88519  0.3382774   0.735376    0.57207
## Nlrc5     -0.848777   0.5924   -0.51083  0.5697001   0.937017    0.99509
## Nme1      -0.210952   1.5690   -0.92397 -0.0354928   0.438094    0.55307
## Oas1a     -0.832728   1.1426   -0.79335  0.0653851   0.535767    0.35262
## Oas2      -0.887888   0.9998   -0.96661 -0.0944791   0.447169    0.56035
## Oas3      -0.578230   1.0561   -0.97332  0.6385077   0.427818    0.16974
## Oasl1     -0.851660   0.6382   -1.56568  0.3186353   0.402184    0.62759
## Oasl2     -1.045235   1.1449   -0.71788  0.4294215   0.488824    0.57542
## Oit3       1.242761  -0.9736    0.63985 -1.0238144  -0.457304   -0.29417
## Parp14    -0.954581   0.8862   -0.81028  0.3805069   0.786591    0.87142
## Parp9     -0.828880   0.9243   -0.84754  0.5254683   0.684355    0.59355
## Phf11a    -1.830497   1.1593   -0.29327  0.2396068   0.569664    0.31035
## Phf11d    -0.845480   1.1842   -0.74702 -0.1173955   0.231848    0.49623
## Pkib      -1.271616   0.9987   -0.83024  0.4194200   0.886897    0.61008
## Pla2g16   -0.974407   1.1819   -0.78044  0.5912197   0.773061    0.37697
## Plau      -0.769812   1.6264   -0.76384  0.2307859   0.127771    0.14834
## Pnp       -0.370907   1.2699   -1.12548  0.6847387   0.479218    0.01527
## Ppa1      -0.730950   1.1875   -1.01527  0.2145155   0.852959    0.49479
## Procr     -0.941462   1.7324   -0.93128 -0.0420114   0.324809    0.30274
## Psmb10    -0.757977   1.1266   -0.85191  0.3677374   0.553877    0.55859
## Ptgs2     -0.911831   1.8589   -0.84814  0.1685095   0.241010    0.15091
## Pydc4     -1.061275   0.2133   -0.99605  0.5825475   0.678454    0.77121
## Rnf213    -0.900257   0.6356   -1.03198  0.3755949   0.545998    0.60130
## Rtp4      -1.246178   0.7743   -0.79808  0.4009643   0.630642    0.62718
## Serpina3f -0.773189   1.2523   -0.73758  0.4437319   0.803032    0.91590
## Serpina3g -0.879204   1.3567   -0.59810  0.4281183   0.784919    0.86113
## Serpina3n -0.310043   0.4155   -0.23049  0.7463056   1.222651    1.04189
## Slamf8    -1.203773   1.5213   -0.73618  0.0483946   0.621533    0.64971
## Slfn4     -0.886211   1.0092   -0.21877 -0.5278365  -0.001034    0.61738
## Smpdl3b   -0.335938   1.6041   -0.39843  0.1684796   0.234765    0.82714
## Socs1     -0.887805   1.1834   -0.93114  0.3351023   0.802524    0.71165
## Socs3     -0.904271   1.7877   -0.44327  0.0343458   0.504529    0.48940
## Srm       -0.753434   1.3037   -1.06393  0.2101428   0.606951    0.27215
## Stat1     -0.805112   0.6932   -0.79048  0.5988993   0.850025    1.00404
## Stat2     -0.992289   0.7940   -0.78105  0.3175716   0.657312    0.76218
## Steap3     0.411938   0.9859   -1.12532  0.9643731   0.365527   -0.13308
## Syce2     -0.058199   1.2481   -1.10912  0.8384590   0.843710    0.19576
## Tap1      -1.042218   1.1129   -0.41769  0.4196578   0.636701    0.89998
## Tgm2      -0.898778   1.5852   -0.86010  0.2496520   0.497070    0.47398
## Tgtp1     -0.785544   1.0565   -0.83481  0.5284628   0.803172    0.72010
## Tgtp2     -0.785673   0.8928   -0.70569  0.5221855   0.866434    0.81734
## Timp1     -0.807550   1.2413   -0.55812  0.3030225   0.845385   -0.32096
## Tmem255a   0.403720  -2.0304    0.77634 -0.3645285  -0.255565    0.35629
## Tnc       -1.855952   1.4820   -0.06680  0.1510668  -0.294146    1.14544
## Tubb3     -0.975045   1.7706   -0.71086  0.0852845   0.644707    0.15050
## Tubb6     -0.779705   1.5667   -1.16596  0.5670802   0.729532    0.45478
## Ubd       -0.869986   1.5123   -0.88682  0.3505216   0.744957    0.87262
## Upp1      -0.937719   1.8717   -0.48427 -0.0507237   0.476065    0.31927
## Usp18     -0.995894   0.5272   -0.95683  0.1660283   0.523158    0.39134
## Vdr       -0.232632   1.5016   -0.73483  0.0874288   0.449741    0.64547
## Wars      -1.064358   1.1535   -0.82411  0.4137854   0.900180    0.85047
## Xaf1      -0.865759   0.5846   -1.09198  0.6113997   0.599121    0.61136
## Zbp1      -0.831118   1.0238   -0.77614  0.4782392   0.711561    0.75059
##           naive.r1 naive.r2 naive.r3 naive.r4
## Apol10b    -1.4750  -1.0621 -0.86759 -0.44850
## Apol6      -0.8674  -1.3543 -1.03983 -0.72572
## Asns       -1.6345  -0.9565 -0.30537 -1.97332
## Aunip      -1.2526  -1.0391 -0.24653 -1.84023
## Batf2      -1.1021  -0.8736 -0.99783 -1.06414
## Bcl2l14    -0.9517  -0.9464 -1.30618 -0.92888
## Ccl2       -1.0354  -1.0024 -0.95414 -0.93838
## Cd163       1.1942   0.9002  1.17049  1.13081
## Cd274      -1.1458  -1.0297 -1.22342 -0.95679
## Cdc45      -1.6194  -0.7630 -0.34559 -1.65936
## Chaf1a     -1.5445  -1.2244 -0.40394 -1.31231
## Cmpk2      -1.5952  -1.1642 -0.15998 -1.32646
## Cxcl10     -1.1633  -1.1775 -1.05589 -1.05486
## Cxcl9      -1.0042  -1.3495 -1.35403 -1.06587
## Dtl        -1.4596  -1.0282 -0.22764 -1.86650
## Fam132a    -1.5462  -0.8105 -0.52259 -1.98331
## Fam13a      1.5896   0.8121  0.66748  1.52986
## Fam26f     -1.0649  -1.1965 -1.23567 -0.82792
## Fanci      -1.5756  -0.9854 -0.55958 -1.55777
## Fcgr4      -1.3463  -0.9625 -1.12069 -1.02943
## Fos        -1.0351  -0.7014 -2.04499 -0.40070
## Gbp11      -1.5027  -1.4864 -1.03473 -0.61058
## Gbp2       -1.2056  -1.1229 -1.27494 -0.99891
## Gbp3       -1.2477  -0.9285 -1.10259 -0.84008
## Gbp4       -1.1120  -1.1569 -1.39501 -1.00718
## Gbp2b      -1.1623  -0.9022 -1.03637 -0.84439
## Gm43302    -0.8405  -1.4637 -1.34114 -0.28926
## Gbp7       -1.3096  -1.0998 -1.10660 -1.04820
## Gm12185    -0.8760  -1.2622 -1.13329 -1.02433
## Gm12250    -1.2520  -1.1104 -1.27644 -1.04503
## Ifit1bl1   -1.2510  -0.7526 -1.23397 -0.82687
## Gm17334    -1.2675  -0.8550 -1.21474 -1.09393
## Gm1966     -1.2403  -1.0057 -1.30793 -1.07971
## Gm4070     -1.4606  -1.1192 -1.38484 -0.91970
## Gm4841     -1.3058  -1.0366 -1.17277 -0.74209
## Gm4951     -1.1234  -1.1073 -1.32299 -0.68756
## Gvin1      -1.3075  -1.1218 -1.34693 -1.00690
## Has2       -1.3805  -1.1279 -1.03423 -1.06867
## Hk3        -1.3055  -1.0252 -1.08819 -0.91376
## Hspa1a     -0.3705  -0.3775 -1.93261 -1.14881
## Hspa1b     -0.7843  -0.7462 -1.63254 -1.09634
## Htra3       1.2215   1.3211  0.68414  1.28473
## Ifi204     -1.4841  -0.8835 -1.04969 -0.86665
## Ifi44      -1.4285  -0.9927 -0.98632 -0.71627
## Ifi47      -1.2341  -1.0679 -1.29387 -1.09786
## Ifit1      -1.1479  -1.1623 -0.75274 -0.88864
## Ifit2      -1.1878  -0.8538 -1.05273 -0.74415
## Ifit3      -1.1321  -0.9548 -0.90939 -0.60721
## Igfbp3      1.2759   1.1092  0.88959  1.32788
## Igtp       -1.2773  -1.1470 -1.31188 -1.12330
## Iigp1      -1.2446  -1.2356 -1.22689 -0.90078
## Il12rb1    -1.0811  -0.6705 -0.93382 -1.32973
## Il1rn      -0.9807  -1.3421 -1.02763 -0.67688
## Il2ra      -1.1678  -1.0811 -1.11751 -1.09728
## Irf1       -1.1644  -1.1860 -1.41010 -1.06426
## Irf7       -1.4153  -1.0967 -0.86143 -0.84102
## Acod1      -0.9823  -1.0414 -1.04615 -0.85162
## Irgm1      -1.3040  -1.1603 -1.18830 -1.04998
## Irgm2      -1.2739  -1.1160 -1.25320 -0.89448
## Klra2      -1.4428  -0.8560 -0.81331 -0.82834
## Lgals9     -1.2500  -1.0921 -0.88225 -1.05533
## Lif        -1.1196  -1.2966 -0.66979 -1.18530
## Lox         1.4550   0.8430  0.17276  1.34394
## Lrr1       -1.4689  -0.6389 -0.37655 -1.27892
## Ly6a       -1.3037  -0.9469 -1.21078 -0.83694
## Ly6i       -1.0783  -1.0850 -0.99250 -0.80897
## Mab21l3    -1.8109  -1.8055 -0.90818 -0.58602
## Maff       -0.8081  -1.6700 -1.52001 -1.23018
## Mcm10      -1.3778  -1.1804 -0.14503 -1.68025
## Mlkl       -1.2658  -1.0122 -0.96278 -0.69034
## Mmp13      -0.9167  -1.1401 -1.02950 -0.80970
## Mnda       -1.3384  -1.1398 -1.16680 -0.77313
## Mt2        -1.6043  -0.8950 -0.46683 -1.70919
## Mx1        -1.1570  -0.9840 -0.98250 -0.72057
## Nampt      -1.3047  -1.0810 -1.05394 -0.96846
## Nlrc5      -1.2375  -0.9388 -1.69600 -0.70404
## Oas3       -1.6267  -1.3017 -0.06213 -1.24305
## Oasl2      -1.3696  -1.1705 -1.03251 -0.61133
## Oit3        1.5397   1.0455  0.63696  1.09085
## Parp9      -1.1787  -1.1729 -1.10603 -1.08483
## Pla2g16    -1.2366  -1.2472 -0.39834 -1.57024
## Ppa1       -1.4482  -0.8813 -1.17583 -0.98363
## Ptgs2      -1.0518  -0.8595 -0.86511 -0.89542
## Rad51      -2.1641  -0.9101 -0.14311 -1.35914
## Rnd1       -0.3828  -1.7156 -1.52187 -0.42426
## Rtp4       -1.3826  -1.0706 -1.01898 -0.45378
## Serpina3f  -1.3007  -1.1587 -1.26469 -0.93370
## Serpina3g  -1.2826  -1.2239 -1.25348 -0.91025
## Serpina3n  -0.8520  -0.8452 -2.05278 -1.20708
## Shcbp1     -1.8142  -0.9970  0.09238 -1.25222
## Slamf8     -0.8319  -0.8786 -1.21659 -0.87647
## Slc7a11    -1.3491  -1.6647 -1.48703 -0.77641
## Smpdl3b    -1.5101  -1.1926 -1.20627 -0.83326
## Socs1      -1.2287  -1.1762 -1.11367 -1.01144
## Socs3      -1.1679  -1.1384 -1.49068 -0.97972
## Sphk1      -1.0482  -1.2942 -0.08330 -1.71014
## Stat1      -1.2473  -1.1704 -1.28649 -0.87188
## Steap3     -1.5759  -1.0646 -0.41645 -1.95819
## Syce2      -1.6606  -1.0240 -0.38806 -1.79073
## Tap1       -1.1954  -1.0848 -1.43788 -1.13448
## Tgtp1      -1.2063  -1.1000 -1.32352 -1.09182
## Tgtp2      -1.2873  -1.3296 -1.16488 -1.04485
## Tnip3      -0.9128  -0.5357 -0.93379 -0.89492
## Trip13     -1.2337  -1.0661 -0.58439 -1.08260
## Tubb3      -0.8346  -0.9727 -1.02798 -0.95786
## Ubd        -1.0891  -1.1517 -1.06557 -1.12908
## Upp1       -1.2481  -0.7999 -1.06116 -1.04748
## Vdr        -1.3254  -1.3883 -0.90670 -1.09787
## Wars       -0.8876  -0.9233 -1.38659 -1.06270
## Xaf1       -1.3447  -1.2951 -0.94235 -0.63765
## Zbp1       -1.2165  -1.0606 -1.42137 -1.01553
## Abca9       1.0877   0.9860  0.96226  0.97186
## Apol10b    -1.4750  -1.0621 -0.86759 -0.44850
## Apol6      -0.8674  -1.3543 -1.03983 -0.72572
## Asns       -1.6345  -0.9565 -0.30537 -1.97332
## Aunip      -1.2526  -1.0391 -0.24653 -1.84023
## Bag2       -0.7837  -1.0599 -0.30615 -2.00127
## Batf2      -1.1021  -0.8736 -0.99783 -1.06414
## Bcl2l14    -0.9517  -0.9464 -1.30618 -0.92888
## Bst2       -1.3310  -1.0721 -1.13289 -0.72761
## Ccl19      -1.1011  -1.1081 -1.68594 -0.82553
## Ccl2       -1.0354  -1.0024 -0.95414 -0.93838
## Cd163       1.1942   0.9002  1.17049  1.13081
## Cd274      -1.1458  -1.0297 -1.22342 -0.95679
## Cdc45      -1.6194  -0.7630 -0.34559 -1.65936
## Cdkn1a     -1.0313  -1.2776 -1.25114 -1.01790
## Cebpb      -1.4832  -1.2045 -1.69883 -0.36823
## Cela1      -0.7957   0.3682 -0.53358 -1.07854
## Cmpk2      -1.5952  -1.1642 -0.15998 -1.32646
## Ctrl       -0.9124   0.4040 -0.61492 -0.73229
## Ctsf        0.6481   0.9201  1.51501  0.74146
## Cxcl10     -1.1633  -1.1775 -1.05589 -1.05486
## Cxcl9      -1.0042  -1.3495 -1.35403 -1.06587
## Dhx58      -1.2542  -0.8743 -1.18724 -0.65387
## Dram1      -1.4900  -1.0881 -1.05930 -0.87603
## Dtl        -1.4596  -1.0282 -0.22764 -1.86650
## Fam132a    -1.5462  -0.8105 -0.52259 -1.98331
## Fam13a      1.5896   0.8121  0.66748  1.52986
## Fam26f     -1.0649  -1.1965 -1.23567 -0.82792
## Fanci      -1.5756  -0.9854 -0.55958 -1.55777
## Fcgr4      -1.3463  -0.9625 -1.12069 -1.02943
## Fpr2       -0.9746  -1.1954 -0.60020 -0.51050
## Gbp11      -1.5027  -1.4864 -1.03473 -0.61058
## Gbp2       -1.2056  -1.1229 -1.27494 -0.99891
## Gbp3       -1.2477  -0.9285 -1.10259 -0.84008
## Gbp4       -1.1120  -1.1569 -1.39501 -1.00718
## Gbp2b      -1.1623  -0.9022 -1.03637 -0.84439
## Gm43302    -0.8405  -1.4637 -1.34114 -0.28926
## Gbp7       -1.3096  -1.0998 -1.10660 -1.04820
## Gbp8       -1.2398  -1.0863 -1.08047 -0.92009
## Gbp9       -1.2133  -1.1416 -1.26963 -0.87372
## Gm12185    -0.8760  -1.2622 -1.13329 -1.02433
## Gm12250    -1.2520  -1.1104 -1.27644 -1.04503
## Ifit1bl1   -1.2510  -0.7526 -1.23397 -0.82687
## Gm17334    -1.2675  -0.8550 -1.21474 -1.09393
## Gm1966     -1.2403  -1.0057 -1.30793 -1.07971
## Gm4070     -1.4606  -1.1192 -1.38484 -0.91970
## Gm4841     -1.3058  -1.0366 -1.17277 -0.74209
## Gm4951     -1.1234  -1.1073 -1.32299 -0.68756
## Gm5431     -1.1667  -0.9390 -0.94815 -0.23280
## Gvin1      -1.3075  -1.1218 -1.34693 -1.00690
## Has2       -1.3805  -1.1279 -1.03423 -1.06867
## Hdc        -1.4224  -1.1171 -1.20963 -0.94984
## Hk3        -1.3055  -1.0252 -1.08819 -0.91376
## Hspa1a     -0.3705  -0.3775 -1.93261 -1.14881
## Hspa1b     -0.7843  -0.7462 -1.63254 -1.09634
## Hsph1      -0.6184  -0.1929 -1.69022 -1.82955
## Htra3       1.2215   1.3211  0.68414  1.28473
## Ifit3b     -1.0485  -0.7553 -1.01988 -0.16786
## Ifi204     -1.4841  -0.8835 -1.04969 -0.86665
## Ifi205     -1.1370  -0.9502 -1.03566 -0.94198
## Ifi44      -1.4285  -0.9927 -0.98632 -0.71627
## Ifi47      -1.2341  -1.0679 -1.29387 -1.09786
## Ifit1      -1.1479  -1.1623 -0.75274 -0.88864
## Ifit2      -1.1878  -0.8538 -1.05273 -0.74415
## Ifit3      -1.1321  -0.9548 -0.90939 -0.60721
## Ifitm3     -1.2058  -0.9200 -1.06040 -0.76977
## Igfbp3      1.2759   1.1092  0.88959  1.32788
## Igtp       -1.2773  -1.1470 -1.31188 -1.12330
## Iigp1      -1.2446  -1.2356 -1.22689 -0.90078
## Il12rb1    -1.0811  -0.6705 -0.93382 -1.32973
## Il1rn      -0.9807  -1.3421 -1.02763 -0.67688
## Irf1       -1.1644  -1.1860 -1.41010 -1.06426
## Irf7       -1.4153  -1.0967 -0.86143 -0.84102
## Acod1      -0.9823  -1.0414 -1.04615 -0.85162
## Irgm1      -1.3040  -1.1603 -1.18830 -1.04998
## Irgm2      -1.2739  -1.1160 -1.25320 -0.89448
## Isg15      -1.4408  -1.0359 -0.10274 -1.26115
## Lgals9     -1.2500  -1.0921 -0.88225 -1.05533
## Lif        -1.1196  -1.2966 -0.66979 -1.18530
## Ly6a       -1.3037  -0.9469 -1.21078 -0.83694
## Ly6c2      -1.3443  -1.0029 -1.13349 -0.87563
## Ly6i       -1.0783  -1.0850 -0.99250 -0.80897
## Maff       -0.8081  -1.6700 -1.52001 -1.23018
## Mcm10      -1.3778  -1.1804 -0.14503 -1.68025
## Mlkl       -1.2658  -1.0122 -0.96278 -0.69034
## Mmp13      -0.9167  -1.1401 -1.02950 -0.80970
## Mnda       -1.3384  -1.1398 -1.16680 -0.77313
## Mt1        -1.7511  -0.9465 -0.81545 -1.95169
## Mt2        -1.6043  -0.8950 -0.46683 -1.70919
## Mx1        -1.1570  -0.9840 -0.98250 -0.72057
## Nampt      -1.3047  -1.0810 -1.05394 -0.96846
## Nlrc5      -1.2375  -0.9388 -1.69600 -0.70404
## Nme1       -1.6221  -0.4167 -1.36678 -1.45854
## Oas1a      -1.5023  -1.2965 -0.94415 -0.53434
## Oas2       -1.3638  -1.0233 -1.05796 -0.56764
## Oas3       -1.6267  -1.3017 -0.06213 -1.24305
## Oasl1      -1.2070  -0.9619 -0.90571 -0.83367
## Oasl2      -1.3696  -1.1705 -1.03251 -0.61133
## Oit3        1.5397   1.0455  0.63696  1.09085
## Parp14     -1.2835  -1.0071 -1.09373 -0.87941
## Parp9      -1.1787  -1.1729 -1.10603 -1.08483
## Phf11a     -1.1315  -0.8452 -1.05911 -0.41580
## Phf11d     -1.5435  -0.6092 -1.19003 -0.64720
## Pkib       -1.0573  -1.5047 -1.22970 -1.06373
## Pla2g16    -1.2366  -1.2472 -0.39834 -1.57024
## Plau       -0.9075  -0.9656 -0.91947 -0.85331
## Pnp        -1.4629  -1.1618 -0.23253 -1.63808
## Ppa1       -1.4482  -0.8813 -1.17583 -0.98363
## Procr      -0.6950  -1.0323 -1.19941 -0.80580
## Psmb10     -1.2617  -1.1801 -1.11692 -1.14153
## Ptgs2      -1.0518  -0.8595 -0.86511 -0.89542
## Pydc4      -1.2626  -0.8754 -1.32879 -0.69985
## Rnf213     -1.3174  -0.9378 -1.06848 -0.80623
## Rtp4       -1.3826  -1.0706 -1.01898 -0.45378
## Serpina3f  -1.3007  -1.1587 -1.26469 -0.93370
## Serpina3g  -1.2826  -1.2239 -1.25348 -0.91025
## Serpina3n  -0.8520  -0.8452 -2.05278 -1.20708
## Slamf8     -0.8319  -0.8786 -1.21659 -0.87647
## Slfn4      -1.5390  -0.9195 -0.76606 -0.08473
## Smpdl3b    -1.5101  -1.1926 -1.20627 -0.83326
## Socs1      -1.2287  -1.1762 -1.11367 -1.01144
## Socs3      -1.1679  -1.1384 -1.49068 -0.97972
## Srm        -1.1036  -0.8061 -1.44517 -1.32488
## Stat1      -1.2473  -1.1704 -1.28649 -0.87188
## Stat2      -1.2464  -1.1446 -1.17238 -0.77574
## Steap3     -1.5759  -1.0646 -0.41645 -1.95819
## Syce2      -1.6606  -1.0240 -0.38806 -1.79073
## Tap1       -1.1954  -1.0848 -1.43788 -1.13448
## Tgm2       -1.0616  -1.3045 -1.06941 -0.92349
## Tgtp1      -1.2063  -1.1000 -1.32352 -1.09182
## Tgtp2      -1.2873  -1.3296 -1.16488 -1.04485
## Timp1      -0.5555  -1.5640 -0.92957 -1.03549
## Tmem255a    0.9568   1.4593  0.83406  1.31550
## Tnc        -0.7693  -0.8696 -0.55021 -1.11784
## Tubb3      -0.8346  -0.9727 -1.02798 -0.95786
## Tubb6      -1.4114  -0.8273 -1.09900 -1.18500
## Ubd        -1.0891  -1.1517 -1.06557 -1.12908
## Upp1       -1.2481  -0.7999 -1.06116 -1.04748
## Usp18      -1.1548  -1.0552 -0.92030 -1.10476
## Vdr        -1.3254  -1.3883 -0.90670 -1.09787
## Wars       -0.8876  -0.9233 -1.38659 -1.06270
## Xaf1       -1.3447  -1.2951 -0.94235 -0.63765
## Zbp1       -1.2165  -1.0606 -1.42137 -1.01553
##     heat.list day delivery rep
## 13   naive.r1   0    naive   1
## 14   naive.r2   0    naive   2
## 15   naive.r3   0    naive   3
## 16   naive.r4   0    naive   4
## 1   sbp.d4.r1   4      sbp   1
## 2   sbp.d4.r2   4      sbp   2
## 3   sbp.d4.r3   4      sbp   3
## 4   sbp.d4.r4   4      sbp   4
## 9  rtmt.d4.r1   4     rtmt   1
## 10 rtmt.d4.r2   4     rtmt   2
## 11 rtmt.d4.r3   4     rtmt   3
## 12 rtmt.d4.r4   4     rtmt   4
## 5    mt.d4.r1   4       mt   1
## 6    mt.d4.r2   4       mt   2
## 7    mt.d4.r3   4       mt   3
## 8    mt.d4.r4   4       mt   4